Sekiyama Naotaka 関山直孝

Researcher Number	50758810
Other IDs
Affiliation (Current)	2025: 京都大学, 理学研究科, 助教
Affiliation (based on the past Project Information) *help	2016 – 2024: 京都大学, 理学研究科, 助教 2015: 京都大学, 理学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 43040:Biophysics-related / Biophysics / Structural biochemistry
Keywords	Principal Investigator 天然変性タンパク質 / 液-液相分離 / 液液相分離 / RNA / アミロイド線維化 / アミロイド線維 / 非膜型オルガネラ / 構造生物学 / タンパク質 / 蛋白質 … More / 動的溶液環境 / 天然変性領域 / 相分離 / 神経変性疾患 / 天然変性蛋白質 / ストレス顆粒 / 発現制御 / 凝集体 / RNA結合蛋白質 / 翻訳制御 / 生物物理 / 分子動力学シミュレーション / リン酸化 / 翻訳 Less

Multi-scale understanding of Self-condensation mechanism driven by Dynamic solution environmentsArea Organizer
- Area Organizer
  
  関山直孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
動的溶液科学の推進Principal Investigator
- Principal Investigator
  
  関山直孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
生化学的手法を用いた天然変性タンパク質の自己凝縮過程を制御する動的溶液環境の解明Principal Investigator
- Principal Investigator
  
  関山直孝
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (B)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kyoto University
Structural analysis of the reversible self-assembly mechanism by intrinsically disordered proteinsPrincipal Investigator
- Principal Investigator
  
  Sekiyama Naotaka
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Kyoto University
Self-assembly mechanism of intrinsically disordered proteins in stress granulesPrincipal Investigator
- Principal Investigator
  
  Sekiyama Naotaka
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Kyoto University
Regulation mechanisms of TOP mRNA translation in proliferationPrincipal Investigator
- Principal Investigator
  
  Sekiyama Naotaka
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyoto University

All 2024 2023 2022 2016

All Journal Article Presentation

[Journal Article] Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy2024
- Author(s)
  Imamura Kayo、Akagi Ken-Ichi、Miyanoiri Yohei、Tsujimoto Hirokazu、Hirokawa Takatsugu、Ashida Hideo、Murakami Kaori、Inoue Asuka、Suno Ryoji、Ikegami Takahisa、Sekiyama Naotaka、Iwata So、Kobayashi Takuya、Tochio Hidehito
- Journal Title
  
  Structure
  
  Volume: 32 Issue: 3 Pages: 352-361
- DOI
  10.1016/j.str.2023.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05653, KAKENHI-PROJECT-23K05667, KAKENHI-PROJECT-20K06509, KAKENHI-PROJECT-21K19360, KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-21H05112, KAKENHI-PLANNED-21H05113, KAKENHI-PLANNED-22H05090, KAKENHI-PROJECT-19H00923, KAKENHI-PROJECT-21H04791, KAKENHI-PROJECT-19H03428
[Journal Article] Toward a high-resolution mechanism of intrinsically disordered protein self-assembly2023
- Author(s)
  Sekiyama Naotaka、Kobayashi Ryoga、Kodama Takashi S
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 5 Pages: 391-398
- DOI
  10.1093/jb/mvad056
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05090
[Journal Article] ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures2022
- Author(s)
  Sekiyama Naotaka、Takaba Kiyofumi、Maki-Yonekura Saori、Akagi Ken-ichi、Ohtani Yasuko、Imamura Kayo、Terakawa Tsuyoshi、Yamashita Keitaro、Inaoka Daigo、Yonekura Koji、Kodama Takashi S.、Tochio Hidehito
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 38
- DOI
  10.1073/pnas.2122523119
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H00252, KAKENHI-PLANNED-22H05090
[Presentation] 複数残基モデルによるアミロイド線維化の分子メカニズムの解明2023
- Author(s)
  小林凌河、児玉高志、杤尾豪人、関山直孝
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PLANNED-22H05090
[Presentation] TIA-1プリオン様ドメインのALS変異は高度に凝縮した病原性構造体を形成する2022
- Author(s)
  関山直孝, 高場圭章, 眞木さおり, 赤木謙一, 大谷寧子, 今村香代, 寺川剛, 山下恵太郎, 米倉功治, 児玉高志, 杤尾豪人
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PLANNED-22H05090
[Presentation] TIA-1プリオン様ドメインのALS関連変異は高度に凝縮した病原体構造を引き起こす2022
- Author(s)
  関山直孝, 高場圭章, 眞木さおり, 赤木謙一, 大谷寧子, 今村香代, 寺川剛, 山下恵太郎, 米倉功治, 児玉高志, 杤尾豪人
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PLANNED-22H05090
[Presentation] TIA-1 プリオン様ドメインの ALS 関連変異は高度に凝縮した病原体構造を引き起こす2022
- Author(s)
  関山直孝、高場圭章、赤木謙一、大谷寧子、今村香代、寺川剛、山下恵太郎、米倉功治、児玉高志、杤尾豪人
- Organizer
  蛋白質科学会
- Data Source
  KAKENHI-PROJECT-19K06584
[Presentation] Structural Analysis of eIF4E and 4E-BP1 Interactions2016
- Author(s)
  Naotaka Sekiyama, Haribabu Arthanari, Ricard A. Rodriguez-Mias, Meissa Leger-Abraham, Gerhard Wagner
- Organizer
  27th ICMRBS
- Place of Presentation
  京都
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H06325
[Presentation] Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G but stabilizing the unphosphorylated form of 4E-BP12016
- Author(s)
  Naotaka Sekiyama, Haribabu Arthanari, Evangelos Papadopoulos, Ricard A. Rodriguez Mias, Gerhard Wagner & Melissa Leger-Abraham
- Organizer
  第42回内藤コンファレンス
- Place of Presentation
  札幌
- Year and Date
  2016-10-04
- Data Source
  KAKENHI-PROJECT-15H06325

1. 菅瀬謙治 (00300822)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 吉田紀生 (10390650)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中村秀樹 (50435666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山口毅 (80345917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 寺川剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 今村香代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekiyama Naotaka 関山 直孝

Research Projects

Research Products

Co-Researchers

Multi-scale understanding of Self-condensation mechanism driven by Dynamic solution environmentsArea Organizer

Area Organizer

Project Period (FY)

Research Category

動的溶液科学の推進Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生化学的手法を用いた天然変性タンパク質の自己凝縮過程を制御する動的溶液環境の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural analysis of the reversible self-assembly mechanism by intrinsically disordered proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Self-assembly mechanism of intrinsically disordered proteins in stress granulesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation mechanisms of TOP mRNA translation in proliferationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Toward a high-resolution mechanism of intrinsically disordered protein self-assembly2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 複数残基モデルによるアミロイド線維化の分子メカニズムの解明2023

Author(s)

Organizer

Data Source

[Presentation] TIA-1プリオン様ドメインのALS変異は高度に凝縮した病原性構造体を形成する2022

Author(s)

Organizer

Data Source

[Presentation] TIA-1プリオン様ドメインのALS関連変異は高度に凝縮した病原体構造を引き起こす2022

Author(s)

Organizer

Data Source

[Presentation] TIA-1 プリオン様ドメインの ALS 関連変異は高度に凝縮した病原体構造を引き起こす2022

Author(s)

Organizer

Data Source

[Presentation] Structural Analysis of eIF4E and 4E-BP1 Interactions2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G but stabilizing the unphosphorylated form of 4E-BP12016

Author(s)

Organizer

Place of Presentation

Year and Date

Sekiyama Naotaka 関山直孝