HIRAYAMA MASATOSHI 平山真敏

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Hirayama Masatoshi 平山真敏

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Researcher Number	50779171
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2024: 熊本大学, 大学院生命科学研究部(医), 助教 2022: 熊本大学, 大学院生命科学研究部(医), 助教 2021: 熊本大学, 生命科学研究部歯科口腔外科学講座, 助教 2020: 熊本大学, 病院, 医員 2019: 熊本大学, 病院, 非常勤診療医師 … More 2018: 熊本大学, 医学部附属病院, 非常勤診療医師 2017: 熊本大学, 医学部附属病院, 診療助手 2016: 熊本大学, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords	Principal Investigator 口腔癌 / 腫瘍浸潤リンパ球 / 制御性T細胞 / 免疫チェックポイント阻害薬 / 癌ペプチドワクチン療法 / 腫瘍免疫 / がん免疫療法 / 口腔がん / ネオアンチゲン / ペプチドワクチン療法 … More / 癌免疫療法 / 腫瘍関連抗原 / がんペプチワクチン療法 / がんペプチドワクチン療法 Less

EGFRシグナルに着目した口腔がん微小環境の免疫動態の解明と新規がん免疫療法への応用Principal Investigator
- Principal Investigator
  
  平山真敏
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Identification of neoantigens in oral cancer and development of novel personalized cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  Hirayama Masatoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Genetic analysis of immunological status in oral cancer patients and applications for cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  Hirayama Masatoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kumamoto University
Development of peptide-based cancer immunotherapy using tumor antigen-derived long peptides for oral cancer patientsPrincipal Investigator
- Principal Investigator
  
  Hirayama Masatoshi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Surgical dentistry
- Research Institution
  Kumamoto University

All 2022 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] 遺伝子医学MOOK 31号（CTLとTh細胞を共に活性化できるがんペプチドワクチン療法の開発）2017
- Author(s)
  平山真敏、西村泰治
- Total Pages
  6
- Publisher
  洋土社
- Data Source
  KAKENHI-PROJECT-16H07082
[Book] がん抗原ワクチン療法の現状と展望2016
- Author(s)
  平山真敏、西村泰治
- Total Pages
  8
- Publisher
  羊土社　実験医学
- Data Source
  KAKENHI-PROJECT-16H07082
[Journal Article] Development of HLA-modified induced pluripotent stem cell-derived dendritic cells applicable for a novel cancer immunotherapy2022
- Author(s)
  Taku Kojima, Akira Yuno, Masatoshi Hirayama, Daiki Fukuma, Masanori Shinohara, Yasuharu Nishimura, Hideki Nakayama
- Journal Title
  
  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology
  
  Volume: 34 Issue: 5 Pages: 896-907
- DOI
  10.1016/j.ajoms.2022.02.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18730
[Journal Article] Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method2020
- Author(s)
  Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Masafumi Nakamoto, Masatoshi Hirayama, Nozomu Takahashi, Yuichiro Matsuoka, Junki Sakata, Hikaru Nakashima, Hidetaka Arita, Akimitsu Hiraki, Masanori Shinohara, Ken Kikuchi, Hideki Nakayama
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 4 Pages: e0231656-e0231656
- DOI
  10.1371/journal.pone.0231656
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18730, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19237
[Journal Article] HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma.2019
- Author(s)
  Sakata J,Hirosue A,Yoshida R,Kawahara K,Matsuoka Y,Yamamoto T,Nakamoto M,Hirayama M,Takahashi N,Nakamura T,Arita H,Nakashima H,Nagata M,Hiraki A,Shinohara M,Nakayama H
- Journal Title
  
  International journal of molecular sciences
  
  Volume: 20 Issue: 10 Pages: 2473-2473
- DOI
  10.3390/ijms20102473
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19204, KAKENHI-PROJECT-19K19237, KAKENHI-PROJECT-18K17202, KAKENHI-PROJECT-19K21413
[Journal Article] Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro2018
- Author(s)
  Tsuruta Miki、Ueda Shohei、Yew Poh Yin、Fukuda Isao、Yoshimura Sachiko、Kishi Hiroyuki、Hamana Hiroshi、Hirayama Masatoshi、Yatsuda Junji、Irie Atsushi、Senju Satoru、Yuba Eiji、Kamba Tomomi、Eto Masatoshi、Nakayama Hideki、Nishimura Yasuharu
- Journal Title
  
