Nakano Naoko 中野なおこ

Researcher Number	50733218
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2024: 昭和薬科大学, 薬学部, 講師 2019 – 2021: 昭和薬科大学, 薬学部, 助教 2015 – 2016: 昭和薬科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 49030:Experimental pathology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy
Keywords	Principal Investigator TMEPAI / C18ORF1 / ApcΔ716/+マウス / YAP / 腸上皮オルガノイド / オルガノイド / TMEPAI KOマウス / 腸オルガノイド / ノックアウトマウス / ApcΔ716/+ … More / 悪性中皮腫 / TMEPAIファミリー / TGF-βsignal / Hippo pathway / TMEPAI family Less

TMEPAIによる消化管腺腫形成制御機構の解明およびTMEPAI機能阻害化合物の探索Principal Investigator
- Principal Investigator
  
  中野なおこ
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Showa Pharmaceutical University
Regulatory mechanism of intestinal tumorigenesis by TMEPAIPrincipal Investigator
- Principal Investigator
  
  NAKANO Naoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Showa Pharmaceutical University
Elucidation of TMEPAI family-mediated inhibitory mechanism for YAP activityPrincipal Investigator
- Principal Investigator
  
  Nakano Naoko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa Pharmaceutical University
TMEPAI family inhibits proliferation of malignant mesothelioma cells.Principal Investigator
- Principal Investigator
  
  Nakano Naoko
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Showa Pharmaceutical University

All 2022 2021 2020 2017 2016 2015

All Journal Article Presentation

[Journal Article] Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader2022
- Author(s)
  Nakano Naoko、Fukuda Kazuo、Tashiro Etsu、Ishikawa Haruka、Nagano Waka、Kawamoto Rie、Mori Alice、Watanabe Misao、Yamazaki Ryu、Nakane Takahisa、Naito Mikihiko、Okamoto Iwao、Itoh Susumu
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: - Issue: 6 Pages: 631-640
- DOI
  10.1093/jb/mvac021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06975, KAKENHI-PROJECT-20K05732, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H03456
[Journal Article] Narciclasine is a novel YAP inhibitor that disturbs interaction between YAP and TEAD42021
- Author(s)
  Rie Kawamoto, Naoko Nakano, Haruka Ishikawaa, Etsu Tashiroa, Waka Nagano, Keigo Sano, Miki Irie, Mariko Ikuta, Fukuko Kishi, Takahisa Nakane, Mikihiko Naito, Susumu Itoh
- Journal Title
  
  BBA advances
  
  Volume: 1 Pages: 100008-100008
- DOI
  10.1016/j.bbadva.2021.100008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16360, KAKENHI-PROJECT-19H03456
[Journal Article] TMED10 protein interferances with transforming growth factor-β signaling by disrupting TGF-β receptor complex formation2017
- Author(s)
  Naoko　Nakano, Yuki Tsuchiya, kenro Kako, Kenryu Umezaki, Keigo Sano, Souichi Ikeno, Eri Otsuka, Masashi Shigeta, Ai Nakagawa, Nobuo Sakata, Fumiko Itoh, Yota Nakano, Shun-ichiro Iemura, Maarten van Dinther, Tohru Natsume, Peter teb Dijke and Susumu Itoh
- Journal Title
  
  The joural of biological chemistry
  
  Volume: 292 Pages: 4099-4112
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18866
[Journal Article] Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene2016
- Author(s)
  Naoko Nakano, Mitsuyasu Kato & Susumu Itoh
- Journal Title
  
