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HIRAYAMA MASATOSHI  平山 真敏

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Hirayama Masatoshi  平山 真敏

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Researcher Number 50779171
Other IDs
Affiliation (Current) 2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help 2024: 熊本大学, 大学院生命科学研究部(医), 助教
2022: 熊本大学, 大学院生命科学研究部(医), 助教
2021: 熊本大学, 生命科学研究部 歯科口腔外科学講座, 助教
2020: 熊本大学, 病院, 医員
2019: 熊本大学, 病院, 非常勤診療医師 … More
2018: 熊本大学, 医学部附属病院, 非常勤診療医師
2017: 熊本大学, 医学部附属病院, 診療助手
2016: 熊本大学, 医学部附属病院, 医員 Less
Review Section/Research Field
Principal Investigator
Basic Section 57060:Surgical dentistry-related / Surgical dentistry
Keywords
Principal Investigator
口腔癌 / 腫瘍浸潤リンパ球 / 制御性T細胞 / 免疫チェックポイント阻害薬 / 癌ペプチドワクチン療法 / 腫瘍免疫 / がん免疫療法 / 口腔がん / ネオアンチゲン / ペプチドワクチン療法 … More / 癌免疫療法 / 腫瘍関連抗原 / がんペプチワクチン療法 / がんペプチドワクチン療法 Less
  • Research Projects

    (4 results)
  • Research Products

    (21 results)
  • Co-Researchers

    (7 People)
  •  EGFRシグナルに着目した口腔がん微小環境の免疫動態の解明と新規がん免疫療法への応用Principal Investigator

    • Principal Investigator
      平山 真敏
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kumamoto University
  •  Identification of neoantigens in oral cancer and development of novel personalized cancer immunotherapyPrincipal Investigator

    • Principal Investigator
      Hirayama Masatoshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kumamoto University
  •  Genetic analysis of immunological status in oral cancer patients and applications for cancer immunotherapyPrincipal Investigator

    • Principal Investigator
      Hirayama Masatoshi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Kumamoto University
  •  Development of peptide-based cancer immunotherapy using tumor antigen-derived long peptides for oral cancer patientsPrincipal Investigator

    • Principal Investigator
      Hirayama Masatoshi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Surgical dentistry
    • Research Institution
      Kumamoto University

All 2022 2020 2019 2018 2017 2016

All Journal Article Presentation Book

  • [Book] 遺伝子医学MOOK 31号(CTLとTh細胞を共に活性化できるがんペプチドワクチン療法の開発)2017

    • Author(s)
      平山真敏、西村泰治
    • Total Pages
      6
    • Publisher
      洋土社
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Book] がん抗原ワクチン療法の現状と展望2016

    • Author(s)
      平山真敏、西村泰治
    • Total Pages
      8
    • Publisher
      羊土社 実験医学
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Journal Article] Development of HLA-modified induced pluripotent stem cell-derived dendritic cells applicable for a novel cancer immunotherapy2022

    • Author(s)
      Taku Kojima, Akira Yuno, Masatoshi Hirayama, Daiki Fukuma, Masanori Shinohara, Yasuharu Nishimura, Hideki Nakayama
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 34 Issue: 5 Pages: 896-907

    • DOI

      10.1016/j.ajoms.2022.02.002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K18730
  • [Journal Article] Efficacy of adjuvant chemotherapy with S-1 in stage II oral squamous cell carcinoma patients: A comparative study using the propensity score matching method2020

    • Author(s)
      Ryoji Yoshida, Masashi Nagata, Akiyuki Hirosue, Kenta Kawahara, Masafumi Nakamoto, Masatoshi Hirayama, Nozomu Takahashi, Yuichiro Matsuoka, Junki Sakata, Hikaru Nakashima, Hidetaka Arita, Akimitsu Hiraki, Masanori Shinohara, Ken Kikuchi, Hideki Nakayama
    • Journal Title

      PLoS One

      Volume: 15 Issue: 4 Pages: e0231656-e0231656

    • DOI

      10.1371/journal.pone.0231656

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K18730, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19237
  • [Journal Article] HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma.2019

    • Author(s)
      Sakata J,Hirosue A,Yoshida R,Kawahara K,Matsuoka Y,Yamamoto T,Nakamoto M,Hirayama M,Takahashi N,Nakamura T,Arita H,Nakashima H,Nagata M,Hiraki A,Shinohara M,Nakayama H
    • Journal Title

