Kohara Yukihiro 小原幸弘

Researcher Number	50792214
Other IDs	https://orcid.org/0000-0003-0341-6872
Affiliation (Current)	2024: 東京理科大学, 薬学部生命創薬科学科, 助教
Affiliation (based on the past Project Information) *help	2018 – 2022: 愛媛大学, 医学系研究科, 助教 2017: 国立研究開発法人国立長寿医療研究センター, 運動器疾患研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 49020:Human pathology-related
Keywords	Principal Investigator 走化性 / 骨芽細胞 / 破骨細胞 / モノカイン / 骨吸収 / 骨形成 / Emilin2 / 骨リモデリング / マクロファージ / 骨代謝 … More / 血管新生 / 骨折治癒 / 老化 / RNA-seq / 骨再生 / カップリング機構 / 骨代謝学 … More Except Principal Investigator RANKL / 破骨細胞 / 遺伝子発現制御 / 遺伝子改変動物 / TATAボックス / メチル化DNA / DNAメチル化 / 転写調節因子 / 破骨細胞分化因子 / エピジェネティクス / 転写因子 / 骨破壊 / 腫瘍随伴症候群 / 骨芽細胞 / 骨代謝 / 転写調節陰性 / 酸化的ストレス / 骨粗鬆症 / 加齢 / メチル化 / 遺伝子プロモータ / RANK Less

肝臓から同定した破骨細胞阻害因子Calreticulinの骨代謝制御機構の解明Principal Investigator
- Principal Investigator
  
  小原幸弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Ehime University
Pathophysiology of bone disorder in light of epigenetic alteration and comprehensive network of transcription factors
- Principal Investigator
  
  北澤荘平
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Ehime University
Pathogenesis of senile osteoporosis: regulation of RANKL expression in aging model
- Principal Investigator
  
  KITAZAWA RIKO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Ehime University
Functional elucidation of Emilin2 secreted by macrophages in bone metabolism and its potential for clinical applicationPrincipal Investigator
- Principal Investigator
  
  Kohara Yukihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Ehime University
The identification of osteoblast migration factors secreted by macrophagesPrincipal Investigator
- Principal Investigator
  
  Kohara Yukihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Ehime University
  National Center for Geriatrics and Gerontology

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage2022
- Author(s)
  Haraguchi Ryuma、Kitazawa Riko、Kohara Yukihiro、Imai Yuuki、Kitazawa Sohei
- Journal Title
  
  Cell and Tissue Research
  
  Volume: 388 Issue: 1 Pages: 63-73
- DOI
  10.1007/s00441-022-03578-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-21K06755, KAKENHI-PROJECT-22K06981, KAKENHI-PROJECT-23K20314
[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice2022
- Author(s)
  Kohara Yukihiro、Kitazawa Riko、Haraguchi Ryuma、Imai Yuuki、Kitazawa Sohei
- Journal Title
  
  Bone
  
  Volume: 154 Pages: 116200-116200
- DOI
  10.1016/j.bone.2021.116200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-21K06755, KAKENHI-PROJECT-21K09373, KAKENHI-PROJECT-22K06981, KAKENHI-PROJECT-23K20314
[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice.2021
- Author(s)
  Kohara Y, Kitazawa R, Haraguchi R, Imai Y, Kitazawa S.
- Journal Title
  
  Bone
  
  Volume: 54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07435
[Journal Article] RANK- NFATc1 signaling forms positive feedback loop on rank gene expression via functional NFATc1 responsive element in rank gene promoter.2021
- Author(s)
  Kitazawa R, Haraguchi R, Kohara Y, Kitazawa S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 572 Pages: 86-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07435
[Journal Article] Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of Smo in macrophage/osteoclast lineage prevents age-related bone loss.2020
- Author(s)
  Kohara Y（責任共著者）, Haraguchi R, Kitazawa R, Imai Y, Kitazawa S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K18438
[Journal Article] New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney2020
- Author(s)
  Ryuma Haraguchi, Yukihiro Kohara, Kanako Matsubayashi, Riko Kitazawa, Sohei Kitazawa
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 53 Issue: 2 Pages: 21-31
- DOI
  10.1267/ahc.20008
- NAID
  130007836959
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2020-04-28
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K20314
[Journal Article] New insights into the pathogenesis of diabetic nephropathy: proximal renal tubules are primary target of oxidative stress in diabetic kidney.2020
- Author(s)
  Haraguchi R, Kohara Y, Matsubayashi K, Kitazawa R, Kitazawa S.
- Journal Title
  
