Abd Aziz lbrahim アブドゥルアジズ

… Alternative Names

IBRAHIM Abd Aziz アブドゥルアジズ

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Researcher Number	50738789
Other IDs	https://orcid.org/0000-0003-1374-1089
Affiliation (Current)	2025: 東海大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 東海大学, 医学部, 特任講師 2018 – 2021: 東海大学, 医学部, 特定研究員 2017: 東海大学, 医学部, 特定研究員(PD) 2014 – 2015: 東海大学, 医学部, 奨励研究員 2014: 東海大学, 医学部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 44010:Cell biology-related / Tumor therapeutics Except Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / General medical chemistry
Keywords	Principal Investigator PAI-1 / がん幹細胞 / 幹細胞 / プラスミノーゲン活性化抑制因子（PAI-1） / 運動能の制御 / がん治療 / 再生医療 / 細胞運動能制御 / ニッチ / 細胞運動制御 … More / 細胞内PAI-1 / PKA-CREB-p300 / 白血病幹細胞 / がん幹細胞治療 / ヒトCD34+CD38-細胞 / マウスLSK細胞 / p300 / PKA-CREB-P300 / P300 / 細胞運動能の制御 / 造血幹細胞 / 完全寛解 / 分子標的薬 / 線維素溶解系 / 白血病 … More Except Principal Investigator PAI-1 / 分子標的薬 / 低分子化合物 / 線維素溶解系 / プラスミノーゲン活性化阻害因子（PAI-1） / 腫瘍生物学 / 線維素溶解径 / 線溶系 / 創薬 / 免疫チェックポイント / がん免疫療法 / がん / MT1-MMP / 治療抵抗性 / 繊維素溶解系 / 薬剤耐性 / がん幹細胞 / TGF-b / 白血病幹細胞 / TGF-beta / ニッチ / 幹細胞 / 白血病 / 再生医療 / 再生 / 造血再生 / 造血幹細胞 Less

Elucidation of stem cell motility mechanism and its application to regeneration and cancer therapyPrincipal Investigator
- Principal Investigator
  
  アブドゥルアジズ
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokai University
Establishment of novel combination cancer immunotherapy targeting regulators of the fibrinolytic system
- Principal Investigator
  
  八幡崇
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokai University
To Elucidate the Regulation Mechanism of Hematopoietic Stem Cell's MobilityPrincipal Investigator
- Principal Investigator
  
  IBRAHIM ABD AZIZ
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Tokai University
Blockade of PAI-1 eliminates leukemic stem cells
- Principal Investigator
  
  YAHATA Takashi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokai University
Establishment of new method for leukemia therapy by targeting fibrinolytic pathwayPrincipal Investigator
- Principal Investigator
  
  ABD Aziz
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokai University
Establishment of hematopoietic regeneration by the novel molecular targeting drug
- Principal Investigator
  
  YAHATA Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokai University

All 2023 2021 2020 2019 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 12023
- Author(s)
  Ibrahim Abd Aziz, Fujimura Taku, Uno Tomoko, Terada Tomoya, Hirano Ken-ichi, Hosokawa Hiroyuki, Ohta Akio, Miyata Toshio, Ando Kiyoshi, Yahata Takashi,
- Journal Title
  
  Frontiers in Immunology
  
  Volume: -
- DOI
  10.21203/rs.3.rs-3637984/v1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07820
[Journal Article] Mitochondrial Electron Transport Chain Complex II Dysfunction Causes Premature Aging of Hematopoietic Stem Cells2023
- Author(s)
  Kaito Harada, Takashi Yahata, Makoto Onizuka, Takamasa Ishii, Abd Aziz Ibrahim, Eri Kikkawa, Yoichi Gondo, Kiyoshi Ando
- Journal Title
  
  Stem Cells
  
  Volume: 41(1) Issue: 1 Pages: 39-49
- DOI
  10.1093/stmcls/sxac072
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-23K21386
[Journal Article] Plasminogen activator inhibitor type-1 is a negative regulator of hematopoietic regeneration in the adipocyte-rich bone marrow microenvironment2021
- Author(s)
  Harada Kaito、Yahata Takashi、Onizuka Makoto、Ibrahim Abd Aziz、Kikkawa Eri、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 557 Pages: 180-186
- DOI
  10.1016/j.bbrc.2021.04.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-18K07073, KAKENHI-PROJECT-20K22941, KAKENHI-PROJECT-23K21386
[Journal Article] IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform2021
- Author(s)
  Harama Daisuke、Yahata Takashi、Kagami Keiko、Abe Masako、Ando Norie、Kasai Shin、Tamai Minori、Akahane Koshi、Inukai Takeshi、Kiyokawa Nobutaka、Ibrahim Abd Aziz、Ando Kiyoshi、Sugita Kanji
- Journal Title
  
  Cell Death Discovery
  
  Volume: 7 Issue: 1 Pages: 1-14
- DOI
  10.1038/s41420-021-00523-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-23K21386
[Journal Article] Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells2020
- Author(s)
  Yahata Takashi、Ibrahim Abd Aziz、Hirano Ken-ichi、Muguruma Yukari、Naka Kazuhito、Hozumi Katsuto、Vaughan Douglas E.、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Haematologica
  
  Volume: 105 Issue: 2 Pages: 483-494
- DOI
  10.3324/haematol.2019.230227
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03578, KAKENHI-PROJECT-18K14702
[Journal Article] Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice2019
- Author(s)
  Imai J, Yahata T, Ichikawa H, Ibrahim AA, Yazawa M, Sumiyoshi H, Inagaki Y, Matsushima M, Suzuki T, Mine T, Ando K, Miyata T, Hozumi K.
- Journal Title
  
