Aoyama Kazumasa 青山和正

… Alternative Names

青山和正アオヤマカズマサ

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Researcher Number	50734266
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 助教
Affiliation (based on the past Project Information) *help	2023: 慶應義塾大学, 薬学部(芝共立), 助教 2017 – 2018: 千葉大学, 大学院医学研究院, 特任助教 2016: 千葉大学, 大学院医学研究院, 特任研究員 2014 – 2015: 千葉大学, 医学(系)研究科(研究院), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 癌 / 造血器腫瘍 / 遺伝子発現制御 / エピジェネティック制御 / 骨髄異形成症候群（MDS） / ポリコーム抑制複合体（PRC） / ポリコーム / シグナル伝達 / 次世代シーケンス / 創薬研究 … More / Ezh1,2 / 発現制御 / 遺伝子発現 / ヒストン修飾 / チロシンキナーゼ / エピジェネティックス Less

PRC2機能低下型MDSのがん幹細胞維持機構の解明と新規創薬標的の探索Principal Investigator
- Principal Investigator
  
  青山和正
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Keio University
ポリコーム機能低下型造血腫瘍におけるエピゲノム基盤の解析Principal Investigator
- Principal Investigator
  
  青山和正
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Chiba University
Role of polycomb histone methyltransferase EZH1 in hematologic malignancesPrincipal Investigator
- Principal Investigator
  
  Aoyama Kazumasa
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Chiba University
Role of epigenetic regulation by nuclear tyrosine kinases in hematologic malignanciesPrincipal Investigator
- Principal Investigator
  
  Aoyama Kazumasa
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  Chiba University

All 2024 2023 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023
- Author(s)
  Rizq Ola、Mimura Naoya、Oshima Motohiko、Momose Shuji、Takayama Naoya、Itokawa Naoki、Koide Shuhei、Shibamiya Asuka、Miyamoto-Nagai Yurie、Rizk Mohamed、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Wang Changshan、Saraya Atsunori、Ito Ryoji、Seimiya Masanori、et al
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 9 Pages: 1895-1907
- DOI
  10.1038/s41375-023-01928-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07858, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K05608, KAKENHI-PROJECT-23K06449, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-20K07396, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16318, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023
- Author(s)
  1.Shibamiya A, Miyamoto-Nagai Y, Koide S, Oshima M, Rizq O, Aoyama K, Nakajima-Takagi Y, Kato R, Kayamori K, Isshiki Y, Oshima-Hasegawa N, Muto T, Tsukamoto S, Takeda Y, Koyama-Nasu R, Chiba T, Honda H, Yokote K, Iwama A, Sakaida E, Mimura N.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: － Issue: 8 Pages: 2635-2648
- DOI
  10.1007/s00262-023-03447-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19497, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023
- Author(s)
  Nakajima-Takagi Yaeko、Oshima Motohiko、Takano Junichiro、Koide Shuhei、Itokawa Naoki、Uemura Shun、Yamashita Masayuki、Andoh Shohei、Aoyama Kazumasa、Isshiki Yusuke、Shinoda Daisuke、Saraya Atsunori、Arai Fumio、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Ikawa Tomokatsu、Iwama Atsushi
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.83004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07806, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653
[Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.2019
- Author(s)
  Yuki R, Tatewaki T, Yamaguchi N, Aoyama K, Honda T, Kubota S, Morii M, Manabe I, Kuga T, Tomonaga T, Yamaguchi N
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 5 Pages: 637-655
- DOI
  10.1038/s41388-018-0481-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08293, KAKENHI-PROJECT-16J04363, KAKENHI-PROJECT-17J02389, KAKENHI-PROJECT-18J01777, KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-17K15985, KAKENHI-PROJECT-18K16078, KAKENHI-PROJECT-16H06276
[Journal Article] Ezh2 loss propagates hypermethylation at T cell differentiation?regulating genes to promote leukemic transformation2018
- Author(s)
  Wang Changshan、Oshima Motohiko、Sato Daisuke、Matsui Hirotaka、Kubota Sho、Aoyama Kazumasa、Nakajima-Takagi Yaeko、Koide Shuhei、Matsubayashi Jun、Mochizuki-Kashio Makiko、Nakano-Yokomizo Takako、Bai Jie、Nagao Toshitaka、Kanai Akinori、Iwama Atsushi、Sashida Goro
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 9 Pages: 3872-3886
- DOI
  10.1172/jci94645
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08705, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-18K18196, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-18H02842, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-18K16078, KAKENHI-PROJECT-16H06276
[Journal Article] Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.2017
- Author(s)
  Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 23(16) Issue: 16 Pages: 4817-4830
- DOI
  10.1158/1078-0432.ccr-16-2735
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09839, KAKENHI-INTERNATIONAL-15K21751, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies2017
- Author(s)
  Tanaka Tomoyuki、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Tara Shiro、Oshima Motohiko、Saraya Atsunori、Koide Shuhei、Si Sha、Manabe Ichiro、Sanada Masashi、Nakayama Manabu、Masuko Masayoshi、Sone Hirohito、Koseki Haruhiko、Iwama Atsushi
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 214 Issue: 10 Pages: 2901-2913
- DOI
  10.1084/jem.20170167
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09868, KAKENHI-PROJECT-17K10136, KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-16K15498, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Hmga2 collaborates with JAK2 V617F in the development of myeloproliferative neoplasms2017
- Author(s)
  Ueda K, Ikeda K, Ikezoe T, Harada-Shirado K, Ogawa K, Hashimoto Y, Sano T, Ohkawara H, Kimura S, Shichishima-Nakamura A, Nakamura Y, Shikama Y, Mori T, Mason PJ, Bessler M, Morishita S, Komatsu N, Shide K, Shimoda K, Koide S, Aoyama K, Oshima M, Iwama Aand Takeishi Y.
- Journal Title
  
