Nomura Naohiro 野村尚弘

Researcher Number	50735800
Other IDs	https://orcid.org/0000-0002-6998-1922
Affiliation (based on the past Project Information) *help	2019: 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 2016 – 2018: 東京医科歯科大学, 大学院医歯学総合研究科, 助教 2015: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 2014: 東京医科歯科大学, 大学院医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related
Keywords	Principal Investigator 高血圧 / カルシニューリン / ナトリウム輸送体 / カリウム / シグナル伝達 / カリウム排泄機構 / カルシニューリン阻害剤 / ギッテルマン症候群 / バーター症候群 / 電解質 … More / 血圧 / 電解質輸送 / 生理学 / ナトリウムチャネル / クロライドチャネル / 水・電解質輸送 / 尿崩症 / カリウム4 / NCC / EGFR / アクアポリン２ Less

How does potassium regulate blood pressure through sodium-transporter?Principal Investigator
- Principal Investigator
  
  Nomura Naohiro
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tokyo Medical and Dental University
Investigation of potassium related regulation of blood pressurePrincipal Investigator
- Principal Investigator
  
  NOMURA Naohiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University
Development of novel antihypertensive drugs and diuretics with exocytosis assay using chemical libraryPrincipal Investigator
- Principal Investigator
  
  Nomura Naohiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Kidney internal medicine
- Research Institution
  Tokyo Medical and Dental University

All 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020
- Author(s)
  Furusho T, Sohara E, Mandai S, Kikuchi H, Takahashi N, Fujimaru T, Hashimoto H, Arai Y, Ando F, Zeniya M, Mori T, Susa K, Isobe K, Nomura N, Yamamoto K, Okado T, Rai T, Uchida S
- Journal Title
  
  Kidney International
  
  Volume: 97 Issue: 4 Pages: 713-727
- DOI
  10.1016/j.kint.2019.11.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-20K17244, KAKENHI-PROJECT-20K17276, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672
[Journal Article] Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium?potassium?2 chloride cotransporter and sodium?chloride cotransporter2019
- Author(s)
  Matsuura Yoshiaki、Nomura Naohiro、Shoda Wakana、Mori Takayasu、Isobe Kiyoshi、Susa Koichiro、Ando Fumiaki、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 517 Issue: 2 Pages: 364-368
- DOI
  10.1016/j.bbrc.2019.07.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-19H03672, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995
[Journal Article] Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease2019
- Author(s)
  Kikuchi H, Sasaki E, Nomura N, Mori T, Minamishima YA, Yoshizaki Y, Takahashi N, Furusho T, Arai Y, Mandai S, Yamashita T, Ando F, Maejima Y, Isobe K, Okado T, Rai T, Uchida S, Sohara E
- Journal Title
  
  Kidney international
  
  Volume: 95 Issue: 1 Pages: 123-137
- DOI
  10.1016/j.kint.2018.08.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-19H03556, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-16H04723
[Journal Article] Clinical importance of potassium intake and molecular mechanism of potassium regulation2019
- Author(s)
  Nomura N, Shoda W, Uchida S
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: 23 Issue: 10 Pages: 1175-1180
- DOI
  10.1007/s10157-019-01766-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995
[Journal Article] Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter2018
- Author(s)
  Hashimoto Hiroko、Nomura Naohiro、Shoda Wakana、Isobe Kiyoshi、Kikuchi Hiroaki、Yamamoto Kouhei、Fujimaru Takuya、Ando Fumiaki、Mori Takayasu、Okado Tomokazu、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
- Journal Title
  
  Metabolism
  
  Volume: 85 Pages: 23-31
- DOI
  10.1016/j.metabol.2018.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15970, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314
[Journal Article] High potassium concentration regulates the WNK3-SPAK-NKCC1 phosphorylation cascade via kelch-like protein 2 in mouse vascular smooth muscle cells2018
- Author(s)
  Yuanlong Wang, Naohiro Nomura, Moko Zeniya, Yutaro Mori, Daiei Takahashi, Shotaro Naito, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
- Journal Title
  
