Nakayama Ryoko 中山亮子

Researcher Number	50749843
Other IDs	https://orcid.org/0000-0002-6688-0413
Affiliation (Current)	2025: 鶴見大学, 歯学部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 鶴見大学, 歯学部, 助教 2018: 鶴見大学, 歯学部, 学部助手 2015 – 2016: 鶴見大学, 歯学部, 学部助手
Review Section/Research Field	Principal Investigator Basic Section 57020:Oral pathobiological science-related / Pathobiological dentistry/Dental radiology Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Basic Section 57040:Regenerative dentistry and dental engineering-related / Basic Section 59040:Nutrition science and health science-related / Social dentistry / Morphological basic dentistry / Applied health science / Pathobiological dentistry/Dental radiology
Keywords	Principal Investigator 女性ホルモン / シェーグレン症候群 / OVX / 唾液 / エストロゲン / EBV / オルガノイド / 唾液腺 / シェーグレン症候群 / 唾液分泌障害 … More / 自己免疫疾患 / EBウイルス / 唾液分泌 / マウス / ミトコンドリア / ドライマウス / 口腔乾燥症 … More Except Principal Investigator 口腔乾燥症 / 組織傷害 / 唾液腺 / フードファクター / EBウイルス / レスベラトロール / Epstein-Barr virus / 唾液分泌 / シェーグレン症候群 / ドライマウス / SASP因子 / 老化細胞除去薬 / 老化細胞 / p16INK4a / 再生 / 脂肪幹細胞 / 間質血管細胞群 / 再生医療 / 脂肪由来幹細胞 / 慢性疲労 / ヘルペスウイルス / 疲労 / ストレス / fatique / 唾液分泌促進 / 抗酸化物質 / 唾液 / 酸化ストレス / フィトケミカル / 唾液分泌低下 / 口腔病理学 / apoptosis / MUC-1 / EGFR2 / 唾液腺傷害 / 遺伝子改変動物 / 遺伝子改変マウス / 食品 / ウイルス / AhR/Arnt / 加齢 / EBVウイルス / 網羅的解析 / 炎症性サイトカイン / nodマウス / NODマウス / セリン / カロリー制限 Less

Mechanism of Sjögren's syndrome pathogenesis in an EB virus-infected human salivary gland organoid modelPrincipal Investigator
- Principal Investigator
  
  中山亮子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Tsurumi University
老化細胞除去薬によるSjogren症候群の新規治療戦略
- Principal Investigator
  
  尾曲大輔
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Tsurumi University
Elucidation of the mechanism of Sjogren's syndrome pathogenesis by EBV reactivation promoter gene transgenic micePrincipal Investigator
- Principal Investigator
  
  Nakayama Ryoko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Tsurumi University
Comprehensive analysis of tissue regeneration and promoting factors in a mouse model of salivary gland-specific injury by adipose-derived stem cells.
- Principal Investigator
  
  Matsumoto Naoyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Tsurumi University
Elucidation of the onset mechanism of chronic fatigue mediated by herpes virus and search for its regulator
- Principal Investigator
  
  Inoue Hiroko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Nihon Pharmaceutical University
Generation of salivary gland-specific injury model mouse and elucidation of repair mechanism by EGFR2 / MUC1 pathway
- Principal Investigator
  
  MATSUMOTO Naoyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tsurumi University
高齢者の唾液分泌促進を目指したフィトケミカルの効果の検討
- Principal Investigator
  
  梁洪淵
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Tsurumi University
Pathogenesis and regulation of herpes virus related diseases
- Principal Investigator
  
  Inoue Hiroko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied health science
- Research Institution
  Nihon Pharmaceutical University
Elucidation of the salivary secretion regulation mechanism through mitochondrial function control by estrogenPrincipal Investigator
- Principal Investigator
  
  Nakayama Ryoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tsurumi University
The molecular mechanism of salivary dysfunction amelioration by calorie restriction
- Principal Investigator
  
  Saito Ichiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Tsurumi University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Evaluation of the benefits of neutral bicarbonate ionized water baths in an open-label, randomized, crossover trial2024
- Author(s)
  Ushikoshi-Nakayama Ryoko、Yamazaki Tomoe、Omagari Daisuke、Matsumoto Naoyuki、Inoue Hiroko、Nukuzuma Chiyoko、Nishino Seiji、Saito Ichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 1261-1261
- DOI
  10.1038/s41598-024-51851-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10002
[Journal Article] Effects of polyphenols in non-centrifugal cane sugar on saliva secretion: in vitro and in vivo experiments and a randomized controlled trial2023
- Author(s)
 Supriya Shakya、Ushikoshi-Nakayama Ryoko、Yamazaki Tomoe、Omagari Daisuke、Aota Keiko、Inoue Hiroko、Matsumoto Naoyuki、Saito Ichiro
- Journal Title
 
