Okuma Yusuke 大熊裕介

Researcher Number	50788768
Other IDs	https://orcid.org/0000-0001-5743-0149
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 中央病院, 医員 2025: 地方独立行政法人東京都立病院機構東京都立駒込病院(臨床研究室), 呼吸器内科, 医員
Affiliation (based on the past Project Information) *help	2022: 地方独立行政法人東京都立病院機構東京都立駒込病院(臨床研究室), 呼吸器内科, 医員 2022: 地方独立行政法人東京都立病院機構東京都立駒込病院(臨床研究室), 呼吸器内科, 非常勤医師 2021: 東京都立駒込病院(臨床研究室), 呼吸器内科, 医員 2020: 東京都立駒込病院(臨床研究室), 呼吸器内科, 医員(非常勤) 2019: 東京都立駒込病院(臨床研究室), 呼吸器内科, 医員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 免疫チェックポイント / 末梢血単核細胞（PBMC） / 抗PD-1/PD-L1抗体 / 進行非小細胞肺癌 / 免疫チェックポイント療法 / PBMC / 免疫チェックポイント阻害剤 / 免疫チェックポイント阻害薬 / 非小細胞肺癌 / 可溶性PD-L1 / バイオマーカー / 腸内細菌叢 / 肺癌

Research Projects
(1 results)
Research Products
(5 results)

The prospective study of blood biomarker and gut microbiota in the patients treated with immunocheckpoint inhibitors for advanced non-small cell lung cancerPrincipal Investigator
- Principal Investigator
  
  Okuma Yusuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tokyo Metropolitan Hospital Organization Tokyo Metropolitan Komagome Hospital

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] Cancer Cachexia among Patients with Advanced Non-Small-Cell Lung Cancer on Immunotherapy: An Observational Study with Exploratory Gut Microbiota Analysis2022
- Author(s)
  Hakozaki T, Nolin-Lapalme A, Kogawa M, Okuma Y, Nakamura S, Moreau-Amaru D, Tamura T, Hosomi Y, Takeyama H, Richard C, Hosokawa M, Routy B.
- Journal Title
  
  Cancers
  
  Volume: 14 Issue: 21 Pages: 5405-5405
- DOI
  10.3390/cancers14215405
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16820
[Journal Article] A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors2021
- Author(s)
  2.Fyza Y Shaikh, James R White, Joell J Gills, Taiki Hakozaki, Corentin Richard, Bertrand Routy, Yusuke Okuma, Mykhaylo Usyk, Abhishek Pandey, Jeffrey S Weber, Jiyoung Ahn, Evan J Lipson, Jarushka Naidoo, Drew M Pardoll, Cynthia L Sears
- Journal Title
  
  Clin Cancer Res
  
  Volume: 29 Issue: 9 Pages: 2571-2583
- DOI
  10.1158/1078-0432.ccr-20-4834
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16820
[Journal Article] The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non-Small Cell Lung Cancer2020
- Author(s)
  Taiki Hakozaki, Corentin Richard, Arielle Elkrief, Yukio Hosomi, Myriam Benlafaoui, Iris Mimpen, Safae Terrisse, Lisa Derosa, Laurence Zitvogel, Bertrand Routy, Yusuke Okuma
- Journal Title
  
  Cancer Immunology Research
  
  Volume: 8 Issue: 10 Pages: 1243-1250
- DOI
  10.1158/2326-6066.cir-20-0196
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16820
[Presentation] マイクロバイオームとがん発症・進展、がん免疫研究の最前線がん免疫療法を受ける進行肺癌患者における腸内細菌叢のバイオマーカーとしての有用性に関する検討2020
- Author(s)
  箱崎泰貴, 細見幸生, 大熊裕介
- Organizer
  日本癌学会総会
- Data Source
  KAKENHI-PROJECT-19K16820
[Presentation] Gut microbiome to predict efficacy and immune-related toxicities in patients with advanced non-small cell lung cancer treated with anti-PD-1/PD-L1 antibody-based immunotherapy.2020
- Author(s)
  Taiki Hakozaki, Corentin Richard, Yusuke Okuma, et al.
- Organizer
  ASCO Annual meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16820

Okuma Yusuke 大熊 裕介

Research Projects

Research Products

The prospective study of blood biomarker and gut microbiota in the patients treated with immunocheckpoint inhibitors for advanced non-small cell lung cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cancer Cachexia among Patients with Advanced Non-Small-Cell Lung Cancer on Immunotherapy: An Observational Study with Exploratory Gut Microbiota Analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Uniform Computational Approach Improved on Existing Pipelines to Reveal Microbiome Biomarkers of Nonresponse to Immune Checkpoint Inhibitors2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Gut Microbiome Associates with Immune Checkpoint Inhibition Outcomes in Patients with Advanced Non-Small Cell Lung Cancer2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] マイクロバイオームとがん発症・進展、がん免疫研究の最前線 がん免疫療法を受ける進行肺癌患者における腸内細菌叢のバイオマーカーとしての有用性に関する検討2020

Author(s)

Organizer

Data Source

[Presentation] Gut microbiome to predict efficacy and immune-related toxicities in patients with advanced non-small cell lung cancer treated with anti-PD-1/PD-L1 antibody-based immunotherapy.2020

Author(s)

Organizer

Data Source

Okuma Yusuke 大熊裕介

[Presentation] マイクロバイオームとがん発症・進展、がん免疫研究の最前線がん免疫療法を受ける進行肺癌患者における腸内細菌叢のバイオマーカーとしての有用性に関する検討2020