Hijioka Masanori 肱岡雅宣

Researcher Number	50780061
Other IDs	https://orcid.org/0000-0001-6912-3496
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(医学), 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 助教 2016 – 2019: 立命館大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 48030:Pharmacology-related / Pharmacology in pharmacy Except Principal Investigator Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator ミクログリア / 脳内出血 / 生理活性脂質 / 好中球 / 細胞間相互作用 / 認知症 / 脳卒中 / ケモカイン / PIC RNA-seq / 空間的トランスクリプトーム解析 … More / CCL3 / アミロイドβ / アルツハイマー病 / lipoxin A4 / リポキシンA4 / ロイコトリエンB4 / ファゴサイトーシス / タンパク質分解系 / オートファジー / NF-κB / 神経細胞 / DJ-1 / α-シヌクレイン … More Except Principal Investigator アルツハイマー病 / パーキンソン病 / 神経保護作用 / PARK7/DJ-1 / αシヌクレイン / 神経細胞 / ミクログリア / α-シヌクレイン / DJ-1結合化合物 / DJ-1 / PARK7 Less

脳卒中・認知症治療標的の探索を企図した細胞間相互作用の時空間的解析Principal Investigator
- Principal Investigator
  
  肱岡雅宣
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Nagoya City University
Effect of the regulation of bioactive lipid mediators production on the pathophysiology of intracerebral hemorrhagePrincipal Investigator
- Principal Investigator
  
  Hijioka Masanori
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Nagoya City University
Developmental drug study targeting PARK7/DJ-1, a causetive gene of familial Parkinson's disease
- Principal Investigator
  
  Kitamura Yoshihisa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Ritsumeikan University
Research for therapeutic targets for intracerebral hemorrhage based on the regulation of bioactive lipid mediatorsPrincipal Investigator
- Principal Investigator
  
  Masanori HIJIOKA
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Ritsumeikan University
Exploratory research of therapeutic agents for neurodegenerative diseases based on clearance of alpha-synucleinPrincipal Investigator
- Principal Investigator
  
  Hijioka Masanori
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  Ritsumeikan University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 認知症plus予防教育2020
- Author(s)
  肱岡雅宣, 天ヶ瀬紀久子, 北村佳久.
- Total Pages
  216
- Publisher
  日本看護協会出版会
- ISBN
  9784818022485
- Data Source
  KAKENHI-PROJECT-18K06904
[Book] 臨床薬学テキストシリーズ第5巻［薬理・病態・薬物治療］『神経・筋・精神／麻酔・鎮痛』2019
- Author(s)
  北村佳久, 肱岡雅宣, 髙橋良輔.
- Total Pages
  372
- Publisher
  中山書店
- ISBN
- Data Source
  KAKENHI-PROJECT-18K06904
[Journal Article] Multifactorial glial responses and their contributions to Alzheimer's disease continuum2023
- Author(s)
  Hijioka Masanori, Manabe Tatsuya, Saito Takashi
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: - Issue: 2 Pages: 1-10
- DOI
  10.1111/cen3.12745
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06865, KAKENHI-PROJECT-22K20688, KAKENHI-PROJECT-20H03564
[Journal Article] Lipoxin A4 Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage2022
- Author(s)
  Futokoro Risa, Hijioka Masanori, Arata Moe, Kitamura Yoshihisa
- Journal Title
  
  Brain Sciences
  
  Volume: 12 Issue: 2 Pages: 162-162
- DOI
  10.3390/brainsci12020162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-21K06586
[Journal Article] MEK/ERK Signaling Regulates Reconstitution of the Dopaminergic Nerve Circuit in the Planarian Dugesia japonica2021
- Author(s)
  Hijioka Masanori, Ikemoto Yusuke, Fukao Kosuke, Inoue Takeshi, Kobayakawa Tatsuki, Nishimura Kaneyasu, Takata Kazuyuki, Agata Kiyokazu, Kitamura Yoshihisa
- Journal Title
  
  Neurochemical Research
  
  Volume: － Issue: 9 Pages: 2558-2567
- DOI
  10.1007/s11064-020-03226-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-21K06586, KAKENHI-PROJECT-18K06341
[Journal Article] Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage.2020
- Author(s)
  Hijioka M, Futokoro R, Ohto-Nakanishi T, Nakanishi H, Katsuki H, Kitamura Y.
- Journal Title
  
  Int Immunopharmacol.
  
