Ihara Kensuke 井原健介

… Alternative Names

IHARA Kensuke 井原健介

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Researcher Number	50770210
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 特任助教
Affiliation (based on the past Project Information) *help	2023: 東京医科歯科大学, 大学院医歯学総合研究科, 特任助教 2016 – 2023: 東京医科歯科大学, 難治疾患研究所, 助教 2017: 東京医科歯科大学, 難治疾患研究所, 教授
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine Except Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 53020:Cardiology-related / General pharmacology
Keywords	Principal Investigator RNA顆粒 / 心房細動 / 拡張型心筋症 / ゲノム編集 / 生物学的ペースメーカ / Rbm20 / RNA代謝 / 選択的スプライシング / RBM20 / 徐脈性不整脈 … More / ペースメーカ / 循環器 / 不整脈 / 遺伝子治療 … More Except Principal Investigator TBX5 / 先天性心疾患 / 非コードRNA / 心疾患 / 非コード領域 / 転写制御 / GPC5 / 非コード長鎖RNA / Tbx5 / エピゲノム / 先天性疾患 / 心房細動 / 非コードゲノム領域 / bioinformatics analysis / lncRNA / Holt-Oram症候群 / 心臓発生 / 炎症 / 自律神経 / 全エクソン相関解析 / マイトファジー / マクロファージ / 自然免疫 / バイオマーカー / セルフリーDNA / ミトコンドリア / 転写制御機構 / TBX5遺伝子 / Sall4 / Nkx2-5 / バイオインフォマティクス / iPS / RIP解析 / エピゲノム解析 / SALL4 / NKX2-5 / 肉腫化 / 先天異常 / 疾患生体モデル / ヒト疾患iPSモデル / 非コードRNA転写制御解析 / i-GONAD / in utero KO / CRISPR-Cas9 / in utero / in uterus / 胎児器官形成 / 心臓オルガノイド / 心臓疾患 / クロマチン制御機構 / マイクロRNA / 循環器・高血圧 / 薬理学 / 遺伝子多型 / 不整脈 / 交感神経 / 酸化ストレス / GWAS / 1塩基多型 / ゲノムワイド関連解析 Less

異常RNA顆粒による心臓病態形成メカニズムの検討Principal Investigator
- Principal Investigator
  
  井原健介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokyo Medical and Dental University
Study of epigenetic function as rick factors in human congenital diseases
- Principal Investigator
  
  竹内純
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of an autonomous and self-amplifying mechanism to explain the increased incidence and chronicity of atrial fibrillation in the elderly
- Principal Investigator
  
  Furukawa Tetsushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokyo Medical and Dental University
Elucidation of the Mechanism of Cardiac Pathology Caused by Mutations in the Splicing Regulator Rbm20Principal Investigator
- Principal Investigator
  
  Ihara Kensuke
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokyo Medical and Dental University
Molecular mechanisms of non-coding genome regions causing age-dependent arrhythmia in human
- Principal Investigator
  
  Takeuchi Jun
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
Roles of non-coding genomic regions for understanding congenital heart defects in human
- Principal Investigator
  
  Takeuchi Jun
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Tokyo Medical and Dental University
Generation of biological pacemaker by in vivo genome editingPrincipal Investigator
- Principal Investigator
  
  Ihara Kensuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokyo Medical and Dental University
Pacemaker activity generated by in vivo genome editingPrincipal Investigator
- Principal Investigator
  
  IHARA Kensuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Tokyo Medical and Dental University
Post-GWAS study for identification of druggable target of AF
- Principal Investigator
  
  FURUKAWA Tetsushi
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Tokyo Medical and Dental University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Sacubitril/valsartan attenuates atrial conduction disturbance and electrophysiological heterogeneity with ameliorating fibrosis in mice2024
- Author(s)
  Iwamiya Satoshi、Ihara Kensuke、Furukawa Tetsushi、Sasano Tetsuo
- Journal Title
  
  Frontiers in Cardiovascular Medicine
  
  Volume: 11 Pages: 1341601-1341601
- DOI
  10.3389/fcvm.2024.1341601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08152, KAKENHI-PROJECT-23K07474, KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-21H02909
[Journal Article] Extracellular Vesicles for the Treatment of Atrial Fibrillation.2023
- Author(s)
  Ihara K and Sasano T.
- Journal Title
  
  JACC Clin Electrophysiol.
  
