Hangai Sho 半谷匠

Researcher Number	50785350
Other IDs
Affiliation (Current)	2025: 東京大学, 先端科学技術研究センター, 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 東京大学, 先端科学技術研究センター, 客員研究員 2018 – 2020: 東京大学, 先端科学技術研究センター, 特任助教 2017: 東京大学, 生産技術研究所, 特任助教 2016: 東京大学, 生産技術研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator がん微小環境 / 炎症 / ダメージ関連分子 / 線維化 / HMGB1 / 造血幹細胞 / ダメージ関連分子パターン / MDSC / MDSCs / 骨髄由来免疫抑制細胞 / DAMPs / 生体分子 … More Except Principal Investigator … More 疾患 / DAMP / 自己免疫疾患 / サイトカイン / 核酸 / DAMPs / がん / 恒常性維持 / 免疫原性核酸 / 腫瘍免疫 / U11snRNA / TCTP / HMGB1 / 自然免疫受容体 / 炎症 / 免疫シグナル伝達 Less

Elucidation of Fibrosis Regulation Mechanisms by Damage-Associated Molecular PatternsPrincipal Investigator
- Principal Investigator
  
  Hangai Sho
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  The University of Tokyo
Elucidation of the regulatory mechanisms of inflammation and immune responses by damage-associated molecules
- Principal Investigator
  
  Taniguchi Tadatsugu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  The University of Tokyo
Identification of self-derived molecules that orchestrate tumor microenvironmentPrincipal Investigator
- Principal Investigator
  
  Hangai Sho
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  The University of Tokyo
Identification of novel DAMP molecules involved in inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  Hangai Sho
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] Oncoimmunology2018
- Author(s)
  Sho Hangai, Yoshitaka Kimura, Tadatsugu Taniguchi, Hideyuki Yanai
- Total Pages
  724
- Publisher
  Springer International Publishing
- ISBN
  9783319624303
- Data Source
  KAKENHI-PROJECT-16H06747
[Journal Article] Tumor cell-derived spermidine is an oncometabolite that suppress TCR clustering for intratumoral CD8+ T cell activation2023
- Author(s)
  Sana Hibino, Shotaro Eto, Sho Hangai, Keiko Endo, Sanae Ashitani, Maki Sugaya, Tsuyoshi Osawa, Tomoyoshi Soga, Tadatsugu Taniguchi, Hideyuki Yanai
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15465
[Journal Article] Tumor cell derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation2023
- Author(s)
  Hibino S, Eto S, Hangai S, Endo K, Ashitani S, Sugaya M, Osawa T, Soga T, Taniguchi T and Yanai H
- Journal Title
  
  PNAS
  
  Volume: 120 (24) Issue: 24
- DOI
  10.1073/pnas.2305245120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18234, KAKENHI-PUBLICLY-23H04772, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-23K24149
[Journal Article] Damage-associated molecular patterns and Toll-like receptors in the tumor immune microenvironment2021
- Author(s)
  Yanai Hideyuki、Hangai Sho、Taniguchi Tadatsugu
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 841-846
- DOI
  10.1093/intimm/dxab050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-21K15465
[Journal Article] Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells2021
- Author(s)
  Hangai Sho、Kawamura Takeshi、Kimura Yoshitaka、Chang Ching-Yun、Hibino Sana、Yamamoto Daisuke、Nakai Yousuke、Tateishi Ryosuke、Oshima Masanobu、Oshima Hiroko、Kodama Tatsuhiko、Moriya Kyoji、Koike Kazuhiko、Yanai Hideyuki、Taniguchi Tadatsugu
- Journal Title
  
  Nature Immunology
  
  Volume: 22 Issue: 8 Pages: 947-957
- DOI
  10.1038/s41590-021-00967-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-19H03498, KAKENHI-PROJECT-21K15465, KAKENHI-PROJECT-21K15499, KAKENHI-PROJECT-19J00887
[Journal Article] HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis2021
- Author(s)
  Senda N, Yanai H, Hibino S, Li L, Mizushima Y, Miyagaki T, Saeki M, Kishi Y, Hangai S, Nishio J, Sugaya M, Taniguchi T, Sato S
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 118 Issue: 1
- DOI
  10.1073/pnas.2022343118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08683, KAKENHI-PUBLICLY-19H05253, KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-19J00887, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K14622, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-19K16736, KAKENHI-PROJECT-16H06279, KAKENHI-PUBLICLY-20H05383, KAKENHI-PUBLICLY-21H00242, KAKENHI-PROJECT-20H03179
[Journal Article] The impact of damage-associated molecules released from canine tumor cells on gene expression in macrophages2021
- Author(s)
  Eto Shotaro、Yanai Hideyuki、Hangai Sho、Kato Daiki、Nishimura Ryohei、Nakagawa Takayuki
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 8525-8525
- DOI
  10.1038/s41598-021-87979-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-20J12432, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-20H03144, KAKENHI-PROJECT-21K15465
[Journal Article] Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis2021
- Author(s)
  Nishio Junko、Negishi Hideo、Yasui-Kato Mika、Miki Shoji、Miyanaga Kazuhiko、Aoki Kotaro、Mizusawa Takuma、Ueno Masami、Ainai Akira、Muratani Masafumi、Hangai Sho、Yanai Hideyuki、Hasegawa Hideki、Ishii Yoshikazu、Tanji Yasunori、Taniguchi Tadatsugu
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 20231-20231
- DOI
  10.1038/s41598-021-99602-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07166, KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-21K08482, KAKENHI-PROJECT-21K15465
[Journal Article] Signal transducing innate receptors in tumor immunity2021
- Author(s)
  Hangai Sho、Kimura Yoshitaka、Taniguchi Tadatsugu、Yanai Hideyuki
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 7 Pages: 2578-2591
- DOI
  10.1111/cas.14848
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-20H00504, KAKENHI-PROJECT-21K15465
[Journal Article] Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.2019
- Author(s)
  Negishi H, Endo N, Nakajima Y, Nishiyama T, Tabunoki Y, Nishio J, Koshiba R, Matsuda A, Matsuki K, Okamura T, Negishi-Koga T, Ichinohe T, Takemura S, Ishiwata H, Iemura SI, Natsume T, Abe T, Kiyonari H, Doi T, Hangai S, Yanai H, Fujio K, Yamamoto K, Taniguchi T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 116 Issue: 47 Pages: 23653-23661
- DOI
  10.1073/pnas.1915326116
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07166, KAKENHI-PROJECT-18K07167, KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-19H03697, KAKENHI-PROJECT-17H04050
[Journal Article] Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways2018
- Author(s)
  Kimura Yoshitaka、Negishi Hideo、Matsuda Atsushi、Endo Nobuyasu、Hangai Sho、Inoue Asuka、Nishio Junko、Taniguchi Tadatsugu、Yanai Hideyuki
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 9 Pages: 2687-2696
- DOI
  10.1111/cas.13726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18K07167
[Journal Article] Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice2018
- Author(s)
  Yanai Hideyuki、Chiba Shiho、Hangai Sho、Kometani Kohei、Inoue Asuka、Kimura Yoshitaka、Abe Takaya、Kiyonari Hiroshi、Nishio Junko、Taguchi-Atarashi Naoko、Mizushima Yu、Negishi Hideo、Grosschedl Rudolf、Taniguchi Tadatsugu
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 20 Pages: 5253-5258
- DOI
  10.1073/pnas.1803936115
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15179, KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-18K07167
[Journal Article] The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis.2016
- Author(s)
  Kimura Y., Inoue A.., Hangai S.., Saijo S., Negishi H., Nishio J., Yamasaki S., Iwakura Y., Yanai H., Taniguchi T.
- Journal Title
  
