Shimada Mihoko 嶋多美穂子

… Alternative Names

杉本美穂子スギモトミホコ

嶋多美穂子

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Researcher Number	50792727
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主席研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人東京都医学総合研究所, 臨床医科学研究分野, 主席研究員 2023 – 2024: 国立研究開発法人国立国際医療研究センター, 研究所, ゲノム医科学プロジェクト上級研究員 2021 – 2023: 国立研究開発法人国立国際医療研究センター, 研究所, ゲノム医科学プロジェクト特任研究員 2019 – 2020: 東京大学, 大学院医学系研究科(医学部), 助教 2018: 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 48040:Medical biochemistry-related Except Principal Investigator Basic Section 52030:Psychiatry-related / Basic Section 80010:Area studies-related
Keywords	Principal Investigator ナルコレプシー / シングルセル解析 / 脳 / ロングリードシークエンス / RNA-seq / ロングリード法 / アイソフォーム / 側頭葉皮質 / 視床下部 / 小脳 … More / 免疫系 / 過眠症 / 後部視床下部 / CD8+ T細胞 / CD4+ T細胞 / DNAメチル化 … More Except Principal Investigator 睡眠 / 過眠症 / ナルコレプシー / ゲノムワイド関連解析（GWAS） / ポリジェニックリスクスコア（PRS） / ナルコレプシータイプ2（NT2） / ポリジェニックリスクスコア / 非感染性疾患 / 幼少期の逆境体験 / ベトナム / トランスクリプトーム解析 / HLA（ヒト白血球抗原） / DNAメチル化 / HLA / 遺伝子発現解析 / DNAメチル化解析 / フェノムワイド関連解析 / 遺伝要因 / 関連解析 / バイオバンク / 眠気 / ゲノム解析 / 東北メディカルメガバンク機構 / 変異 / ゲノム / オレキシン / 特発性過眠症 Less

ゲノム解析によるナルコレプシータイプ2のサブタイプ分類
- Principal Investigator
  
  児玉亨
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidating the pathogenesis of narcolepsy through short- and long-read single-cell RNA sequencingPrincipal Investigator
- Principal Investigator
  
  嶋多美穂子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  National Center for Global Health and Medicine
Childhood adversity, genetic risk and health outcomes: An epidemiological study of rural Vietnamese adults
- Principal Investigator
  
  井上陽介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 80010:Area studies-related
- Research Institution
  National Center for Global Health and Medicine
DNAメチル化異常がもたらすナルコレプシー発症機構の解明
- Principal Investigator
  
  宮川卓
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Analysis of splicing variant-related polymorphisms by long-read sequencing and its application to disease researchPrincipal Investigator
- Principal Investigator
  
  Shimada Mihoko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  National Center for Global Health and Medicine
Phenome-wide association analysis and elucidation of the molecular basis of hypersomnia by Japanese-specific genetic variants
- Principal Investigator
  
  KODAMA Tohru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Elucidation of the mechanism of neurodegeneration in narcolepsy by cross-tissue genome-wide methylation analysisPrincipal Investigator
- Principal Investigator
  
  Shimada Mihoko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  The University of Tokyo
  Tokyo Metropolitan Institute of Medical Science

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing2024
- Author(s)
  Shimada Mihoko、Omae Yosuke、Kakita Akiyoshi、Gabdulkhaev Ramil、Hitomi Yuki、Miyagawa Taku、Honda Makoto、Fujimoto Akihiro、Tokunaga Katsushi
- Journal Title
  
  Science Advances
  
  Volume: 10 Issue: 4
- DOI
  10.1126/sciadv.adj5279
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07534, KAKENHI-PROJECT-21K15360, KAKENHI-PROJECT-23H00434
[Journal Article] Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region2023
- Author(s)
  Yoshida-Tanaka Kugui、Shimada Mihoko、Honda Yoshiko、Fujimoto Akihiro、Tokunaga Katsushi、Honda Makoto、Miyagawa Taku
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 10464-10464
- DOI
  10.1038/s41598-023-37511-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07534
[Journal Article] Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire2023
- Author(s)
  Hanna M Ollila, (76人省略), Miyagawa Taku, Shimada Mihoko (12人省略)
- Journal Title
  
  Nature Communications
  
  Volume: 印刷中
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24267
[Journal Article] A variant in orexin receptor-2 is associated with self-reported daytime sleepiness in the Japanese population2022
- Author(s)
  Miyagawa Taku、Shimada Mihoko、Honda Yoshiko、Kodama Tohru、Tokunaga Katsushi、Honda Makoto
- Journal Title
  
  Journal of Human Genetics
  
  Volume: ー Issue: 6 Pages: 377-380
- DOI
  10.1038/s10038-022-01015-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07534
[Journal Article] Genome-wide association study of idiopathic hypersomnia in a Japanese population2021
- Author(s)
  Tanida Kotomi、Shimada Mihoko、Khor Seik-Soon、Toyoda Hiromi、Kato Kayoko、Kotorii Nozomu、Kotorii Tatayu、Ariyoshi Yu、Kato Takao、Hiejima Hiroshi、Ozone Motohiro、Uchimura Naohisa、他15名、Kodama Tohru、Inoue Yuichi、Mishima Kazuo、Honda Makoto、Tokunaga Katsushi、Miyagawa Taku
- Journal Title
  