  Volume: 9 Issue: 2 Pages: 159-160
- DOI
  10.1016/j.jacep.2023.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-22K08152, KAKENHI-PROJECT-19K08536
[Journal Article] Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers2023
- Author(s)
  Sasano Tetsuo、Ihara Kensuke、Tanaka Toshihiro、Furukawa Tetsushi
- Journal Title
  
  PLOS ONE
  
  Volume: 18 Issue: 10 Pages: e0292118-e0292118
- DOI
  10.1371/journal.pone.0292118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08152, KAKENHI-PROJECT-23K07474, KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-21H02909
[Journal Article] Genetic risk score of cerebral infarction in atrial fibrillation genome‐wide association study2023
- Author(s)
  Ebana Yusuke、Liu Lian、Ihara Kensuke、Abe Keiko、Terao Chikashi、Kamatani Yoichiro、Sasano Tetsuo、Furukawa Tetsushi
- Journal Title
  
  European Journal of Clinical Investigation
  
  Volume: 53 Issue: 12
- DOI
  10.1111/eci.14084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08152, KAKENHI-PROJECT-23K07474, KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-21H02909
[Journal Article] Local Injection of Hydroxyapatite Electret Ameliorated Infarct Size After Myocardial Infarction2022
- Author(s)
  Yamaguchi Junji、Chiba Risako、Komuro Hiroaki、Ihara Kensuke、Nozaki Kosuke、Nagai Akiko、Furukawa Tetsushi、Sasano Tetsuo
- Journal Title
  
  Circulation Reports
  
  Volume: 4 Issue: 1 Pages: 38-47
- DOI
  10.1253/circrep.CR-21-0100
- NAID
  130008140051
- ISSN
  2434-0790
- Year and Date
  2022-01-07
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-19K08536, KAKENHI-PROJECT-21K19477
[Journal Article] Systemic DNA/RNA heteroduplex oligonucleotide administration for regulating the gene expression of dorsal root ganglion and sciatic nerve.2022
- Author(s)
  Kaburagi H, Nagata T, Enomoto M, Hirai T, Ohyagi M, Ihara K, Yoshida-Tanaka K, Ebihara S, Asada K, Yokoyama H, Okawa A, Yokota T.
- Journal Title
  
  Mol. Ther. Nucleic. Acids.
  
  Volume: 6 Pages: 910-919
- DOI
  10.1016/j.omtn.2022.05.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-22K09419, KAKENHI-PROJECT-19K09543, KAKENHI-PROJECT-20K09455
[Journal Article] 遺伝性不整脈・心筋疾患の遺伝子診断の現状と未来2022
- Author(s)
  井原健介、古川哲史
- Journal Title
  
  循環器内科
  
  Volume: 91 Pages: 260-264
- Data Source
  KAKENHI-PROJECT-21H02909
[Journal Article] Role of Inflammation in the Pathogenesis of Atrial Fibrillation2022
- Author(s)
  Ihara Kensuke、Sasano Tetsuo
- Journal Title
  
  Frontiers in Physiology
  
  Volume: 13 Pages: 862164-862164
- DOI
  10.3389/fphys.2022.862164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-22K08152, KAKENHI-PROJECT-19K08536
[Journal Article] Effect of the recording condition on the quality of a single-lead electrocardiogram.2022
- Author(s)
  Hamada S, Sasaki K, Kito H, Tooyama Y, Ihara K, Aoyagi E, Ichimura N, Tohda S, Sasano T.
- Journal Title
  
  Heart Vessel.
  
  Volume: 37 Issue: 6 Pages: 1010-1026
- DOI
  10.1007/s00380-021-01991-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-22K08152, KAKENHI-PROJECT-19K08536
[Journal Article] I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy.2022
- Author(s)
  Yamamoto T, Sano R, Miura A, Imasaka M, Naito Y, Nishiguchi M, Ihara K, Otani N, Kominato Y, Ohmuraya M, Karangi H, Nishio H.
- Journal Title
  
  J. Mol. Med.
  
  Volume: 100 Issue: 12 Pages: 1741-1754
- DOI
  10.1007/s00109-022-02262-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-19H03916, KAKENHI-PROJECT-20H03958, KAKENHI-PROJECT-20K10551, KAKENHI-PROJECT-20K21385, KAKENHI-PROJECT-20K21697
[Journal Article] Gene therapy to terminate tachyarrhythmias.2022
- Author(s)
  Kawajiri K, Ihara K, Sasano T.
- Journal Title
  
  Expert Rev Cardiovasc Ther.
  
