Kohara Yukihiro 小原幸弘

Researcher Number	50792214
Other IDs	https://orcid.org/0000-0003-0341-6872
Affiliation (based on the past Project Information) *help	2025: 東京理科大学, 薬学部生命創薬科学科, 助教 2018 – 2022: 愛媛大学, 医学系研究科, 助教 2017: 国立研究開発法人国立長寿医療研究センター, 運動器疾患研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 49020:Human pathology-related
Keywords	Principal Investigator 走化性 / 骨芽細胞 / 破骨細胞 / モノカイン / 骨吸収 / 骨形成 / Emilin2 / 骨リモデリング / マクロファージ / 骨代謝 … More / 血管新生 / 骨折治癒 / 老化 / RNA-seq / 骨再生 / カップリング機構 / 骨代謝学 … More Except Principal Investigator 遺伝子プロモータ / RANKL / 破骨細胞 / 遺伝子発現制御 / TATAボックス / メチル化DNA / DNAメチル化 / 転写調節因子 / 破骨細胞分化因子 / 転写因子 / 骨破壊 / 腫瘍随伴症候群 / 骨芽細胞 / 骨代謝 / 転写調節陰性 / 遺伝子改変動物 / エピジェネティクス / 酸化的ストレス / 骨粗鬆症 / 加齢 / メチル化 / RANK Less

骨常在型マクロファージに着目した骨形成維持機構の解明Principal Investigator
- Principal Investigator
  
  小原幸弘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Tokyo University of Science
肝臓から同定した破骨細胞阻害因子Calreticulinの骨代謝制御機構の解明Principal Investigator
- Principal Investigator
  
  小原幸弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Ehime University
Pathophysiology of bone disorder in light of epigenetic alteration and comprehensive network of transcription factors
- Principal Investigator
  
  北澤荘平
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Ehime University
Pathogenesis of senile osteoporosis: regulation of RANKL expression in aging model
- Principal Investigator
  
  KITAZAWA RIKO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Ehime University
Functional elucidation of Emilin2 secreted by macrophages in bone metabolism and its potential for clinical applicationPrincipal Investigator
- Principal Investigator
  
  Kohara Yukihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Ehime University
The identification of osteoblast migration factors secreted by macrophagesPrincipal Investigator
- Principal Investigator
  
  Kohara Yukihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Ehime University
  National Center for Geriatrics and Gerontology

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage2022
- Author(s)
  Haraguchi Ryuma、Kitazawa Riko、Kohara Yukihiro、Imai Yuuki、Kitazawa Sohei
- Journal Title
  
  Cell and Tissue Research
  
  Volume: 388 Issue: 1 Pages: 63-73
- DOI
  10.1007/s00441-022-03578-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-21K06755, KAKENHI-PROJECT-22K06981, KAKENHI-PROJECT-23K20314
[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice2022
- Author(s)
  Kohara Yukihiro、Kitazawa Riko、Haraguchi Ryuma、Imai Yuuki、Kitazawa Sohei
- Journal Title
  
  Bone
  
  Volume: 154 Pages: 116200-116200
- DOI
  10.1016/j.bone.2021.116200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-21K06755, KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-22K06981, KAKENHI-PROJECT-23K20314
[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice.2021
- Author(s)
  Kohara Y, Kitazawa R, Haraguchi R, Imai Y, Kitazawa S.
- Journal Title
  
