Nishihara Hideaki 西原秀昭

… Alternative Names

西原秀昭ニシハラヒデアキ

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Researcher Number	50780798
Other IDs	https://orcid.org/0000-0002-2990-835X
Affiliation (Current)	2025: 山口大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 山口大学, 大学院医学系研究科, 助教 2023: 山口大学, 大学院医学系研究科, 助教 2022: 山口大学, 医学部, 助教(連携講座) 2016 – 2017: 山口大学, 医学部附属病院, 診療助教(4日/週)
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology
Keywords	Principal Investigator 多発性硬化症 / 血液脳関門 / 免疫細胞浸潤 / iPS細胞 / 脳神経疾患 / 脳・神経 / 視神経脊髄炎 / galectin-3 / SPMS / 抗内皮抗体

血液脳関門の遺伝的脆弱性が多発性硬化症の臨床病型に与える影響の解析Principal Investigator
- Principal Investigator
  
  西原秀昭
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
iPSCs modeling of blood brain barrier disruption in multiple sclerosisPrincipal Investigator
- Principal Investigator
  
  Nishihara Hideaki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Yamaguchi University
進行期多発性硬化症の診断マーカー・新規治療戦略の開発：血液脳関門に着目してPrincipal Investigator
- Principal Investigator
  
  西原秀昭
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Yamaguchi University

All 2023 2022 2017 2016

All Journal Article Presentation

[Journal Article] Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype2023
- Author(s)
  Matsuo Kinya、Engelhardt Britta、Nishihara Hideaki
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 195 Issue: 195
- DOI
  10.3791/65134
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Journal Article] Antineutrophil cytoplasmic antibody-associated vasculitis with predominant truncal muscle weakness: a retrospective case series2023
- Author(s)
  Nemoto J, Nishihara H, Yasuhi T、Sato R, Koga M, Kanda T, Nakamori M.
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 14 Pages: 1277337-1277337
- DOI
  10.3389/fneur.2023.1277337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07437, KAKENHI-PROJECT-22K15711
[Journal Article] The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis2023
- Author(s)
  Lazarevic Ivana、Soldati Sasha、Mapunda Josephine A.、Rudolph Henriette、Rosito Maria、de Oliveira Alex Cardoso、Enzmann Gaby、Nishihara Hideaki、Ishikawa Hiroshi、Tenenbaum Tobias、Schroten Horst、Engelhardt Britta
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 20 Issue: 1 Pages: 39-39
- DOI
  10.1186/s12987-023-00441-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Journal Article] High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro2023
- Author(s)
  Soldati Sasha、Bar Alexander、Vladymyrov Mykhailo、Glavin Dale、McGrath James L.、Gosselet Fabien、Nishihara Hideaki、Goelz Susan、Engelhardt Britta
- Journal Title
  
  Journal of Neuroinflammation
  
  Volume: 20 Issue: 1
- DOI
  10.1186/s12974-023-02797-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Journal Article] SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier2023
- Author(s)
  Studle Chiara、Nishihara Hideaki、Wischnewski Sven、Kulsvehagen Laila、Perriot Sylvain、Ishikawa Hiroshi、Schroten Horst、Frank Stephan、Deigendesch Nikolaus、Du Pasquier Renaud、Schirmer Lucas、Probstel Anne-Katrin、Engelhardt Britta
- Journal Title
  
  Fluids and Barriers of the CNS
  
  Volume: 20 Issue: 1 Pages: 76-76
- DOI
  10.1186/s12987-023-00479-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Journal Article] Clinical features of 8 patients with multifocal motor neuropathy in the long-term follow-up2023
- Author(s)
  Nemoto Joe、Shimizu Fumitaka、Maeda Toshihiko、Nishihara Hideaki、Koga Michiaki、Kanda Takashi
- Journal Title
  
  Rinsho Shinkeigaku
  
  Volume: 63 Issue: 4 Pages: 209-213
- DOI
  10.5692/clinicalneurol.cn-001810
- ISSN
  0009-918X, 1882-0654
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15711, KAKENHI-PROJECT-21K07437
[Journal Article] Modeling Brain Vasculature Immune Interactions In Vitro2022
- Author(s)
  Lyck Ruth、Nishihara Hideaki、Aydin Sidar、Soldati Sasha、Engelhardt Britta
- Journal Title
  