  Volume: 20 Issue: 6 Pages: 431-442
- DOI
  10.1080/14779072.2022.2085686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-22K08152, KAKENHI-PROJECT-19K08536
[Journal Article] Seeking a Better Experimental Model of Atrial Fibrillation2022
- Author(s)
  Ihara Kensuke、Sasano Tetsuo
- Journal Title
  
  Circ J
  
  Volume: 86 Issue: 2 Pages: 330-331
- DOI
  10.1253/circj.CJ-21-0770
- NAID
  130008144187
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2022-01-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-19K08536
[Journal Article] Exosomeを心不全の診断に生かす2021
- Author(s)
  井原健介、笹野哲郎
- Journal Title
  
  Cardiac practice
  
  Volume: 31 Pages: 125-128
- Data Source
  KAKENHI-PROJECT-21H02909
[Journal Article] DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo2021
- Author(s)
  Ohyagi Masaki、Nagata Tetsuya、Ihara Kensuke、Yoshida-Tanaka Kie、Nishi Rieko、Miyata Haruka、Abe Aya、Mabuchi Yo、Akazawa Chihiro、Yokota Takanori
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 7344-7344
- DOI
  10.1038/s41467-021-26902-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-21H03328, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
[Journal Article] 秒で見抜くヤバい心電図2021
- Author(s)
  井原健介、中釜瞬
- Journal Title
  
  EmerLog
  
  Volume: 34 Pages: 6-93
- Data Source
  KAKENHI-PROJECT-21H02909
[Journal Article] 12誘導心電図2021
- Author(s)
  井原健介、古川哲史
- Journal Title
  
  診断と治療
  
  Volume: 109 Pages: 147-151
- Data Source
  KAKENHI-PROJECT-21H02909
[Journal Article] Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.2021
- Author(s)
  Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T
- Journal Title
  
  Nat Biotechnol
  
  Volume: 39 Issue: 12 Pages: 1529-1536
- DOI
  10.1038/s41587-021-00972-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-23K21353, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
[Journal Article] Functional Role of the L396R Mutation of Tks5 Identified by an Exome-Wide Association Study in Atrial Fibrillation2020
- Author(s)
  Yang Xiaoxi、Sasano Tetsuo、Ebana Yusuke、Takeuchi Jun K.、Ihara Kensuke、Yamazoe Masahiro、Furukawa Tetsushi
- Journal Title
  
  Circ J
  
  Volume: 84 Issue: 12 Pages: 2148-2157
- DOI
  10.1253/circj.CJ-20-0101
- NAID
  130007942473
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2020-11-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07251, KAKENHI-PROJECT-19K08536, KAKENHI-PROJECT-20K21598, KAKENHI-PROJECT-19KK0218, KAKENHI-PROJECT-18H02803, KAKENHI-PROJECT-16H06279
[Journal Article] In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix2020
- Author(s)
  Lee Jiyoung、Sutani Akito、Kaneko Rin、Takeuchi Jun、Sasano Tetsuo、Kohda Takashi、Ihara Kensuke、Takahashi Kentaro、Yamazoe Masahiro、Morio Tomohiro、Furukawa Tetsushi、Ishino Fumitoshi
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 4283-4283
- DOI
  10.1038/s41467-020-18031-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08536, KAKENHI-PROJECT-20K06652, KAKENHI-PROJECT-20K20584, KAKENHI-PROJECT-20K21598, KAKENHI-PROJECT-19KK0182, KAKENHI-PROJECT-19KK0218, KAKENHI-PROJECT-19H00978, KAKENHI-PROJECT-18H02803, KAKENHI-PROJECT-17K07498
[Journal Article] A missense mutation in the RSRSP stretch of Rbm20 causes dilated cardiomyopathy and atrial fibrillation in mice2020
- Author(s)
  Ihara K, Sasano T, Hiraoka Y, Togo-Ohno M, Soejima Y, Sawabe M, Tsuchiya M, Ogawa H, Furukawa T, Kuroyanagi H
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 17894-17894
- DOI
  10.1038/s41598-020-74800-8
- NAID
  120007031666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06488, KAKENHI-PROJECT-19K08536, KAKENHI-PROJECT-20K07029, KAKENHI-PROJECT-20K08467, KAKENHI-PROJECT-20K21385, KAKENHI-PUBLICLY-20H05322, KAKENHI-PROJECT-18H02803
[Journal Article] Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping2018
- Author(s)
  Ihara Kensuke、Sugiyama Koji、Takahashi Kentaro、Yamazoe Masahiro、Sasano Tetsuo、Furukawa Tetsushi
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 132 Issue: 132 Pages: 56478-56478
- DOI
  10.3791/56478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09494, KAKENHI-PROJECT-16K19393, KAKENHI-PROJECT-18H02803
[Journal Article] Combined analysis of human and experimental murine samples identified novel circulating microRNAs as biomarker for atrial fibrillation2018
- Author(s)
  Natusme Y, Oaku K, Takahashi K, Nakamura W, Oono A, Hamada S, Yamazoe M, Ihara K, Sasaki T, Goya M, Hirao K, Furukawa T, Sasano T
- Journal Title
  