      International journal of molecular sciences

      Volume: 20 Issue: 10 Pages: 2473-2473

    • DOI

      10.3390/ijms20102473

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09727, KAKENHI-PROJECT-19K19204, KAKENHI-PROJECT-19K19237, KAKENHI-PROJECT-18K17202, KAKENHI-PROJECT-19K21413
  • [Journal Article] Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro2018

    • Author(s)
      Tsuruta Miki、Ueda Shohei、Yew Poh Yin、Fukuda Isao、Yoshimura Sachiko、Kishi Hiroyuki、Hamana Hiroshi、Hirayama Masatoshi、Yatsuda Junji、Irie Atsushi、Senju Satoru、Yuba Eiji、Kamba Tomomi、Eto Masatoshi、Nakayama Hideki、Nishimura Yasuharu
    • Journal Title

      OncoImmunology

      Volume: 7 Issue: 4 Pages: 1415687-1415687

    • DOI

      10.1080/2162402x.2017.1415687

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06498, KAKENHI-PLANNED-16H06499, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-15H04308, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-17H04272, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-18K17202, KAKENHI-PROJECT-18H03005, KAKENHI-PROJECT-18K08008
  • [Journal Article] Myeloid cell-derived soluble IL-6 receptor diminishes the differentiation of tumor-specific Th1 cells to exacerbate tumor progression2017

    • Author(s)
      Tsukamoto H., Fujieda K., Hirayama M., Yuno A., Ikeda T., Matsumura K., Fukuma D., Araki K., Mizuta H., Nakayama H., Senju S., Nishimura Y.
    • Journal Title

      Cancer Research

      Volume: 77 Pages: 2279-2291

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Journal Article] Predictive value of the combination of SMAD4 expression and lymphocyte infiltration in malignant transformation of oral leukoplakia.2017

    • Author(s)
      Sakata J, Yoshida R, Matsuoka Y, Nagata M, Hirosue A, Kawahara K, Nakamura T, Nakamoto M, Hirayama M, Takahashi N, Nakashima H, Arita H, Ogi H, Hiraki A, Shinohara M, Nakayama H
    • Journal Title

      Cancer medicine

      Volume: 6 Issue: 4 Pages: 730-738

    • DOI

      10.1002/cam4.1005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K20592, KAKENHI-PROJECT-16K20595, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-17H06974, KAKENHI-PROJECT-15K11296
  • [Journal Article] An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs2016

    • Author(s)
      M. Hirayama, Y. Tomita, A. Yuno, H. Tsukamoto, S. Sejju, Y. Imamura, M. A. Sayem, A. Irie, Y. Yoshitake, D. Fukuma, M. Shinohara, A. Hamada, H. Jono, E. Yuba, K. Kono, K. Yoshida, T. Tsunoda, H. Nakayama, Y. Nishimura
    • Journal Title

      OncoImmunology

      Volume: 5 Issue: 6 Pages: e1123368-e1123368

    • DOI

      10.1080/2162402x.2015.1123368

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26242049, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-25461918, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-26460972, KAKENHI-PROJECT-16K11725
  • [Journal Article] The present status and future prospects of peptide-based cancer vaccines.2016

    • Author(s)
      Hirayama M, Nishimura Y
    • Journal Title

      Int Immunol

      Volume: 28 Issue: 7 Pages: 319-328

    • DOI

      10.1093/intimm/dxw027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-16H07082
  • [Journal Article] Generation of Large Numbers of Antigen-Expressing Human Dendritic Cells Using CD14-ML Technology2016

    • Author(s)
      Yuya Imamura, Miwa Haruta, Yusuke Tomita, Keiko Matsumura, Tokunori Ikeda, Akira Yuno1, Masatoshi Hirayama, Hideki Nakayama, Hiroshi Mizuta, Yasuharu Nishimura, Satoru Senju
    • Journal Title

      Plos One

      Volume: 11 Issue: 4 Pages: e0152384-e0152384

    • DOI

      10.1371/journal.pone.0152384

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25640091, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-15K19493, KAKENHI-PROJECT-15K11296
  • [Presentation] 舌癌における頸部後発転移予測システムの開発2020