  OncoImmunology
  
  Volume: 7 Issue: 4 Pages: 1415687-1415687
- DOI
  10.1080/2162402x.2017.1415687
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06498, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-15H04308, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-17H04272, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-18K17202, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K08008
[Journal Article] Myeloid cell-derived soluble IL-6 receptor diminishes the differentiation of tumor-specific Th1 cells to exacerbate tumor progression2017
- Author(s)
  Tsukamoto H., Fujieda K., Hirayama M., Yuno A., Ikeda T., Matsumura K., Fukuma D., Araki K., Mizuta H., Nakayama H., Senju S., Nishimura Y.
- Journal Title
  
  Cancer Research
  
  Volume: 77 Pages: 2279-2291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H07082
[Journal Article] Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.2017
- Author(s)
  Sakata J, Yoshida R, Matsuoka Y, Nagata M, Hirosue A, Kawahara K, Nakamura T, Nakamoto M, Hirayama M, Takahashi N, Nakashima H, Arita H, Ogi H, Hiraki A, Shinohara M, Nakayama H
- Journal Title
  
  Cancer medicine
  
  Volume: 6 Issue: 4 Pages: 730-738
- DOI
  10.1002/cam4.1005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K20592, KAKENHI-PROJECT-16K20595, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-17H06974, KAKENHI-PROJECT-15K11296
[Journal Article] An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs2016
- Author(s)
  M. Hirayama, Y. Tomita, A. Yuno, H. Tsukamoto, S. Sejju, Y. Imamura, M. A. Sayem, A. Irie, Y. Yoshitake, D. Fukuma, M. Shinohara, A. Hamada, H. Jono, E. Yuba, K. Kono, K. Yoshida, T. Tsunoda, H. Nakayama, Y. Nishimura
- Journal Title
  
  OncoImmunology
  
  Volume: 5 Issue: 6 Pages: e1123368-e1123368
- DOI
  10.1080/2162402x.2015.1123368
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242049, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-25461918, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-26460972, KAKENHI-PROJECT-16K11725
[Journal Article] The present status and future prospects of peptide-based cancer vaccines.2016
- Author(s)
  Hirayama M, Nishimura Y
- Journal Title
  
  Int Immunol
  
  Volume: 28 Issue: 7 Pages: 319-328
- DOI
  10.1093/intimm/dxw027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-16H07082
[Journal Article] Generation of Large Numbers of Antigen-Expressing Human Dendritic Cells Using CD14-ML Technology2016
- Author(s)
  Yuya Imamura, Miwa Haruta, Yusuke Tomita, Keiko Matsumura, Tokunori Ikeda, Akira Yuno1, Masatoshi Hirayama, Hideki Nakayama, Hiroshi Mizuta, Yasuharu Nishimura, Satoru Senju
- Journal Title
  