  Acta Histochem Cytochem
  
  Volume: 53 Pages: 21-31
- NAID
  130007836959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07435
[Journal Article] Knockdown of Lrp1 in RAW264?cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in?vitro2020
- Author(s)
  Kohara Yukihiro、Haraguchi Ryuma、Kitazawa Riko、Kitazawa Sohei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Issue: 4 Pages: 961-965
- DOI
  10.1016/j.bbrc.2020.01.065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-17K18438, KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-23K20314
[Journal Article] Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of smo in macrophage/osteoclast lineage prevents age-related bone loss.2020
- Author(s)
  Kohara Y, Haraguchi R, Kitazawa R, Imai Y, Kitazawa S.
- Journal Title
  
  Int J Mol Sci
  
  Volume: 21 Issue: 8 Pages: 2745-2745
- DOI
  10.3390/ijms21082745
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-19H03786, KAKENHI-PROJECT-18K06832
[Journal Article] Localization of DLL1- and NICD-positive osteoblasts in cortical bone during postnatal growth in rats.2020
- Author(s)
  Kohara Y, Kitazawa S, Kitazawa R, Haraguchi R, Arai K, Amasaki H, Soeta S.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 529 Issue: 2 Pages: 186-190
- DOI
  10.1016/j.bbrc.2020.06.039
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19K18514, KAKENHI-PROJECT-18K06832
[Journal Article] Modulation of αvβ3 Integrin via Transactivation of β3 Integrin Gene on Murine Bone Marrow Macrophages by 1,25(OH)2D3, Retinoic Acid and Interleukin-42019
- Author(s)
 Kitazawa Sohei、Haraguchi Ryuma、Kohara Yukihiro、Kitazawa Riko
- Journal Title
 
