Seto Yosuke 瀬戸陽介

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SETO Yosuke 瀬戸陽介

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Researcher Number	50738614
Affiliation (Current)	2025: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員 2020 – 2023: 公益財団法人がん研究会, がん化学療法センター基礎研究部, 研究員 2016: 首都大学東京, 理工学研究科, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related Except Principal Investigator Evolutionary biology
Keywords	Principal Investigator 肺がん / 薬剤耐性 / DNA修飾 / DNAメチル化 / シングルセル / シングルセル解析 Except Principal Investigator ショウジョウバエ / 遺伝子発現 / トランスクリプトーム / 環境適応 … More / RNA-seq / 比較トランスクリプトーム / カビ耐性 / 遺伝子進化 / 適応進化 / 食物選択 / 進化 / 腸内細菌叢 / 抗カビ耐性 / 遺伝子重複 / 微生物耐性 / 抗菌ペプチド / 分布域拡大 / 遺伝子改変 / アカショウジョウバエ / 分布拡大 / 低温順化 / 低温耐性 Less

肺がんにおけるAPOBEC/ADARを介した薬剤耐性変異獲得メカニズムの解明Principal Investigator
- Principal Investigator
  
  瀬戸陽介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
肺がんにおけるエピジェネティックスを介した薬剤耐性変異獲得メカニズムの解明Principal Investigator
- Principal Investigator
  
  瀬戸陽介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Elucidating molecular mechanisms of anti-cancer drug resistance of EGFR mutation-positive lung cancer by using single-cell technologyPrincipal Investigator
- Principal Investigator
  
  SETO Yosuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Japanese Foundation for Cancer Research
Molecular mechanisms to strengthen cold tolerance in Drosophila albomicans
- Principal Investigator
  
  Tamura Koichiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Evolutionary biology
- Research Institution
  Tokyo Metropolitan University
Evolution of genomic structure and expression pattern of antimicrobial peptide genes in Drosophila species
- Principal Investigator
  
  Tamura Koichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Evolutionary biology
- Research Institution
  Tokyo Metropolitan University

All 2023 2022 2021 2020 2016 2015 2014

All Journal Article Presentation

[Journal Article] APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells2023
- Author(s)
  Chen M, Mashima T, Oishi T, Muramatsu Y, Seto Y, Takamatsu M, Kawata N, Morino S, Nakamura A, Inaba S, Yuan X, Maruyama K, Suzuki M, Sato A, Yoshida H, Jang MK, Mizutani A, Takeuchi K, Yamaguchi K, Shirai F, Nagayama S, Katayama R, Seimiya H
- Journal Title
  
  British Journal of Cancer
  
  Volume: 130 Issue: 1 Pages: 151-162
- DOI
  10.1038/s41416-023-02484-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07199, KAKENHI-PROJECT-21K07251, KAKENHI-PROJECT-22K19469, KAKENHI-PROJECT-23K24192
[Journal Article] Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation2022
- Author(s)
  Sagawa Ray、Sakata Seiji、Gong Bo、Seto Yosuke、Takemoto Ai、Takagi Satoshi、Ninomiya Hironori、Yanagitani Noriko、Nakao Masayuki、Mun Mingyon、Uchibori Ken、Nishio Makoto、Miyazaki Yasunari、Shiraishi Yuichi、Ogawa Seishi、Kataoka Keisuke、Fujita Naoya、Takeuchi Kengo、Katayama Ryohei
- Journal Title
  
  JCI Insight
  
  Volume: 7 Issue: 1 Pages: 1-19
- DOI
  10.1172/jci.insight.153323
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-20K07399
[Journal Article] Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis2021
- Author(s)
  Takagi Satoshi、Sasaki Yuki、Koike Sumie、Takemoto Ai、Seto Yosuke、Haraguchi Mizuki、Ukaji Takao、Kawaguchi Tokuichi、Sugawara Minoru、Saito Masanori、Funauchi Yuki、Ae Keisuke、Matsumoto Seiichi、Fujita Naoya、Katayama Ryohei
- Journal Title
  
