TAKAGAKI Yuta 高垣雄太

Researcher Number	50759123
Other IDs	https://orcid.org/0009-0002-0490-1458
Affiliation (based on the past Project Information) *help	2018 – 2022: 金沢医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related Except Principal Investigator Basic Section 53040:Nephrology-related
Keywords	Principal Investigator EMTプログラム / インクレチン / mTOR / CXCL12/CXCR4 / 上皮間葉系細胞分化 / 乳癌 / 癌 / DPP-4 / 糖尿病 Except Principal Investigator マグネシウム … More / サイアザイド / DOHaD / COMT / エストロゲン / 腎臓 / 妊娠高血圧腎症 / 塩分感受性高血圧 / 高血圧 / エストロゲン代謝 / カテコール代謝 Less

内皮細胞オートファジー不全による代謝異常および臓器障害のメカニズム解明Principal Investigator
- Principal Investigator
  
  高垣雄太
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kanazawa Medical University
Interaction between genetic COMT deficiency and Mg defects induced diseases: mechanisms and therapeutic strategy
- Principal Investigator
  
  KANASAKI Keizo
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Shimane University
Elucidation of the molecular mechanisms by which DPP-4 plays a role in the development and metastasis of malignant tumorsPrincipal Investigator
- Principal Investigator
  
  TAKAGAKI Yuta
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Kanazawa Medical University

All 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Adenosine/adenosine type?1 receptor signaling pathway did not play dominant roles on the influence of sodium?glucose cotransporter?2 inhibitor in the kidney of bovine serum albumin‐overloaded streptozotocin‐induced diabetic mice2022
- Author(s)
  Shimada Keiji、Kanasaki Keizo、Kato Makoto、Ogura Yoshio、Takagaki Yuta、Monno Itaru、Hirai Taro、Kitada Munehiro、Koya Daisuke
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: Online ahead of print Issue: 6 Pages: 955-964
- DOI
  10.1111/jdi.13760
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773, KAKENHI-PROJECT-22K08330
[Journal Article] Classical molecule in diabetic kidney hypertrophy is linked to defects in self-eating through fine-tuning.2021
- Author(s)
  Takagaki Y, Kanasaki K.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 12 Issue: 5 Pages: 686-688
- DOI
  10.1111/jdi.13508
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738
[Journal Article] The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation.2021
- Author(s)
  Liu H, Takagaki Y, Kumagai A, Kanasaki K, Koya D.
- Journal Title
  
  J Diabetes Investig
  
  Volume: 12 Issue: 5 Pages: 697-709
- DOI
  10.1111/jdi.13478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] CD‐1db/db mice: a novel type 2 diabetic mouse model with progressive kidney fibrosis2020
- Author(s)
  Mizunuma Yuiko、Kanasaki Keizo、Nitta Kyoko、Nakamura Yuka、Ishigaki Yasuhito、Takagaki Yuta、Kitada Munehiro、Li Shaolan、Liu Haijie、Li Jinpeng、Usui Isao、Aso Yoshimasa、Koya Daisuke
- Journal Title
  
  Journal of Diabetes Investigation
  
  Volume: 10.1111/jdi.13311 Issue: 6 Pages: 1-23
- DOI
  10.1111/jdi.13311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18015, KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling2020
- Author(s)
  Kawakita Emi、Yang Fan、Kumagai Asako、Takagaki Yuta、Kitada Munehiro、Yoshitomi Yasuo、Ikeda Takayuki、Nakamura Yuka、Ishigaki Yasuhito、Kanasaki Keizo、Koya Daisuke
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 19 Issue: 1 Pages: 61-73
- DOI
  10.1158/1541-7786.mcr-20-0115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07407, KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-21K09031, KAKENHI-PROJECT-20K21773
[Journal Article] Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis.2020
- Author(s)
  Takagaki Y, Lee SM, Dongqing Z, Kitada M, Kanasaki K, Koya D
- Journal Title
  
  Autophagy.
  
  Volume: - Issue: 10 Pages: 1-10
- DOI
  10.1080/15548627.2020.1713641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08738, KAKENHI-PROJECT-20K21773
[Journal Article] Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice.2019
- Author(s)
  Takagaki Y, Shi S, Katoh M, Kitada M, Kanasaki K, and Koya D.
- Journal Title
  
  Sci Rep
  
  Volume: 1 Issue: 1 Pages: 7519-7519
- DOI
  10.1038/s41598-019-43730-5
- Data Source
  KAKENHI-PROJECT-19K08738
[Journal Article] Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial?Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis2018
- Author(s)
  Yang Fan、Takagaki Yuta、Yoshitomi Yasuo、Ikeda Takayuki、Li Jinpeng、Kitada Munehiro、Kumagai Asako、Kawakita Emi、Shi Sen、Kanasaki Keizo、Koya Daisuke
- Journal Title
  
  Cancer Research
  
  Volume: 79 Issue: 4 Pages: 735-746
- DOI
  10.1158/0008-5472.can-18-0620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16214, KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-19K08738
[Presentation] メトホルミンとDPP-4阻害薬の併用が乳癌細胞の肺転移に与える影響についての検討2019
- Author(s)
  川北恵美、熊谷麻子、高垣雄太、金崎啓造、古家大祐
- Organizer
  第34回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-18K16214
[Presentation] Dipeptidyl peptidase-4 inhibition may accelerates cancer metastasis via SDF-1/CXCR4 pathway dependent epithelial-mesenchymal transition2018
- Author(s)
  Yuta Takagaki, FanYang, Keizo Kanasaki, Daisuke Koya
- Organizer
  the 2018 Asia Islet Biology & Incretin Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16214

1. KANASAKI Keizo (60589919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. 飯島洋 (30465281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 川北恵美 (70835884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 水沼有威子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 池田崇之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 吉冨泰央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAGAKI Yuta 高垣 雄太

Research Projects

Research Products

Co-Researchers

内皮細胞オートファジー不全による代謝異常および臓器障害のメカニズム解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Interaction between genetic COMT deficiency and Mg defects induced diseases: mechanisms and therapeutic strategy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanisms by which DPP-4 plays a role in the development and metastasis of malignant tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Adenosine/adenosine type?1 receptor signaling pathway did not play dominant roles on the influence of sodium?glucose cotransporter?2 inhibitor in the kidney of bovine serum albumin‐overloaded streptozotocin‐induced diabetic mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Classical molecule in diabetic kidney hypertrophy is linked to defects in self-eating through fine-tuning.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD‐1db/db mice: a novel type 2 diabetic mouse model with progressive kidney fibrosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosis.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Dipeptidyl Peptidase-4 Accelerates Epithelial?Mesenchymal Transition and Breast Cancer Metastasis via the CXCL12/CXCR4/mTOR Axis2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] メトホルミンとDPP-4阻害薬の併用が乳癌細胞の肺転移に与える影響についての検討2019

Author(s)

Organizer

Data Source

[Presentation] Dipeptidyl peptidase-4 inhibition may accelerates cancer metastasis via SDF-1/CXCR4 pathway dependent epithelial-mesenchymal transition2018

Author(s)

Organizer

Data Source

TAKAGAKI Yuta 高垣雄太