Saga Ryo 嵯峨涼

Researcher Number	50794145
Other IDs
Affiliation (Current)	2025: 弘前大学, 保健学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 弘前大学, 保健学研究科, 助教 2017 – 2023: 弘前大学, 保健学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science
Keywords	Principal Investigator 癌幹細胞 / 放射線治療 / 放射線抵抗性 / ヒアルロン酸 / インターロイキン６ / インターロイキン / 放射線感受性 / インターロイキン6 / 炎症性サイトカイン / 4-メチルウンベリフェロン

腫瘍内低酸素領域を加味した治療計画に資する数理モデル開発Principal Investigator
- Principal Investigator
  
  嵯峨涼
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hirosaki University
放射線治療の予後不良因子に関わるヒアルロン酸分子量の解明Principal Investigator
- Principal Investigator
  
  嵯峨涼
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hirosaki University
Control of radiosensitivity of cancer cells using interleukin-6 blockersPrincipal Investigator
- Principal Investigator
  
  Saga Ryo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Radiation science
- Research Institution
  Hirosaki University

All 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability2022
- Author(s)
  Fukui Roman、Saga Ryo、Matsuya Yusuke、Tomita Kazuo、Kuwahara Yoshikazu、Ohuchi Kentaro、Sato Tomoaki、Okumura Kazuhiko、Date Hiroyuki、Fukumoto Manabu、Hosokawa Yoichiro
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1056-1056
- DOI
  10.1038/s41598-022-05172-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12326, KAKENHI-PROJECT-19K17215, KAKENHI-PROJECT-19K08141, KAKENHI-PROJECT-19K10342, KAKENHI-PROJECT-20K16814, KAKENHI-PROJECT-20K12173
[Journal Article] 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression2022
- Author(s)
  Hasegawa Kazuki、Saga Ryo、Ohuchi Kentaro、Kuwahara Yoshikazu、Tomita Kazuo、Okumura Kazuhiko、Sato Tomoaki、Fukumoto Manabu、Tsuruga Eichi、Hosokawa Yoichiro
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 23 Pages: 3780-3780
- DOI
  10.3390/cells11233780
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12173, KAKENHI-PROJECT-22K07789, KAKENHI-PROJECT-22K10151, KAKENHI-PROJECT-20K16814, KAKENHI-PROJECT-19K08141
[Journal Article] 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication2021
- Author(s)
  Ryo Saga, Yusuke Matsuya, Rei Takahashi, Kazuki Hasegawa, Hiroyuki Date, Yoichiro Hosokawa
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 8258-8258
- DOI
  10.1038/s41598-021-87850-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08141, KAKENHI-PROJECT-20K16814
[Journal Article] Prognostic value of quantitative FDGFPET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy2020
- Author(s)
  TOMOYUKI OYAMA, YOICHIRO HOSOKAWA, KAZUKI ABE, KAZUKI HASEGAWA, ROMAN FUKUI, MASAHIKO AOKI and WATARU KOBAYASHI
- Journal Title
  
  ONCOLOGY LETTERS
  
  Volume: 19 Pages: 3775-3780
- DOI
  10.3892/ol.2020.11370
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08141, KAKENHI-PROJECT-17K16413, KAKENHI-PROJECT-17H04761
[Journal Article] Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells2019
- Author(s)
  Saga R, Hasegawa K, Murata K, Chiba M, Nakamura T, Okumura K, Tsuruga E, Hosokawa Y.
- Journal Title
  