 Journal of Clinical Biochemistry and Nutrition
 
 Volume: 72 Issue: 2 Pages: 171-182
- DOI
 10.3164/jcbn.22-114
- ISSN
 0912-0009, 1880-5086
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-20K09928, KAKENHI-PROJECT-20K10002, KAKENHI-PROJECT-22K09936
[Journal Article] Hyperglycemia Induces Generation of Reactive Oxygen Species and Accelerates Apoptotic Cell Death in Salivary Gland Cells2021
- Author(s)
  Matsumoto Naoyuki、Omagari Daisuke、Ushikoshi-Nakayama Ryoko、Yamazaki Tomoe、Inoue Hiroko、Saito Ichiro
- Journal Title
  
  Pathobiology
  
  Volume: 88 Issue: 3 Pages: 234-241
- DOI
  10.1159/000512639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K10002
[Journal Article] What Are the Major Causes of Dry Mouth in Elderly Adults?2020
- Author(s)
  Matsumoto Naoyuki、Ushikoshi-Nakayama Ryoko、Yamazaki Tomoe、Kaneko Mie、Saito Ichiro
- Journal Title
  
  Current Oral Health Reports
  
  Volume: - Issue: 2 Pages: 165-167
- DOI
  10.1007/s40496-020-00262-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11633
[Journal Article] Pulmonary activation of vitamin D3 and preventive effect against interstitial pneumonia2019
- Author(s)
 Tsujino Ichiro、Ushikoshi-Nakayama Ryoko、Yamazaki Tomoe、Matsumoto Naoyuki、Saito Ichiro
- Journal Title
 
 Journal of Clinical Biochemistry and Nutrition
 
 Volume: 65 Issue: 3 Pages: 245-251
- DOI
 10.3164/jcbn.19-48
- NAID
 130007740756
- ISSN
 0912-0009, 1880-5086
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-17K11633
[Journal Article] Effect of gummy candy containing ubiquinol on secretion of saliva: A randomized, double-blind, placebo-controlled parallel-group comparative study and an in vitro study2019
- Author(s)
  Ushikoshi-Nakayama Ryoko、Ryo Koufuchi、Yamazaki Tomoe、Kaneko Mie、Sugano Tomoko、Ito Yumi、Matsumoto Naoyuki、Saito Ichiro
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 4 Pages: e0214495-e0214495
- DOI
  10.1371/journal.pone.0214495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11633
[Journal Article] Evaluation of the effect of a heat-killed lactic acid bacterium, Enterococcus faecalis 2001, on oral candidiasis2019
- Author(s)
  Yamazaki T.、Ushikoshi-Nakayama R.、Shirone K.、Suzuki M.、Abe S.、Matsumoto N.、Inoue H.、Saito I.
- Journal Title
  
  Beneficial Microbes
  
  Volume: 10 Issue: 6 Pages: 661-669
- DOI
  10.3920/bm2018.0115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11633
[Journal Article] Resveratrol improves salivary dysfunction in a non-obese diabetic (NOD) mouse model of Sjogren’s syndrome.2016
- Author(s)
  Inoue H., Kishimoto A., Ushikoshi-Nakayama R., Hasaka A., Takahashi A., Ryo K., Muramatsu T., Ide F., Mishima K., Saito I.
- Journal Title
  
  J.Clin. Biochem. Nutr.
  