  Intestinal Research
  
  Volume: 18 Issue: 2 Pages: 219-228
- DOI
  10.5217/ir.2019.00037
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08603, KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-19K22627, KAKENHI-PROJECT-19K17413, KAKENHI-PROJECT-17H04166
[Journal Article] Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning2019
- Author(s)
  Ibrahim Abd Aziz、Yahata Takashi、Muguruma Yukari、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 516(2) Issue: 2 Pages: 500-505
- DOI
  10.1016/j.bbrc.2019.06.076
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702, KAKENHI-PROJECT-17H03572
[Journal Article] TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche2017
- Author(s)
  Yahata Takashi、Ibrahim Abd Aziz、Muguruma Yukari、Eren Mesut、Shaffer Alexander M.、Watanabe Nobuo、Kaneko Satoko、Nakabayashi Tetsuo、Dan Takashi、Hirayama Noriaki、Vaughan Douglas E.、Miyata Toshio、Ando Kiyoshi
- Journal Title
  
  Blood
  
  Volume: 130 Issue: 21 Pages: 2283-2294
- DOI
  10.1182/blood-2017-02-767384
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301, KAKENHI-PROJECT-17H03572, KAKENHI-PROJECT-15K10523
[Journal Article] Inhibition of plasminogen activator inhibitor type-1 activity enhances rapid and sustainable hematopoietic regeneration.2014
- Author(s)
  IbrahimAA,Yahata T,Onizuka M,Dan T,Van Yperscle De Stribou C,Miyata T,Ando K
- Journal Title
  
  Stem Cells,
  
  Volume: 32 Issue: 4 Pages: 946-958
- DOI
  10.1002/stem.1577
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390248, KAKENHI-PROJECT-24590361, KAKENHI-PROJECT-26890022
[Presentation] Bone Marrow Adipocyte-Derived PAI-1 As a Negative Regulator of Hematopoietic Regeneration2019
- Author(s)
  Kaito Harada, Makoto Onizuka, Takashi Yahata, Abd Aziz Ibrahim, Eri Kikkawa, Toshio Miyata, Kiyoshi Ando
- Organizer
  The 61st American Society of Hematology Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702
[Presentation] Pharmacological Inhibition of PAI-1 Empties Bone Marrow Niche Without Myeloablative Conditioning2019
- Author(s)
  Abd Aziz Ibrahim, Takashi Yahata, Yukari Muguruma, Toshio Miyata, and Kiyoshi Ando
- Organizer
  The 81st Annual Meeting of the Japanese Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14702
[Presentation] G-CSF-induced cAMP-PKA-CREB pathway counteracts TGF-β-PAI-1 signaling-dependent retention of HSCs2017
- Author(s)
  Abd Aziz Ibrahim, Takashi Yahata
- Organizer
  第７９回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] TGF-b induced intracellular PAI-1 is a critical regulator HSC localization in the niche2016
- Author(s)
  アブドゥルアジズ、八幡　崇
- Organizer
  第７８回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] Intracellular PAI-1 is a critical regulator of hematopoietic stem and progenitor cell localization in the niche2016
- Author(s)
  Yahata T, Ibrahim AA, Muguruma Y, Kaneko S, Miata T, Ando K
- Organizer
  Gordon Research Conference
- Place of Presentation
  Ventura, CA
- Year and Date
  2016-02-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04301
[Presentation] Plasminogen Activator Inhibitor Tye-1 Regulates Hematopoietic Stem/Progenitor Cell Homing2015
- Author(s)
  Abd Aziz Ibrahim
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  ホテル日航金沢、石川県金沢市
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26890022

1. YAHATA Takashi (10398753)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
2. ANDO Kiyoshi (70176014)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. MIYATA Toshio (10222332)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 藤村卓 (50396496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 犬飼岳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 赤羽弘資

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 原間大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 住吉秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 仲一仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Abd Aziz lbrahim アブドゥル アジズ

IBRAHIM Abd Aziz アブドゥル アジズ

Research Projects

Research Products

Co-Researchers

Elucidation of stem cell motility mechanism and its application to regeneration and cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of novel combination cancer immunotherapy targeting regulators of the fibrinolytic system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To Elucidate the Regulation Mechanism of Hematopoietic Stem Cell's MobilityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Blockade of PAI-1 eliminates leukemic stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of new method for leukemia therapy by targeting fibrinolytic pathwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of hematopoietic regeneration by the novel molecular targeting drug

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 12023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitochondrial Electron Transport Chain Complex II Dysfunction Causes Premature Aging of Hematopoietic Stem Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Plasminogen activator inhibitor type-1 is a negative regulator of hematopoietic regeneration in the adipocyte-rich bone marrow microenvironment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IMiDs uniquely synergize with TKIs to upregulate apoptosis of Philadelphia chromosome-positive acute lymphoblastic leukemia cells expressing a dominant-negative IKZF1 isoform2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting of plasminogen activator inhibitor-1 activity promotes elimination of chronic myeloid leukemia stem cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of plasminogen activator inhibitor-1 attenuates against intestinal fibrosis in mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Blockade of plasminogen activator inhibitor-1 empties bone marrow niche sufficient for donor hematopoietic stem cell engraftment without myeloablative conditioning2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TGF-β-induced intracellular PAI-1 is responsible for retaining hematopoietic stem cells in the niche2017

Author(s)

Journal Title

DOI

Abd Aziz lbrahim アブドゥルアジズ

IBRAHIM Abd Aziz アブドゥルアジズ