  Journal of Medical and Dental Sciences
  
  Volume: 65 Pages: 35-44
- NAID
  130006516286
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19478
[Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus2018
- Author(s)
  Ando Fumiaki、Mori Shuichi、Yui Naofumi、Morimoto Tetsuji、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Sasaki Sei、Kondo Yoshiaki、Kagechika Hiroyuki、Uchida Shinichi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1411-1411
- DOI
  10.1038/s41467-018-03771-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-18K08233, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-17H06656, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K09642
[Journal Article] Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney2018
- Author(s)
  Nomura Naohiro、Shoda Wakana、Wang Yuanlong、Mandai Shintaro、Furusho Taisuke、Takahashi Daiei、Zeniya Moko、Sohara Eisei、Rai Tatemitsu、Uchida Shinichi
- Journal Title
  
  Bioscience Reports
  
  Volume: 38 Issue: 1 Pages: 20171243-1243
- DOI
  10.1042/bsr20171243
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K19478, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-17K16077
[Journal Article] Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity in Renal Epithelial Cells Through Cellular Oxidative Stress and Cytoskeleton Modulations2018
- Author(s)
  Wang Tse-En J.、Liu Hung-Ting、Lai Yu-Hua、Jan Tong-Rong、Nomura Naohiro、Chang Hui-Wen、Chou Chi-Chung、Lee Ya-Jane、Tsai Pei-Shiue J.
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 9 Pages: 357-357
- DOI
  10.3389/fphar.2018.00357
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15995
[Journal Article] WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO42018
- Author(s)
  Mandai S, Mori T, Nomura N, Furusho T, Arai Y, Kikuchi H, Sasaki E, Sohara E, Rai T, Uchida S
- Journal Title
  
  Scientific reports
  
  Volume: 8 Issue: 1 Pages: 9101-9101
- DOI
  10.1038/s41598-018-27414-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-19K21299, KAKENHI-PROJECT-16K09642
[Journal Article] Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake.2017
- Author(s)
  Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S.
- Journal Title
  
  Kidney Int.
  
  Volume: 91 Issue: 2 Pages: 402-411
- DOI
  10.1016/j.kint.2016.09.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16H06772, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K19478
[Journal Article] Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.2017
- Author(s)
  Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 487 Issue: 2 Pages: 368-374
- DOI
  10.1016/j.bbrc.2017.04.068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-16K19478
[Journal Article] EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption2016
- Author(s)
  Cheung PW, Nomura N, Nair AV, Pathomthongtaweechai N, Ueberdiek L, Jenny Lu HA, Brown D, Bouley R
- Journal Title
  