  Sleep and Biological Rhythms
  
  Volume: 20 Issue: 1 Pages: 137-148
- DOI
  10.1007/s41105-021-00349-2
- NAID
  40022811037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07534
[Journal Article] Epigenome-wide association study of narcolepsy-affected lateral hypothalamic brains, and overlapping DNA methylation profiles between narcolepsy and multiple sclerosis2020
- Author(s)
  Shimada M, Miyagawa T, Takeshima A, Kakita A, Toyoda H, Niizato K, Oshima K, Tokunaga K, Honda M
- Journal Title
  
  Sleep
  
  Volume: 43 Issue: 1
- DOI
  10.1093/sleep/zsz198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15053, KAKENHI-PROJECT-17J01616
[Journal Article] Metabolome Analysis Using Cerebrospinal Fluid From Narcolepsy Type 1 Patients2020
- Author(s)
  Mihoko Shimada, Taku Miyagawa, Tohru Kodama, Hiromi Toyoda, Katsushi Tokunaga, Makoto Honda
- Journal Title
  
  Sleep
  
  Volume: 未定 Issue: 11
- DOI
  10.1093/sleep/zsaa095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15053, KAKENHI-PROJECT-17J01616, KAKENHI-PROJECT-19H03588
[Presentation] A Genetic Variant in prepro-orexin is Associated with Idiopathic Hypersomnia.2023
- Author(s)
  Miyagawa T, Shimada M, Honda M.
- Organizer
  3rd Asian Narcolepsy & Hypersomnolence Society Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07534
[Presentation] オレキシン前駆体遺伝子の稀な変異と特発性過眠症との関連2023
- Author(s)
  宮川卓、田中進、嶋多美穂子、三島和夫、徳永勝士、本多真
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K07534
[Presentation] Region-specific gene isoforms in the human brain using long-read sequencing and their correlation with DNA methylation2023
- Author(s)
  Mihoko Shimada, Yosuke Omae, Akiyoshi Kakita, Ramil Gabdulkhaev, Taku Miyagawa, Makoto Honda, Akihiro Fujimoto, and Katsushi Tokunaga
- Organizer
  日本人類遺伝学会
- Data Source
  KAKENHI-PROJECT-21K15360
[Presentation] ロングリードRNAシークエンスIso-Seqを用いたヒトの脳の部位間でのトランスクリプトームの比較2023
- Author(s)
  嶋多美穂子
- Organizer
  日本人類遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15360
[Presentation] 後部視床下部と側頭葉皮質サンプルを用いたナルコレプシーに関連するDNAメチル化の探索2019
- Author(s)
  嶋多美穂子, 宮川卓, 本多真
- Organizer
  日本睡眠学会第44回定期学術集会
- Data Source
  KAKENHI-PROJECT-18K15053
[Presentation] 後部視床下部と側頭葉皮質サンプルを用いたナルコレプシーに関連するDNAメチル化の探索2019
- Author(s)
  嶋多美穂子
- Organizer
  日本睡眠学会第44回定期学術集会
- Data Source
  KAKENHI-PROJECT-18K15053
[Presentation] EWAS of narcolepsy-affected lateral hypothalamic brain and overlapping methylation profile between narcolepsy and multiple sclerosis2019
- Author(s)
  Mihoko Shimada, Taku Miyagawa, Katsushi Tokunaga, Makoto Honda
- Organizer
  国際ゲノム会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15053
[Presentation] DNA methylation profile of narcolepsy-affected brain and overlapping methylation profile between narcolepsy and multiple sclerosis2019
- Author(s)
  Mihoko Shimada, Taku Miyagawa, Katsushi Tokunaga, Makoto Honda
- Organizer
  アメリカ人類遺伝学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15053

1. 宮川卓 (20512263)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. KODAMA Tohru (20195746)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. 井上陽介 (80722016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松山祐輔 (80830124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 本多真 (50370979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Shimada Mihoko 嶋多 美穂子

杉本 美穂子 スギモト ミホコ

嶋多美穂子

Research Projects

Research Products

Co-Researchers

ゲノム解析によるナルコレプシータイプ2のサブタイプ分類

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the pathogenesis of narcolepsy through short- and long-read single-cell RNA sequencingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Childhood adversity, genetic risk and health outcomes: An epidemiological study of rural Vietnamese adults

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNAメチル化異常がもたらすナルコレプシー発症機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of splicing variant-related polymorphisms by long-read sequencing and its application to disease researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Phenome-wide association analysis and elucidation of the molecular basis of hypersomnia by Japanese-specific genetic variants

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of neurodegeneration in narcolepsy by cross-tissue genome-wide methylation analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of region-specific gene isoforms in the human brain using long-read transcriptome sequencing2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Narcolepsy type I-associated DNA methylation and gene expression changes in the human leukocyte antigen region2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Narcolepsy risk loci are enriched in immune cells and suggest autoimmune modulation of the T cell receptor repertoire2023

Author(s)

Journal Title

Data Source

[Journal Article] A variant in orexin receptor-2 is associated with self-reported daytime sleepiness in the Japanese population2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide association study of idiopathic hypersomnia in a Japanese population2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Epigenome-wide association study of narcolepsy-affected lateral hypothalamic brains, and overlapping DNA methylation profiles between narcolepsy and multiple sclerosis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metabolome Analysis Using Cerebrospinal Fluid From Narcolepsy Type 1 Patients2020

Author(s)

Shimada Mihoko 嶋多美穂子

杉本美穂子スギモトミホコ