  Oncogene
  
  Volume: 40 Issue: 36 Pages: 5548-5558
- DOI
  10.1038/s41388-021-01956-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-ORGANIZER-17H06324
[Journal Article] Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity2021
- Author(s)
  Yoshizawa Takahiro、Uchibori Ken、Araki Mitsugu、Matsumoto Shigeyuki、Ma Biao、Kanada Ryo、Seto Yosuke、Oh-hara Tomoko、Koike Sumie、Ariyasu Ryo、Kitazono Satoru、Ninomiya Hironori、Takeuchi Kengo、Yanagitani Noriko、Takagi Satoshi、Kishi Kazuma、Fujita Naoya、Okuno Yasushi、Nishio Makoto、Katayama Ryohei
- Journal Title
  
  npj Precision Oncology
  
  Volume: 5 Issue: 1 Pages: 32-32
- DOI
  10.1038/s41698-021-00170-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K15936, KAKENHI-PROJECT-18K06594, KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524
[Journal Article] Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay2021
- Author(s)
  Hiroaki Tachiwana, Mariko Dacher, Kazumitsu Maehara, Akihito Harada, Yosuke Seto, Ryohei Katayama, Yasuyuki Ohkawa, Hiroshi Kimura, Hitoshi Kurumizaka, Noriko Saitoh
- Journal Title
  
  eLife
  
  Volume: 10
- DOI
  10.7554/elife.66290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H04970, KAKENHI-PUBLICLY-20H05393, KAKENHI-PROJECT-19H03158, KAKENHI-PROJECT-20K21398, KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-18H05527, KAKENHI-PLANNED-18H05534, KAKENHI-PUBLICLY-20H04846, KAKENHI-PUBLICLY-20H05397, KAKENHI-PUBLICLY-21H00232, KAKENHI-PUBLICLY-21H00430, KAKENHI-PROJECT-20H00449, KAKENHI-PROJECT-20H00456, KAKENHI-PROJECT-19H03211, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-20H03520, KAKENHI-PROJECT-20K06496, KAKENHI-PROJECT-16H06279, KAKENHI-PLANNED-18H05531
[Journal Article] Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non‐small cell lung cancer2020
- Author(s)
  Takahashi、Seto、Okada、Uematsu、Uchibori、Tsukahara、Oh‐hara、Fujita、Yanagitani、Nishio、Okubo、Katayama R.
- Journal Title
  
  Thoracic Cancer
  
  Volume: 11 Issue: 3 Pages: 581-587
- DOI
  10.1111/1759-7714.13299
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02368, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-20K16370
[Journal Article] Comprehensive identification of odorant-binding protein genes in the seed fly, Delia platura (Diptera: Anthomyiidae)2015
- Author(s)
  Ohta S, Seto Y, Tamura K, Ishikawa Y, Matsuo T.
- Journal Title
  
