Uehata Takuya 植畑拓也

Researcher Number	50785970
Other IDs
Affiliation (Current)	2022: 京都大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2019 – 2021: 京都大学, 医学研究科, 助教 2017 – 2019: 京都大学, ウイルス・再生医科学研究所, 助教 2016: 京都大学, ウイルス・再生医科学研究所, 特定助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Transformative Research Areas, Section (II) / Broad Section H
Keywords	Principal Investigator 転写後制御 / RNA結合タンパク質 / mRNA分解 / RNA結合蛋白質 / 炎症制御 / RNA結合タンパク / RBPome / 免疫細胞 / プロテオーム / 免疫学 … More Except Principal Investigator 免疫応答 / 弱い相互作用 / mRNA分解 / mRNA修飾 / サイトカイン / 自然免疫応答 / mRNA制御 / ｍRNA分解 / 免疫制御 / 物質共生 / マテリアル・シンバイオシス / 物理化学 / シンバイオティクス / マテリアル・シンバオシス / シンバイオティックマテリアル / シンバイオティックス / 核酸医薬 / エクソソーム / 抗体産生 Less

mRNA分解酵素Regnase-1の新規ユビキチン化を介した免疫制御機構の解明Principal Investigator
- Principal Investigator
  
  植畑拓也
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
Biophysical Chemistry for Material Symbiosis
- Principal Investigator
  
  山吉麻子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagasaki University
Identification of Symbiotic Communication between Artificial Nucleic Acids and Human Immune Systems
- Principal Investigator
  
  山吉麻子
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Nagasaki University
Elucidation of a novel posttranscriptional mechanism regulating early lymphopoiesisPrincipal Investigator
- Principal Investigator
  
  Uehata Takuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kyoto University
mRNA代謝が司る免疫制御機構の解明
- Principal Investigator
  
  竹内理
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Kyoto University
Comprehensive analysis of RNA binding proteins in the immune systemPrincipal Investigator
- Principal Investigator
  
  Uehata Takuya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Kyoto University

All 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] 生化学2018
- Author(s)
  植畑　拓也、竹内　理
- Total Pages
  10
- Publisher
  日本生化学会
- Data Source
  KAKENHI-PROJECT-18K15185
[Book] 医学のあゆみ2018
- Author(s)
  植畑　拓也、竹内　理
- Total Pages
  7
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-18K15185
[Journal Article] The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.2020
- Author(s)
  Miyazaki Kazuko、Watanabe Hitomi、Yoshikawa Genki、Chen Kenian、Hidaka Reiko、Aitani Yuki、Osawa Kai、Takeda Rie、Ochi Yotaro、Tani-ichi Shizue、Uehata Takuya、Takeuchi Osamu、Ikuta Koichi、Ogawa Seishi、Kondoh Gen、Lin Yin C.、Ogata Hiroyuki、Miyazaki Masaki
- Journal Title
  
  Science Immunology,
  
  Volume: 5 Pages: 1455-1455
- DOI
  10.1126/sciimmunol.abb1455
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H03487, KAKENHI-PROJECT-19J13775
[Journal Article] RNA Recognition and Immunity-Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms2020
- Author(s)
  Takuya Uehata, Osamu Takeuchi
- Journal Title
  
  Cells
  
  Volume: 9 Pages: 1701-1701
- DOI
  10.3390/cells9071701
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-16H06279
[Journal Article] Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-12020
- Author(s)
  Yoshinari Nakatsuka, Ai Yaku, Tomohiro Handa, Alexis Vandenbon, Yuki Hikichi, Yasutaka Motomura, Yutaka Suzuki, Takuya Uehata, Takashi Mino, Tohru Tsujimura, Kazuyo Moro, Osamu Takeuchi, et al.
- Journal Title
  
  European Respiratory Journal
  
  Volume: 57 Pages: 2000018-2000018
- DOI
  10.1183/13993003.00018-2020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H05286, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279
[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation2019
- Author(s)
  Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O.
- Journal Title
  
  Nature Microbiology
  
  Volume: 印刷中
- NAID
  120006731123
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Journal Article] NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements2019
- Author(s)
  Hirabayashi Shigeki、Bhagat Shruti、Matsuki Yu、Takegami Yujiro、Uehata Takuya、Kanemaru Ai、Itoh Masayoshi、Shirakawa Kotaro、Takaori-Kondo Akifumi、Takeuchi Osamu、Carninci Piero、Katayama Shintaro、Hayashizaki Yoshihide、Kere Juha、Kawaji Hideya、Murakawa Yasuhiro
- Journal Title
  
  Nature Genetics
  
  Volume: 51 Pages: 1369-1379
- DOI
  10.1038/s41588-019-0485-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H03992, KAKENHI-PROJECT-16H02902, KAKENHI-PROJECT-18K15185
[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation2019
- Author(s)
  Yamasoba D, Sato K, Ichinose T, Imamura T, Koepke L, Joas S, Reith E, Hotter D, Misawa N, Akaki K, Uehata T, Mino T, Miyamoto S, Noda T, Yamashita A, Standley DM, Kirchhoff F, Sauter D, Koyanagi Y, Takeuchi O.
- Journal Title
  
  Nat Microbiol.
  