  Bone
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07435
[Journal Article] RANK- NFATc1 signaling forms positive feedback loop on rank gene expression via functional NFATc1 responsive element in rank gene promoter.2021
- Author(s)
  Kitazawa R, Haraguchi R, Kohara Y, Kitazawa S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 572 Pages: 86-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07435
[Journal Article] Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of Smo in macrophage/osteoclast lineage prevents age-related bone loss.2020
- Author(s)
  Kohara Y（責任共著者）, Haraguchi R, Kitazawa R, Imai Y, Kitazawa S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18438
[Journal Article] New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney2020
- Author(s)
  Ryuma Haraguchi, Yukihiro Kohara, Kanako Matsubayashi, Riko Kitazawa, Sohei Kitazawa
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 53 Issue: 2 Pages: 21-31
- DOI
  10.1267/ahc.20008
- NAID
  130007836959
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2020-04-28
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20314
[Journal Article] New insights into the pathogenesis of diabetic nephropathy: proximal renal tubules are primary target of oxidative stress in diabetic kidney.2020
- Author(s)
  Haraguchi R, Kohara Y, Matsubayashi K, Kitazawa R, Kitazawa S.
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 53 Pages: 21-31
- NAID
  130007836959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07435
[Journal Article] Knockdown of Lrp1 in RAW264?cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in?vitro2020
- Author(s)
  Kohara Yukihiro、Haraguchi Ryuma、Kitazawa Riko、Kitazawa Sohei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 4 Pages: 961-965
- DOI
  10.1016/j.bbrc.2020.01.065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-17K18438, KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-23K20314
[Journal Article] Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of smo in macrophage/osteoclast lineage prevents age-related bone loss.2020
- Author(s)
  Kohara Y, Haraguchi R, Kitazawa R, Imai Y, Kitazawa S.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 21 Issue: 8 Pages: 2745-2745
- DOI
  10.3390/ijms21082745
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-18K06832
[Journal Article] Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats.2020
- Author(s)
  Kohara Y, Kitazawa S, Kitazawa R, Haraguchi R, Arai K, Amasaki H, Soeta S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 529 Issue: 2 Pages: 186-190
- DOI
  10.1016/j.bbrc.2020.06.039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-18K06832
[Journal Article] Modulation of αvβ3 Integrin via Transactivation of β3 Integrin Gene on Murine Bone Marrow Macrophages by 1,25(OH)2D3, Retinoic Acid and Interleukin-42019
- Author(s)
 Kitazawa Sohei、Haraguchi Ryuma、Kohara Yukihiro、Kitazawa Riko
- Journal Title
 