    • Author(s)
      井上 淳貴, 吉田 遼司, 坂田 純基, 川原 健太, 平山 真敏, 廣末 晃之, 永田 将士, 中山 秀樹
    • Organizer
      日本癌学会
    • Data Source
      KAKENHI-PROJECT-20K18730
  • [Presentation] Identification of bladder cancer-associated cancer-testis antigens-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes2018

    • Author(s)
      Yasuharu Nishimura, Miki Tsuruta, Shohei Ueda, Poh Yin Yew, Isao Fukuda, Sachiko Yoshimura, Hiroyuki Kishi, Hiroshi Hamana, Masatoshi Hirayama, Junji Yatsuda, Atsushi Irie, Satoru Senju, Eiji Yuba, Tomomi Kamba, Masatoshi Eto and Hideki Nakayama
    • Organizer
      AACR Annual Meeting 2018
    • Data Source
      KAKENHI-PROJECT-18K17202
  • [Presentation] 口腔癌患者に対する放射線外照射治療における金属補綴物除去の有効性の検討2018

    • Author(s)
      井上 和繁、平山 真敏、吉田 遼司、廣末 晃之、川原 健太、高橋 望、有田 英生、中山 秀樹
    • Organizer
      第36回日本口腔腫瘍学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Presentation] 2種類の膀胱癌関連がん精巣抗原に由来する長鎖ペプチドにより誘導されるCTL/TH1細胞とTCRの解析2017

    • Author(s)
      鶴田 未季、上田 翔平、平山 真敏、矢津田 旬二、入江 厚、千住 覚、江藤 正俊、中山 秀樹、西村 泰治
    • Organizer
      第21回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Presentation] 右側下顎歯肉に生じた分類不能肉腫の1例2017

    • Author(s)
      大山徹、平山真敏、廣末晃之、吉田遼司、永田将士、川原健太、尾木秀直、田中拓也、福間大喜、三上芳喜、中山秀樹
    • Organizer
      第36回日本口腔腫瘍学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Presentation] 口腔癌術後患者に対する Adjuvant ペプチドワクチン療法の臨床試験に関する検討2017

    • Author(s)
      平山真敏、福間大喜、 湯野晃、中根未季、小島拓、吉武義泰、尾木秀直、廣末晃之、吉田遼司、田中拓也、川原健太、篠原正徳、城野博史、西村泰治、中山秀樹
    • Organizer
      第55回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Presentation] 膀胱癌関連がん精巣抗原由来の長鎖ペプチドに特異的な HLA 拘束性 T 細胞の免疫応答と TCR の解析2017

    • Author(s)
      鶴田未季、上田翔平、平山真敏、矢津田旬二、入江厚 、千住覚 、 神波大己 、江藤正俊、中山秀樹、西村泰治
    • Organizer
      第26回日本組織適合性学会大会
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Presentation] 口腔癌での化学放射線治療におけるスぺーサー、および補綴物除去の有効性の検討2017

    • Author(s)
      井上 和繁、平山 真敏、吉田 遼司、廣末 晃之、川原 健太、高橋 望、有田 英生、中山 秀樹
    • Organizer
      第55回日本癌治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Presentation] Identification of cancer-testis antigen (DEPDC1 and MPHOSPH1)-derived long peptides encompassing both CTL and HLA class II-restricted Th cell epitopes.2016

    • Author(s)
      NAKANE Miki, HIRAYAMA Masatoshi, UEDA Shohei, SAYEM Mohammad Abu, YATSUDA Junji, IRIE Atsushi, SENJU Satoru, ETO Masatoshi, NAKAYAMA Hideki and NISHIMURA Yasuharu
    • Organizer
      第45回 日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター、沖縄
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16H07082
  • [Presentation] 腫瘍関連抗原IMP-3由来のCTLとTh細胞の誘導活性を併せ持つ長鎖ペプチドの同定2016

    • Author(s)
      平山真敏、湯野晃、中根未季、小島拓、福間大喜、中山秀樹
    • Organizer
      第61回 日本口腔外科学会総会・学術大会
    • Place of Presentation
      幕張メッセ、千葉
    • Year and Date
      2016-11-25
    • Data Source
      KAKENHI-PROJECT-16H07082
  • 1.  HIROSUE Akiyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 2.  NAGATA MASASHI
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  河野 健司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  冨田 章裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  弓場 英司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  西村 康治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  千住 覚
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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