  Volume: 4 Pages: 1532-1544
- DOI
  10.1038/s41564-019-0460-3
- NAID
  120006731123
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22529, KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-18KK0447, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-17H04082, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-17J10132, KAKENHI-PROJECT-18K15185
[Journal Article] Translation-dependent unwinding of stem-loops by UPF1 licenses Regnase-1 to degrade inflammatory mRNAs.2019
- Author(s)
  Mino, T., Iwai, N., Endo, M., Inoue, K., Akaki, K., Hia, F., Uehata, T., Emura, T., Hidaka, K., Suzuki, Y., Standley, D. M., Okada-Hatakeyama, M., Ohno, S., Sugiyama, H., Yamashita, A., Takeuchi, O.
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 47 Pages: 8838-8859
- DOI
  10.1093/nar/gkz628
- NAID
  120006708220
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22601, KAKENHI-PROJECT-18KK0139, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H06356, KAKENHI-PROJECT-18K15185
[Journal Article] Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.2018
- Author(s)
  Nakatsuka, Y., Vandenbon, A., Mino, T., Yoshinaga, M., Uehata, T., Cui, X., Sato, A., Tsujimura, T., Suzuki, Y., Sato, A., Handa, T., Chin, K., Sawa, T., Hirai, T., Takeuchi, O.
- Journal Title
  
  Mucosal Immunology
  
  Volume: AOP Pages: 1203-1218
- DOI
  10.1038/s41385-018-0024-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-17K08731, KAKENHI-PROJECT-18K15185, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-18H04027, KAKENHI-PROJECT-18H02905, KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-16H06279
[Journal Article] Regnase-1 Is an Endoribonuclease Essential for the Maintenance of Immune Homeostasis2017
- Author(s)
  Uehata Takuya、Takeuchi Osamu
- Journal Title
  
  Journal of Interferon & Cytokine Research
  
  Volume: 37 Pages: 220-229
- DOI
  10.1089/jir.2017.0001
- Data Source
  KAKENHI-PROJECT-16H06898
[Journal Article] Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.2017
- Author(s)
  Yoshinaga, M., Nakatsuka, Y., Vandenbon, A., Ori, D., Uehata, T., Tsujimura, T., Suzuki, Y., Mino, T., Takeuchi, O.
- Journal Title
  
