Utsunomiya Natsuko 宇都宮夏子

Researcher Number	50792090
Other IDs
Affiliation (Current)	2025: 福井大学, 学術研究院医学系部門, 特別研究員
Affiliation (based on the past Project Information) *help	2017 – 2022: 福井大学, 学術研究院医学系部門(附属病院部), 医員
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Dermatology
Keywords	Principal Investigator 皮膚診断学 / ECM1 / 硬化性苔癬 / 疾患感受性遺伝子 / 二次性発癌 / 皮膚基底膜 / 化性苔癬 / 皮膚線維芽細胞 / collagen 7 / collagen 4 … More / laminin 332 / 細胞外基質 / 皮膚腫瘍 / 基底膜 / 自己抗体 Less

A novel pathomechanism of carcinogenesis caused by immune dysregulation to extracellular matrix molecules in lichen sclerosis.Principal Investigator
- Principal Investigator
  
  Utsunomiya Natsuko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  University of Fukui
Impaired function of extracellular matrix 1 alters the fibrogenic and carcinogenic properties: implications of underlying mechanisms for the pathogenesis of lichen sclerosusPrincipal Investigator
- Principal Investigator
  
  Utsunomiya Natsuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  University of Fukui

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] ミドリムシ製剤服用後に発症した多形紅斑の1例―薬剤リンパ球刺激試験(DLST)の偽陽性についてー2020
- Author(s)
  宇都宮　夏子
- Total Pages
  3
- Publisher
  秀潤社
- Data Source
  KAKENHI-PROJECT-17K16334
[Journal Article] The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling2022
- Author(s)
  Utsunomiya A, Hasegawa M, et al.
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 24 Issue: 1 Pages: 94-94
- DOI
  10.1186/s13075-022-02773-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08769, KAKENHI-PROJECT-21K08321, KAKENHI-PROJECT-20K17313
[Journal Article] Gene silencing of extracellular matrix protein 1 (ECM1) results in phenotypic alterations of dermal fibroblasts reminiscent of clinical features of lichen sclerosus2020
- Author(s)
  Utsunomiya Natsuko、Utsunomiya Akira、Chino Takenao、Hasegawa Minoru、Oyama Noritaka
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 100 Issue: 2 Pages: 99-109
- DOI
  10.1016/j.jdermsci.2020.06.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17313
[Journal Article] Dietary supplement product composed of natural ingredients as a suspected cause of erythema multiforme: a case report and identification for the confident false-positivity of lymphocyte transformation test.2019
- Author(s)
  Natsuko Utsunomiya
- Journal Title
  
  Journal of Dermatology
  
  Volume: 46 Issue: 3 Pages: 234-239
- DOI
  10.1111/1346-8138.14739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16334
[Presentation] Antifibrotic effects of a calpain inhibitor ALLN on bleomycin-induced systemic sclerosis model via antagonizing TGF-β /Smad signaling pathway.2022
- Author(s)
  Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Noritaka Oyama, Masami Yamada, Minoru Hasegawa
- Organizer
  51st European Society for Dermatological Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17313
[Presentation] Blockade of calpain enzymatic activity exerts anti-fibrotic effects in bleomycin-induced systemic sclerosis model mice.2022
- Author(s)
  Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Noritaka Oyama, Masami Yamada, Minoru Hasegawa
- Organizer
  47th Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17313
[Presentation] A calpain inhibitor ALLN attenuates bleomycin-induced skin fibrosis in a mice model2021
- Author(s)
  Kasamatsu H, Chino T, Hasegawa T, Utsunomiya N, Utsunomiya A, Oyama N, Yamada M, Hasegawa M
- Organizer
  46th Annual Meeting, Japanese Society for Investigative Deramtology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17313
[Presentation] A calpain inhibitor ALLN alleviates bleomycin-induced skin fibrosis via antagonizing TGF-β/Smad signaling pathway2021
- Author(s)
  Kasamatsu H, Chino T, Hasegawa T, Utsunomiya N, Utsunomiya A, Oyama N, Yamada M, Hasegawa M
- Organizer
  79th Annual Meeting, Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17313
[Presentation] Impaired function of ECM1 underlies the pathogenic disorganization of vascular and basement membrane molecules in lichen sclerosus2019
- Author(s)
  Natsuko Utsunomiya
- Organizer
  49th Annual ESDR Meeting 2019
- Data Source
  KAKENHI-PROJECT-17K16334
[Presentation] Detection of serum autoantibodies to extracellular matrix protein 1 (ECM1) and relevant abnormal expression of hemidesmosomal antigens in lichen sclerosus2018
- Author(s)
  Natsuko Utsunomiya
- Organizer
  International Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16334
[Presentation] Serodiagnostic utility and in vivo expression profile of hemidesmosomal antigens in lichen sclerosus: a confocal laser scanning immunofluorescence microscopic study2017
- Author(s)
  Natsuko Utsunomiya
- Organizer
  2017 Annual Meeting-Society For Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16334
[Presentation] Circulating IgG autoantibodies to ECM1 contribute to the altered expression of hemidesmosomal and vascular antigens in lichen sclerosus skin2017
- Author(s)
  Natsuko Utsunomiya
- Organizer
  The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16334

1. 長谷川稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Utsunomiya Natsuko 宇都宮 夏子

Research Projects

Research Products

Co-Researchers

A novel pathomechanism of carcinogenesis caused by immune dysregulation to extracellular matrix molecules in lichen sclerosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Impaired function of extracellular matrix 1 alters the fibrogenic and carcinogenic properties: implications of underlying mechanisms for the pathogenesis of lichen sclerosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ミドリムシ製剤服用後に発症した多形紅斑の1例―薬剤リンパ球刺激試験(DLST)の偽陽性についてー2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene silencing of extracellular matrix protein 1 (ECM1) results in phenotypic alterations of dermal fibroblasts reminiscent of clinical features of lichen sclerosus2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dietary supplement product composed of natural ingredients as a suspected cause of erythema multiforme: a case report and identification for the confident false-positivity of lymphocyte transformation test.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Antifibrotic effects of a calpain inhibitor ALLN on bleomycin-induced systemic sclerosis model via antagonizing TGF-β /Smad signaling pathway.2022

Author(s)

Organizer

Data Source

[Presentation] Blockade of calpain enzymatic activity exerts anti-fibrotic effects in bleomycin-induced systemic sclerosis model mice.2022

Author(s)

Organizer

Data Source

[Presentation] A calpain inhibitor ALLN attenuates bleomycin-induced skin fibrosis in a mice model2021

Author(s)

Organizer

Data Source

[Presentation] A calpain inhibitor ALLN alleviates bleomycin-induced skin fibrosis via antagonizing TGF-β/Smad signaling pathway2021

Author(s)

Organizer

Data Source

[Presentation] Impaired function of ECM1 underlies the pathogenic disorganization of vascular and basement membrane molecules in lichen sclerosus2019

Author(s)

Organizer

Data Source

[Presentation] Detection of serum autoantibodies to extracellular matrix protein 1 (ECM1) and relevant abnormal expression of hemidesmosomal antigens in lichen sclerosus2018

Author(s)

Organizer

Data Source

[Presentation] Serodiagnostic utility and in vivo expression profile of hemidesmosomal antigens in lichen sclerosus: a confocal laser scanning immunofluorescence microscopic study2017

Author(s)

Organizer

Data Source

[Presentation] Circulating IgG autoantibodies to ECM1 contribute to the altered expression of hemidesmosomal and vascular antigens in lichen sclerosus skin2017

Author(s)

Organizer

Data Source

Utsunomiya Natsuko 宇都宮夏子