  Circ. J.
  
  Volume: 82 Issue: 6 Pages: 965-973
- DOI
  10.1177/1358863x17724263
- NAID
  130006528576
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293052
[Journal Article] Overexpression of KCNJ2 in induced pluripotent stem cell-derived cardiomyocytes for the assessment of QT-prolonging drugs.2017
- Author(s)
  Li, M., Kanda, Y., Ashihara, T., Sasano, T., Nakai, Y., Kodama, M., Hayashi, E., Sekino, Y., Furukawa, T., and Kurokawa, J.
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 134 Issue: 2 Pages: 75-85
- DOI
  10.1016/j.jphs.2017.05.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07726, KAKENHI-PROJECT-16K09431, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-15H04684, KAKENHI-PROJECT-26293052, KAKENHI-PROJECT-16H05238
[Presentation] Cytoplasmic RBM20 Granules Cause Atrial Arrhythmogenicity in Mice2024
- Author(s)
  Ihara K、Iwamiya S、Hiraoka Y、Kuroyanagi H、Furukawa T、Sasano T
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] Genome-wide association analysis and construction of polygenic risk score model for predicting paroxysmal atrial fibrillation using LightGBM model2024
- Author(s)
  Shiomi M, Nagata Y, Sudo T, Ichikawa T, Ihara K, Asada K, Tanaka Y, Yamauchi Y, Sasaki T, Hachiya H, Imai Y, Fujita H, Sasano T, Furukawa T, Tanaka T
- Organizer
  The 7th JCS Council Forum on Basic CardioVascular Research
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] The Electrophysiological Properties against Atrial Arrhythmogenicity in Murine Heart Failure Treated with Sacubitril/Valsartan.2024
- Author(s)
  Iwamiya S、Ihara K、Furukawa T、Sasano T.
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] Cytoplasmic RBM20 Granules Cause Atrial Arrhythmogenicity in Mice.2024
- Author(s)
  Ihara K、Iwamiya S、Hiraoka Y、Kuroyanagi H、Furukawa T、Sasano T.
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] Cytoplasmic RBM20 Granules Cause Atrial Arrhythmogenicity in Mice.2024
- Author(s)
  Ihara K、Iwamiya S、Hiraoka Y、Kuroyanagi H、Furukawa T、Sasano T.
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-23K07474
[Presentation] The Electrophysiological Properties against Atrial Arrhythmogenicity in Murine Heart Failure Treated with Sacubitril/Valsartan2024
- Author(s)
  Iwamiya S、Ihara K、Furukawa T、Sasano T
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] RBM20変異と心房性不整脈.2023
- Author(s)
  井原健介
- Organizer
  日本心血管作動物質学会若手研究者交流シンポジウム
- Data Source
  KAKENHI-PROJECT-23K07474
[Presentation] RBM20変異と心房性不整脈2023
- Author(s)
  井原健介
- Organizer
  日本心血管作動物質学会若手研究者交流シンポジウム
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] RBM20変異と心房性不整脈.2023
- Author(s)
  井原健介.
- Organizer
  日本心血管作動物質学会若手研究者交流シンポジウム.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] The Electrophysiological Properties against Atrial Arrhythmogenicity in Murine Heart Failure Treated with Sacubitril/Valsartan.2023
- Author(s)
  Iwamiya S、Ihara K、Furukawa T、Sasano T.
- Organizer
  The 88th Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-23K07474
[Presentation] 心房細動時に心房筋が心外膜脂肪組織に与える影響の解明.2022
- Author(s)
  石川紗佳、鈴木杏奈、岩嵜利奈、井原健介、古川哲史、笹野哲郎.
- Organizer
  第266回日本循環器学会関東甲信越地方会.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] Involvement of Potential microRNAs in Signaling Pathway Networks in Murine Angiotensin II-Mediated Atrial Fibrillation Model.2022
- Author(s)
  Sun Y, Kawajiri K, Iwamiya S, Abe K, Ihara K, Sasano T, Furukawa T.
- Organizer
  The 68th Annual Meeting of the Japanese Heart Rhythm Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] 異常RNA顆粒による心筋症・不整脈発症機序の検討.2022
- Author(s)
  井原健介.
- Organizer
  第22回関東心・血管フォーラム.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] Atrial Fibrillation in Cardiomyopathy Mice with Rbm20 Mutation.2022
- Author(s)
  Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T.
- Organizer
  The 86th Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] Epicardial Adipose Tissue Remodeling Evoked by Extracellular Vesicles Released from Atrial Myocytes.2022
- Author(s)
  Ishikawa S, Suzuki A, Iwasaki R, Ihara K, Furukawa T, Sasano T.
- Organizer
