KAMIYA Nobuhiro 神谷宣広

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Kamiya Nobuhiro 神谷宣広

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Researcher Number	50735876
Other IDs
Affiliation (Current)	2025: 天理大学, 体育学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 天理大学, 体育学部, 教授 2014 – 2017: 天理大学, 体育学部, 教授
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Experimental pathology Except Principal Investigator Basic Section 59020:Sports sciences-related
Keywords	Principal Investigator 小児 / 骨壊死 / 動物モデル / インターロイキン６ / 中和抗体 / 大腿骨頭 / ペルテス病 / 臨床応用 / マウス / 軟骨 … More / 実験動物 / IL-6 / HMGB1 / インターロイキン-6 / モデル / ヒト / 炎症性起因物質 / ネズミ / ブタ / 骨形成 / 骨吸収 / 国際情報交換 / 炎症性サイトカイン / 股関節 … More Except Principal Investigator 健康診断 / 学生アスリート / 臨床検査判断値 Less

大学生アスリート健診のための臨床検査判断値の作成と指導介入への臨床検査値の活用
- Principal Investigator
  
  畑中徳子
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59020:Sports sciences-related
- Research Institution
  Tenri University
小児大腿骨頭壊死症に対する治療法の開発：IL-6抑制による骨治癒促進メカニズムの解明Principal Investigator
- Principal Investigator
  
  神谷宣広
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tenri University
Molecular pathogenesis and novel therapeutic strategy for osteonecrosis of the femoral head in childhood from the view of interleukin-6Principal Investigator
- Principal Investigator
  
  KAMIYA Nobuhiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tenri University
Osteonecrosis of the femoral head in childhoodPrincipal Investigator
- Principal Investigator
  
  Kamiya Nobuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tenri University
ペルテス病(小児大腿骨頭壊死症）の分子レベルでの病態解析Principal Investigator
- Principal Investigator
  
  神谷宣広
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Experimental pathology
- Research Institution
  Tenri University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Interleukin-6 receptor blockade improves bone healing following ischemic osteonecrosis in adolescent mice2023
- Author(s)
  Kuroyanagi Gen、Kamiya Nobuhiro、Yamaguchi Ryosuke、Kim Harry K.W.
- Journal Title
  
  Osteoarthritis and Cartilage Open
  
  Volume: 5 Issue: 4 Pages: 100386-100386
- DOI
  10.1016/j.ocarto.2023.100386
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18471, KAKENHI-PROJECT-23K08663
[Journal Article] 小児整形外科領域における基礎研究から臨床応用へ　小児整形外科の基礎研究　Perthes病とIL-62022
- Author(s)
  神谷　宣広
- Journal Title
  
  日本整形外科学会雑誌
  
  Volume: 96(8)
- Data Source
  KAKENHI-PROJECT-19K09563
[Journal Article] Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice2022
- Author(s)
  Kato Daisaku、Matsushita Masaki、Takegami Yasuhiko、Mishima Kenichi、Kamiya Nobuhiro、Osawa Yusuke、Imagama Shiro、Kitoh Hiroshi
- Journal Title
  
  Calcified Tissue International
  
  Volume: 111 Issue: 6 Pages: 622-633
- DOI
  10.1007/s00223-022-01019-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09646, KAKENHI-PROJECT-22K09398, KAKENHI-PROJECT-21H03063, KAKENHI-PROJECT-19K09563
[Journal Article] 小児整形外科疾患に対する新しい治療法-その展望および問題点-　Perthes病に対する抗IL-6受容体中和抗体を用いた新規治療戦略2022
- Author(s)
  神谷　宣広
- Journal Title
  
  日本整形外科学会雑誌
  
  Volume: 96(2)
- Data Source
  KAKENHI-PROJECT-19K09563
[Journal Article] Elevation of Proinflammatory Cytokine <scp>HMGB1</scp> in the Synovial Fluid of Patients With <scp>Legg‐Calv?‐Perthes</scp> Disease and Correlation With <scp>IL</scp> ‐62021
- Author(s)
  Kamiya Nobuhiro、Kim Harry KW
- Journal Title
  
  JBMR Plus
  
  Volume: 5 Issue: 2 Pages: 1-11
- DOI
  10.1002/jbm4.10429
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09563
[Journal Article] Development of a murine model of ischemic osteonecrosis to study the effects of aging on bone repair2021
- Author(s)
  Yamaguchi Ryosuke、Kamiya Nobuhiro、Kuroyanagi Gen、Ren Yinshi、Kim Harry K. W.
- Journal Title
  