  Plos One
  
  Volume: 11 Issue: 4 Pages: e0152384-e0152384
- DOI
  10.1371/journal.pone.0152384
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25640091, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-15K19493, KAKENHI-PROJECT-15K11296
[Presentation] 舌癌における頸部後発転移予測システムの開発2020
- Author(s)
  井上淳貴, 吉田遼司, 坂田純基, 川原健太, 平山真敏, 廣末晃之, 永田将士, 中山秀樹
- Organizer
  日本癌学会
- Data Source
  KAKENHI-PROJECT-20K18730
[Presentation] Identification of bladder cancer-associated cancer-testis antigens-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes2018
- Author(s)
  Yasuharu Nishimura, Miki Tsuruta, Shohei Ueda, Poh Yin Yew, Isao Fukuda, Sachiko Yoshimura, Hiroyuki Kishi, Hiroshi Hamana, Masatoshi Hirayama, Junji Yatsuda, Atsushi Irie, Satoru Senju, Eiji Yuba, Tomomi Kamba, Masatoshi Eto and Hideki Nakayama
- Organizer
  AACR Annual Meeting 2018
- Data Source
  KAKENHI-PROJECT-18K17202
[Presentation] 口腔癌患者に対する放射線外照射治療における金属補綴物除去の有効性の検討2018
- Author(s)
  井上　和繁、平山　真敏、吉田　遼司、廣末　晃之、川原　健太、高橋　望、有田　英生、中山　秀樹
- Organizer
  第36回日本口腔腫瘍学会学術大会
- Data Source
  KAKENHI-PROJECT-16H07082
[Presentation] 2種類の膀胱癌関連がん精巣抗原に由来する長鎖ペプチドにより誘導されるCTL/TH1細胞とTCRの解析2017
- Author(s)
  鶴田未季、上田翔平、平山真敏、矢津田旬二、入江厚、千住覚、江藤正俊、中山秀樹、西村泰治
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-16H07082
[Presentation] 右側下顎歯肉に生じた分類不能肉腫の1例2017
- Author(s)
  大山徹、平山真敏、廣末晃之、吉田遼司、永田将士、川原健太、尾木秀直、田中拓也、福間大喜、三上芳喜、中山秀樹
- Organizer
  第36回日本口腔腫瘍学会学術大会
- Data Source
  KAKENHI-PROJECT-16H07082
[Presentation] 口腔癌術後患者に対する Adjuvant ペプチドワクチン療法の臨床試験に関する検討2017
- Author(s)
  平山真敏、福間大喜、湯野晃、中根未季、小島拓、吉武義泰、尾木秀直、廣末晃之、吉田遼司、田中拓也、川原健太、篠原正徳、城野博史、西村泰治、中山秀樹
- Organizer
  第55回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H07082
[Presentation] 膀胱癌関連がん精巣抗原由来の長鎖ペプチドに特異的な HLA 拘束性 T 細胞の免疫応答と TCR の解析2017
- Author(s)
  鶴田未季、上田翔平、平山真敏、矢津田旬二、入江厚、千住覚、神波大己、江藤正俊、中山秀樹、西村泰治
- Organizer
  第26回日本組織適合性学会大会
- Data Source
  KAKENHI-PROJECT-16H07082
[Presentation] 口腔癌での化学放射線治療におけるスぺーサー、および補綴物除去の有効性の検討2017
- Author(s)
  井上　和繁、平山　真敏、吉田　遼司、廣末　晃之、川原　健太、高橋　望、有田　英生、中山　秀樹
- Organizer
  第55回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16H07082
[Presentation] Identification of cancer-testis antigen (DEPDC1 and MPHOSPH1)-derived long peptides encompassing both CTL and HLA class II-restricted Th cell epitopes.2016
- Author(s)
  NAKANE Miki, HIRAYAMA Masatoshi, UEDA Shohei, SAYEM Mohammad Abu, YATSUDA Junji, IRIE Atsushi, SENJU Satoru, ETO Masatoshi, NAKAYAMA Hideki and NISHIMURA Yasuharu
- Organizer
  第45回　日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16H07082
[Presentation] 腫瘍関連抗原IMP-3由来のCTLとTh細胞の誘導活性を併せ持つ長鎖ペプチドの同定2016
- Author(s)
  平山真敏、湯野晃、中根未季、小島拓、福間大喜、中山秀樹
- Organizer
  第61回　日本口腔外科学会総会・学術大会
- Place of Presentation
  幕張メッセ、千葉
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16H07082

1. HIROSUE Akiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. NAGATA MASASHI

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 河野健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 冨田章裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 弓場英司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 西村康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 千住覚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIRAYAMA MASATOSHI 平山 真敏

Hirayama Masatoshi 平山 真敏

Research Projects

Research Products

Co-Researchers

EGFRシグナルに着目した口腔がん微小環境の免疫動態の解明と新規がん免疫療法への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of neoantigens in oral cancer and development of novel personalized cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genetic analysis of immunological status in oral cancer patients and applications for cancer immunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of peptide-based cancer immunotherapy using tumor antigen-derived long peptides for oral cancer patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 遺伝子医学MOOK 31号（CTLとTh細胞を共に活性化できるがんペプチドワクチン療法の開発）2017

Author(s)

Total Pages

Publisher

Data Source

[Book] がん抗原ワクチン療法の現状と展望2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Development of HLA-modified induced pluripotent stem cell-derived dendritic cells applicable for a novel cancer immunotherapy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Myeloid cell-derived soluble IL-6 receptor diminishes the differentiation of tumor-specific Th1 cells to exacerbate tumor progression2017

Author(s)

Journal Title

Data Source

[Journal Article] Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The present status and future prospects of peptide-based cancer vaccines.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of Large Numbers of Antigen-Expressing Human Dendritic Cells Using CD14-ML Technology2016

Author(s)

HIRAYAMA MASATOSHI 平山真敏

Hirayama Masatoshi 平山真敏