  The 68th Annual Meeting of the Japanese Heart Rhythm Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] 心房筋細胞から放出された細胞外小胞による心外膜脂肪の炎症誘導機転.2022
- Author(s)
  石川紗佳、鈴木杏奈、岩嵜利奈、井原健介、古川哲史、笹野哲郎.
- Organizer
  心電学関連春季大会2022.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] The effects of Sacubitril/Valsartan on murine atria with pressure overload2022
- Author(s)
  Iwamiya S, Ihara K, Furukawa T, Sasano T
- Organizer
  The 86th Annual Scientific Meeting of the Japanese Circulation Society
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] The Exosomal miRNA Secreted by Paced Cardiomyocytes Regulates Adipocyte Differentiation.2022
- Author(s)
  Kawajiri K, Nyo ZLM, Ihara K, Furukawa T, Sasano T.
- Organizer
  The 68th Annual Meeting of the Japanese Heart Rhythm Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] The effects of Sacubitril/Valsartan on murine atria with pressure overload.2022
- Author(s)
  Iwamiya S, Ihara K, Furukawa T, Sasano T.
- Organizer
  The 86th Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] 心不全モデルのマウス心房に対するSacubitril/Valsartanの電気生理学的効果2022
- Author(s)
  岩宮賢、井原健介、古川哲史、笹野哲郎
- Organizer
  第262回日本循環器学会関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] ペーシング刺激を受けた心筋細胞から分泌されたexosome含有miRNAの、脂肪細胞分化に対する影響.2022
- Author(s)
  川尻紘平、ニョジンレイモン、井原健介、古川哲史、笹野哲郎.
- Organizer
  心電学関連春季大会2022.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] Atrial Fibrillation in Cardiomyopathy Mice with Rbm20 Mutation2022
- Author(s)
  Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T
- Organizer
  The 86th Annual Scientific Meeting of the Japanese Circulation Society
- Invited
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] 不整脈原性拡張型心筋症の新規発症機序2021
- Author(s)
  井原健介、黒柳秀人、平岡優一、笹野哲郎、古川哲史
- Organizer
  第25回日本心不全学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] 不整脈原性拡張型心筋症の新規発症機序.2021
- Author(s)
  井原健介、黒柳秀人、平岡優一、笹野哲郎、古川哲史.
- Organizer
  第25回日本心不全学会学術集会.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] 心不全モデルマウスにおけるSacubitril/Valsartanの心房への電気生理学的効果.2021
- Author(s)
  岩宮賢、井原健介、古川哲史、笹野哲郎.
- Organizer
  心電学関連春季大会2021.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] The effects of Sacubitril/Valsartan on electrophysiological properties of atria in murine hearts with pressure overload2021
- Author(s)
  Iwamiya S, Ihara K, Furukawa T, Sasano T
- Organizer
  The 5th JCS Council Forum on Basic CardioVascular Research
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] 心不全モデルマウスにおけるSacubitril/Valsartanの心房への電気生理学的効果2021
- Author(s)
  岩宮賢、井原健介、古川哲史、笹野哲郎
- Organizer
  心電学関連春季大会2021
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] 心房細動モデルマウスのoptical mapping による評価2021
- Author(s)
  岩宮賢、井原健介、富井直輝、山崎正俊、黒柳秀人、佐久間一郎、古川哲史、笹野哲郎
- Organizer
  心電学関連春季大会2021
- Invited
- Data Source
  KAKENHI-PROJECT-21H02909
[Presentation] Pannexin-1 Contributes to Maintenance of Cardiac Function against Acute Pressure-overload and Rapid Ventricular Pacing.2020
- Author(s)
  Ihara K, Sasano T, Kentaro T, Yamazoe M, Furukawa T.
- Organizer
  The 97th Annual Meeting of the Physiological Society of Japan.
- Data Source
  KAKENHI-PROJECT-18K15882
[Presentation] 光学マッピング法による心不全モデルマウスにおける心房性不整脈の電気生理学的特性評価.2020
- Author(s)
  岩宮賢, 井原健介, 富井直輝, 山崎正俊, 黒柳秀人, 佐久間一郎, 古川哲史, 笹野哲郎.
- Organizer
  心電学関連研究会2020.
- Data Source
  KAKENHI-PROJECT-18K15882
[Presentation] Cytoplasmic Expansion of RNA-Binding Motif Protein 20 (RBM20) is Critical for Development of Atrial Fibrillation in Mice.2020
- Author(s)
  Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T.
- Organizer
  The 84th Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] A mutation in the RSRSP stretch of Rbm20 causes atrial fibrillation in mice.2020
- Author(s)
  Ihara K, Kuroyanagi H, Hiraoka Y, Sasano T, Furukawa T.
- Organizer
  The 4th JCS Council Forum on Basic CardioVascular Research.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] スプライシング制御因子RBM20変異を持つ心房細動モデルマウスの確立.2020
- Author(s)
  井原健介、黒柳秀人、平岡優一、笹野哲郎、古川哲史.
- Organizer
  心電学関連研究会2020.
- Data Source
  KAKENHI-PROJECT-20K08467
[Presentation] Local Injection of Charged Hydroxyapatite Nanoparticle Attenuates the Myocardial Injury in Murine Myocardial Infarction Model.2019
