Yamashita Yusuke 山下友佑

Researcher Number	50794153
Other IDs
Affiliation (Current)	2025: 和歌山県立医科大学, 医学部, 博士研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 和歌山県立医科大学, 医学部, 助教 2020: 和歌山県立医科大学, 医学部, 学内助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator ABL / IRE1α / UPR / 小胞体ストレス / 多発性骨髄腫 / NFκB / EBV-HLH / CCDC22

ABL-IRE1α経路に着目した多発性骨髄腫のUPR制御機構解明と新規治療薬開発Principal Investigator
- Principal Investigator
  
  山下友佑
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Wakayama Medical University
The altered immune response caused by CCDC22 mutation and its association with EBV-HLH development and severity.Principal Investigator
- Principal Investigator
  
  Yamashita Yusuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Wakayama Medical University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma2024
- Author(s)
  Hosoi Hiroki、Tabata Shotaro、Kosako Hideki、Hori Yoshikazu、Okamura Tadashi、Yamashita Yusuke、Fujimoto Kota、Kajioka Daiki、Suzuki Kentaro、Osato Motomi、Yamada Gen、Sonoki Takashi
- Journal Title
  
  Leukemia Research Reports
  
  Volume: 21 Pages: 100451-100451
- DOI
  10.1016/j.lrr.2024.100451
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16248, KAKENHI-PROJECT-22K16308, KAKENHI-PROJECT-21K19538, KAKENHI-PROJECT-23K24165
[Journal Article] Guillain-Barré syndrome associated with Epstein-Barr virus and cytomegalovirus reactivation during treatment for chronic graft-versus-host disease after allogeneic bone marrow transplantation2023
- Author(s)
  細井裕樹、蒸野寿紀、村田祥吾、西川彰則、宮本勝一、伊東秀文、園木孝志、太根美聡、小浴秀樹、榊絢朱、和田嘉允、中山宜昭、弘井孝幸、堀善和、山下友佑
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 64 Issue: 10 Pages: 1280-1285
- DOI
  10.11406/rinketsu.64.1280
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16248, KAKENHI-PROJECT-22K16308
[Journal Article] Clinical Characteristics and Diagnostic Prediction of Severe Fever with Thrombocytopenia Syndrome and Rickettsiosis in the Co-Endemic Wakayama Prefecture, Japan.2023
- Author(s)
  Teramoto K, Tamura S, Yoshida K, Inada Y, Yamashita Y, Morimoto M, Mushino T, Koreeda D, Miyamoto K, Komiya N, Nakano Y, Takagaki Y, Koizumi Y.
- Journal Title
  
  Medicina (Kaunas)
  
  Volume: 59(11) Issue: 11 Pages: 2024-2024
- DOI
  10.3390/medicina59112024
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16308, KAKENHI-PROJECT-23K07865, KAKENHI-PROJECT-20K08718
[Journal Article] Administration of combined venetoclax and azacitidine in a patient with acute myeloid leukemia and multiple comorbidities undergoing dialysis: A case report2023
- Author(s)
  Akagi Yuina、Yamashita Yusuke、Kosako Hideki、Furuya Yoshiaki、Hosoi Hiroki、Mushino Toshiki、Murata Shogo、Nishikawa Akinori、Tamura Shinobu、Nakao Taisei、Sonoki Takashi
- Journal Title
  
  eJHaem
  
  Volume: 4 Issue: 3 Pages: 841-843
- DOI
  10.1002/jha2.732
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16248, KAKENHI-PROJECT-22K16308, KAKENHI-PROJECT-23K07865, KAKENHI-PROJECT-20K08718
[Journal Article] Angioimmunoblastic T-Cell Lymphoma after Treatment of Classic Hodgkin Lymphoma: A Case Report.2023
- Author(s)
  Tanaka K, Miyoshi H, Yamashita Y, Iwamoto R, Yokoya Y, Tochino Y, Arakawa F, Tamura S, Murata SI, Sonoki T, Ohshima K.
- Journal Title
  