 ACTA HISTOCHEMICA ET CYTOCHEMICA
 
 Volume: 52 Issue: 4 Pages: 77-83
- DOI
 10.1267/ahc.19015
- NAID
 130007696918
- ISSN
 0044-5991, 1347-5800
- Year and Date
 2019-08-30
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-19K07435
[Journal Article] Activation of protein kinase C accelerates murine osteoclastogenesis partly via transactivation of RANK gene through functional AP-1 responsive element in RANK gene promoter2019
- Author(s)
  Kitazawa Riko、Kinto-Shibahara Satomi、Haraguchi Ryuma、Kohara Yukihiro、Kitazawa Sohei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Issue: 2 Pages: 268-274
- DOI
  10.1016/j.bbrc.2019.05.144
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-19K07435
[Journal Article] Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate2019
- Author(s)
  Haraguchi、Kitazawa、Kohara、Ikedo、Imai、Kitazawa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 23 Pages: 5840-5840
- DOI
  10.3390/ijms20235840
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19H03786
[Journal Article] WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation.2018
- Author(s)
  Matsuoka K, Kohara Y, Naoe Y, Watanabe A, Ito M, Ikeda K, Takeshita S.
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: - Issue: 8 Pages: 1500-1512
- DOI
  10.1002/jbmr.3436
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08681, KAKENHI-PROJECT-17K18438
[Presentation] Recombinant Calreticulin inhibits osteoclast differentiation via suppression of JNK pathway2021
- Author(s)
  Yukihiro Kohara, Riko Kitazawa, Ryuma Haraguchi, Yuuki Imai, Sohei Kitazawa
- Organizer
  ASBMR2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Role of Hedgehog signal modulator gene, Hedgehog Interacting Protein (Hhip), in growing long bone2021
- Author(s)
  Haraguchi R, Kitazawa R, Kohara Y, Imai Y, Kitazawa S
- Organizer
  ASBMR 2021 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 加齢モデルにおける破骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御.2021
- Author(s)
  北澤理子,原口竜摩,小原幸弘,北澤荘平.
- Organizer
  第110回日本病理学会 2021.4.22-24 WEB開催
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 分泌型Calreticulinは破骨細胞形成を抑制する2021
- Author(s)
  小原幸弘、北澤理子、原口竜摩、今井祐記、北澤荘平
- Organizer
  日本組織細胞化学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice2021
- Author(s)
  Yukihiro Kohara, Riko Kitazawa, Ryuma Haraguchi, Yuuki Imai, Sohei Kitazawa
- Organizer
  ASBMR2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Senescence-dependent increase of CpG methylation at receptor activator NF-κB (RANK) gene promoter impairs osteoclastogenesis by decreasing RANK-positive osteoclast precursors2021
- Author(s)
  Kitazawa, R Haraguchi, Y Kohara, S Kitazawa.
- Organizer
  ASBMR 2021 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] Calreticulinは破骨細胞分化を直接抑制するだけでなく、骨細胞でのSclerostin発現を抑制する2021
- Author(s)
  小原幸弘、北澤理子、原口竜摩、今井祐記、北澤荘平
- Organizer
  日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Calreticulinは直接破骨細胞形成を阻害するとともに骨細胞でのSclerostin発現を抑制する2021
- Author(s)
  小原幸弘、原口竜摩、北澤理子、北澤荘平
- Organizer
  日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] エピジェネティクスの組織化学2021
- Author(s)
  北澤荘平, 原口竜摩, 小原幸弘, 北澤理子
- Organizer
  第62回日本組織細胞化学会総会・学術集会(2021.9.24-26) WEB開催
- Invited
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 長期継代培養・老化ストレスが前破骨細胞の破骨細胞最終分化能に与える影響2021
- Author(s)
  井上潮音, 北澤理子, 原口竜摩, 小原幸弘, 遠香薫, 小野真理, 北澤荘平
- Organizer
  第110回日本病理学会 2021.4.22-24 WEB開催
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] Role of Lrp1 in RAW264 cells on osteoclast differentiation2020
- Author(s)
  Yukihiro Kohara, Ryuma Haraguchi, Riko Kitazawa, Sohei Kitazawa
- Organizer
  The American Society for Bone and Mineral Research Annual Meeting
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Senescence-dependent increase of CpG methylation at receptor activator NF-kB (RANK) gene promoter impairs osteoclastogenesis by decreasing RANK-positive osteoclast precursors.2020
- Author(s)
  Kitazawa R, Haraguchi R, Kohara Y, Kitazawa S.
- Organizer
  ASBMR 2020 Annual Meeting September 11-15, 2020 Virtual Event
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] Role of Lrp1 in RAW264 cells on osteoclast differentiation.2020
- Author(s)
  Kohara Y, Haraguchi R, Kitazawa R, Kitazawa S.
- Organizer
  ASBMR 2020 Annual Meeting September 11-15, 2020 Virtual Event
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 骨以外の臓器における破骨細胞形成に対する負の制御機構の解明2020
- Author(s)
  小原幸弘、原口竜摩、北澤理子、北澤荘平
- Organizer
  第61回日本組織細胞化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] 肝臓抽出液から分離・同定した新規破骨細胞形成阻害因子Calreticulinの機能解明2020
- Author(s)
  小原幸弘、原口竜摩、今井祐記、北澤理子、北澤荘平
- Organizer
  第38回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] 肝臓抽出液からの新規破骨細胞阻害因子の同定2020
- Author(s)
  小原幸弘、原口竜摩、北澤理子、北澤荘平
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Specific role of Hh signaling pathway in bone resorption.2020
- Author(s)
  Haraguchi R, Kohara Y, Kitazawa R, Imai Y, Kitazawa S
- Organizer
  ASBMR 2020 Annual Meeting September 11-15, 2020 Virtual Event
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 破骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御2020
- Author(s)
  北澤理子, 原口竜摩, 小原幸弘, 北澤荘平.
- Organizer
  第38回日本骨代謝学会学術集会(2020.10.9-11)
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 加齢モデルにおける破骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御.2020
- Author(s)
  北澤理子, 原口竜摩, 小原幸弘, 福島万奈, 北澤荘平.
- Organizer
  第109回日本病理学会　2021.4.16-18 WEB開催 (7.1-7.31)
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナル調節因子Hhipの骨形成過程における役割.2019
- Author(s)
  原口竜摩, 小原幸弘, 今井祐記, 北澤理子, 北澤荘平
- Organizer
  日本骨代謝学会学術集会2019
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナル阻害剤であるCyclopamineは破骨細胞形成を抑制する.2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤荘平.
- Organizer
  日本骨代謝学会学術集会2019
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナル阻害剤であるCyclopamineは破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤荘平
- Organizer
  日本骨代謝学会学
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] ヘッジホッグシグナルトランスデューサーSmoothenedの阻害は破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤理子, 北澤荘平
- Organizer
  日本組織細胞化学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] ヘッジホッグシグナル阻害剤であるCyclopamineは破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤荘平
- Organizer
  日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] 骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御.2019
- Author(s)
  北澤理子, 村田夕紀, 小原幸弘, 原口竜摩, 北澤荘平.
- Organizer
  日本骨代謝学会学術集会2019
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナルトランスデューサーSmoothenedの阻害は破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤理子, 北澤荘平
- Organizer
  日本組織細胞化学会総会
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Waif1 on osteoblasts regulates bone remodeling as a receptor for osteoclast-derived Cthrc12018
- Author(s)
  Yukihiro Kohara, Kazuhiko Matsuoka, Atsushi Watanabe, Masako Ito, Kyoji Ikeda, Sunao Takeshita
- Organizer
  第10回NAGOYAグローバルリトリート
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Macrophage-secreted Emilin2 Stimulates Chemotaxis and Differentiation in Stromal/Osteoblastic Cells2018
- Author(s)
  Yukihiro Kohara, Atsuchi Watanabe, Noboru Ogiso, Sunao Takeshita
- Organizer
  The 40th Annual Meeting of the American Society for Bone & Mineral Research 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Waif1 on osteoblasts functions as a receptor for osteoclast-derived Cthrc1 in bone remodeling2018
- Author(s)
  Yukihiro Kohara, Kazuhiko Matsuoka, Atsushi Watanabe, Masako Ito, Kyoji Ikeda, Sunao Takeshita
- Organizer
  Protein Island Matsuyama 2018 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Osteoclast-secreted Cthrc1 Regulates Bone Remodeling through Waif1, a Receptor on Stromal/Osteoblastic Cells2017
- Author(s)
  Yukihiro Kohara, Kazuhiko Matsuoka, Masako Ito, Kyoji Ikeda, Sunao Takeshita
- Organizer
  The 39th Annual Meeting of the American Society for Bone & Mnineral Research 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Cthrc1はWaif1を介して骨カップリング機構を制御する2017
- Author(s)
  小原幸弘、松岡和彦、直江吉則、渡邉淳、伊東昌子、池田恭治、竹下淳
- Organizer
  日本骨代謝学会 The 2nd Skeletal Science Retreat
- Data Source
  KAKENHI-PROJECT-17K18438

