Iemura Kenji 家村顕自

… Alternative Names

家村顕自イエムラケンジ

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Researcher Number	50778058
Other IDs	https://orcid.org/0000-0003-0829-5299
Affiliation (Current)	2025: 東北大学, 加齢医学研究所, 助教
Affiliation (based on the past Project Information) *help	2023: 東北大学, 加齢医学研究所, 助教 2016 – 2021: 東北大学, 加齢医学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 43010:Molecular biology-related / Molecular biology
Keywords	Principal Investigator 染色体不安定性 / 細胞分裂 / がん / クローン進化 / 増殖優位性 / 細胞増殖 / 染色体分配 / 分裂期 / 液性因子 / 異数性パラドックス … More / 多様性 / ヘテロジェナイエティ / 悪性進展 / がん化 / ヘテロジェナイティ / スフィアアッセイ / 腫瘍内不均一性 / 染色体 / 細胞・組織 / 癌 / 動原体 / ゲノム安定性 / リン酸化 / 異数性 / 染色体動態 Less

Mechanisms of chromosomal instability induction via extracellular factorsPrincipal Investigator
- Principal Investigator
  
  家村顕自
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Tohoku University
Elucidation of the molecular mechanism required for the acquisition of growth advantage in CIN cancer cellPrincipal Investigator
- Principal Investigator
  
  Iemura Kenji
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Elucidation of the role of chromosomal instability in cancer heterogeneityPrincipal Investigator
- Principal Investigator
  
  Iemura Kenji
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Analysis of robust equal chromosome segregation system by mitotic kinase Aurora APrincipal Investigator
- Principal Investigator
  
  Iemura Kenji
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University

All 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity2021
- Author(s)
  Kenji Iemura, Toyoaki Natsume, Kayoko Maehara, Masato T. Kanemaki, and Kozo Tanaka
- Journal Title
  
  Journal of Cell Biology
  
  Volume: in press Issue: 7
- DOI
  10.1083/jcb.202006116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02434, KAKENHI-PROJECT-20K16295, KAKENHI-PUBLICLY-21H05738, KAKENHI-PROJECT-21H04719
[Journal Article] A mathematical model of kinetochore-microtubule attachment regulated by Aurora A activity gradient describes chromosome oscillation and correction of erroneous attachments2021
- Author(s)
  Campos Medina Manuel Alejandro、Iemura Kenji、Kimura Akatsuki、Tanaka Kozo
- Journal Title
  
  Biomed. Res.
  
  Volume: 42 Issue: 5 Pages: 203-219
- DOI
  10.2220/biomedres.42.203
- NAID
  130008090723
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2021-09-21
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16295, KAKENHI-PROJECT-18H02414, KAKENHI-PUBLICLY-21H05738
[Journal Article] Attenuated Chromosome Oscillation as a Cause of Chromosomal Instability in Cancer Cells2021
- Author(s)
  Iemura Kenji、Yoshizaki Yujiro、Kuniyasu Kinue、Tanaka Kozo
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 18 Pages: 4531-4531
- DOI
  10.3390/cancers13184531
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16295, KAKENHI-PUBLICLY-21H05738
[Journal Article] Chromosome alignment‐maintaining phosphoprotein CHAMP1 plays a role in cell survival through regulating Mcl‐1 expression2021
- Author(s)
  Hino Maho、Iemura Kenji、Ikeda Masanori、Itoh Go、Tanaka Kozo
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 9 Pages: 3711-3721
- DOI
  10.1111/cas.15018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16295, KAKENHI-PUBLICLY-21H05738
[Journal Article] Delayed Chromosome Alignment to the Spindle Equator Increases the Rate of Chromosome Missegregation in Cancer Cell Lines2018
- Author(s)
  Kuniyasu Kinue、Iemura Kenji、Tanaka Kozo
- Journal Title
  