  Oncology Letters
  
  Volume: 17 Pages: 3555-3561
- DOI
  10.3892/ol.2019.9990
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11068, KAKENHI-PROJECT-17K16413, KAKENHI-PROJECT-15K11265
[Presentation] HAS3抑制を介した放射線抵抗性癌細胞の新規放射線増感戦略の検討2022
- Author(s)
  長谷川　和輝、嵯峨　涼、敦賀　英知、細川　洋一郎
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K16814
[Presentation] 4-methylumbelliferone enhances the radiosensitivity of the radioresistant oral squamous cell carcinoma cells through hyaluronan synthase 3 suppression2022
- Author(s)
  Kazuki Hasegawa, Ryo Saga, Eichi Tsuruga, Yoichiro Hosokawa
- Organizer
  The 47th Annual Meeting of the European Radiation Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16814
[Presentation] Hyaluronan synthesis inhibitor suppresses the invasive ability and sensitizes radiosensitivity of human fibrosarcoma cells2019
- Author(s)
  Ryo Saga, Kazuki Hasegawa, Kosho Murata, Rei Takahashi, Mitsuru Chiba, Toshiya Nakamura, Kazuhiko Okumura, Eichi Tsuruga, Yoichiro Hosokawa
- Organizer
  16th International Congress of Radiation Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16413
[Presentation] 4-メチルウンベリフェロン投与によるヒト線維肉腫細胞の放射線感受性調節2018
- Author(s)
  嵯峨　涼、長谷川　和輝、高橋　玲、細川　洋一郎
- Organizer
  第56回日本放射線腫瘍学会生物部会学術大会/第47回放射線による制癌シンポジウム
- Data Source
  KAKENHI-PROJECT-17K16413
[Presentation] Regulation of radiosensitivity by 4-methylumbelliferone via suppression of interleukin-1 in fibrosarcoma cells2018
- Author(s)
  Ryo Saga, Kazuki Hasegawa, Rei Takahashi, Yoichiro Hosokawa
- Organizer
  5th Educational Symposium on Radiation and Health by Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16413
[Presentation] 炎症抑制剤による癌細胞の放射線感受性の調節2017
- Author(s)
  嵯峨涼
- Organizer
  第60回放射線影響学会
- Data Source
  KAKENHI-PROJECT-17K16413
[Presentation] Radiosensitivity regulation in fibrosarcoma cells by anti-inflammatory agents2017
- Author(s)
  Ryo Saga
- Organizer
  4th Educational Symposium on Radiation and Health by Young Scientists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16413

1. 中村敏也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 佐藤友昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 桑原義和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 富田和男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 福本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 細川洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Saga Ryo 嵯峨 涼

Research Projects

Research Products

Co-Researchers

腫瘍内低酸素領域を加味した治療計画に資する数理モデル開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

放射線治療の予後不良因子に関わるヒアルロン酸分子量の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Control of radiosensitivity of cancer cells using interleukin-6 blockersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 4-Methylumebelliferone Enhances Radiosensitizing Effects of Radioresistant Oral Squamous Cell Carcinoma Cells via Hyaluronan Synthase 3 Suppression2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 4-Methylumbelliferone administration enhances radiosensitivity of human fibrosarcoma by intercellular communication2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic value of quantitative FDGFPET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra&#8209;arterial chemoradiotherapy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of radiosensitivity by 4-methylumbelliferone via the suppression of interleukin-1 in fibrosarcoma cells2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] HAS3抑制を介した放射線抵抗性癌細胞の新規放射線増感戦略の検討2022

Author(s)

Organizer

Data Source

[Presentation] 4-methylumbelliferone enhances the radiosensitivity of the radioresistant oral squamous cell carcinoma cells through hyaluronan synthase 3 suppression2022

Author(s)

Organizer

Data Source

[Presentation] Hyaluronan synthesis inhibitor suppresses the invasive ability and sensitizes radiosensitivity of human fibrosarcoma cells2019

Author(s)

Organizer

Data Source

[Presentation] 4-メチルウンベリフェロン投与によるヒト線維肉腫細胞の放射線感受性調節2018

Author(s)

Organizer

Data Source

[Presentation] Regulation of radiosensitivity by 4-methylumbelliferone via suppression of interleukin-1 in fibrosarcoma cells2018

Author(s)

Organizer

Data Source

[Presentation] 炎症抑制剤による癌細胞の放射線感受性の調節2017

Author(s)

Organizer

Data Source

[Presentation] Radiosensitivity regulation in fibrosarcoma cells by anti-inflammatory agents2017

Author(s)

Organizer

Data Source

Saga Ryo 嵯峨涼

[Journal Article] Prognostic value of quantitative FDGFPET in the prediction of survival and local recurrence for patients with advanced oral cancer treated with superselective intra‑arterial chemoradiotherapy2020