  Hematology Reports
  
  Volume: 15(4) Issue: 4 Pages: 662-669
- DOI
  10.3390/hematolrep15040067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16308, KAKENHI-PROJECT-23K07865, KAKENHI-PROJECT-20K08718
[Journal Article] Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma2022
- Author(s)
  Kosako Hideki、Yamashita Yusuke、Morita Shuhei、Iwabuchi Sadahiro、Hashimoto Shinichi、Matsuoka Taka-Aki、Sonoki Takashi、Tamura Shinobu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 24 Pages: 16162-16162
- DOI
  10.3390/ijms232416162
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-22K16308, KAKENHI-PROJECT-20K17405
[Journal Article] Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma Transforming into Diffuse Large B-Cell Lymphoma in a Young Adult Patient with Neurofibromatosis Type 1: A Case Report2022
- Author(s)
  Kosako Hideki、Yamashita Yusuke、Tanaka Ken、Mishima Hiroyuki、Iwamoto Ryuta、Kinoshita Akira、Murata Shin-ichi、Ohshima Koichi、Yoshiura Koh-ichiro、Sonoki Takashi、Tamura Shinobu
- Journal Title
  
  Medicina
  
  Volume: 58 Issue: 12 Pages: 1830-1830
- DOI
  10.3390/medicina58121830
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-22K16308, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K17405
[Journal Article] Risk Factors for Therapeutic Intervention of Remdesivir in Mild to Moderate COVID-19?A Single-Center Retrospective Study of the COVID-19 Fourth Pandemic Period in Wakayama, Japan2022
- Author(s)
  Tamura Shinobu、Kaki Takahiro、Niwa Mayako、Yamano Yukiko、Kawai Shintaro、Yamashita Yusuke、Tanaka Harumi、Saito Yoshinobu、Kajimoto Yoshinori、Koizumi Yusuke、Yamaue Hiroki、Nakao Naoyuki、Nojiri Takako、Hironishi Masaya
- Journal Title
  
  Medicina
  
  Volume: 58 Issue: 1 Pages: 118-118
- DOI
  10.3390/medicina58010118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-20K17405
[Journal Article] Sudden Cardiac Death in a Patient with Thrombotic Thrombocytopenic Purpura: A Case Report2022
- Author(s)
  Yoshida Kikuaki、Murata Shogo、Morimoto Masaya、Mushino Toshiki、Tanaka Ken、Yamashita Yusuke、Hosoi Hiroki、Nishikawa Akinori、Tamura Shinobu、Hatakeyama Kinta、Matsumoto Masanori、Sonoki Takashi
- Journal Title
  
  Hematology Reports
  
  Volume: 14 Issue: 2 Pages: 203-209
- DOI
  10.3390/hematolrep14020027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-21K16248, KAKENHI-PROJECT-22K16308, KAKENHI-PROJECT-20K17405
[Journal Article] A Patient with Kabuki Syndrome Mutation Presenting with Very Severe Aplastic Anemia2021
- Author(s)
  Tamura Shinobu、Kosako Hideki、Furuya Yoshiaki、Yamashita Yusuke、Mushino Toshiki、Mishima Hiroyuki、Kinoshita Akira、Nishikawa Akinori、Yoshiura Ko-Ichiro、Sonoki Takashi
- Journal Title
  
  Acta Haematologica
  
  Volume: 145 Issue: 1 Pages: 89-96
- DOI
  10.1159/000518227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-20K17405
[Journal Article] Progressive Massive Splenomegaly in an Adult Patient with Kabuki Syndrome Complicated with Immune Thrombocytopenic Purpura2021
- Author(s)
  Mushino Toshiki、Hiroi Takayuki、Yamashita Yusuke、Suzaki Norihiko、Mishima Hiroyuki、Ueno Masaki、Kinoshita Akira、Minami Koichi、Imai Kohsuke、Yoshiura Ko-ichiro、Sonoki Takashi、Tamura Shinobu
- Journal Title
  
  Intern. Med.
  