  Cell Reports
  
  Volume: 19 Issue: 8 Pages: 1614-1630
- DOI
  10.1016/j.celrep.2017.05.009
- NAID
  120006305989
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-17K15726, KAKENHI-PROJECT-15H05713, KAKENHI-PROJECT-16H06898, KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-16H06279
[Journal Article] Regnase-1 and Roquin Nonredundantly Regulate Thl Differentiation Cansing Cardiac Inflammation and Fibrosis.2017
- Author(s)
  Cui, X., Mino, T., Yoshinaga, M., Nakatsuka, Y., Hia, F., Yamasoba, D., Tsujimura, T., Tomonaga, K., Suzuki, Y., Uehata, T., Takeuchi, O.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 199 Issue: 12 Pages: 4066-4077
- DOI
  10.4049/jimmunol.1701211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08832, KAKENHI-PROJECT-16H06898, KAKENHI-PROJECT-16J08040, KAKENHI-PROJECT-16H06279
[Presentation] Manipulation of Regnase-1 mRNA stability alleviates inflammatory responses in diseased models2020
- Author(s)
  Tse, K.M., Cui, X., Uehata, T., Takeuchi, O.
- Organizer
  RNA2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Manipulation of Regnase-1 mRNA stability alleviates inflammatory responses in diseased models2020
- Author(s)
  Tse, K.M., Cui, X., Uehata, T., Takeuchi, O
- Organizer
  MBSJ2020
- Invited
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Endonucleases Regnase-1 and Regnase-3 regulate transcriptome biases to ensure lymphopoiesis.2019
- Author(s)
  Takuya Uehata, Osamu Takeuchi
- Organizer
  CiRA 2019 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Critical roles of endonucleases Regnase-1 and Regnase-3 in early lymphopoiesis2019
- Author(s)
  Takuya Uehata
- Organizer
  17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] 免疫細胞を制御するRNA結合タンパク質の機能解析2019
- Author(s)
  植畑拓也
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Critical roles of endonucleases Regnase-1 and Regnase-3 in early lymphopoiesis.2019
- Author(s)
  Takuya Uehata, Osamu Takeuchi
- Organizer
  17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] Ribonucleases Regnase-1 and Regnase-3 have a critical role in cotrolling transcriptome biases in LMPP to ensure lymphopoiesis.2019
- Author(s)
  Shinnosuke Yamada, Takuya Uehata, Osamu Takeuchi
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18H05278
[Presentation] 免疫細胞を制御するRNA結合タンパク質の機能解析2019
- Author(s)
  植畑拓也、山田信之輔、織大祐、今見考志、宮崎正輝、石濱泰、河本宏、竹内理
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Critical Roles of Endonucleases Regnase-1 and Regnase-3 in Early Lymphopoiesis2019
- Author(s)
  Takuya Uehata
- Organizer
  Keystone symposia
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Critical Roles of Endonucleases Regnase-1 and Regnase-3 in Early Lymphopoiesis2019
- Author(s)
  Takuya Uehata
- Organizer
  Keystone symposia, Transcription and RNA Regulation in Inflammation and Immunity
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Endonucleases Regnase-1 and Regnase-3 regulate transcriptome biases to ensure lymphopoiesis2019
- Author(s)
  Takuya Uehata, Shinnosuke Yamada, Masaki Miyazaki, Amir Giladi, Alexis Vandenbon, Ido Amit, Hirohi Kawamoto and Osamu Takeuchi
- Organizer
  CiRA 2019 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Ribonuclease Regnase-1 and Regnase-3 have a critical role in controlling transcriptome biases in LMPP to ensure lymphopoiesis2019
- Author(s)
  Shinnosuke Yamada, Daisuke Ori, Masaki Miyazaki, Takuya Uehata, Osamu Takeuchi
- Organizer
  The 48th Annual Meeting of The Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Regnase-1 and Regnase-3 regulate cell fate of early lymphoid progenitors in the bone marrow2018
- Author(s)
  植畑拓也
- Organizer
  第４７回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15185
[Presentation] Critical roles of endonucleases Regnase-1 and Regnase-3 in early lymphopoiesis2018
- Author(s)
  Takuya Uehata, Shinnosuke Yamada, Masaki Miyazaki, Hiroshi Kawamoto, Osamu Takeuchi
- Organizer
  Keystone Symposia, Transcription and RNA Regulation in Inflammation and Immunity (B1)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05278

1. 山吉麻子 (70380532)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 山本剛史 (80636994)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 竹内理 (10379092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
4. 三野享史 (60646149)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
5. 前仲勝実 (10322752)

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6. 荏原充宏 (10452393)

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7. 望月慎一 (10520702)

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8. 長谷耕二 (20359714)

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9. 大場雄介 (30333503)

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10. 白石貢一 (40426284)

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11. 森健 (70335785)

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12. 天野麻穂 (80365808)

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13. 宇都甲一郎 (30597034)

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14. KAWAJI Hideya

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15. MORO Kazuyo

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16. 織大祐

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17. 辻村亨

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18. 鈴木穣

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19. 小川誠司

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20. 昆彩奈

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21. 宮崎正輝

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22. 高折晃史

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23. 村川泰裕

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24. 白川康太郎

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25. 佐藤鮎子

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26. 佐和貞治

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27. 野田岳志

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28. 山下暁朗

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29. 佐藤佳

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30. 澤洋文

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31. STANDLEY Daron

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32. 遠藤政幸

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33. 鈴木勇輝

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34. 杉山弘

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Uehata Takuya 植畑 拓也

Research Projects

Research Products

Co-Researchers

mRNA分解酵素Regnase-1の新規ユビキチン化を介した免疫制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biophysical Chemistry for Material Symbiosis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of Symbiotic Communication between Artificial Nucleic Acids and Human Immune Systems

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of a novel posttranscriptional mechanism regulating early lymphopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

mRNA代謝が司る免疫制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive analysis of RNA binding proteins in the immune systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 生化学2018

Author(s)

Total Pages

Publisher

Data Source

[Book] 医学のあゆみ2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA Recognition and Immunity-Innate Immune Sensing and Its Posttranscriptional Regulation Mechanisms2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation2019

Author(s)

Journal Title

DOI

NAID

Uehata Takuya 植畑拓也