 ACTA HISTOCHEMICA ET CYTOCHEMICA
 
 Volume: 52 Issue: 4 Pages: 77-83
- DOI
 10.1267/ahc.19015
- NAID
 130007696918
- ISSN
 0044-5991, 1347-5800
- Year and Date
 2019-08-30
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-19K07435
[Journal Article] Activation of protein kinase C accelerates murine osteoclastogenesis partly via transactivation of RANK gene through functional AP-1 responsive element in RANK gene promoter2019
- Author(s)
  Kitazawa Riko、Kinto-Shibahara Satomi、Haraguchi Ryuma、Kohara Yukihiro、Kitazawa Sohei
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Issue: 2 Pages: 268-274
- DOI
  10.1016/j.bbrc.2019.05.144
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-19K07435
[Journal Article] Recent Insights into Long Bone Development: Central Role of Hedgehog Signaling Pathway in Regulating Growth Plate2019
- Author(s)
  Haraguchi、Kitazawa、Kohara、Ikedo、Imai、Kitazawa
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 23 Pages: 5840-5840
- DOI
  10.3390/ijms20235840
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06832, KAKENHI-PROJECT-19K07435, KAKENHI-PROJECT-19H03786
[Journal Article] WAIF1 is a cell-surface CTHRC1 binding protein coupling bone resorption and formation.2018
- Author(s)
  Matsuoka K, Kohara Y, Naoe Y, Watanabe A, Ito M, Ikeda K, Takeshita S.
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: - Issue: 8 Pages: 1500-1512
- DOI
  10.1002/jbmr.3436
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08681, KAKENHI-PROJECT-17K18438
[Presentation] Recombinant Calreticulin inhibits osteoclast differentiation via suppression of JNK pathway2021
- Author(s)
  Yukihiro Kohara, Riko Kitazawa, Ryuma Haraguchi, Yuuki Imai, Sohei Kitazawa
- Organizer
  ASBMR2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Role of Hedgehog signal modulator gene, Hedgehog Interacting Protein (Hhip), in growing long bone2021
- Author(s)
  Haraguchi R, Kitazawa R, Kohara Y, Imai Y, Kitazawa S
- Organizer
  ASBMR 2021 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 加齢モデルにおける破骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御.2021
- Author(s)
  北澤理子,原口竜摩,小原幸弘,北澤荘平.
- Organizer
  第110回日本病理学会 2021.4.22-24 WEB開催
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 分泌型Calreticulinは破骨細胞形成を抑制する2021
- Author(s)
  小原幸弘、北澤理子、原口竜摩、今井祐記、北澤荘平
- Organizer
  日本組織細胞化学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice2021
- Author(s)
  Yukihiro Kohara, Riko Kitazawa, Ryuma Haraguchi, Yuuki Imai, Sohei Kitazawa
- Organizer
  ASBMR2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Senescence-dependent increase of CpG methylation at receptor activator NF-κB (RANK) gene promoter impairs osteoclastogenesis by decreasing RANK-positive osteoclast precursors2021
- Author(s)
  Kitazawa, R Haraguchi, Y Kohara, S Kitazawa.
- Organizer
  ASBMR 2021 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] Calreticulinは破骨細胞分化を直接抑制するだけでなく、骨細胞でのSclerostin発現を抑制する2021
- Author(s)
  小原幸弘、北澤理子、原口竜摩、今井祐記、北澤荘平
- Organizer
  日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Calreticulinは直接破骨細胞形成を阻害するとともに骨細胞でのSclerostin発現を抑制する2021
- Author(s)
  小原幸弘、原口竜摩、北澤理子、北澤荘平
- Organizer
  日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] エピジェネティクスの組織化学2021
- Author(s)
  北澤荘平, 原口竜摩, 小原幸弘, 北澤理子
- Organizer
  第62回日本組織細胞化学会総会・学術集会(2021.9.24-26) WEB開催
- Invited
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 長期継代培養・老化ストレスが前破骨細胞の破骨細胞最終分化能に与える影響2021
- Author(s)
  井上潮音, 北澤理子, 原口竜摩, 小原幸弘, 遠香薫, 小野真理, 北澤荘平
- Organizer
  第110回日本病理学会 2021.4.22-24 WEB開催
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] Role of Lrp1 in RAW264 cells on osteoclast differentiation2020
- Author(s)
  Yukihiro Kohara, Ryuma Haraguchi, Riko Kitazawa, Sohei Kitazawa
- Organizer
  The American Society for Bone and Mineral Research Annual Meeting
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Senescence-dependent increase of CpG methylation at receptor activator NF-kB (RANK) gene promoter impairs osteoclastogenesis by decreasing RANK-positive osteoclast precursors.2020
- Author(s)
  Kitazawa R, Haraguchi R, Kohara Y, Kitazawa S.
- Organizer
  ASBMR 2020 Annual Meeting September 11-15, 2020 Virtual Event
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] Role of Lrp1 in RAW264 cells on osteoclast differentiation.2020
- Author(s)
  Kohara Y, Haraguchi R, Kitazawa R, Kitazawa S.
- Organizer
  ASBMR 2020 Annual Meeting September 11-15, 2020 Virtual Event
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 骨以外の臓器における破骨細胞形成に対する負の制御機構の解明2020
- Author(s)
  小原幸弘、原口竜摩、北澤理子、北澤荘平
- Organizer
  第61回日本組織細胞化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] 肝臓抽出液から分離・同定した新規破骨細胞形成阻害因子Calreticulinの機能解明2020
- Author(s)
  小原幸弘、原口竜摩、今井祐記、北澤理子、北澤荘平
- Organizer
  第38回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] 肝臓抽出液からの新規破骨細胞阻害因子の同定2020
- Author(s)
  小原幸弘、原口竜摩、北澤理子、北澤荘平
- Organizer
  第109回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] Specific role of Hh signaling pathway in bone resorption.2020
- Author(s)
  Haraguchi R, Kohara Y, Kitazawa R, Imai Y, Kitazawa S
- Organizer
  ASBMR 2020 Annual Meeting September 11-15, 2020 Virtual Event
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 破骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御2020
- Author(s)
  北澤理子, 原口竜摩, 小原幸弘, 北澤荘平.
- Organizer
  第38回日本骨代謝学会学術集会(2020.10.9-11)
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] 加齢モデルにおける破骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御.2020
- Author(s)
  北澤理子, 原口竜摩, 小原幸弘, 福島万奈, 北澤荘平.
- Organizer
  第109回日本病理学会　2021.4.16-18 WEB開催 (7.1-7.31)
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナル調節因子Hhipの骨形成過程における役割.2019
- Author(s)
  原口竜摩, 小原幸弘, 今井祐記, 北澤理子, 北澤荘平
- Organizer
  日本骨代謝学会学術集会2019
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナル阻害剤であるCyclopamineは破骨細胞形成を抑制する.2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤荘平.
- Organizer
  日本骨代謝学会学術集会2019
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナル阻害剤であるCyclopamineは破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤荘平
- Organizer
  日本骨代謝学会学
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] ヘッジホッグシグナルトランスデューサーSmoothenedの阻害は破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤理子, 北澤荘平
- Organizer
  日本組織細胞化学会総会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] ヘッジホッグシグナル阻害剤であるCyclopamineは破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤荘平
- Organizer
  日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18514
[Presentation] 骨細胞分化因子受容体RANKのプロモータ領域メチル化による発現制御.2019
- Author(s)
  北澤理子, 村田夕紀, 小原幸弘, 原口竜摩, 北澤荘平.
- Organizer
  日本骨代謝学会学術集会2019
- Data Source
  KAKENHI-PROJECT-19K07435
[Presentation] ヘッジホッグシグナルトランスデューサーSmoothenedの阻害は破骨細胞形成を抑制する2019
- Author(s)
  小原幸弘, 原口竜摩, 北澤理子, 北澤理子, 北澤荘平
- Organizer
  日本組織細胞化学会総会
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Waif1 on osteoblasts regulates bone remodeling as a receptor for osteoclast-derived Cthrc12018
- Author(s)
  Yukihiro Kohara, Kazuhiko Matsuoka, Atsushi Watanabe, Masako Ito, Kyoji Ikeda, Sunao Takeshita
- Organizer
  第10回NAGOYAグローバルリトリート
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Macrophage-secreted Emilin2 Stimulates Chemotaxis and Differentiation in Stromal/Osteoblastic Cells2018
- Author(s)
  Yukihiro Kohara, Atsuchi Watanabe, Noboru Ogiso, Sunao Takeshita
- Organizer
  The 40th Annual Meeting of the American Society for Bone & Mineral Research 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Waif1 on osteoblasts functions as a receptor for osteoclast-derived Cthrc1 in bone remodeling2018
- Author(s)
  Yukihiro Kohara, Kazuhiko Matsuoka, Atsushi Watanabe, Masako Ito, Kyoji Ikeda, Sunao Takeshita
- Organizer
  Protein Island Matsuyama 2018 International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Osteoclast-secreted Cthrc1 Regulates Bone Remodeling through Waif1, a Receptor on Stromal/Osteoblastic Cells2017
- Author(s)
  Yukihiro Kohara, Kazuhiko Matsuoka, Masako Ito, Kyoji Ikeda, Sunao Takeshita
- Organizer
  The 39th Annual Meeting of the American Society for Bone & Mnineral Research 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K18438
[Presentation] Cthrc1はWaif1を介して骨カップリング機構を制御する2017
- Author(s)
  小原幸弘、松岡和彦、直江吉則、渡邉淳、伊東昌子、池田恭治、竹下淳
- Organizer
  日本骨代謝学会 The 2nd Skeletal Science Retreat
- Data Source
  KAKENHI-PROJECT-17K18438