  Journal of American Society of Nephrology
  
  Volume: Online first
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893064
[Presentation] TNFαは腎臓でのWNK1 分解を抑制し慢性腎臓病の塩分感受性を亢進させる2019
- Author(s)
  古荘泰佑, 蘇原映誠, 萬代新太郎, 菊池寛昭, 高橋直宏, 藤丸拓也, 橋本博子, 新井洋平, 安藤史顕, 銭谷慕子, 森崇寧, 須佐紘一郎, 磯部清志, 野村尚弘, 岡戸丈和, 頼建光, 内田信一
- Organizer
  第 10 回分子腎臓フォーラム
- Data Source
  KAKENHI-PROJECT-18K15995
[Presentation] タクロリムスは NCC のリン酸化を亢進し 4 型 Bartter 症候群の症状を改善する.2019
- Author(s)
  松浦喜明, 野村尚弘, 正田若菜, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第 62 回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15995
[Presentation] NCX1 を介した NCC の脱リン酸化と尿中カリウム排泄機構の解明2019
- Author(s)
  正田若菜, 野村尚弘, 安藤史顕, 田頭秀章, 岩本隆宏, 太田哲人, 磯部清志, 森崇寧, 須佐紘一郎, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第 62 回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15995
[Presentation] 水・電解質輸送体の制御機構解明と新規治療薬の開発2018
- Author(s)
  野村　尚弘
- Organizer
  第61回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-18K15995
[Presentation] Role of ClC-K and Barttin in Low-Potassium induced Sodium-Chloride Cotransporter Activation and Hypertension in Mouse Kidney.2018
- Author(s)
  Nomura N, Shoda W, Wang Y, Takahashi D, Zeniya M, Sohara E, Rai T, Uchida S.
- Organizer
  ISN Frontiers Meetings 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] CIC-Kチャネルはカリウム摂取不足時のNCC活性化と血圧上昇に重要である.2017
- Author(s)
  野村尚弘, 正田若菜, 高橋大栄, 銭谷慕子, 蘇原映誠, 頼建光, 内田信一.
- Organizer
  第60回日本腎臓学会学術総会.
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] Role of ClC-K and Barttin in Low-Potassium induced Sodium-Chloride Cotransporter Activation and Hypertension in Mouse Kidney.2017
- Author(s)
  Nomura N, Shoda W, Wang Y, Takahashi D, Zeniya M, Sohara E, Rai T, Uchida S.
- Organizer
  The 50th Annual Meeting of the American Society of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] 高カリウムはカリシニューリンを活性化しNa-Cl共輸送体(NCC)を脱リン酸化して尿中カリウム排泄を促進する2017
- Author(s)
  正田若菜, 野村尚弘, 安藤史顕, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第27回バゾプレシン研究会
- Place of Presentation
  TKP有楽町会議室・東京都・中央区
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] ClC-Kチャネルはカリウム摂取不足時のNCC活性化と血圧上昇に重要である2017
- Author(s)
  野村尚弘、正田若菜、高橋大栄、銭谷慕子、蘇原映誠、頼縦光、内田信一
- Organizer
  第60回日本腎臓学会学術総会
- Place of Presentation
  仙台国際センター・宮城県・仙台
- Year and Date
  2017-05-26
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] 急性カリウム負荷はカルシニューリンを活性し、Na-Ｃｌ共輸送体（NCC）を脱リン酸化して尿中カリウム排泄を促進する2016
- Author(s)
  正田若菜, 野村尚弘, 安藤史顕, 蘇原映誠, 頼建光, 内田信一
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜・神奈川県・横浜
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] 急性カリウム負荷はカリシニューリンを活性しNa-Cl共輸送体(NCC)を脱リン酸化して尿中カリウム排泄を促進する2016
- Author(s)
  正田若菜、野村尚弘、安藤史顕、蘇原映誠、頼建光、内田信一
- Organizer
  第５９回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-26893064
[Presentation] Calcineurin Rapidly Dephosphorylates Sodium-ChlorideCotransporter in Response to High Potassium Intake2016
- Author(s)
  Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S
- Organizer
  第26回御茶ノ水腎研究会
- Place of Presentation
  山の上ホテル・東京都・千代田区
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] Calcineurin Rapidly Dephosphorylates Sodium-ChlorideCotransporter in Response to High Potassium Intake2016
- Author(s)
  Shoda W, Nomura N, Ando F, Mori Y, Mori T, Sohara E, Rai T, Uchida S
- Organizer
  The 49th Annual Meeting of American Society of Nephrology
- Place of Presentation
  Chicago, USA
- Year and Date
  2016-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19478
[Presentation] Potassium-induced dephosphoryla4on of renal sodium-chloride cotransporter is NOT dependent on the anions.2015
- Author(s)
  Nomura N, Shoda W, Sohara E, Rai T, Uchida S.
- Organizer
  Annual Meeting of the American Society of Nephrology
- Place of Presentation
  San Diego (USA)
- Year and Date
  2015-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26893064

1. 内田信一

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
2. 頼建光

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 佐々木成

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nomura Naohiro 野村 尚弘

Research Projects

Research Products

Co-Researchers

How does potassium regulate blood pressure through sodium-transporter?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of potassium related regulation of blood pressurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel antihypertensive drugs and diuretics with exocytosis assay using chemical libraryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Renal TNFα activates the WNK phosphorylation cascade and contributes to salt-sensitive hypertension in chronic kidney disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tacrolimus ameliorates the phenotypes of type 4 Bartter syndrome model mice through activation of sodium?potassium?2 chloride cotransporter and sodium?chloride cotransporter2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical importance of potassium intake and molecular mechanism of potassium regulation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin increases urinary sodium excretion by reducing phosphorylation of the sodium-chloride cotransporter2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High potassium concentration regulates the WNK3-SPAK-NKCC1 phosphorylation cascade via kelch-like protein 2 in mouse vascular smooth muscle cells2018

Author(s)

Journal Title

NAID

Data Source

[Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrogenic diabetes insipidus2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Honokiol, a Polyphenol Natural Compound, Attenuates Cisplatin-Induced Acute Cytotoxicity in Renal Epithelial Cells Through Cellular Oxidative Stress and Cytoskeleton Modulations2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO42018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calcineurin inhibitors block sodium-chloride cotransporter dephosphorylation in response to high potassium intake.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.2017

Author(s)

Journal Title

Nomura Naohiro 野村尚弘