  Biomolecules
  
  Volume: 9 Issue: 1 Pages: 10-10
- DOI
  10.3390/biom9010010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15234, KAKENHI-PROJECT-18H02434, KAKENHI-PUBLICLY-18H04896
[Presentation] Reduced mitotic chromosome dynamics causes chromosomal instability in cancer cells2021
- Author(s)
  Kenji Iemura, Kozo Tanaka
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] クロモキネシンは染色体腕部の早期分離を抑制する2021
- Author(s)
  家村顕自、石川裕大、都築美香、國安絹枝、田中耕三
- Organizer
  第39回染色体ワークショップ・第20回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] 染色体オシレーション運動による染色体安定性の維持機構2021
- Author(s)
  家村顕自、田中耕三
- Organizer
  第73回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] 増殖選択圧下のがん細胞増殖における染色体不安定性の役割2021
- Author(s)
  家村顕自、田中耕三
- Organizer
  日本生化学会東北支部第87回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] がん細胞の増殖優位性獲得過程における染色体不安定性の役割2021
- Author(s)
  家村顕自、田中耕三
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] 染色体オシレーション運動による堅牢な染色体分配システムは細胞老化の進行とともに抑制される2021
- Author(s)
  家村顕自、田中耕三
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] 分裂期染色体動態による染色体安定性の維持機構2020
- Author(s)
  家村顕自、田中耕三
- Organizer
  第1回癌学会若手の会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] Metaphase chromosome dynamics ensures faithful chromosome segregation2020
- Author(s)
  Kenji Iemura, Kozo Tanaka
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] 増殖選択圧を受けたがん細胞の増殖優位性獲得過程における染色体不安定性の役割2020
- Author(s)
  家村顕自、田中耕三
- Organizer
  第72回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] 分裂期中期のキネトコアにおける空間的制御は染色体分配の堅牢性に寄与する2020
- Author(s)
  家村顕自、田中耕三
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16295
[Presentation] 分裂期染色体動態による染色体安定性の維持機構2020
- Author(s)
  家村顕自、田中耕三
- Organizer
  第1回癌学会若手の会
- Data Source
  KAKENHI-PROJECT-18K15234
[Presentation] がん細胞における染色体不安定性は増殖選択圧を受けた際の増殖優位性獲得に寄与する2019
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第36回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-18K15234
[Presentation] 小胞体ストレス応答経路は染色体不安定性がん細胞のクローン進化に寄与する2019
- Author(s)
  家村顕自、田中耕三
- Organizer
  第37回染色体ワークショップ・第18回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-18K15234
[Presentation] The role of chromosomal instability in cancer cell proloferation2018
- Author(s)
  Kenji Iemura, Kozo Tanaka
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15234
[Presentation] 染色体オシレーション運動は染色体均等分配の堅牢性に寄与する2018
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第84回日本生化学会東北支部例会
- Data Source
  KAKENHI-PROJECT-18K15234
[Presentation] 中心体キナーゼAurora Aによる染色体振幅運動は染色体均等分配の堅牢性に寄与する2018
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15234
[Presentation] 分裂期染色体動態による染色体安定性の維持機構2018
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第90回日本遺伝学会大会
- Data Source
  KAKENHI-PROJECT-18K15234
[Presentation] A novel mechanism for maintenance of chromosomal stability2017
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H06635
[Presentation] Aurora Aは正常細胞における染色体均等分配システムの堅牢性を保証する2017
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第69回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-16H06635
[Presentation] Centrosomal kinase Aurora A is required for the robust system of equal chromosome segregation2017
- Author(s)
  Kenji Iemura, Kozo Tanaka
- Organizer
  2017 Japan-NIH joint Symposium
- Place of Presentation
  東北大学（仙台市・宮城県）
- Year and Date
  2017-02-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06635
[Presentation] 中心体キナーゼAurora Aは染色体均等分配の堅牢性の維持に寄与する2017
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第34回染色体ワークショップ・第15回核ダイナミクス研究会
- Place of Presentation
  かずさアカデミアホール（木更津市・千葉県）
- Year and Date
  2017-01-11
- Data Source
  KAKENHI-PROJECT-16H06635
[Presentation] Chromosome oscillation ensures faithful chromosome segregation through Hec1 phosphorylation by Aurora A2017
- Author(s)
  家村顕自, 田中耕三
- Organizer
  Dynamic kinetochore workshop
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06635
[Presentation] 中心体キナーゼAurora Aは分裂期染色体動態に応答して動原体分子をリン酸化する2016
- Author(s)
  家村顕自, 田中耕三
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市・神奈川県）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H06635

1. 田中耕三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Iemura Kenji 家村 顕自

家村 顕自 イエムラ ケンジ

Research Projects

Research Products

Co-Researchers

Mechanisms of chromosomal instability induction via extracellular factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanism required for the acquisition of growth advantage in CIN cancer cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of chromosomal instability in cancer heterogeneityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of robust equal chromosome segregation system by mitotic kinase Aurora APrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mathematical model of kinetochore-microtubule attachment regulated by Aurora A activity gradient describes chromosome oscillation and correction of erroneous attachments2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Attenuated Chromosome Oscillation as a Cause of Chromosomal Instability in Cancer Cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromosome alignment‐maintaining phosphoprotein CHAMP1 plays a role in cell survival through regulating Mcl‐1 expression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Delayed Chromosome Alignment to the Spindle Equator Increases the Rate of Chromosome Missegregation in Cancer Cell Lines2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] Reduced mitotic chromosome dynamics causes chromosomal instability in cancer cells2021

Author(s)

Organizer

Data Source

[Presentation] クロモキネシンは染色体腕部の早期分離を抑制する2021

Author(s)

Organizer

Data Source

[Presentation] 染色体オシレーション運動による染色体安定性の維持機構2021

Author(s)

Organizer

Data Source

[Presentation] 増殖選択圧下のがん細胞増殖における染色体不安定性の役割2021

Author(s)

Organizer

Data Source

[Presentation] がん細胞の増殖優位性獲得過程における染色体不安定性の役割2021

Author(s)

Organizer

Data Source

[Presentation] 染色体オシレーション運動による堅牢な染色体分配システムは細胞老化の進行とともに抑制される2021

Author(s)

Iemura Kenji 家村顕自

家村顕自イエムラケンジ