  Cold Spring Harbor Perspectives in Medicine
  
  Volume: - Issue: 9 Pages: a041185-a041185
- DOI
  10.1101/cshperspect.a041185
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Journal Article] Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis2022
- Author(s)
  Nishihara Hideaki、Perriot Sylvain、Gastfriend Benjamin D、Steinfort Marel、Cibien Celine、Soldati Sasha、Matsuo Kinya、Guimbal Sarah、Mathias Amandine、Palecek Sean P、Shusta Eric V、Pasquier Renaud Du、Engelhardt Britta
- Journal Title
  
  Brain
  
  Volume: 145 Issue: 12 Pages: 4334-4348
- DOI
  10.1093/brain/awac019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Journal Article] The Modular μSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro2022
- Author(s)
  McCloskey Molly C.、Kasap Pelin、Ahmad S. Danial、Su Shiuan‐Haur、Chen Kaihua、Mansouri Mehran、Ramesh Natalie、Nishihara Hideaki、Belyaev Yury、Abhyankar Vinay V.、Begolo Stefano、Singer Benjamin H.、Webb Kevin F.、Kurabayashi Katsuo、Flax Jonathan、Waugh Richard E.、Engelhardt Britta、McGrath James L.
- Journal Title
  
  Advanced Healthcare Materials
  
  Volume: 11 Issue: 18 Pages: 2200804-2200804
- DOI
  10.1002/adhm.202200804
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Journal Article] Identification of galectin-3 as a possible antibody target for secondary progressive multiple sclerosis2017
- Author(s)
  Nishihara, H. Shimizu, F. Kitagawa, T. Yamanaka, N. Akada, J. Kuramitsu, Y. Sano, Y. Takeshita, Y. Maeda, T. Abe, M. Koga, M. Nakamura, K. Kanda, T.
- Journal Title
  
  Multiple Sclerosis Journal
  
  Volume: 3 Issue: 3 Pages: 382-394
- DOI
  10.1177/1352458516655217
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H07008, KAKENHI-PROJECT-15K08464
[Journal Article] サルコイドニューロパチーのCase approach．2017
- Author(s)
  西原秀昭，神田隆
- Journal Title
  
  神経内科clinical questions and pearls『末梢神経疾患』
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-16H07008
[Journal Article] アスペルギルス・ムコール症による中枢神経系感染症はどのような病気で、どのように診断・治療するのですか？2017
- Author(s)
  西原秀昭，小笠原淳一，神田　隆
- Journal Title
  
  神経内科clinical questions and pearls『神経感染症』
  
  Volume: 印刷中
- Data Source
  KAKENHI-PROJECT-16H07008
[Journal Article] Establishment of a New Conditionally Immortalized Human Skeletal Muscle Microvascular Endothelial Cell Line2017
- Author(s)
  Sano, H. Sano, Y. Ishiguchi, E. Shimizu, F. Omoto, M. Maeda, T. Nishihara, H. Takeshita, Y. Takahashi, S. Oishi, M. Kanda, T.
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 印刷中 Issue: 12 Pages: 3286-3295
- DOI
  10.1002/jcp.25772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H07008, KAKENHI-PROJECT-26461271
[Journal Article] 【よくわかる中枢神経系血管炎】小血管炎　ANCA関連血管炎　顕微鏡的多発血管炎の中枢神経病変2016
- Author(s)
  西原秀昭，神田　隆
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 34 Pages: 539-541
- Data Source
  KAKENHI-PROJECT-16H07008
[Journal Article] 自律神経障害をきたすニューロパチーファブリー病患者の末梢神経障害　早期発見・早期治療のために2016
- Author(s)
  西原秀昭，古賀道明，神田　隆
- Journal Title
  