  The journal of biochemistry
  
  Volume: 159 Issue: 1 Pages: 27-30
- DOI
  10.1093/jb/mvv117
- NAID
  120007129718
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18866, KAKENHI-PROJECT-25293092, KAKENHI-PROJECT-26305006
[Presentation] Role of the TMEPAI family gene in intestinal tumorigenesis2021
- Author(s)
  中野なおこ、伊東史子、渡邊幸秀、武藤誠、加藤光保、伊東進
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K06975
[Presentation] マウス消化管腫瘍形成におけるTMEPAIファミリー分子の役割2021
- Author(s)
  星名黎、中野なおこ、伊東史子、渡邊幸秀、加藤光保、武藤誠、伊東進
- Organizer
  2021年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-21K06975
[Presentation] 中皮腫進展抑制を目指したSNIPER化合物の開発2021
- Author(s)
  永野和果、内藤幹彦、伊東進、中野なおこ、田代悦
- Organizer
  第25回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-21K06975
[Presentation] Elucidation of molecular mechanism for intestinal tumorigenesis controlled by TMEPAI family2021
- Author(s)
  中野なおこ、星名黎、内田吉美、伊東史子、渡邊幸秀、武藤誠、加藤光保、伊東進
- Organizer
  第94回生化学会学大会
- Data Source
  KAKENHI-PROJECT-21K06975
[Presentation] YAPシグナルを標的とした新規抗がん剤の開発2021
- Author(s)
  中野なおこ、田代悦、永野和果、内藤幹彦、伊東進
- Organizer
  第25回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-21K06975
[Presentation] TMEPAI遺伝子ファミリー欠損マウスにおける消化管腫瘍形成抑制機構の解明2021
- Author(s)
  星名黎、伊東進、中野なおこ
- Organizer
  第25回日本がん分子標的治療学会
- Data Source
  KAKENHI-PROJECT-21K06975
[Presentation] がん遺伝子YAPタンパク質を分解する抗がん剤開発2020
- Author(s)
  中野　なおこ
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16360
[Presentation] Establishment of protein knockdown specific for transcriptional co-activator YAP2016
- Author(s)
  中野なおこ、服部隆行、内藤幹彦、伊東進
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜　(神奈川県　横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K18866
[Presentation] TMED10はTGF-β受容体複合体形成を抑制しTGF-βシグナル伝達を阻害する2016
- Author(s)
  中野なおこ、土屋裕樹、加古拳朗、梅嵜乾隆、佐野圭吾、池野聡一、大塚愛理、中川愛、坂田宣夫、伊東史子、家村俊一郎、夏目徹、伊東進
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜　(神奈川県　横浜市)
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18866
[Presentation] がん遺伝子YAPを標的としたプロテインノックダウン法の確立2016
- Author(s)
  中野なおこ、正田卓司、服部隆行、栗原正明、内藤幹彦、伊東進
- Organizer
  第20回　日本癌分子標的治療学会学術集会
- Place of Presentation
  別府国際コンベンションセンター　(大分県　別府市)
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-15K18866
[Presentation] TMED10 dissociates TGF-beta receptor complex to inhibit TGF-beta signal2015
- Author(s)
  Naoko Nakano
- Organizer
  第74回　日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場　(名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K18866

1. 内藤幹彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nakano Naoko 中野 なおこ

Research Projects

Research Products

Co-Researchers

TMEPAIによる消化管腺腫形成制御機構の解明およびTMEPAI機能阻害化合物の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanism of intestinal tumorigenesis by TMEPAIPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of TMEPAI family-mediated inhibitory mechanism for YAP activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

TMEPAI family inhibits proliferation of malignant mesothelioma cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Hybrid molecule between platanic acid and LCL-161 as a yes-associated protein degrader2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Narciclasine is a novel YAP inhibitor that disturbs interaction between YAP and TEAD42021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TMED10 protein interferances with transforming growth factor-β signaling by disrupting TGF-β receptor complex formation2017

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of the TMEPAI promoter by TCF7L2: the C-terminal tail of TCF7L2 is essential to activate the TMEPAI gene2016

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Role of the TMEPAI family gene in intestinal tumorigenesis2021

Author(s)

Organizer

Data Source

[Presentation] マウス消化管腫瘍形成におけるTMEPAIファミリー分子の役割2021

Author(s)

Organizer

Data Source

[Presentation] 中皮腫進展抑制を目指したSNIPER化合物の開発2021

Author(s)

Organizer

Data Source

[Presentation] Elucidation of molecular mechanism for intestinal tumorigenesis controlled by TMEPAI family2021

Author(s)

Organizer

Data Source

[Presentation] YAPシグナルを標的とした新規抗がん剤の開発2021

Author(s)

Organizer

Data Source

[Presentation] TMEPAI遺伝子ファミリー欠損マウスにおける消化管腫瘍形成抑制機構の解明2021

Author(s)

Organizer

Data Source

[Presentation] がん遺伝子YAPタンパク質を分解する抗がん剤開発2020

Author(s)

Organizer

Data Source

[Presentation] Establishment of protein knockdown specific for transcriptional co-activator YAP2016

Author(s)

Organizer

Place of Presentation

Nakano Naoko 中野なおこ