  Applied Entomology and Zoology
  
  Volume: 50 Issue: 4 Pages: 457-463
- DOI
  10.1007/s13355-015-0353-8
- NAID
  40020659575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14584, KAKENHI-PROJECT-26660263, KAKENHI-PROJECT-26291074
[Presentation] Elucidating molecular mechanisms of anti-cancer drug tolerance in lung cancer using single-cell technology.2023
- Author(s)
  Yosuke Seto, Naoya Fujita, Ryohei Katayama
- Organizer
  SMBE2023: Annual meeting of the Society for Molecular Biology and Evolution, Ferrara, Italy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07199
[Presentation] Elucidating mechanisms of the emergence of acquired anti-cancer drug resistance in lung cancer.2023
- Author(s)
  瀬戸陽介、藤田直也、片山量平
- Organizer
  日本進化学会第25回大会
- Data Source
  KAKENHI-PROJECT-22K07199
[Presentation] シングルセル技術を用いたがん進化メカニズムの解明2022
- Author(s)
  瀬戸陽介、藤田直也、片山量平
- Organizer
  日本遺伝学会第９４回大会
- Data Source
  KAKENHI-PROJECT-22K07199
[Presentation] シングルセル解析によるがんの薬剤抵抗性メカニズムの解明2022
- Author(s)
  瀬戸陽介、藤田直也、片山量平
- Organizer
  日本進化学会第24回大会
- Data Source
  KAKENHI-PROJECT-22K07199
[Presentation] EGFR-TKI tolerant mechanisms of non-small cell lung cancer revealed by single-cell technologies2021
- Author(s)
  Yosuke Seto, Naoya Fujita, Ryohei Katayama
- Organizer
  第44回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16370
[Presentation] シングルセル技術を用いたがんの薬剤耐性メカニズムの解明2021
- Author(s)
  瀬戸陽介、藤田直也、片山量平
- Organizer
  日本遺伝学会第93回大会
- Data Source
  KAKENHI-PROJECT-20K16370
[Presentation] シングルセルレベルで解き明かすがんの薬剤耐性の分子メカニズム2021
- Author(s)
  瀬戸陽介、藤田直也、片山量平
- Organizer
  日本進化学会第23回大会
- Data Source
  KAKENHI-PROJECT-20K16370
[Presentation] Comparative RNA-seq analysis of antifungal immune responses among Drosophila species2016
- Author(s)
  Yosuke Seto, Koichiro Tamura
- Organizer
  Annual Meeting of the Society for Molecular Biology and Evolution 2016
- Place of Presentation
  Gold Coast Convention & Exhibition Centre, Australia
- Year and Date
  2016-07-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] キイロショウジョウバエ種群におけるカビ感染時の腸内細菌叢の変動2016
- Author(s)
  清野健司，瀬戸陽介，田村浩一郎
- Organizer
  日本進化学会第18回大会
- Place of Presentation
  東京工業大学　大岡山キャンパス
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] 食性の異なるショウジョウバエにおける抗真菌免疫システムの分子進化2016
- Author(s)
  瀬戸陽介，田村浩一郎
- Organizer
  日本進化学会第18回大会
- Place of Presentation
  東京工業大学　大岡山キャンパス
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] キイロショウジョウバエ種群におけるカビ感染時の腸内細菌叢の変動2016
- Author(s)
  清野健司，瀬戸陽介，田村浩一郎
- Organizer
  日本遺伝学会第88回大会
- Place of Presentation
  日本大学国際関係学部三島駅北口校舎
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] 食性の異なるショウジョウバエにおける抗カビ免疫システムの種間比較解析2016
- Author(s)
  瀬戸陽介，田村浩一郎
- Organizer
  日本遺伝学会第88回大会
- Place of Presentation
  日本大学国際関係学部三島駅北口校舎
- Year and Date
  2016-09-07
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] Evolution of the immigrans species group revealed by using big sequence data2015
- Author(s)
  Seto Y and Tamura K
- Organizer
  SMBE 2015
- Place of Presentation
  Hofburg Palace (Austria)
- Year and Date
  2015-07-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] キハダショウジョウバエ種内における抗菌ペプチドDrosomycin遺伝子の多様性2015
- Author(s)
  市川里紗，瀬戸陽介，田村浩一郎
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] ショウジョウバエ抗カビ免疫システムの種間比較解析2015
- Author(s)
  瀬戸陽介，田村浩一郎
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] Evolution of the immigrans species group revealed by using big sequence data2015
- Author(s)
  Seto Y and Tamura K
- Organizer
  SMBE 2015
- Place of Presentation
  Hofburg Palace (Austria)
- Year and Date
  2015-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14584
[Presentation] キハダショウジョウバエ種内における抗菌ペプチドDrosomycin遺伝子の多様性2015
- Author(s)
  市川里紗，瀬戸陽介，田村浩一郎
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-15K14584
[Presentation] キハダショウジョウバエ種内における抗菌ペプチドDrosomycin遺伝子の分子進化2015
- Author(s)
  市川里紗，瀬戸陽介，田村浩一郎
- Organizer
  日本進化学会第17回大会
- Place of Presentation
  中央大学（東京都文京区）
- Year and Date
  2015-08-20
- Data Source
  KAKENHI-PROJECT-15K14584
[Presentation] ショウジョウバエ抗カビ免疫システムの種間比較解析2015
- Author(s)
  瀬戸陽介，田村浩一郎
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-25
- Data Source
  KAKENHI-PROJECT-15K14584
[Presentation] 抗真菌耐性の異なるショウジョウバエ種間における比較トランスクリプトーム解析2015
- Author(s)
  瀬戸陽介，田村浩一郎
- Organizer
  日本進化学会第17回大会
- Place of Presentation
  中央大学（東京都文京区）
- Year and Date
  2015-08-20
- Data Source
  KAKENHI-PROJECT-15K14584
[Presentation] キハダショウジョウバエ種内における抗菌ペプチドDrosomycin遺伝子の分子進化2015
- Author(s)
  市川里紗，瀬戸陽介，田村浩一郎
- Organizer
  日本進化学会第17回大会
- Place of Presentation
  中央大学（東京都文京区）
- Year and Date
  2015-08-20
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] 抗真菌耐性の異なるショウジョウバエ種間における比較トランスクリプトーム解析2015
- Author(s)
  瀬戸陽介，田村浩一郎
- Organizer
  日本進化学会第17回大会
- Place of Presentation
  中央大学（東京都文京区）
- Year and Date
  2015-08-20
- Data Source
  KAKENHI-PROJECT-26291074
[Presentation] カビ感染に対するショウジョウバエ免疫応答の比較発現解析2014
- Author(s)
  瀬戸陽介
- Organizer
  日本比較免疫学会第26回学術集会
- Place of Presentation
  東北大学（宮城県・仙台市）
- Year and Date
  2014-07-09
- Data Source
  KAKENHI-PROJECT-26291074