  Volume: 85 Pages: 106678-106678
- DOI
  10.1016/j.intimp.2020.106678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-20H04126, KAKENHI-PROJECT-17K07194, KAKENHI-PROJECT-18K06904
[Journal Article] Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke2020
- Author(s)
  Hijioka Masanori, Kitamura Kanori, Yanagisawa Daijiro, Nishimura Kaneyasu, Takata Kazuyuki, Inden Masatoshi, Kitamura Yoshihisa
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 144 Issue: 3 Pages: 183-187
- DOI
  10.1016/j.jphs.2020.07.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16138, KAKENHI-PROJECT-18K06904
[Journal Article] DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders2017
- Author(s)
  Hijioka Masanori、Inden Masatoshi、Yanagisawa Daijiro、Kitamura Yoshihisa
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 5 Pages: 548-552
- DOI
  10.1248/bpb.b16-01006
- NAID
  130005631951
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-16H07341
[Presentation] Reconstitution of dopaminergic nerve circuit in planarian, an invertebrate flatworm2023
- Author(s)
  Matsubayashi Koto, Wen Xiaopeng, Hijioka Masanori, Inoue Takeshi, Agata Kiyokazu, Tamura Yoshihisa
- Organizer
  第21回武田科学振興財団生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K06865
[Presentation] Elucidation of the pathophysiological roles of leukotriene B4 in a mouse model of intracerebral hemorrhage2023
- Author(s)
  Hijioka Masanori
- Organizer
  3rd EMBO Workshop Stroke-Immunology Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06865
[Presentation] タウオパチーモデルマウスにおけるケモカインCXCL10の機能解析2023
- Author(s)
  上西涼平, 肱岡雅宣, 齊藤貴志
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K06865
[Presentation] CXCL10の欠損はtauopathy モデルマウスでタウ病理を軽減する2023
- Author(s)
  上西涼平, 肱岡雅宣, 齊藤貴志
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06865
[Presentation] Reversibility of tau hyperphosphorylation in response to hypothermia2022
- Author(s)
  髙木智之, 眞鍋達也, 土肥名月, 肱岡雅宣, 齊藤貴志
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06865
[Presentation] ロイコトリエンB4およびリポキシンA4産生系調節が脳内出血病態に与える作用2022
- Author(s)
  肱岡雅宣, 懐理紗, 荒田萌衣, 香月博志, 北村佳久
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K16138
[Presentation] タウ性状に対する腸内細菌の影響-野生型マウスでの解析-2022
- Author(s)
  青木聡吾, 髙木智之, 肱岡雅宣, 眞鍋達也, 土肥名月, 朝光かおり, 齊藤貴志
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-22K06865
[Presentation] プラナリアにおけるドパミン神経の再生に関するアセチルコリンの作用解析2020
- Author(s)
  深尾昂佑, 肱岡雅宣, 北村佳久.
- Organizer
  第70回日本薬学会関西支部大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ニコチン性アセチルコリン受容体を介したガランタミンのα-シヌクレイン凝集抑制作用2020
- Author(s)
  野崎空, 肱岡雅宣, 辻尚仁, 北村佳久.
- Organizer
  第70回日本薬学会関西支部大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ヒト神経芽細胞腫SH-SY5Y細胞におけるα-シヌクレインタンパク質の細胞内凝集体形成に対するガランタミンの抑制作用2020
- Author(s)
  野崎空, 肱岡雅宣, 辻尚仁, 北村佳久.
- Organizer
  第43回日本神経科学大会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] 抗炎症性生理活性脂質リポキシンA4の受容体刺激による脳内出血病態軽減作用の解析2020
- Author(s)
  懐理紗, 肱岡雅宣, 北村佳久.
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] Stimulation of LXA4 receptor alleviates motor dysfunction in intracerebral hemorrhage model mice.2020
- Author(s)
  Futokoro R., Hijioka M. and Kitamura Y.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] 半側性パーキンソン病モデルラットにおけるドパミン神経細胞死に対する 5-アミノレブリン酸の抑制作用2020
- Author(s)
  北村佳久, 肱岡雅宣, 北村叶里, 柳沢大治郎, 西村周泰, 高田和幸, 位田雅俊.
- Organizer
  第137回日本薬理学会近畿部会（オンライン開催）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ヒト神経芽細胞腫SH-SY5Y細胞におけるα-シヌクレイン凝集に対するガランタミンの作用.2020
- Author(s)
  野崎空, 肱岡雅宣, 辻尚仁, 北村佳久.
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ロイコトリエンB4およびその受容体を標的とした脳内出血治療薬の創薬研究2020
- Author(s)
  肱岡雅宣
- Organizer
  第70回日本薬学会関西支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-20K16138
[Presentation] Stimulation of LXA4 receptor attenuates pathological changes and ensuing motor dysfunction in intracerebral hemorrhage model mouse.2020
- Author(s)
  Futokoro Risa, Hijioka Masanori, Yoshihisa.
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-20K16138
[Presentation] LXA4受容体刺激は脳内出血モデルマウスの運動機能障害を軽減する.2020