- Author(s)
  Chiba R, Yamazoe M, Ihara K, Komuro H, Nagai A, Furukawa T, Sasano T.
- Organizer
  The 83rd Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Local Injection of Charged Hydroxyapatite Nanoparticle Attenuates the Myocardial Injury in Murine Myocardial Infarction Model.2019
- Author(s)
  Chiba R, Yamazoe M, Ihara K, Komuro H, Nagai A, Furukawa T, Sasano T.
- Organizer
  The 83rd Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-18K15882
[Presentation] Intolerance to Rapid Ventricular Pacing and Coronary Hypoplasty in Pannexin-1 Knockout Mouse Heart.2019
- Author(s)
  Ihara K, Sasano T, Yamazoe M, Furukawa T.
- Organizer
  The 83rd Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-18K15882
[Presentation] Pannexin-1 Maintains Cardiac Function under the Electrical Pacing and/or Hypoxia in Mice.2018
- Author(s)
  Ihara K, Sasano T, Takahashi K, Yamazoe M, Furukawa T.
- Organizer
  The 82nd Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Pacemaker activity generated by CRISPR/Cas9 based genome editing for Kcnj2.2018
- Author(s)
  Ihara K, Sasano T, Yamazoe M, Furukawa T.
- Organizer
  The 2nd JCS Council Forum on Basic CardioVascular Research.
- Data Source
  KAKENHI-PROJECT-18K15882
[Presentation] Cardioprotective effect of Pannexin-1 against Pacing-induced Cardiac Dysfunction in Mice.2018
- Author(s)
  Ihara K, Sasano T, Takahashi K, Yamazoe M, Furukawa T.
- Organizer
  The 1st JCS Council Forum on Basic CardioVascular Research.
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Pacemaker activity generated by CRISPR/Cas9 based genome editing for Kcnj2.2018
- Author(s)
  Ihara K, Sasano T, Yamazoe M, Furukawa T.
- Organizer
  The 2nd JCS Council Forum on Basic CardioVascular Research.
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Intolerance to Rapid Ventricular Pacing and Coronary Insufficiency in Pannexin-1 Knockout Mouse Heart.2018
- Author(s)
  Ihara K, Sasano T, Yamazoe M, Furukawa T.
- Organizer
  第65回日本不整脈心電学会学術大会.
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Intolerance to Rapid Ventricular Pacing in Pannexin-1 Knockout Mouse Heart.2018
- Author(s)
  Ihara K, Sasano T, Yamazoe M, Furukawa T.
- Organizer
  The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018. Oct. Taipei, Taiwan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15882
[Presentation] Intolerance to Rapid Ventricular Pacing in Pannexin-1 Knockout Mouse Heart.2018
- Author(s)
  Ihara K, Sasano T, Yamazoe M, Furukawa T.
- Organizer
  The 11th Asia-pacific Heart Rhythm Society Scientific Session. 2018. Oct. Taipei, Taiwan.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Intolerance to Rapid Ventricular Pacing and Coronary Insufficiency in Pannexin-1 Knockout Mouse Heart.2018
- Author(s)
  Ihara K, Sasano T, Yamazoe M, Furukawa T.
- Organizer
  第65回日本不整脈心電学会学術大会.
- Data Source
  KAKENHI-PROJECT-18K15882
[Presentation] Pacemaker activity generated by in vivo genome editing.2017
- Author(s)
  Ihara K, Sasano T, Takahashi K, Furukawa T.
- Organizer
  The 10th Asia-pacific Heart Rhythm Society Scientific Session.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Generating biological pacemaker by CRISPR/Cas9 based in vivo genome editing2017
- Author(s)
  Kensuke Ihara, Tetsuo Sasano, Koji Sugiyama, Kentaro Takahashi, Tetsushi Furukawa.
- Organizer
  The 81st Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Kanazawa
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16K19393
[Presentation] Effects of hydrogel culture substrate on contractile properties and gene expression profiles of human iPS cell-derived cardiomyocytes2017
- Author(s)
  Kurokawa J, Fujizuka M, Hayashi E, Ashihara T, Kanda Y, Sekino Y, Furukawa T
- Organizer
  日本薬学会
- Data Source
  KAKENHI-PROJECT-26293052
[Presentation] Generating biological pacemaker by CRISPR/Cas9 based in vivo genome editing.2017
- Author(s)
  Ihara K, Sasano T, Sugiyama K, Takahashi K, Furukawa T.
- Organizer
  The 81st Annual Scientific Meeting of the Japanese Circulation Society.
- Data Source
  KAKENHI-PROJECT-16K19393