1. KITAZAWA RIKO (00273780)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
2. 原口竜摩 (00423690)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
3. 木谷彰岐 (60380234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 福島万奈 (70546225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 北澤荘平 (90186239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. IMAI Yuuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 竹下淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kohara Yukihiro 小原 幸弘

Research Projects

Research Products

Co-Researchers

肝臓から同定した破骨細胞阻害因子Calreticulinの骨代謝制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiology of bone disorder in light of epigenetic alteration and comprehensive network of transcription factors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathogenesis of senile osteoporosis: regulation of RANKL expression in aging model

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional elucidation of Emilin2 secreted by macrophages in bone metabolism and its potential for clinical applicationPrincipal Investigator

Principal Investigator

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The identification of osteoblast migration factors secreted by macrophagesPrincipal Investigator

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[Journal Article] Novel animal model of soft tissue tumor due to aberrant hedgehog signaling activation in pericyte lineage2022

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[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice2022

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[Journal Article] Macrophages are requisite for angiogenesis of type H vessels during bone regeneration in mice.2021

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[Journal Article] RANK- NFATc1 signaling forms positive feedback loop on rank gene expression via functional NFATc1 responsive element in rank gene promoter.2021

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[Journal Article] Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of Smo in macrophage/osteoclast lineage prevents age-related bone loss.2020

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[Journal Article] New Insights into the Pathogenesis of Diabetic Nephropathy: Proximal Renal Tubules Are Primary Target of Oxidative Stress in Diabetic Kidney2020

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[Journal Article] New insights into the pathogenesis of diabetic nephropathy: proximal renal tubules are primary target of oxidative stress in diabetic kidney.2020

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[Journal Article] Knockdown of Lrp1 in RAW264?cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in?vitro2020

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[Journal Article] Hedgehog inhibitors suppress osteoclastogenesis in in vitro cultures, and deletion of smo in macrophage/osteoclast lineage prevents age-related bone loss.2020

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Kohara Yukihiro 小原幸弘