  Blood Advances
  
  Volume: 1 Issue: 15 Pages: 1001-1015
- DOI
  10.1182/bloodadvances.2017004457
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09852, KAKENHI-PROJECT-17H04210, KAKENHI-PROJECT-17H04211, KAKENHI-PROJECT-15K09457, KAKENHI-PROJECT-15K09483, KAKENHI-PROJECT-15K09484, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K19582, KAKENHI-PROJECT-17K19687
[Journal Article] Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).2017
- Author(s)
  Kuki K, Yamaguchi N, Iwasawa S, Takakura Y, Aoyama K, Yuki R, Nakayama Y, Kuga T, Hashimoto Y, Tomonaga T, Yamaguchi N
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 490 Issue: 3 Pages: 1045-1051
- DOI
  10.1016/j.bbrc.2017.06.163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-17K08293, KAKENHI-PROJECT-17K15985, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K19565
[Journal Article] Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.2016
- Author(s)
  Shimizu R, Muto T, Aoyama K, Choi K, Takeuchi M, Koide S, Hasegawa N, Isshiki Y, Togasaki E, Kawajiri-Manako C, Nagao Y, Tsukamoto S, Sakai S, Takeda Y, Mimura N, Ohwada C, Sakaida E, Iseki T, Starczynowski DT, Iwama A, Yokote K, Nakaseko C.
- Journal Title
  
  Leuk Res.
  
  Volume: 50 Pages: 85-94
- DOI
  10.1016/j.leukres.2016.09.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19565
[Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016
- Author(s)
  Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y,Iwama A.
- Journal Title
  
  Blood
  
  Volume: 128(5) Issue: 5 Pages: 638-649
- DOI
  10.1182/blood-2016-01-694810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01513, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-16H02661, KAKENHI-PROJECT-15J04258, KAKENHI-PROJECT-26293228, KAKENHI-PROJECT-15K09478, KAKENHI-PROJECT-16K09340, KAKENHI-PROJECT-16K09840, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] The loss of Ezh2 cooperates with an active JAK2 mutant in the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition.2016
- Author(s)
  Sashida G, Wang S, Tomioka T, Oshima M, Kazumasa Aoyama K, Kanai A, Mochizuki-Kashio M, Harada H, Shimoda K, Iwama A.
- Journal Title
  
