Sekai Miho 瀬海美穂

Researcher Number	50737533
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定助教
Affiliation (based on the past Project Information) *help	2020 – 2022: 京都大学, 医学研究科, 特定助教 2019: 北海道大学, 遺伝子病制御研究所, 特任助教 2015 – 2018: 京都大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology
Keywords	Principal Investigator 免疫 / 胸腺 / 退縮 / 胸腺上皮幹細胞 / コロニー / 胸腺上皮細胞 / コロニー形成能 / 上皮幹細胞 / 幹細胞 / 上皮細胞

Understanding for the mechanism of thymic involution during agingPrincipal Investigator
- Principal Investigator
  
  Sekai Miho
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
  Hokkaido University
Understanding the mechanisms of the maintenance and invlution of thymusPrincipal Investigator
- Principal Investigator
  
  Sekai Miho
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University
  Kyoto University

All 2022 2021 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells2022
- Author(s)
  Kuromiya K, Aoki K, Ishibashi K, Yotabun M, Sekai M, Tanimura N, Iijima S, Ishikawa S, Kamasaki T, Akieda Y, Ishitani T, Hayashi T, Toda S, Yokoyama K, Lee CG, Usami I, Inoue H, Takigawa I, Gauquelin E, Sugimura K, Hino N, Fujita Y
- Journal Title
  
  Cell Reports
  
  Volume: 40 Issue: 2 Pages: 111078-111078
- DOI
  10.1016/j.celrep.2022.111078
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15085, KAKENHI-PROJECT-22K15104, KAKENHI-PLANNED-21H05285, KAKENHI-PLANNED-21H05291, KAKENHI-PROJECT-21H05039, KAKENHI-PROJECT-20J20930, KAKENHI-PROJECT-22KJ2048, KAKENHI-PROJECT-20K07559, KAKENHI-PROJECT-20K21502, KAKENHI-PROJECT-19K16689, KAKENHI-PROJECT-20K15785, KAKENHI-PUBLICLY-22H04845, KAKENHI-PROJECT-23K24082, KAKENHI-ORGANIZER-19H05794, KAKENHI-PLANNED-21H05287
[Journal Article] Basal extrusion of single‐oncogenic mutant cells induces dome‐like structures with altered microenvironments2022
- Author(s)
  Shirai Takanobu、Sekai Miho、Kozawa Kei、Sato Nanami、Tanimura Nobuyuki、Kon Shunsuke、Matsumoto Tomohiro、Murakami Takeru、Ito Shoko、Tilston‐Lunel Andrew、Varelas Xaralabos、Fujita Yasuyuki
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 11 Pages: 3710-3721
- DOI
  10.1111/cas.15483
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07630, KAKENHI-PLANNED-21H05285, KAKENHI-PROJECT-21H05039, KAKENHI-PROJECT-19K16689, KAKENHI-PROJECT-20K15785
[Journal Article] The CD44/COL17A1 Pathway Plays a Vital Role in the Formation of Multilayered, Transformed Epithelia.2021
- Author(s)
  Kozawa K, ,Sekai M, Ohba K, Ito S, Sako H, Maruyama T, Kakeno M , Kuromiya K, Kamasaki T, Kohashi K, Ishikawa S, Sato N, Asano S, Suzuki H, Tanimura N, Mukai Y, Gotoh N, Tanino M, Tanaka S Natsuga K, Soga T. Nakamura T, Yabuta Y, Saitou M, Ito T, Matsuura K, Tsunoda M,et.al..
- Journal Title
  
  Curr Biol
  
  Volume: 31 Issue: 14 Pages: 3086-3097
- DOI
  10.1016/j.cub.2021.04.078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06980, KAKENHI-PROJECT-19K05691, KAKENHI-PROJECT-19K22557, KAKENHI-PROJECT-20K21411, KAKENHI-PUBLICLY-20H05029, KAKENHI-PLANNED-21H05285, KAKENHI-PROJECT-21H05039, KAKENHI-PROJECT-19H01171, KAKENHI-PROJECT-21H02761, KAKENHI-PROJECT-19J40132, KAKENHI-PROJECT-19J40277, KAKENHI-PROJECT-20K07559, KAKENHI-PROJECT-20K07630, KAKENHI-PROJECT-21K19878, KAKENHI-PROJECT-19K16689
[Journal Article] An improved clonogenic culture method for thymic epithelial cells2019
- Author(s)
  Sekai Miho、Wang Jianwei、Minato Nagahiro、Hamazaki Yoko
- Journal Title
  
