Shiga Takahiro 志賀孝宏

… Alternative Names

SHIGA TAKAHIRO 志賀孝宏

Less

Researcher Number	50784378
Other IDs
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 特任助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 特任助教 2018 – 2020: 順天堂大学, 医学(系)研究科(研究院), 特任助教 2017 – 2018: 順天堂大学, 医学(系)研究科(研究院), 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Neurology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related
Keywords	Principal Investigator パーキンソン病 / 神経変性疾患 / iPS細胞 / 老化 / グリア / 病態モデル / 成熟 / 疾患モデル / アストロサイト / 神経発生 / ニューロン / グリア系細胞 / 細胞老化 … More Except Principal Investigator … More 細胞分化誘導 / ヒト人工多能性幹細胞 / 神経変性疾患 / ペリサイト / 内皮細胞 / iPS細胞 / 血液脳関門 Less

Development of a brain environment model and pathological detection system as a basis for iPS cell analysis in Parkinson's diseasePrincipal Investigator
- Principal Investigator
  
  SHIGA Takahiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
神経変性疾患由来iPS細胞を用いたin vitro血液脳関門モデル構築と病態解析
- Principal Investigator
  
  野中里紗
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
Establishment of an aging brain environment model as a basis for iPS cell research on neurodegenerative diseases.Principal Investigator
- Principal Investigator
  
  Takahiro Shiga
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Juntendo University
To establish a new model to co-culture iPSCs derived neurons and glial cells to mimic brain structurePrincipal Investigator
- Principal Investigator
  
  SHIGA TAKAHIRO
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Patent

[Journal Article] Involvement of kallikrein‐PAR2‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity2022
- Author(s)
  Sasaki Ritsuko、Kurebayashi Nagomi、Eguchi Hidetaka、Horimoto Yoshiya、Shiga Takahiro、Miyazaki Sakiko、Kashiyama Taku、Akamatsu Wado、Saito Mitsue
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 10 Pages: 3449-3462
- DOI
  10.1111/cas.15508
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07301, KAKENHI-PROJECT-22K06652, KAKENHI-PROJECT-19K07105
[Journal Article] Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism2022
- Author(s)
  Sarkar Avijite Kumer、Nakamura Shiro、Nakai Kento、Sato Taro、Shiga Takahiro、Abe Yuka、Hoashi Yurie、Inoue Tomio、Akamatsu Wado、Baba Kazuyoshi
- Journal Title
  
  Stem Cell Research
  
  Volume: 59 Pages: 102658-102658
- DOI
  10.1016/j.scr.2022.102658
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09709, KAKENHI-PROJECT-19K22726, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-21K21049, KAKENHI-PROJECT-19K10048, KAKENHI-PROJECT-21K07301, KAKENHI-PROJECT-20K23092
[Journal Article] In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells2021
- Author(s)
  Nakai Kento、Shiga Takahiro、Yasuhara Rika、Sarkar Avijite Kumer、Abe Yuka、Nakamura Shiro、Hoashi Yurie、Kotani Keisuke、Tatsumoto Shoji、Ishikawa Hiroe、Go Yasuhiro、Inoue Tomio、Mishima Kenji、Akamatsu Wado、Baba Kazuyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 15437-15437
- DOI
  10.1038/s41598-021-95041-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09540, KAKENHI-PROJECT-18K09709, KAKENHI-PROJECT-19K22726, KAKENHI-PROJECT-17K17191, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-21K21049, KAKENHI-PLANNED-21H05245, KAKENHI-PROJECT-19H03313, KAKENHI-PROJECT-20H03882, KAKENHI-PROJECT-19K10048, KAKENHI-PROJECT-21K07301, KAKENHI-PROJECT-21K09845, KAKENHI-PROJECT-21K15633, KAKENHI-PROJECT-20K23092, KAKENHI-ORGANIZER-21H05238
[Journal Article] Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons2021
- Author(s)
  Yokota Mutsumi、Kakuta Soichiro、Shiga Takahiro、Ishikawa Kei-ichi、Okano Hideyuki、Hattori Nobutaka、Akamatsu Wado、Koike Masato
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 58-58
- DOI
  10.1186/s13041-021-00771-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07743, KAKENHI-PROJECT-18K15466, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-20K07873, KAKENHI-PROJECT-21K07301
[Journal Article] Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB22021
- Author(s)
  Fukunaga Ichiro、Oe Yoko、Danzaki Keiko、Ohta Sayaka、Chen Cheng、Iizumi Madoka、Shiga Takahiro、Matsuoka Rina、Anzai Takashi、Hibiya-Motegi Remi、Tajima Shori、Ikeda Katsuhisa、Akamatsu Wado、Kamiya Kazusaku
- Journal Title
  
  Stem Cell Research
  
  Volume: 53 Pages: 102290-102290
- DOI
  10.1016/j.scr.2021.102290
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09387, KAKENHI-PROJECT-20K21662, KAKENHI-PROJECT-19K09914, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-18H02953, KAKENHI-PROJECT-21H03089, KAKENHI-PROJECT-21K07301, KAKENHI-PROJECT-21K09617, KAKENHI-PROJECT-18K16857, KAKENHI-PROJECT-18K16905
[Journal Article] Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss2020
- Author(s)
  Fukunaga Ichiro、Shirai Kyoko、Oe Yoko、Danzaki Keiko、Ohta Sayaka、Shiga Takahiro、Chen Cheng、Ikeda Katsuhisa、Akamatsu Wado、Kawano Atsushi、Kamiya Kazusaku
- Journal Title
  