  Volume: 60 Issue: 12 Pages: 1927-1933
- DOI
  10.2169/internalmedicine.6694-20
- NAID
  130008052635
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2021-06-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17868, KAKENHI-PROJECT-18K07814, KAKENHI-PROJECT-18K07850, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-20K17405
[Journal Article] Erdheim-Chester disease diagnosed with right atrium tumors2021
- Author(s)
  Takeda S, Murata S, Tane M, Yoshida K, Iwamoto R, Warigaya K, Sakaki A, Yokoya Y, Tanaka K, Tochino Y, Yamashita Y, Hosoi H, Mushino T, Nishikawa A, Tamura S, Sonoki T.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 62 Pages: 91-93
- NAID
  130007995472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K17405
[Journal Article] Heterozygous missense variant of the proteasome subunit β-type 9 causes neonatal-onset autoinflammation and immunodeficiency2021
- Author(s)
  Kanazawa N, Hemmi H, Kinjo N, Ohnishi H, Hamazaki J, M.H, K.A, M.T, H.S, K.N, K.S, H.Y, I.K, N.R, T.M, Y.Y, T.S, O.T, O.T, K.T, S.I, F.Y, W.N, I.Y, K.K, O.S, T.T, N.K, M.S, Y.K, Kaisho T
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 0-0
- DOI
  10.1038/s41467-021-27085-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07062, KAKENHI-PROJECT-19K07628, KAKENHI-PROJECT-19K08299, KAKENHI-PROJECT-20K16289, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05500, KAKENHI-PROJECT-18H04022, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-20H03505, KAKENHI-PROJECT-20H03591, KAKENHI-PROJECT-21J22615, KAKENHI-PROJECT-19K08754, KAKENHI-PROJECT-19K08798, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08158, KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-21K06956, KAKENHI-PROJECT-21K07770, KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-21K19384, KAKENHI-PROJECT-20K17405
[Journal Article] Pegcetacoplan for refractory paroxysmal nocturnal haemoglobinuria associated with the C5 genetic variant2021
- Author(s)
  Tamura Shinobu、Hori Yoshikazu、Hiroi Takayuki、Morimoto Masaya、Yamashita Yusuke、Mushino Toshiki、Sonoki Takashi
- Journal Title
  
  British Journal of Haematology
  
  Volume: 196 Issue: 6
- DOI
  10.1111/bjh.17963
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-20K17405
[Journal Article] Intracranial Hemorrhage in a Patient with TAFRO Syndrome Treated with Cyclosporine A and Rituximab2021
- Author(s)
  Akagi Yuina、Kato Takashi、Yamashita Yusuke、Hosoi Hiroki、Murata Shogo、Yamamoto Shuto、Warigaya Kenji、Nakao Taisei、Murata Shinichi、Sonoki Takashi、Tamura Shinobu
- Journal Title
  
  Medicina
  
  Volume: 57 Issue: 9 Pages: 971-971
- DOI
  10.3390/medicina57090971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-20K17405, KAKENHI-PROJECT-21K16248
[Journal Article] Brentuximab vedotin for refractory anaplastic lymphoma kinase-negative anaplastic large cell lymphoma in leukemic phase with <em>RUNX3</em> overexpression2020
- Author(s)
  Yamashita Yusuke、Hori Yoshikazu、Kosako Hideki、Oiwa Takehiro、Warigaya Kenji、Mushino Toshiki、Murata Shogo、Fujimoto Masakazu、Nishikawa Akinori、Murata Shin-ichi、Sonoki Takashi、Tamura Shinobu
- Journal Title
  
  Hematology Reports
  
  Volume: 12 Issue: 1 Pages: 8368-8368
- DOI
  10.4081/hr.2020.8368
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-20K17405
[Journal Article] Targeting Adaptive IRE1α Signaling and PLK2 in Multiple Myeloma: Possible Anti-Tumor Mechanisms of KIRA8 and Nilotinib.2020
- Author(s)
  Yamashita Y, Morita S, Hosoi H, Kobata H, Kishimoto S, Ishibashi T, Mishima H, Kinoshita A, Backes BJ, Yoshiura KI, Papa FR, Sonoki T, Tamura S
- Journal Title
  
  Int J Mol Sci.
  
  Volume: Aug 31;21(17) Issue: 17 Pages: 6314-6314
- DOI
  10.3390/ijms21176314
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08821, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-19K22913, KAKENHI-PROJECT-20K17405, KAKENHI-PROJECT-18KK0245, KAKENHI-PROJECT-20H03591, KAKENHI-PROJECT-19K17839
[Journal Article] Two Episodes of Transfusion-related Acute Lung Injury (TRALI) Occurring within a Short Period2020
- Author(s)
  Akagi Yuina、Murata Shogo、Yamashita Yusuke、Tanaka Ken、Hiroi Takayuki、Mushino Toshiki、Hosoi Hiroki、Nishikawa Akinori、Tamura Shinobu、Sonoki Takashi
- Journal Title
  