  J Experimenta l Medicine
  
  Volume: 213 Issue: 8 Pages: 1459-1477
- DOI
  10.1084/jem.20151121
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-26115001, KAKENHI-PLANNED-26115002, KAKENHI-PROJECT-15H02544, KAKENHI-PROJECT-15H03137, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-16KT0113, KAKENHI-PROJECT-15K09460, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells2016
- Author(s)
  Si S, Nakajima-Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, Nakayama M, Ishikura T, Koseki H, Iwama A
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 5 Pages: e0154561-e0154561
- DOI
  10.1371/journal.pone.0154561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02622, KAKENHI-PROJECT-14J40042, KAKENHI-PROJECT-15K19544, KAKENHI-PROJECT-16K19565, KAKENHI-PROJECT-16K20959
[Journal Article] Protective role for lipid modifications of Src-family kinases against chromosome missegregation2016
- Author(s)
  Honda, T., Soeda, S., Tsuda, K., Yamaguchi, C., Aoyama, K., Morinaga, T., Yuki, R., Nakayama, Y., Yamaguchi, N.-t., and Yamaguchi, N.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 38751-38751
- DOI
  10.1038/srep38751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06672, KAKENHI-PROJECT-16J04141, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-16K08227, KAKENHI-PROJECT-16K19565
[Journal Article] Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in its Dissociation from Chromatin and the Nuclear Matrix2015
- Author(s)
  Kubota S, Morii M, Yuki R, Yamaguchi N, Yamaguchi H, Aoyama K, Kuga T, Tomonaga T, Yamaguchi N.
- Journal Title
  
  J Biol Chem
  
  Volume: 290 Issue: 17 Pages: 10891-904
- DOI
  10.1074/jbc.m115.643882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Journal Article] Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms.2015
- Author(s)
  Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Hidaka T, Kubuki Y, Sashida G, Aoyama K, Yoshimitsu M, Abe H, Miike T, Iwakiri H, Tahara Y, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K
- Journal Title
  
  Genom Data.
  
  Volume: 4 Pages: 102-108
- DOI
  10.1016/j.gdata.2015.04.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09479, KAKENHI-PROJECT-15K09480, KAKENHI-PROJECT-15K09507, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461408, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-26860738
[Journal Article] Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator.2015
- Author(s)
  Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K.
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 2 Pages: 304-315
- DOI
  10.1182/blood-2014-04-555508
- NAID
  40020613861
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591401, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K09479, KAKENHI-PROJECT-15K09507, KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26461408, KAKENHI-PROJECT-26860738
[Journal Article] Overexpression of Zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A.2015
- Author(s)
  Yuki, R., Aoyama, K., Kubota, S., Yamaguchi, N.-t., Kubota, S.-i., Hasegawa, H., Morii, M., Huang, X., Liu, K., Williams, R., Fukuda, M.N., and Yamaguchi, N.
- Journal Title
  
  J. Cell. Biochem.
  
  Volume: in press Issue: 6 Pages: 954-968
- DOI
  10.1002/jcb.25046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-25460356, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26893036
[Journal Article] c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.2015
- Author(s)
  Kazumasa Aoyama, Noritaka Yamaguchi, Ryuzaboro Yuki, Mariko Morii, Sho Kubota, Kensuke Hirata, Kohei Abe, Takuya Honda, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi
- Journal Title
  
  Cell Biology International
  
  Volume: 39 Issue: 4 Pages: 446-456
- DOI
  10.1002/cbin.10413
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460356, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Journal Article] Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner.2015
- Author(s)
  Mochizuki-Kashio M, Aoyama K, Sashida G, Oshima M, Tomioka T, Muto T, Wang C, Iwama A.
- Journal Title
  
  Blood
  
  Volume: 126 Issue: 10 Pages: 1172-83
- DOI
  10.1182/blood-2015-03-634428
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461396, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-14J40024
[Journal Article] c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21.2015
- Author(s)
  Noritaka Yamaguchi, Ryuzaburo Yuki, Sho Kubota, Kazumasa Aoyama, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi.
- Journal Title
  