  Journal of Orthopaedic Research
  
  Volume: - Issue: 12 Pages: 2663-2670
- DOI
  10.1002/jor.25006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18534, KAKENHI-PROJECT-19K09563, KAKENHI-PROJECT-19K18471
[Journal Article] Anti‐Interleukin‐ <scp>6</scp> Therapy Decreases Hip Synovitis and Bone Resorption and Increases Bone Formation Following Ischemic Osteonecrosis of the Femoral Head2021
- Author(s)
  Ren Yinshi、Deng Zhuo、Gokani Vishal、Kutschke Michael、Mitchell Thomas Wesley、Aruwajoye Olumide、Adapala Naga Suresh、Kamiya Nobuhiro、Abu‐Amer Yousef、Kim Harry KW
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 36 Issue: 2 Pages: 357-368
- DOI
  10.1002/jbmr.4191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09563
[Journal Article] IL6 Receptor blockade preserves articular cartilage and increases bone volume following ischemic osteonecrosis in immature mice2019
- Author(s)
  Kamiya N, Kuroyanagi G, Aruwajoye O, Kim HKW
- Journal Title
  
  Osteoarthritis and Cartilage
  
  Volume: 27 Pages: 326-335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09563
[Journal Article] :小児関節疾患における生化学的アプローチ（ペルテス病を中心に）2017
- Author(s)
  神谷　宣広
- Journal Title
  
  Ｂｏｎｅ　Ｊｏｉｎｔ　Ｎｅｒｖｅ
  
  Volume: 27 Pages: 557-562
- Data Source
  KAKENHI-PROJECT-15K08437
[Journal Article] In Vivo Monitoring of Activated Macrophages and Neutrophils in Response to Ischemic Osteonecrosis in a Mouse Model2016
- Author(s)
  Phipps, M. C., Huang, Y., Yamaguchi, R., Kamiya, N., Adapala, N. S., Tang, L., Kim, H. K.
- Journal Title
  
  J Orthop Res
  
  Volume: 34（２） Issue: 2 Pages: 307-313
- DOI
  10.1002/jor.22952
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08437
[Journal Article] HIF-1-Dependent IL-6 Activation in Articular Chondrocytes Initiating Synovitis in Femoral Head Ischemic Osteonecrosis2016
- Author(s)
  Yamaguchi R, Kamiya N, Adapala NS, Drissi H, Kim HK
- Journal Title
  
  J Bone Joint Surg Am
  
  Volume: 98 Issue: 13 Pages: 1122-1131
- DOI
  10.2106/jbjs.15.01209
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08437
[Journal Article] Development of a Mouse Model of Ischemic Osteonecrosis2015
- Author(s)
  Kamiya, N., Yamaguchi, R., Aruwajoye, O., Adapala, N.S., Kim, H.K.
- Journal Title
  
  Clinical Orthopaedics and Related Research
  
  Volume: 473(4) Issue: 4 Pages: 1486-1498
- DOI
  10.1007/s11999-015-4172-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26893311, KAKENHI-PROJECT-15K08437
[Journal Article] ぺルテス病の分子レベルでの病態解析2015
- Author(s)
  神谷宣広
- Journal Title
  
  近畿小児整形外科
  
  Volume: 28 Pages: 52-53
- Data Source
  KAKENHI-PROJECT-15K08437
[Journal Article] Legg-Calvé-Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin-6 in the Synovial Fluid2015
- Author(s)
  Kamiya, N., Yamaguchi, R., Adapala, N.S., Chen. E., Neal, D., O’Brien, J., Thovesona, A., Gudmundssona, P., Brabhama, C., Aruwajoye, O., Drissi, H., Kim H.K.
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: in press Issue: 6 Pages: 1009-1013
- DOI
  10.1002/jbmr.2435
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26893311, KAKENHI-PROJECT-15K08437
[Journal Article] Local Administration of Bone Morphogenetic Protein-2 and Bisphosphonate During Non-Weight Bearing Treatment of Ischemic Osteonecrosis of the Femoral Head2014
- Author(s)
  Kim, H. K. W., Aruwajoye, O., Du, J., Kamiya, N.
- Journal Title
  
