MAEDA Kenji 前田賢次

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MAEDA KENJI 前田賢次

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Researcher Number	50758323
Other IDs	https://orcid.org/0000-0002-9424-1491
Affiliation (Current)	2024: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 教授
Affiliation (based on the past Project Information) *help	2023: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 教授 2016 – 2018: 国立研究開発法人国立国際医療研究センター, その他部局等, 室長
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Virology
Keywords	Principal Investigator HIV / 多剤併用療法 / HIV治癒 / cART / HIVリザーバー / 微生物 / 感染症 / ウイルス / 抗ウイルス療法 / 逆転写酵素 … More / 逆転写酵素阻害剤（NRTI） / EFdA/MK-8591 / 新薬開発 / 構造解析 / 薬剤耐性 / 逆転写酵素阻害剤 Less

治療後も残存するHIVリザーバーの定量システム応用したエイズ治癒療法の開発Principal Investigator
- Principal Investigator
  
  前田賢次
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Kagoshima University
Structural analysis of a reverse transcriptase inhibitor, EFdA, potent against drug-resistant HIVPrincipal Investigator
- Principal Investigator
  
  MAEDA KENJI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  National Center for Global Health and Medicine

All 2024 2023 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] HIV Reservoirs and Treatment Strategies toward Curing HIV Infection2024
- Author(s)
  Matsuda Kouki、Maeda Kenji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 25 Issue: 5 Pages: 2621-2621
- DOI
  10.3390/ijms25052621
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15385, KAKENHI-PROJECT-23K07944
[Journal Article] Assessing the effects of antiretroviral therapy-latency-reversing agent combination therapy on eradicating replication-competent HIV provirus in a Jurkat cell culture model2023
- Author(s)
  Matsuda Kouki、Tan Benjy Jek Yang、Rajib Samiul Alam、Tsuchiya Kiyoto、Satou Yorifumi、Maeda Kenji
- Journal Title
  
  STAR Protocols
  
  Volume: 4 Issue: 4 Pages: 102547-102547
- DOI
  10.1016/j.xpro.2023.102547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15385, KAKENHI-PROJECT-23K07944
[Journal Article] Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4?-modified nucleoside RT inhibitors2019
- Author(s)
  Yasutake Yoshiaki、Hattori Shin-ichiro、Tamura Noriko、Matsuda Kouki、Kohgo Satoru、Maeda Kenji、Mitsuya Hiroaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 509 Issue: 4 Pages: 943-948
- DOI
  10.1016/j.bbrc.2019.01.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08826
[Journal Article] The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase2018
- Author(s)
  Takamatsu Yuki、Das Debananda、Kohgo Satoru、Hayashi Hironori、Delino Nicole S.、Sarafianos Stefan G.、Mitsuya Hiroaki、Maeda Kenji
- Journal Title
  
  Cell Chemical Biology
  
  Volume: 25 Issue: 10 Pages: 1268-1278
- DOI
  10.1016/j.chembiol.2018.07.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08826, KAKENHI-PROJECT-17K15710
[Journal Article] Synthesis of 4’‐Substituted Purine 2’‐Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus.2018
- Author(s)
  3.Satoru Kohgo, Shuhei Imoto, Ryoh Tokuda, Yuki Takamatsu, Nobuyo Higashi-Kuwata, Manabu Aoki, Masayuki Amano, Hisao Kansui, Kengo Onitsuka, Kenji Maeda, Hiroaki Mitsuya.
- Journal Title
  
  ChemistrySelect.
  
  Volume: 3(11) Issue: 11 Pages: 3313-3317
- DOI
  10.1002/slct.201800527
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08435, KAKENHI-PROJECT-16K08826, KAKENHI-PROJECT-15K09574
[Journal Article] HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.2018
- Author(s)
  Yasutake Y, Hattori SI, Hayashi H, Matsuda K, Tamura N, Kohgo S, Maeda K, Mitsuya H.
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1) Issue: 1 Pages: 1624-1624
- DOI
  10.1038/s41598-018-19602-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19577, KAKENHI-PROJECT-17H04222, KAKENHI-PROJECT-16K08826, KAKENHI-PROJECT-17K15710
[Journal Article] Synthesis of 4’-Substituted Purine 2’-Deoxyucleosides and Their Activity against Human Immunodeficiency Virus and Hepatitis B Virus.2018
- Author(s)
  Kohgo S, Imoto S, Tokuda R, Takamatsu Y, Higashi-Kuwata N, Aoki M, Amano M, Kansui H, Onitsuka K, Maeda K, and Mitsuya H
- Journal Title
  