  自律神経
  
  Volume: 53 Pages: 17-20
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H07008
[Presentation] Modeling blood-brain barrier dysfunction in amyotrophic lateral sclerosis2023
- Author(s)
  Hideaki Nishihara, Kinya Matsuo, Satoru Morimoto, Hideyuki Okano
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] iPS cell-derived Blood-Brain Barrier (BBB) Model: targeting the BBB for diagnosis and treatment2023
- Author(s)
  Hideaki Nishihara
- Organizer
  Seminar at TKI
- Invited
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] Modeling blood-brain barrier dysfunction in amyotrophic lateral sclerosis (ALS)2023
- Author(s)
  Hideaki Nishihara, Kinya Matsuo, Satoru Morimoto, Hideyuki Okano
- Organizer
  64th Annual Meeting of the Japanese Society of Neurology
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] 多発性硬化症患者では血液脳関門構成内皮細胞が免疫細胞の中枢神経浸潤を促進する2023
- Author(s)
  西原　秀昭，松尾　欣哉，Maud Bagnoud，Robert Hoepner，Andrew Chan，Fabien Gosselet, Britta Engelhardt
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] iPS cell-derived Blood-Brain Barrier (BBB) Model: targeting the BBB for diagnosis and treatment2023
- Author(s)
  Hideaki Nishihara
- Organizer
  第35回日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] Modeling blood-brain barrier dysfunction in amyotrophic lateral sclerosis (ALS)2023
- Author(s)
  Hideaki Nishihara, Kinya Matsuo, Satoru Morimoto, Hideyuki Okano
- Organizer
  CVB2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] Functional analysis of potential target molecules related to blood-brain barrier breakdown in multiple sclerosis2023
- Author(s)
  Kinya Matsuo, Hideaki Nishihara, David Francisco, Remy Bruggmann, Britta Engerhalt.
- Organizer
  第65回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] Modeling blood-brain barrier dysfunction in amyotrophic lateral sclerosis2023
- Author(s)
  Hideaki Nishihara, Kinya Matsuo, Satoru Morimoto, Hideyuki Okano
- Organizer
  Cerebral Vascular Biology meeting CVB 2023 UPPSALA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] 多発性硬化症における血液脳関門破綻に関連する標的分子の機能解析2023
- Author(s)
  松尾欣哉, 西原秀昭, David Francisco, Remy Bruggmann, Britta Engerhalt
- Organizer
  第35回日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] 日本人多発性硬化症患者には血液脳関門を破綻する遺伝的素因が存在するか？2023
- Author(s)
  西原　秀昭
- Organizer
  第35回日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis2022
- Author(s)
  Hideaki Nishihara
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] 疾患由来血液脳関門モデル　多発性硬化症の病態解明に向けて2022
- Author(s)
  西原　秀昭
- Organizer
  第34回日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15711
[Presentation] 神経免疫学会はいかに若手を育て，共に成長していくか～自己免疫性神経疾患患者に存在する血液脳関門破綻に関与する抗内皮抗体の検索～2016
- Author(s)
  西原秀昭
- Organizer
  第28回日本神経免疫学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県長崎市）
- Year and Date
  2016-09-29
- Invited
- Data Source
  KAKENHI-PROJECT-16H07008

1. 古賀道明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishihara Hideaki 西原 秀昭

西原 秀昭 ニシハラ ヒデアキ

Research Projects

Research Products

Co-Researchers

血液脳関門の遺伝的脆弱性が多発性硬化症の臨床病型に与える影響の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

iPSCs modeling of blood brain barrier disruption in multiple sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

進行期多発性硬化症の診断マーカー・新規治療戦略の開発：血液脳関門に着目してPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Differentiation of Human Induced Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-Like Cells with a Mature Immune Phenotype2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antineutrophil cytoplasmic antibody-associated vasculitis with predominant truncal muscle weakness: a retrospective case series2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SARS-CoV-2 infects epithelial cells of the blood-cerebrospinal fluid barrier rather than endothelial cells or pericytes of the blood-brain barrier2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical features of 8 patients with multifocal motor neuropathy in the long-term follow-up2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Modeling Brain Vasculature Immune Interactions In Vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Modular μSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of galectin-3 as a possible antibody target for secondary progressive multiple sclerosis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] サルコイドニューロパチーのCase approach．2017

Author(s)

Journal Title

Data Source

[Journal Article] アスペルギルス・ムコール症による中枢神経系感染症はどのような病気で、どのように診断・治療するのですか？2017

Nishihara Hideaki 西原秀昭

西原秀昭ニシハラヒデアキ

[Journal Article] 【よくわかる中枢神経系血管炎】小血管炎　ANCA関連血管炎　顕微鏡的多発血管炎の中枢神経病変2016

[Journal Article] 自律神経障害をきたすニューロパチーファブリー病患者の末梢神経障害　早期発見・早期治療のために2016

[Presentation] 疾患由来血液脳関門モデル　多発性硬化症の病態解明に向けて2022