- Author(s)
  懐理紗, 肱岡雅宣, 北村佳久.
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] 脳内出血病態形成過程におけるロイコトリエンB4の機能解析.2019
- Author(s)
  肱岡雅宣, 懐理紗, 香月博志, 北村佳久.
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] Effect of lipoxin A4 for pathology of intracerebral hemorrhage mediated by microglial activation.2019
- Author(s)
  Futokoro R., Hijioka M. and Kitamura Y.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] MEK阻害薬によるプラナリアの個体再生およびドパミン神経再生の抑制.2019
- Author(s)
  深尾昂佑, 肱岡雅宣, 小早川達貴, 池本有佑, 北村佳久.
- Organizer
  第69回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] ミクログリアの活性化を介した脳内出血病態形成に対するリポキシンA4の作用解析2019
- Author(s)
  懐理紗, 肱岡雅宣, 北村佳久.
- Organizer
  第69回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] 脳内出血病態形成過程におけるロイコトリエンB4の機能解析2019
- Author(s)
  肱岡雅宣, 懐理紗, 香月博志, 北村佳久.
- Organizer
  第135回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] Analysis of the functions of leukotriene B4 and lipoxin A4 to the neutrophil invasion into hematoma in vitro model of intracerebral hemorrhage2019
- Author(s)
  Hijioka M., Futokoro R. and Kitamura Y.
- Organizer
  Neuro2019 第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] ロイコトリエンB4およびその受容体を標的とした脳内出血治療薬の創薬研究2019
- Author(s)
  肱岡雅宣, 懐理紗, 香月博志, 北村佳久.
- Organizer
  第69回日本薬学会関西支部大会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] Leukotriene B4 secreted by microglia promotes neutrophil invasion into hematoma of mice with intracerebral hemorrhage.2019
- Author(s)
  Hijioka M., Futokoro R. and Kitamura Y.
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] Analysis of the functions of leukotriene B4 and lipoxin A4 to the neutrophil invasion into hematoma in vitro model of intracerebral hemorrhage.2019
- Author(s)
  Hijioka M., Futokoro R. and Kitamura Y.
- Organizer
  Neuro2019 第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] Leukotriene B4 secreted by microglia promotes neutrophil invasion into hematoma of mice with intracerebral hemorrhage.2019
- Author(s)
  Hijioka M., Futokoro R. and Kitamura Y.
- Organizer
  第92回日本薬理学会年会（大阪）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] Leukotriene B4-BLT1 axis exacerbates neutrophil invasion and motor dysfunction after intracerebral hemorrhage in mice.2018
- Author(s)
  Hijioka M., Kurauchi Y., Hisatsune A., Seki T., Koga T., Kitamura Y., Yokomizo T., Shimizu T. and Katsuki H.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology（京都）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] BV-2ミクログリアにおけるTLR2を介した炎症反応に対するDJ-1結合化合物の作用2018
- Author(s)
  尾上徹, 肱岡雅宣, 北村佳久
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2018（福岡）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] アルツハイマー病モデルマウスの認知機能障害に対するDJ-1結合化合物の作用解析2018
- Author(s)
  柴慧司, 肱岡雅宣, 有賀寛芳, 北村佳久
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2018（福岡）
- Data Source
  KAKENHI-PROJECT-18K06904
[Presentation] DJ-1結合化合物はマウスミクログリアにおいてTLR2を介した炎症反応を抑制する2018
- Author(s)
  尾上徹, 肱岡雅宣, 北村佳久
- Organizer
  第138回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-16H07341
[Presentation] 生理活性脂質の代謝制御に注目した脳内出血病態の解析2018
- Author(s)
  肱岡雅宣, 懐理紗, 倉内祐樹, 久恒昭哲, 関貴弘, 古賀友紹, 横溝岳彦, 清水孝雄, 北村佳久, 香月博志.
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2018
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] Leukotriene B4-BLT1 axis exacerbates neutrophil invasion and motor dysfunction after intracerebral hemorrhage in mice2018
- Author(s)
  Hijioka M., Kurauchi Y., Hisatsune A., Seki T., Koga T., Kitamura Y., Yokomizo T., Shimizu T. and Katsuki H.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15034
[Presentation] DJ-1 binding compound attenuates TLR2-mediated inflammatory reactions in BV-2 microglia.2018
- Author(s)
  Tanaka C., Hijioka M., Onoue T. and Kitamura Y.
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16H07341
[Presentation] DJ-1-binding compound ameliorates spatial learning and memory impairment in a mouse model of Alzheimer’s disease.2018
- Author(s)
  Kitamura Y. and Hijioka M.
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07341