  The Journal of bone and joint surgery. American volume
  
  Volume: 96(18) Issue: 18 Pages: 1515-1524
- DOI
  10.2106/jbjs.m.01361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26893311
[Presentation] FGFR3シグナルは、若年マウスの阻血性骨壊死の骨修復を加速する2023
- Author(s)
  加藤大策, 松下　雅樹, 竹上　靖彦, 三島　健一, 神谷　宣広, 大沢　郁介, 今釜　史郎, 鬼頭　浩史
- Organizer
  第35回日本軟骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] 年長児ペルテス病に対する抗IL-6受容体抗体を用いた新規治療戦略2023
- Author(s)
  神谷宣広
- Organizer
  第38回日本整形外科学会基礎学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K08663
[Presentation] 抗インターロイキン6受容体中和抗体を用いた骨壊死に対する新規治療戦略：骨壊死後の骨治癒を促進する2022
- Author(s)
  神谷　宣広
- Organizer
  第40回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] 小児整形外科の基礎研究2022
- Author(s)
  神谷　宣広
- Organizer
  兵庫県整形外科医会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] 虚血性骨壊死マウスモデルを用いた骨壊死修復過程における年齢の影響の検討2022
- Author(s)
  山口　亮介, 神谷　宣広, 田中　秀直,中島　康晴
- Organizer
  第33回日本小児整形外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] 年長児ペルテス病に対する抗IL-6受容体抗体を用いた新規治療戦略2022
- Author(s)
  神谷　宣広, 黒柳　元
- Organizer
  第33回日本小児整形外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] 小児整形外科の基礎研究：ペルテス病とIL-62022
- Author(s)
  神谷　宣広
- Organizer
  シンポジウム15「小児整形外科領域における基礎研究から臨床応用へ」. 第37回日本整形外科学会基礎学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] ペルテス病に対する抗IL-6受容体中和抗体を用いた新規治療戦略2022
- Author(s)
  神谷　宣広
- Organizer
  シンポジウム52「小児整形外科疾患に対する新しい治療法-その展望及び問題点-」.第95回日本整形外科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] IL-6 receptor blockade preserves articular cartilage and increases epiphyseal bone volume following ischemic osteonecrosis in immature mice2022
- Author(s)
  Kamiya Nobuhiro
- Organizer
  American Society of Bone and Mineral Research Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] A new therapeutic strategy for Legg-Calve-Perthes　disease (LCPD) using a monoclonal neutralizing　antibody for interleukin 6 (IL-6) receptor by stimulating　new bone formation and revascularization2021
- Author(s)
  神谷宣広
- Organizer
  13th Combined Meeting of Asia Pacific Spine Society & Asia Pacific Paediatric Orthopaedic Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] Perthes病に対する抗 IL-6受容体中和抗体を用いた新規治療戦略：骨壊死後の骨組織修復を促進する2021
- Author(s)
  神谷宣広
- Organizer
  第36回日本整形外科学会基礎学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] ペルテス病のIL-6を中心とした分子病態の解明と新規治療法の創出2021
- Author(s)
  神谷宣広
- Organizer
  第32回日本小児整形外科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] ペルテス病-疾患の基礎知識と最新の治療法-2020
- Author(s)
  神谷宣広
- Organizer
  第47回日本股関節学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] ぺルテス病に対するインターロイキン6を標的とした骨免疫からの新規治療戦略2019
- Author(s)
  神谷宣広
- Organizer
  第37回日本骨代謝学会
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] 小児整形外科の基礎研究2019
- Author(s)
  神谷宣広
- Organizer
  第34回日本整形外科学会基礎学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09563
[Presentation] 小児整形外科における基礎研究（ペルテス病を中心に）2018
- Author(s)
  神谷　宣広
- Organizer
  小児整形外科学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] HIF-1-dependent IL-6 activation in articular chondrocytes as a mechanism for the initiation of hip synovitis following ischemic osteonecrosis of the femoral head2016
- Author(s)
  Yamaguchi R, Kamiya N
- Organizer
  The 27th Annual Meeting of the Japanese Pediatric Orthopaedic Association
- Place of Presentation
  Miyagi, Japan
- Year and Date
  2016-12-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] A report of 2015 KPOS-TPOS-JPOA Exchange Fellowship in Korea2016
- Author(s)
  KAMIYA N
- Organizer
  The 27th Annual Meeting of the Japanese Pediatric Orthopaedic Association
- Place of Presentation
  Miyagi, Japan
- Year and Date
  2016-12-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] Basic research of Perthes disease2016
- Author(s)
  KAMIYA N
- Organizer
  The annual meeting of Korean Paediatric Orthopaedic Society
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-06-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] Basic research of Perthes disease2016
- Author(s)
  KAMIYA N
- Organizer
  The 27th Annual Meeting of the Japanese Pediatric Orthopaedic Association
- Place of Presentation
  Miyagi, Japan
- Year and Date
  2016-12-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] My basic research in pediatric orthopaedics2016
- Author(s)
  KAMIYA N
- Organizer
  Seoul National University Children's Hospital
- Place of Presentation
  Seoul, Korea
- Year and Date
  2016-06-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] 私の整形外科基礎研究2015
- Author(s)
  神谷宣広
- Organizer
  第１２回ＯＢＭＭＧ
- Place of Presentation
  東京
- Year and Date
  2015-07-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] 小児大腿骨頭壊死症に対する基礎研究（ペルテス病の分子レベルでの病態解析）2015
- Author(s)
  神谷宣広
- Organizer
  第54回日本小児股関節研究会
- Place of Presentation
  東京
- Year and Date
  2015-06-26
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] Legg-Calvé-Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin-6 in the Synovial Fluid2015
- Author(s)
  Kamiya, N.
- Organizer
  The 26th Annual Meeting of the Japanese Pediatric Orthopaedic Association
- Place of Presentation
  Ｇｉｆｕ
- Year and Date
  2015-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08437
[Presentation] ペルテス病の分子レベルでの病態解析2015
- Author(s)
  神谷宣広、西松秀和、Harry Kim
- Organizer
  第55回近畿小児整形外科懇話会
- Place of Presentation
  奈良市
- Year and Date
  2015-01-24
- Data Source
  KAKENHI-PROJECT-26893311
[Presentation] Chondrocytes Produce Inflammatory Cytokine Interleukin 6 (IL-6) Following Pediatric Ischemic Osteonecrosis
- Author(s)
  Kamiya, N., Kim, H.K.W.
- Organizer
  The 28th Annual Meeting of the Japanese Society of Cartilage Meeting
- Place of Presentation
  Tokyo
- Year and Date
  2015-03-06 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-26893311
[Presentation] Legg-Calvé-Perthes Disease Produces Chronic Hip Synovitis and Elevation of Interleukin-6 in the Synovial Fluid
- Author(s)
  Yamaguchi, R., Kamiya, N., Adapala, N.S., Chen. E., Neal, D., Drissi, H., Kim H.K.
- Organizer
  The 60th Annual Meeting of Orthopaedic Research Society
- Place of Presentation
  Las Vegas, NV, USA
- Year and Date
  2015-03-28 – 2015-03-31
- Data Source
  KAKENHI-PROJECT-26893311