1. FURUKAWA Tetsushi (80251552)

# of Collaborated Projects: 4 results

# of Collaborated Products: 23 results
2. Takeuchi Jun (10451999)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 笹野哲郎 (00466898)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. 小川英知 (20370132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小柴和子 (30467005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KUROKAWA junko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAI Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. YOSHIDA Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 土屋惠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ihara Kensuke 井原 健介

IHARA Kensuke 井原 健介

Research Projects

Research Products

Co-Researchers

異常RNA顆粒による心臓病態形成メカニズムの検討Principal Investigator

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Study of epigenetic function as rick factors in human congenital diseases

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Elucidation of an autonomous and self-amplifying mechanism to explain the increased incidence and chronicity of atrial fibrillation in the elderly

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Elucidation of the Mechanism of Cardiac Pathology Caused by Mutations in the Splicing Regulator Rbm20Principal Investigator

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Molecular mechanisms of non-coding genome regions causing age-dependent arrhythmia in human

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Roles of non-coding genomic regions for understanding congenital heart defects in human

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Generation of biological pacemaker by in vivo genome editingPrincipal Investigator

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Pacemaker activity generated by in vivo genome editingPrincipal Investigator

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Post-GWAS study for identification of druggable target of AF

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[Journal Article] Sacubitril/valsartan attenuates atrial conduction disturbance and electrophysiological heterogeneity with ameliorating fibrosis in mice2024

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[Journal Article] Extracellular Vesicles for the Treatment of Atrial Fibrillation.2023

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[Journal Article] Risk stratification of atrial fibrillation and stroke using single nucleotide polymorphism and circulating biomarkers2023

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[Journal Article] Genetic risk score of cerebral infarction in atrial fibrillation genome‐wide association study2023

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[Journal Article] Local Injection of Hydroxyapatite Electret Ameliorated Infarct Size After Myocardial Infarction2022

Ihara Kensuke 井原健介

IHARA Kensuke 井原健介