1. Kitamura Yoshihisa (60195295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
2. 香月博志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hijioka Masanori 肱岡 雅宣

Research Projects

Research Products

Co-Researchers

脳卒中・認知症治療標的の探索を企図した細胞間相互作用の時空間的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Effect of the regulation of bioactive lipid mediators production on the pathophysiology of intracerebral hemorrhagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developmental drug study targeting PARK7/DJ-1, a causetive gene of familial Parkinson's disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research for therapeutic targets for intracerebral hemorrhage based on the regulation of bioactive lipid mediatorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory research of therapeutic agents for neurodegenerative diseases based on clearance of alpha-synucleinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 認知症plus予防教育2020

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] 臨床薬学テキストシリーズ第5巻［薬理・病態・薬物治療］『神経・筋・精神／麻酔・鎮痛』2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Multifactorial glial responses and their contributions to Alzheimer's disease continuum2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipoxin A4 Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MEK/ERK Signaling Regulates Reconstitution of the Dopaminergic Nerve Circuit in the Planarian Dugesia japonica2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microglia-released leukotriene B4 promotes neutrophil infiltration and microglial activation following intracerebral hemorrhage.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuroprotective effects of 5-aminolevulinic acid against neurodegeneration in rat models of Parkinson's disease and stroke2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DJ-1/PARK7: A New Therapeutic Target for Neurodegenerative Disorders2017

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] Reconstitution of dopaminergic nerve circuit in planarian, an invertebrate flatworm2023

Hijioka Masanori 肱岡雅宣