  Internal Medicine
  
  Volume: 59 Issue: 20 Pages: 2577-2581
- DOI
  10.2169/internalmedicine.4700-20
- NAID
  130007926297
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-20K17405, KAKENHI-PROJECT-19K17839
[Journal Article] Paroxysmal nocturnal hemoglobinuria treated with eculizumab in Wakayama, Japan: a retrospective analysis2020
- Author(s)
  田村志宣、花岡伸佳、園木孝志、古家美昭、堀善和、弘井孝幸、山下友佑、大岩健洋、村田祥吾、蒸野寿紀、西川彰則
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 61 Issue: 6 Pages: 605-611
- DOI
  10.11406/rinketsu.61.605
- NAID
  130007869147
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08718, KAKENHI-PROJECT-20K17405
[Presentation] Mutant mice carrying a novel hypomorphic mutation of the DNA ligase IV gene show Th1-skewing intestinal inflammations with severe adaptive immunodeficiency2023
- Author(s)
  Yusuke Yamashita, Takashi Kato, Hideki Kosako, Sadahiro Iwabuchi, Izumi Sasaki, Nobuo Kanazawa, Hiroaki Hemmi, Shinichi Hashimoto, Takashi Sonoki, Shinobu Tamura, Tsuneyasu Kaisho.
- Organizer
  The 12th annual Meeting of the International Society of Systemic Auto-Inflammatory Diseases (ISSAID)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16308
[Presentation] A novel Lig4 hypomorphic mutation in mice can lead to intestinal inflammation evoked by skewing Th12023
- Author(s)
  Yusuke Yamashita, Hideki Kosako, Takashi Kato, Shotaro Tabata, Sadahiro Iwabuchi, Ken Tanaka, Kazutaka Nakashima, Izumi Sasaki, Kouichi Ohshima, Shinichi Hashimoto, Takashi Sonoki, Tsuneyasu Kaisho, Shinobu Tamura.
- Organizer
  The 13th JSH International Symposium 2023 in Tsukuba.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16308
[Presentation] Asciminib Induces Anti-Myeloma Effects Through Terminal Unfolded Protein Response2023
- Author(s)
  Hideki Kosako, Yusuke Yamashita, Shuhei Morita, Sadahiro Iwabuchi, Shinobu Tamura, Shinichi Hashimoto, Takashi Sonoki.
- Organizer
  The 13th JSH International Symposium 2023 in Tsukuba
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16308
[Presentation] ABL inhibitor GNF-2 exerts anti-myeloma effects by controlling IRE1α/XBP1 axis2022
- Author(s)
  Yusuke Yamashita, Hideki Kosako, Shuhei Morita, Takashi Sonoki, Shinobu Tamura.
- Organizer
  第47回日本骨髄腫学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16308
[Presentation] Allosteric ABL inhibitors induce apoptosis in myeloma cells through ABL-mediated IRE1α signaling2022
- Author(s)
  Hideki Kosako, Yusuke Yamashita, Shuhei Morita, Takashi Sonoki, Shinobu Tamura.
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16308

1. 木下晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 細井裕樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 田村志宣

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
4. 園木孝志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 濱崎純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamashita Yusuke 山下 友佑

Research Projects

Research Products

Co-Researchers

ABL-IRE1α経路に着目した多発性骨髄腫のUPR制御機構解明と新規治療薬開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The altered immune response caused by CCDC22 mutation and its association with EBV-HLH development and severity.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] IGLL5 controlled by super-enhancer affects cell survival and MYC expression in mature B-cell lymphoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Guillain-Barré syndrome associated with Epstein-Barr virus and cytomegalovirus reactivation during treatment for chronic graft-versus-host disease after allogeneic bone marrow transplantation2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Clinical Characteristics and Diagnostic Prediction of Severe Fever with Thrombocytopenia Syndrome and Rickettsiosis in the Co-Endemic Wakayama Prefecture, Japan.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Administration of combined venetoclax and azacitidine in a patient with acute myeloid leukemia and multiple comorbidities undergoing dialysis: A case report2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angioimmunoblastic T-Cell Lymphoma after Treatment of Classic Hodgkin Lymphoma: A Case Report.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma Transforming into Diffuse Large B-Cell Lymphoma in a Young Adult Patient with Neurofibromatosis Type 1: A Case Report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Risk Factors for Therapeutic Intervention of Remdesivir in Mild to Moderate COVID-19?A Single-Center Retrospective Study of the COVID-19 Fourth Pandemic Period in Wakayama, Japan2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sudden Cardiac Death in a Patient with Thrombotic Thrombocytopenic Purpura: A Case Report2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Patient with Kabuki Syndrome Mutation Presenting with Very Severe Aplastic Anemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progressive Massive Splenomegaly in an Adult Patient with Kabuki Syndrome Complicated with Immune Thrombocytopenic Purpura2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Erdheim-Chester disease diagnosed with right atrium tumors2021

Author(s)

Journal Title

Yamashita Yusuke 山下友佑