  Journal of Immunological Methods
  
  Volume: 467 Pages: 29-36
- DOI
  10.1016/j.jim.2019.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19442, KAKENHI-PROJECT-19K16689, KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-17H05641, KAKENHI-PROJECT-18H02640
[Journal Article] Clonogenic Culture of Mouse Thymic Epithelial Cells2019
- Author(s)
  Sekai Miho、Wang Jianwei、Hamazaki Yoko
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2048 Pages: 143-153
- DOI
  10.1007/978-1-4939-9728-2_15
- ISBN
  9781493997275, 9781493997282
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19442, KAKENHI-PROJECT-19K16689, KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-17H05641, KAKENHI-PROJECT-18H02640
[Journal Article] Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus2018
- Author(s)
  Wang Jianwei、Sekai Miho、Matsui Takeshi、Fujii Yosuke、Matsumoto Mitsuru、Takeuchi Osamu、Minato Nagahiro、Hamazaki Yoko
- Journal Title
  
  International Immunology
  
  Volume: 31 Issue: 3 Pages: 127-139
- DOI
  10.1093/intimm/dxy073
- NAID
  120007164929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19K16689, KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-17H05641, KAKENHI-PROJECT-18H02640, KAKENHI-PROJECT-18K19442
[Journal Article] Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+T Cells2017
- Author(s)
  Sato Kyosuke、Kato Aiko、Sekai Miho、Hamazaki Yoko、Minato Nagahiro
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199 Issue: 1 Pages: 138-148
- DOI
  10.4049/jimmunol.1602005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-PROJECT-15K15151
[Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production2017
- Author(s)
  Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y.
- Journal Title
  
  JCI Insight
  
  Volume: 2 Issue: 10 Pages: 1-14
- DOI
  10.1172/jci.insight.93664
- NAID
  120006733720
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08884, KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-PROJECT-16H02630, KAKENHI-PROJECT-17H04123, KAKENHI-PROJECT-15K15151, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-15H04716
[Journal Article] Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution2016
- Author(s)
  Hamazaki Y, Sekai M, Minato N
- Journal Title
  
  Immunol Rev.
  
  Volume: 271 Issue: 1 Pages: 38-55
- DOI
  10.1111/imr.12412
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-15K15151, KAKENHI-PROJECT-15K19125
[Journal Article] Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors.2016
- Author(s)
  Baik S, Sekai M, Hamazaki Y, Jenkinson WE, Anderson G.
- Journal Title
  
  Eur J Immunol.
  
  Volume: - Issue: 4 Pages: 857-62
- DOI
  10.1002/eji.201546253
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19125, KAKENHI-PUBLICLY-25111505, KAKENHI-PROJECT-24590580, KAKENHI-PUBLICLY-15H01154, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-15K15151
[Journal Article] Obesity accelerates T-cell senescence in visceral adipose tissue2016
- Author(s)
  Shirakawa K, Yan X, Shinmura K, Endo J, Kataoka M, Katsumata Y, Yamamoto T, Anzai A, Isobe S, Yoshida N, Itoh H, Manabe I, Sekai M, Hamazaki Y, Fukuda K, Minato N, and Sano M.
- Journal Title
  
  J Clin Invest.
  
  Volume: 126 Issue: 12 Pages: 4626-4639
- DOI
  10.1172/jci88606
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008, KAKENHI-PROJECT-15H04825, KAKENHI-PUBLICLY-15H01160, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-15K15151, KAKENHI-PROJECT-15K19125
[Presentation] Thymopoiesis regulates the clonogenic activity of thymic epithelial cells2018
- Author(s)
  Miho Sekai, Yoko Hamazaki, Nagahiro Minato
- Organizer
  日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-15K19125
[Presentation] Thymopoiesis regulates clonogenic activity of thymic epithelial cells2017
- Author(s)
  Miho Sekai, Yoko Hamazaki, Nagahiro Minato
- Organizer
  7th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2017-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19125
[Presentation] Identification and analysis of medullary thymic epithelial cells constituting Hassall’s corpuscles in the murine thymus2017
- Author(s)
  Jianwei Wang, Miho Sekai, NAgahiro Minato, Yoko Hamazaki
- Organizer
  7th International Workshop of Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2017-03-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19125

1. OHIGASHI Izumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. TANINO Mishie

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 濱崎洋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
4. 龝枝佑紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 伊藤祥子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 竹内理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekai Miho 瀬海 美穂

Research Projects

Research Products

Co-Researchers

Understanding for the mechanism of thymic involution during agingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the mechanisms of the maintenance and invlution of thymusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Basal extrusion of single‐oncogenic mutant cells induces dome‐like structures with altered microenvironments2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The CD44/COL17A1 Pathway Plays a Vital Role in the Formation of Multilayered, Transformed Epithelia.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An improved clonogenic culture method for thymic epithelial cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonogenic Culture of Mouse Thymic Epithelial Cells2019

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Hassall’s corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+T Cells2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK+ medullary epithelial progenitors.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Obesity accelerates T-cell senescence in visceral adipose tissue2016

Author(s)

Journal Title

DOI

Data Source

[Presentation] Thymopoiesis regulates the clonogenic activity of thymic epithelial cells2018

Author(s)

Organizer

Data Source

[Presentation] Thymopoiesis regulates clonogenic activity of thymic epithelial cells2017

Author(s)

Sekai Miho 瀬海美穂