ISHIHARA Sayaka 石原沙耶花

Researcher Number	50741865
Other IDs
Affiliation (based on the past Project Information) *help	2020 – 2021: 北里大学, 理学部, 助教 2017 – 2018: 北里大学, 理学部, 助教 2016: 北里大学, 理学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology
Keywords	Principal Investigator Rap1 / 大腸炎 / RORgt+Treg / Th17 / Treg / 腸内細菌 / 免疫学 / 接着カスケード / 免疫動態 / ILC3 / ILC3細胞 / γδT細胞

Elucidate of the onset mechanism of colitis using IBD model mousePrincipal Investigator
- Principal Investigator
  
  石原沙耶花
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kitasato University
The roles of ILC3 and gammadelta T cells in the development of colitis of the model-micePrincipal Investigator
- Principal Investigator
  
  ISHIHARA Sayaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kitasato University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling2022
- Author(s)
  Ishihara Sayaka、Sato Tsuyoshi、Fujikado Noriyuki、Miyazaki Haruka、Yoshimoto Takayuki、Yamamoto Hiromitsu、Fukuda Shinji、Katagiri Koko
- Journal Title
  
  Communications Biology
  
  Volume: 5 Issue: 1 Pages: 206-223
- DOI
  10.1038/s42003-022-03129-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16290, KAKENHI-PROJECT-19K07612, KAKENHI-PROJECT-21K12256, KAKENHI-PROJECT-22K08018, KAKENHI-PROJECT-22K12772
[Journal Article] Rap1 is essential for B-cell locomotion, germinal center formation and normal B-1a cell population.2021
- Author(s)
  Ishihara S, Sato T, Sugioka R, Miwa R, Saito H, Sato R, Fukuyama H, Nakajima A, Sawai S, Kotani A, Katagiri K.
- Journal Title
  
  Front Immunol.
  
  Volume: 12 Pages: 624419-624419
- DOI
  10.3389/fimmu.2021.624419
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21550, KAKENHI-PROJECT-20K16290, KAKENHI-PROJECT-20H03716, KAKENHI-PROJECT-19K07612
[Journal Article] Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking2020
- Author(s)
  Ishihara Sayaka、Sato Tsuyoshi、Du Guangwei、Guardavaccaro Daniele、Nakajima Akihiko、Sawai Satoshi、Kataoka Tohru、Katagiri Koko
- Journal Title
  
  BMC Biology
  
  Volume: 18 Issue: 1 Pages: 75-75
- DOI
  10.1186/s12915-020-00809-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07612, KAKENHI-PROJECT-20K16290, KAKENHI-PROJECT-19K06633, KAKENHI-ORGANIZER-19H05794
[Journal Article] Dissection of α 4 β 7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β 7 antibodies.2020
- Author(s)
  Sato T, Ishihara S, Marui R, Takagi J, Katagiri K
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 13221-13221
- DOI
  10.1038/s41598-020-70111-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07612, KAKENHI-PROJECT-20K16290, KAKENHI-PROJECT-20H00455, KAKENHI-PROJECT-20K20581
[Journal Article] A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing2019
- Author(s)
  Nishiyama K, Sugiyama M, Yamada H, Makino K, Ishihara S, Takaki T, Mukai T, Okada N
- Journal Title
  
  Scientific reports
  
  Volume: 9 Issue: 1 Pages: 4731-4731
- DOI
  10.1038/s41598-019-41151-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15249, KAKENHI-PROJECT-16K19163, KAKENHI-PROJECT-19K15965, KAKENHI-PROJECT-19K07423
[Journal Article] Collagen-derived peptides modulate CD4+ T-cell differentiation and suppress allergic responses in mice.2018
- Author(s)
  Nishikimi A, Koyama YI, Ishihara S, Kobayashi S, Tometsuka C, Kusubata M, Kuwaba K, Hayashida O, Hattori S, Katagiri K
- Journal Title
  
  Immunity, inflammation and disease
  
  Volume: - Issue: 2 Pages: 245-255
- DOI
  10.1002/iid3.213
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19163
[Presentation] Rap1 regulates active conformation of α4β7 and affinity for MadCAM-12018
- Author(s)
  Sato T, Ishihara S, Marui R, Nishikimi A, Takagi J, Katagiri K
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-16K19163
[Presentation] Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.2017
- Author(s)
  Ishihara S, Mamiyoda M, Sato T, Nishikimi A, Saegusa M, Katagiri K.
- Organizer
  5th Annual Meeting of the International Cytokine & Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19163
[Presentation] The roles of ILC3 and γδ T cells in the development of colitis of the model-mice.2017
- Author(s)
  Kikuchi N, Ishihara S, Sato T, Sawa S, Shibata K, Yoshikai Y and Katagiri K.
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19163
[Presentation] T cell specific Rap1-deficient mice develop spontaneous colitis.2017
- Author(s)
  Sato T, Ishihara S, Takagi J, Katagiri K.
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19163
[Presentation] Identification of guanine nucleotide exchange factor (GEF) for Rap1 crucial for lymphocyte trafficking.2016
- Author(s)
  Momoi Y, Ishihara S, Nishikimi A, Katagiri K.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K19163
[Presentation] Regulation of adhesion cascade of naive and effector T cells by Rap1 is critical for mucosal homeostasis2016
- Author(s)
  1.Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K19163
[Presentation] Clathrin-dependent internalization of LFA-1 plays an important role in rear detachment of migrating lymphocytes.2016
- Author(s)
  Nishikimi A, Ishihara S, Katagiri K.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター(沖縄県宜野湾市)
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K19163

1. 片桐晃子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 西山啓太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 幸谷愛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ISHIHARA Sayaka 石原 沙耶花

Research Projects

Research Products

Co-Researchers

Elucidate of the onset mechanism of colitis using IBD model mousePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The roles of ILC3 and gammadelta T cells in the development of colitis of the model-micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Rap1 prevents colitogenic Th17 cell expansion and facilitates Treg cell differentiation and distal TCR signaling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rap1 is essential for B-cell locomotion, germinal center formation and normal B-1a cell population.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dissection of α 4 β 7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β 7 antibodies.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new approach for analyzing an adhesive bacterial protein in the mouse gastrointestinal tract using optical tissue clearing2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Collagen-derived peptides modulate CD4+ T-cell differentiation and suppress allergic responses in mice.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Rap1 regulates active conformation of α4β7 and affinity for MadCAM-12018

Author(s)

Organizer

Data Source

[Presentation] Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.2017

Author(s)

Organizer

Data Source

[Presentation] The roles of ILC3 and γδ T cells in the development of colitis of the model-mice.2017

Author(s)

Organizer

Data Source

[Presentation] T cell specific Rap1-deficient mice develop spontaneous colitis.2017

Author(s)

Organizer

Data Source

[Presentation] Identification of guanine nucleotide exchange factor (GEF) for Rap1 crucial for lymphocyte trafficking.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Regulation of adhesion cascade of naive and effector T cells by Rap1 is critical for mucosal homeostasis2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Clathrin-dependent internalization of LFA-1 plays an important role in rear detachment of migrating lymphocytes.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

ISHIHARA Sayaka 石原沙耶花