  ChemistrySelect
  
  Volume: in press
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08826
[Journal Article] Restoration of immune surface molecules in Kaposi sarcoma-associated herpes virus infected cells by lenalidomide and pomalidomide2017
- Author(s)
  Davis David A.、Mishra Suraj、Anagho Holda A.、Aisabor Ashley I.、Shrestha Prabha、Wang Victoria、Takamatsu Yuki、Maeda Kenji、Mitsuya Hiroaki、Zeldis Jerome B.、Yarchoan Robert
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 31 Pages: 50342-50358
- DOI
  10.18632/oncotarget.17960
- Open Access
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] 新規抗HBV化合物CFCPの発見とその抗HBV活性及び薬理学的動態の解析2018
- Author(s)
  鍬田伸好、青木宏美、林佐奈衣、熊本浩樹、服部真一朗、前田賢次、田中靖人、満屋裕明
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] HIV潜伏感染細胞を標的とした新規治療薬開発に有効なin vitro評価系の開発2017
- Author(s)
  1.松田幸樹、服部真一朗、土屋亮人、小早川拓也、大橋南美、野村渉、原田恵嘉、佐藤賢文、吉村和久、玉村啓和、満屋裕明、前田賢次
- Organizer
  第31回日本エイズ学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] Analysis of molecular mechanism of HIV-1 latent infection & reactivation and development of novel therapeutics active against latent HIV-1 infection.2017
- Author(s)
  3.Kouki Matsuda, Shin-ichiro Hattori, Kiyoto Tsuchiya, Takuya Kobayakawa, Nami Ohashi, Wataru Nomura, Shigeyoshi Harada, Yorifumi Satou, Kazuhisa Yoshimura, Hirokazu Tamamura, Hiroaki Mitsuya, and Kenji Maeda
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] Molecular simulation of EFdA and related analogs to determine the structural basis of HIV-1 drug resistance2017
- Author(s)
  8.Debananda Das, Yuki Takamatsu, Satoru Kohgo, Shinichiro Hattori, Hironori Hayashi, Kouki Matsuda, Stefan G. Sarafianos, Hiroaki Mitsuya, and Kenji Maeda
- Organizer
  ACS' 253rd National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] 4’-Modified NRTIs’ Potent Anti-HIV Activity Stems from Strong RT Active Site Binding.2017
- Author(s)
  Takamatsu Y, Das D, Kohgo S, Hattori S, Hayashi H, Matsuda K, Stefan G. Sarafianos SG, Hiroaki Mitsuya H, and Maeda K.
- Organizer
  2017 Conference on Retroviruses and Opportunistic Infections (CROI)
- Place of Presentation
  Seattle WA
- Year and Date
  2017-02-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] Development of novel nucleoside reverse transcriptase inhibitors active against 4’-ethynyl -2-fluoro-2’-deoxyadenosine (EFdA/MK-8591)-resistant HIV-1s.2016
- Author(s)
  Maeda K, Takamatsu Y, Kohgo S, Das D, Hattori S, Hayashi H, Stefan G. Sarafianos SG, and Mitsuya H.
- Organizer
  The 15th Awaji International Forum on Infection and Immunity.
- Place of Presentation
  兵庫
- Year and Date
  2016-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] 逆転写酵素阻害剤EFdA(MK-8591)に対する薬剤耐性機序の構造学的解析と耐性株に有効な新規薬剤の設計・開発2016
- Author(s)
  前田賢次、高松悠樹、向後悟、服部真一朗、鍬田伸好、林宏典、Debananda Das、満屋裕明.
- Organizer
  第30回日本エイズ学会学術集会・総会.
- Place of Presentation
  鹿児島
- Year and Date
  2016-11-24
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] 新規の逆転写酵素阻害剤EFdA(MK-8591)に対する薬剤耐性機序の構造学的解析と耐性株に有効な新規薬剤の設計・開発.2016
- Author(s)
  前田賢次、高松悠樹、向後悟、服部真一朗、鍬田伸好、林宏典、Debananda Das、満屋裕明.
- Organizer
  第２６回抗ウイルス療法学会総会
- Place of Presentation
  名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16K08826
[Presentation] Progress in the therapy for HIV/AIDS: development of molecular-targeting approach for antiretroviral drugs.2016
- Author(s)
  Maeda K, and Mitsuya H.
- Organizer
  2nd Kumamoto IRCMS International Symposium and 17th Kumamoto AIDS Seminar
- Place of Presentation
  熊本
- Year and Date
  2016-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-16K08826

1. 土屋亮人 (80535708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 天野将之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 満屋裕明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 松田幸樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

MAEDA Kenji 前田 賢次

MAEDA KENJI 前田 賢次

Research Projects

Research Products

Co-Researchers

治療後も残存するHIVリザーバーの定量システム応用したエイズ治癒療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of a reverse transcriptase inhibitor, EFdA, potent against drug-resistant HIVPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] HIV Reservoirs and Treatment Strategies toward Curing HIV Infection2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Assessing the effects of antiretroviral therapy-latency-reversing agent combination therapy on eradicating replication-competent HIV provirus in a Jurkat cell culture model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4?-modified nucleoside RT inhibitors2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of 4’‐Substituted Purine 2’‐Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of 4’-Substituted Purine 2’-Deoxyucleosides and Their Activity against Human Immunodeficiency Virus and Hepatitis B Virus.2018

Author(s)

Journal Title

Data Source

[Journal Article] Restoration of immune surface molecules in Kaposi sarcoma-associated herpes virus infected cells by lenalidomide and pomalidomide2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 新規抗HBV化合物CFCPの発見とその抗HBV活性及び薬理学的動態の解析2018

Author(s)

Organizer

Data Source

[Presentation] HIV潜伏感染細胞を標的とした新規治療薬開発に有効なin vitro評価系の開発2017

Author(s)

Organizer

Data Source

[Presentation] Analysis of molecular mechanism of HIV-1 latent infection & reactivation and development of novel therapeutics active against latent HIV-1 infection.2017

Author(s)

Organizer

Data Source

[Presentation] Molecular simulation of EFdA and related analogs to determine the structural basis of HIV-1 drug resistance2017

Author(s)

Organizer

Data Source

[Presentation] 4’-Modified NRTIs’ Potent Anti-HIV Activity Stems from Strong RT Active Site Binding.2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Development of novel nucleoside reverse transcriptase inhibitors active against 4’-ethynyl -2-fluoro-2’-deoxyadenosine (EFdA/MK-8591)-resistant HIV-1s.2016

Author(s)

MAEDA Kenji 前田賢次

MAEDA KENJI 前田賢次