  Stem Cell Research
  
  Volume: 47 Pages: 101910-101910
- DOI
  10.1016/j.scr.2020.101910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09387, KAKENHI-PROJECT-20K21662, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-19K09914, KAKENHI-PROJECT-18H02953
[Journal Article] Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation2020
- Author(s)
  Fukunaga Ichiro、Shiga Takahiro、Chen Cheng、Oe Yoko、Danzaki Keiko、Ohta Sayaka、Matsuoka Rina、Anzai Takashi、Hibiya-Motegi Remi、Tajima Shori、Ikeda Katsuhisa、Akamatsu Wado、Kamiya Kazusaku
- Journal Title
  
  Stem Cell Research
  
  Volume: 43 Pages: 101674-101674
- DOI
  10.1016/j.scr.2019.101674
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09914, KAKENHI-PROJECT-18K16857, KAKENHI-PROJECT-18K16905, KAKENHI-PROJECT-19K16930, KAKENHI-PROJECT-18H02953
[Patent] 神経細胞の成熟老化促進剤2019
- Inventor(s)
  赤松和土、志賀孝宏、岡野栄之、葛巻直子
- Industrial Property Rights Holder
  順天堂大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-073340
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19K16930
[Presentation] 細胞老化を誘導する化合物の同定と高齢発症神経変性疾患iPS細胞モデルへの活用2023
- Author(s)
  志賀孝宏
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K07301
[Presentation] iPSC-based disease modeling for late onset neurodegenerative diseases using a chemical compound accelerating senescence2020
- Author(s)
  志賀孝宏
- Organizer
  第16回成体脳ニューロン新生懇談会
- Data Source
  KAKENHI-PROJECT-19K16930
[Presentation] 老化を加速する低分子化合物を用いた神経変性疾患 iPS解析システムの構築2019
- Author(s)
  志賀　孝宏
- Organizer
  第18回日本再生医療学会
- Data Source
  KAKENHI-PROJECT-17K16130
[Presentation] iPSC-based disease modeling for late onset neurodegenerative diseases using a chemical compound accelerating senescence2019
- Author(s)
  Takahiro Shiga
- Organizer
  International Society for Stem Cell Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16930
[Presentation] 老化を加速する低分子化合物を用いた神経変性疾患 iPS解析システムの構築2018
- Author(s)
  志賀　孝宏
- Organizer
  第41回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K16130
[Presentation] 低分子化合物による老化促進機構を応用したパーキンソン病iPS細胞モデルの構築2018
- Author(s)
  志賀　孝宏
- Organizer
  日本再生医療学会
- Data Source
  KAKENHI-PROJECT-17K16130
[Presentation] ATM阻害はヒトiPS細胞由来神経細胞の老化を加速させる2018
- Author(s)
  志賀　孝宏
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17K16130
[Presentation] Screening of compounds promoting maturation and ageing in iPSC-derived neurons.2017
- Author(s)
  Takahiro Shiga
- Organizer
  International Society for Stem Cell Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16130

1. 野中里紗 (90614248)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 石川景一 (90733973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 美島健二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 安原理佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 神谷和作

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 福永一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 小池正人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 安部友佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiga Takahiro 志賀 孝宏

SHIGA TAKAHIRO 志賀 孝宏

Research Projects

Research Products

Co-Researchers

Development of a brain environment model and pathological detection system as a basis for iPS cell analysis in Parkinson's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

神経変性疾患由来iPS細胞を用いたin vitro血液脳関門モデル構築と病態解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of an aging brain environment model as a basis for iPS cell research on neurodegenerative diseases.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To establish a new model to co-culture iPSCs derived neurons and glial cells to mimic brain structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Involvement of kallikrein‐PAR2‐proinflammatory pathway in severe trastuzumab‐induced cardiotoxicity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased excitability of human iPSC-derived neurons in HTR2A variant-related sleep bruxism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of two iPSC lines from siblings of a homozygous patient with hearing loss and a heterozygous carrier with normal hearing carrying p.G45E/Y136X mutation in GJB22021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of two induced pluripotent stem cell lines from PBMCs of siblings carrying c.235delC mutation in the GJB2 gene associated with sensorineural hearing loss2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of the induced pluripotent stem cell (hiPSC) line (JUFMDOi004-A) from a patient with hearing loss carrying GJB2 (p.V37I) mutation2020

Author(s)

Journal Title

DOI

Data Source

[Patent] 神経細胞の成熟老化促進剤2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] 細胞老化を誘導する化合物の同定と高齢発症神経変性疾患iPS細胞モデルへの活用2023

Author(s)

Organizer

Data Source

[Presentation] iPSC-based disease modeling for late onset neurodegenerative diseases using a chemical compound accelerating senescence2020

Author(s)

Organizer

Data Source

[Presentation] 老化を加速する低分子化合物を用いた神経変性疾患 iPS解析システムの構築2019

Shiga Takahiro 志賀孝宏

SHIGA TAKAHIRO 志賀孝宏

[Presentation] ATM阻害はヒトiPS細胞由来神経細胞の老化を加速させる2018