1. 黒柳元 (80790831)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 畑中徳子 (40649274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 上岡樹生 (00274374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 岩山海渡 (30781249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Kim Harry

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 山口亮介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 鬼頭浩史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 三島健一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 松下雅樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 神谷庸成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAMIYA Nobuhiro 神谷 宣広

Kamiya Nobuhiro 神谷 宣広

Research Projects

Research Products

Co-Researchers

大学生アスリート健診のための臨床検査判断値の作成と指導介入への臨床検査値の活用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小児大腿骨頭壊死症に対する治療法の開発：IL-6抑制による骨治癒促進メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular pathogenesis and novel therapeutic strategy for osteonecrosis of the femoral head in childhood from the view of interleukin-6Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Osteonecrosis of the femoral head in childhoodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ペルテス病(小児大腿骨頭壊死症）の分子レベルでの病態解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Interleukin-6 receptor blockade improves bone healing following ischemic osteonecrosis in adolescent mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 小児整形外科領域における基礎研究から臨床応用へ 小児整形外科の基礎研究 Perthes病とIL-62022

Author(s)

Journal Title

Data Source

[Journal Article] Gain-of-Function of FGFR3 Accelerates Bone Repair Following Ischemic Osteonecrosis in Juvenile Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 小児整形外科疾患に対する新しい治療法-その展望および問題点- Perthes病に対する抗IL-6受容体中和抗体を用いた新規治療戦略2022

Author(s)

Journal Title

Data Source

[Journal Article] Elevation of Proinflammatory Cytokine <scp>HMGB1</scp> in the Synovial Fluid of Patients With <scp>Legg‐Calv?‐Perthes</scp> Disease and Correlation With <scp>IL</scp> ‐62021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of a murine model of ischemic osteonecrosis to study the effects of aging on bone repair2021

Author(s)

Journal Title

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[Journal Article] Anti‐Interleukin‐ <scp>6</scp> Therapy Decreases Hip Synovitis and Bone Resorption and Increases Bone Formation Following Ischemic Osteonecrosis of the Femoral Head2021

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[Journal Article] IL6 Receptor blockade preserves articular cartilage and increases bone volume following ischemic osteonecrosis in immature mice2019

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[Journal Article] :小児関節疾患における生化学的アプローチ（ペルテス病を中心に）2017

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[Journal Article] In Vivo Monitoring of Activated Macrophages and Neutrophils in Response to Ischemic Osteonecrosis in a Mouse Model2016

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KAMIYA Nobuhiro 神谷宣広

Kamiya Nobuhiro 神谷宣広

[Journal Article] 小児整形外科領域における基礎研究から臨床応用へ　小児整形外科の基礎研究　Perthes病とIL-62022

[Journal Article] 小児整形外科疾患に対する新しい治療法-その展望および問題点-　Perthes病に対する抗IL-6受容体中和抗体を用いた新規治療戦略2022

[Presentation] A new therapeutic strategy for Legg-Calve-Perthes　disease (LCPD) using a monoclonal neutralizing　antibody for interleukin 6 (IL-6) receptor by stimulating　new bone formation and revascularization2021