  Proc. Natl. Acad. Sci. U S A.
  
  Volume: 113 Issue: 49 Pages: 14097-14102
- DOI
  10.1073/pnas.1617903113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05787, KAKENHI-PROJECT-24220011, KAKENHI-PROJECT-16H06747, KAKENHI-PROJECT-26293094, KAKENHI-PROJECT-16K15271
[Patent] がん免疫微小環境の調節物質およびそれによる予防・診断・治療的利用2020
- Inventor(s)
  谷口維紹、半谷匠、柳井秀元
- Industrial Property Rights Holder
  谷口維紹、半谷匠、柳井秀元
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-147222
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20H00504
[Patent] がん免疫微小環境の調節物質およびそれによる予防・診断・治療的利用2020
- Inventor(s)
  谷口維紹、半谷匠、柳井秀元
- Industrial Property Rights Holder
  谷口維紹、半谷匠、柳井秀元
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-147222
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K15179
[Presentation] TCTP released by tumor cells orchestrates dynamics of myeloid-derived suppressor cells in the tumor microenvironmt2022
- Author(s)
  Sho Hangai, Hideyuki Yanai, Tadatsugu Taniguchi
- Organizer
  第81回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15465
[Presentation] Translationally-controlled tumor protein (TCTP) released by tumor cells orchestrates dynamics of myeloid-derived suppressor cells in the tumor microenvironment2021
- Author(s)
  半谷　匠
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15465
[Presentation] Role HMGB1 in regulation of stem cell homeostasis2019
- Author(s)
  半谷　匠
- Organizer
  第48回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15179
[Presentation] PROSTAGLANDIN E2 IS AN INHIBITORY DAMAGE ASSOCIATED MOLECULAR PATTERN WHICH CRITICALLY REGULATES STERILE INFLAMMATION-RELATED DISEASES INDUCED BY DEAD CELLS2018
- Author(s)
  Sho Hangai, Hideyuki Yanai, Tadatsugu Taniguchi
- Organizer
  Cytokines 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15179
[Presentation] Prostaglandin E2 released by dying cells functions as an inhibitory DAMP2017
- Author(s)
  Sho Hangai, Hideyuki Yanai, Tadatsugu Taniguchi
- Organizer
  The 5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06747
[Presentation] PGE2 induced in and released by dying cells functions as an inhibitory DAMP2016
- Author(s)
  半谷　匠、柳井　秀元、谷口　維紹
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県・宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16H06747

1. Taniguchi Tadatsugu (50133616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 柳井秀元 (70431765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. MIYAGAKI Tomomitsu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. NEGISHI Hideo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 岩倉洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 西尾純子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 大澤毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hangai Sho 半谷 匠

Research Projects

Research Products

Co-Researchers

Elucidation of Fibrosis Regulation Mechanisms by Damage-Associated Molecular PatternsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the regulatory mechanisms of inflammation and immune responses by damage-associated molecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of self-derived molecules that orchestrate tumor microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel DAMP molecules involved in inflammatory diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Oncoimmunology2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Tumor cell-derived spermidine is an oncometabolite that suppress TCR clustering for intratumoral CD8+ T cell activation2023

Author(s)

Journal Title

Data Source

[Journal Article] Tumor cell derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8+ T cell activation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Damage-associated molecular patterns and Toll-like receptors in the tumor immune microenvironment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The impact of damage-associated molecules released from canine tumor cells on gene expression in macrophages2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and characterization of a novel Enterococcus bacteriophage with potential to ameliorate murine colitis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Signal transducing innate receptors in tumor immunity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of U11snRNA as an endogenous agonist of TLR7-mediated immune pathogenesis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel chemical compound SINCRO with dual function in STING-type I interferon and tumor cell death pathways2018

Author(s)

Hangai Sho 半谷匠