  Volume: 59(2) Issue: 6 Pages: 107-112
- DOI
  10.1159/000446000
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05020
[Presentation] Influence of non-centrifugal cane sugar (NCS) polyphenols on saliva secretion - a randomized controlled trial study2023
- Author(s)
  Shakya S、Ushikoshi-Nakayama R、Yamazaki T、Omagari D、Matsumoto N、Inoue H、Saito I
- Organizer
  第23回抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K10002
[Presentation] Influence of NCS polyphenols on saliva secretion -a randomized controlled trial2023
- Author(s)
  Supriya Shakya, Ryoko Ushikoshi-Nakayama, Tomoe Yamazaki, Daisuke Omagari, Naoyuki Matsumoto, Hiroko Inoue, Ichiro Saito
- Organizer
  第23回抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-22K09936
[Presentation] Possible effects of brown sugar polyphenols on saliva secretion2022
- Author(s)
  シャッキャ・スプリヤ、中山亮子、山崎智恵、尾曲大輔、松本直行、井上裕子、斎藤一郎
- Organizer
  第22回抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K09928
[Presentation] 中性重炭酸イオン水の温浴効果2022
- Author(s)
  中山亮子、山崎智恵、シャッキャ・スプリヤ、尾曲大輔、松本直行、奴久妻智代子、小松知子、李昌一、井上裕子、斎藤一郎
- Organizer
  第22回抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K09928
[Presentation] ２型糖尿病の高血糖を介した唾液分泌障害の検討2020
- Author(s)
  松本直行, 中山亮子, 山崎智恵, 井上裕子, 斎藤一郎
- Organizer
  第20回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-20K10002
[Presentation] 早期閉経モデルマウスを用いた唾液分泌障害におけるミトコンドリアの解析2018
- Author(s)
  中山亮子、井上裕子、金子三恵、梁洪淵、伊藤正、斎藤一郎
- Organizer
  第17回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17K12066
[Presentation] エクオール含有大豆イソフラボンの唾液分泌に与える効果の検討2018
- Author(s)
  金子三恵、梁洪淵、中山亮子、玉置洋、斎藤一郎
- Organizer
  第17回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-17K12066
[Presentation] 早期閉経モデルマウスを用いた唾液分泌障害におけるミトコンドリアの解析2017
- Author(s)
  中山亮子、井上裕子、金子三恵、梁　洪淵、伊藤正孝、斎藤一郎
- Organizer
  第17回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-15H05020
[Presentation] 早期閉経モデルマウスを用いた唾液分泌障害におけるミトコンドリアの解析2017
- Author(s)
  中山亮子、井上裕子、金子三恵、梁洪淵、伊藤正孝、斎藤一郎
- Organizer
  第17回日本抗加齢医学会総会
- Place of Presentation
  東京国際フォーラム　(東京都千代田区）
- Year and Date
  2017-06-02
- Data Source
  KAKENHI-PROJECT-15K11091
[Presentation] エクオール含有大豆イソフラボンの唾液分泌に与える効果の検討2017
- Author(s)
  金子三恵、梁　洪淵、菅野智子、中山亮子、玉置　洋、斎藤一郎
- Organizer
  第17回日本抗加齢医学会総会
- Data Source
  KAKENHI-PROJECT-15H05020
[Presentation] ミトコンドリアのエストロゲンを介した唾液分泌制御機構の検討2016
- Author(s)
  中山亮子
- Organizer
  第16回日本抗加齢医学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-15K11091
[Presentation] ミトコンドリアのエストロゲンを介した唾液分泌制御の検討2016
- Author(s)
  中山　亮子、井上　裕子、金子　三恵、梁　洪淵、斎藤　一郎
- Organizer
  第16回日本抗加齢医学会
- Place of Presentation
  パシフィコ横浜　神奈川県横浜市
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-15H05020

1. Saito Ichiro (60147634)

# of Collaborated Projects: 8 results

# of Collaborated Products: 16 results
2. Inoue Hiroko (50367306)

# of Collaborated Projects: 8 results

# of Collaborated Products: 11 results
3. MATSUMOTO Naoyuki (20386080)

# of Collaborated Projects: 8 results

# of Collaborated Products: 10 results
4. 梁洪淵 (10298268)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
5. 内田仁司 (20736996)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. 山崎智恵 (80817122)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
7. 尾曲大輔 (10608699)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
8. 美島健二 (50275343)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. 葉阪彩加 (30749841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 岡田直子 (50636165)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nakayama Ryoko 中山 亮子

Research Projects

Research Products

Co-Researchers

Mechanism of Sj&#246;gren's syndrome pathogenesis in an EB virus-infected human salivary gland organoid modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

老化細胞除去薬によるSjogren症候群の新規治療戦略

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of Sjogren's syndrome pathogenesis by EBV reactivation promoter gene transgenic micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of tissue regeneration and promoting factors in a mouse model of salivary gland-specific injury by adipose-derived stem cells.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the onset mechanism of chronic fatigue mediated by herpes virus and search for its regulator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of salivary gland-specific injury model mouse and elucidation of repair mechanism by EGFR2 / MUC1 pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

高齢者の唾液分泌促進を目指したフィトケミカルの効果の検討

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathogenesis and regulation of herpes virus related diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the salivary secretion regulation mechanism through mitochondrial function control by estrogenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanism of salivary dysfunction amelioration by calorie restriction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Evaluation of the benefits of neutral bicarbonate ionized water baths in an open-label, randomized, crossover trial2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of polyphenols in non-centrifugal cane sugar on saliva secretion: <i>in vitro</i> and <i>in vivo</i> experiments and a randomized controlled trial2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Hyperglycemia Induces Generation of Reactive Oxygen Species and Accelerates Apoptotic Cell Death in Salivary Gland Cells2021

Author(s)

Journal Title

DOI

Nakayama Ryoko 中山亮子

Mechanism of Sjögren's syndrome pathogenesis in an EB virus-infected human salivary gland organoid modelPrincipal Investigator