1. KITAZAWA RIKO (00273780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
2. 原口竜摩 (00423690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
3. 木谷彰岐 (60380234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 福島万奈 (70546225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 北澤荘平 (90186239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IMAI Yuuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 竹下淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kohara Yukihiro 小原 幸弘

Research Projects

Research Products

Co-Researchers

骨常在型マクロファージに着目した骨形成維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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肝臓から同定した破骨細胞阻害因子Calreticulinの骨代謝制御機構の解明Principal Investigator

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Pathophysiology of bone disorder in light of epigenetic alteration and comprehensive network of transcription factors

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Pathogenesis of senile osteoporosis: regulation of RANKL expression in aging model

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Functional elucidation of Emilin2 secreted by macrophages in bone metabolism and its potential for clinical applicationPrincipal Investigator

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The identification of osteoblast migration factors secreted by macrophagesPrincipal Investigator

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[Journal Article] Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage2022

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[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice2022

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[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice.2021

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[Journal Article] RANK- NFATc1 signaling forms positive feedback loop on rank gene expression via functional NFATc1 responsive element in rank gene promoter.2021

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[Journal Article] Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of Smo in macrophage/osteoclast lineage prevents age-related bone loss.2020

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[Journal Article] New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney2020

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[Journal Article] New insights into the pathogenesis of diabetic nephropathy: proximal renal tubules are primary target of oxidative stress in diabetic kidney.2020

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[Journal Article] Knockdown of Lrp1 in RAW264?cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in?vitro2020

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Kohara Yukihiro 小原幸弘