1. Tamura Koichiro (00254144)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. 高橋文 (90370121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NAKAMURA Yo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. KIMURA Tomohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUZUKI Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUZUKI Marina

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYASHITA Takayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ICHIKAWA Risa

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. SEINO Kenji

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. RYOUHEI Katayama

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. 高木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 藤田直也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 前原一満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Seto Yosuke 瀬戸 陽介

SETO Yosuke 瀬戸 陽介

Research Projects

Research Products

Co-Researchers

肺がんにおけるAPOBEC/ADARを介した薬剤耐性変異獲得メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺がんにおけるエピジェネティックスを介した薬剤耐性変異獲得メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating molecular mechanisms of anti-cancer drug resistance of EGFR mutation-positive lung cancer by using single-cell technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms to strengthen cold tolerance in Drosophila albomicans

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evolution of genomic structure and expression pattern of antimicrobial peptide genes in Drosophila species

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soluble PD-L1 works as a decoy in lung cancer immunotherapy via alternative polyadenylation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Platelet-derived lysophosphatidic acid mediated LPAR1 activation as a therapeutic target for osteosarcoma metastasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overcoming resistance by ALK compound mutation (I1171S + G1269A) after sequential treatment of multiple ALK inhibitors in non‐small cell lung cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comprehensive identification of odorant-binding protein genes in the seed fly, Delia platura (Diptera: Anthomyiidae)2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Elucidating molecular mechanisms of anti-cancer drug tolerance in lung cancer using single-cell technology.2023

Author(s)

Organizer

Data Source

[Presentation] Elucidating mechanisms of the emergence of acquired anti-cancer drug resistance in lung cancer.2023

Author(s)

Organizer

Data Source

[Presentation] シングルセル技術を用いたがん進化メカニズムの解明2022

Seto Yosuke 瀬戸陽介

SETO Yosuke 瀬戸陽介