  Biochemical Journal
  
  Volume: 471 Issue: 1 Pages: 67-77
- DOI
  10.1042/bj20150372
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K07922, KAKENHI-PROJECT-26460081, KAKENHI-PROJECT-15K19545, KAKENHI-PROJECT-26893036, KAKENHI-PROJECT-14J04367, KAKENHI-PROJECT-25460356, KAKENHI-PROJECT-26670614, KAKENHI-PROJECT-25290054
[Presentation] EZH2機能喪失型骨髄異形成症候群 (MDS) に対する創薬標的分子の探索2024
- Author(s)
  青山和正
- Organizer
  第144回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-23K07851
[Presentation] The core targets of polycomb repressive complex 2 in the maintenance of myelodysplastic syndrome stem cells2018
- Author(s)
  Kazumasa Aoyama, Motohiko Oshima, Makiko Mochizuki-Kashio, Shuhei Koide, Emi Suzuki, Yuko Kato, Yaeko Nakajima-Takagi, Nobuhiro Hiura, Goro Sashida, Atsushi Iwama
- Organizer
  The 16th Stem Cell Research Symposium
- Data Source
  KAKENHI-PROJECT-18K16078
[Presentation] Profiling of the critical targets of polycomb repressive complex 2 in the maintenance of myelodysplastic syndrome stem cells2018
- Author(s)
  Kazumasa Aoyama, Emi Suzuki, Motohiko Oshima, Makiko Mochizuki-Kashio1, Shuhei Koide1, Yuko Kato, Yaeko Nakajima-Takagi, Goro Sashida, Atsushi Iwama
- Organizer
  Keystone Syposia, Cancer Epigenetics: New Mechanisms, New Therapies (B4)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19565
[Presentation] Ezh2 欠損造血幹細胞維持における Ezh1 によるエピジェネティック制御2017
- Author(s)
  青山和正, 鈴木瑛美, 大島基彦, 望月-樫尾牧子, 小出周平, 加藤裕子, 中島やえ子, 指田吾郎, 岩間厚志
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K19565
[Presentation] Role of the polycomb methyltransferase Ezh1 in myelodysplastic syndrome induced by Ezh2 insufficiency2016
- Author(s)
  Kazumasa Aoyama, Makiko Mochizuki-Kashio, Motohiko Oshima, Shuhei Koide, Yaeko Nakajima-Takagi, Mitsutaka Maeda, Goro Sashida, Atsushi Iwama
- Organizer
  58th American Society of Hematology (ASH) Annual Meeting
- Place of Presentation
  San Diego (USA)
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19565
[Presentation] Role of Ezh1 in hematopoietic malignancies induced by Ezh2 insufficiency2016
- Author(s)
  Kazumasa Aoyama, Makiko Mochizuki-Kashio, Motohiko Oshima, Shuhei Koide, Atsushi Iwama
- Organizer
  JSPS-NUS Joint Symposium
- Place of Presentation
  Singapore　（Singapore）
- Year and Date
  2016-01-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893036
[Presentation] Ezh2 欠損造血細胞における Ezh1 によるエピジェネティック制御2016
- Author(s)
  青山和正, 望月-樫尾牧子, 大島基彦, 小出周平, 中島やえ子, 指田吾郎, 岩間厚志
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス (宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16K19565
[Presentation] Role of histone methyltransferase Ezh1 in Ezh2-deficient hematopoietic stem cells2015
- Author(s)
  Kazumasa Aoyama, Makiko Mochizuki-Kashio, Motohiko Oshima, Shuhei Koide, Goro Sashida, Atsushi Iwama
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫・神戸）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26893036

1. KUBUKI Yohko

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# of Collaborated Products: 1 results
2. NAKASEKO Chiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. ISEKI Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. OHSHIMA Motohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. Hara Eiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SHIDE Kotaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. SEIMIYA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KUGA Takahisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YAMAGUCHI Noritaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
10. 下田和哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 北中明

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 岩間厚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 三村尚也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 増子正義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 古関明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 朝長毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 長尾俊孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 幸龍三郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 指田吾郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 中島やえ子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 山口直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Aoyama Kazumasa 青山 和正

青山 和正 アオヤマ カズマサ

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PRC2機能低下型MDSのがん幹細胞維持機構の解明と新規創薬標的の探索Principal Investigator

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ポリコーム機能低下型造血腫瘍におけるエピゲノム基盤の解析Principal Investigator

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Role of polycomb histone methyltransferase EZH1 in hematologic malignancesPrincipal Investigator

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Role of epigenetic regulation by nuclear tyrosine kinases in hematologic malignanciesPrincipal Investigator

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[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023

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[Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023

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[Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023

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[Journal Article] Desuppression of TGF-β signaling via nuclear c-Abl-mediated phosphorylation of TIF1γ/TRIM33 at Tyr-524, -610, and -1048.2019

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[Journal Article] Ezh2 loss propagates hypermethylation at T cell differentiation?regulating genes to promote leukemic transformation2018

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[Journal Article] Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition.2017

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[Journal Article] Internal deletion of BCOR reveals a tumor suppressor function for BCOR in T lymphocyte malignancies2017

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[Journal Article] Hmga2 collaborates with JAK2 V617F in the development of myeloproliferative neoplasms2017

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[Journal Article] Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP).2017

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[Journal Article] Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia.2016

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[Journal Article] Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes.2016

Aoyama Kazumasa 青山和正

青山和正アオヤマカズマサ