Yano Shuya 矢野修也

Researcher Number	50794624
Other IDs
Affiliation (Current)	2025: 川崎医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 川崎医科大学, 医学部, 講師 2021 – 2022: 川崎医科大学, 医学部, 助教 2018 – 2020: 岡山大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 蛍光イメージング / PDX / EMT / イメージング / 分子イメージング / 上皮間葉転換 / 大腸癌 / mRNA創薬 / RNA解析 / CRISPR/Cas13 … More / 人工知能 / 膵癌 / EMT阻害薬 / 間葉型EMT / 大腸癌分類 / 遺伝子発現分類 / EMT(上皮間葉転換) / 高度進行大腸癌 / 人工知能と深層学習 / 難治性大腸癌 / 治療抵抗性 / CMS4大腸癌 / precision medicine / 予後不良間葉型大腸癌 / PDXマウスモデル / 化学療法抵抗性 / 患者由来腫瘍組織片 … More Except Principal Investigator 脱メチル化 / メチル化 / 癌免疫 / 癌性腹膜炎 / 新規養子免疫細胞療法 / 脱メチル化剤 / 難治性癌性腹水 Less

AIとイメージングでEMT型膵癌の機能を定量化しCRISPRで機能的RNAを狙う新規治療の探索Principal Investigator
- Principal Investigator
  
  矢野修也
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kawasaki Medical School
Fluorescence imaging of EMT demonstrates overcoming of EMT is a therapeutic strategy for poor prognosis colorectal cancer.Principal Investigator
- Principal Investigator
  
  Yano Shuya
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kawasaki Medical School
Development of a new strategy to treat cancerous peritonitis
- Principal Investigator
  
  Nagasaka Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kawasaki Medical School
Real-time imaging and PDX based treatment strategy for poor-prognosis mesenchymal-type colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Yano Shuya
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction. In: Hoffman R. (eds) Methionine Dependence of Cancer and Aging. Methods in Molecular Biology, vol 18662019
- Author(s)
  Hoffman RM, Yano S
- Total Pages
  329
- Publisher
  Humana Press, New York, NY
- ISBN
  9781493987955
- Data Source
  KAKENHI-PROJECT-18K16313
[Book] Methioninase Cell-Cycle Trap Cancer Chemotherapy. In: Hoffman R. (eds) Methionine Dependence of Cancer and Aging. Methods in Molecular Biology2019
- Author(s)
  Hoffman RM, Yano S
- Total Pages
  329
- Publisher
  Humana Press, New York, NY
- ISBN
  9781493987955
- Data Source
  KAKENHI-PROJECT-18K16313
[Journal Article] Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles2024
- Author(s)
  Yasui Kazuya、Toshima Toshiaki、Inada Ryo、Umeda Yuzo、Yano Shuya、Tanioka Hiroaki、Nyuya Akihiro、Fujiwara Toshiyoshi、Yamada Takeshi、Naomoto Yoshio、Goel Ajay、Nagasaka Takeshi
- Journal Title
  
  Molecular Cancer
  
  Volume: 23 Issue: 1
- DOI
  10.1186/s12943-023-01910-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08775, KAKENHI-PROJECT-21K16474
[Journal Article] ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer2023
- Author(s)
  Nanako Hata, Kunitoshi Shigeyasu, Sho Takeda, et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 2078-2078
- DOI
  10.1038/s41598-023-29397-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16533, KAKENHI-PROJECT-20K09110, KAKENHI-PROJECT-21K09176, KAKENHI-PROJECT-21K16474, KAKENHI-PROJECT-23K24407
[Journal Article] Genomically Stable Gastric Cancer Characterized by Hypomethylation in Wnt Signal Cascade2023
- Author(s)
  Toshima Toshiaki、Tanioka Hiroaki、Mori Yoshiko、Tanaka Takehiro、Yasui Kazuya、Kimura Keisuke、Umeda Yuzo、Fujiwara Toshiyoshi、Nyuya Akihiro、Yano Shuya、Nagasaka Takeshi
- Journal Title
  
  Oncology
  
  Volume: 101 Issue: 2 Pages: 105-116
- DOI
  10.1159/000527098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07185, KAKENHI-PROJECT-21K16474, KAKENHI-PROJECT-19K07787, KAKENHI-PROJECT-20K09110
[Journal Article] Neutrophil and lymphocyte ratio before each chemotherapy line predicts clinical outcomes in patients with unresectable gastric cancer.2023
- Author(s)
  Tanioka H, Okawaki M, Yano S, Yoshimitsu T, Tokuda K, Nyuya A, Yamaguchi Y, Nagasaka T.
- Journal Title
  
  Oncol Lett.
  
  Volume: 25 Issue: 3 Pages: 98-98
- DOI
  10.3892/ol.2023.13684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16474, KAKENHI-PROJECT-19K07787, KAKENHI-PROJECT-21K07185
[Journal Article] Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma2022
- Author(s)
  Konishi DaisukeKishimoto Hiroyuki、Michiue Hiroyuki、Teraishi Fuminori、Kato Hironari、Tazawa Hiroshi、Yanai Hiroyuki、Yagi Takahito、Goel Ajay、Fujiwara Toshiyoshi
- Journal Title
  
  British Journal of Cancer
  
  Volume: 127 Issue: 4 Pages: 757-765
- DOI
  10.1038/s41416-022-01838-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09176, KAKENHI-PROJECT-22K08775, KAKENHI-PROJECT-21K16474, KAKENHI-PROJECT-19K18121, KAKENHI-PROJECT-23K24407
[Journal Article] RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer2022
- Author(s)
  Komatsu Yasuhiro、Shigeyasu Kunitoshi、Kagawa Shunsuke、Michiue Hiroyuki、Tazawa Hiroshi、Goel Ajay、Fujiwara Toshiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 00-00
- DOI
  10.1038/s41598-022-17773-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09176, KAKENHI-PROJECT-22K08775, KAKENHI-PROJECT-20K17653, KAKENHI-PROJECT-21K16474, KAKENHI-PROJECT-20K09110, KAKENHI-PROJECT-23K24407, KAKENHI-PROJECT-22K08873
[Journal Article] Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model.2021
- Author(s)
  Matsumi Y, Kagawa T, Yano S, Tazawa H, Shigeyasu K, Takeda S, Ohara T, Aono H, Hoffman RM, Fujiwara T, Kishimoto H.
- Journal Title
  
  Cell Cycle
  
  Volume: 20 Pages: 1122-1133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16474
[Journal Article] Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells.2021
- Author(s)
  Kagawa T, Matsumi Y, Aono H, Ohara T, Tazawa H, Shigeyasu K, Yano S, Takeda S, Komatsu Y, Hoffman RM, Fujiwara T, Kishimoto H.
- Journal Title
  
  Cell Cycle
  
  Volume: 20(13) Issue: 13 Pages: 1221-1230
- DOI
  10.1080/15384101.2021.1915604
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07730, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-21K16474
[Journal Article] eal-time fluorescence image-guided oncolytic virotherapy for precise cancer treatment.2021
- Author(s)
  Yano S, Tazawa H, Kishimoto, H, Kagawa S, Fujiwara T, Hoffman RM
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 2 Pages: 879-888
- DOI
  10.3390/ijms22020879
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16313, KAKENHI-PROJECT-21K16474
[Journal Article] FUCCI real-time cell-cycle imaging as a guide for designing improved cancer therapy: A review of innovative strategies to target quiescent chemoresistant cancer cells.2020
- Author(s)
  Yano S, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM.
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 9 Pages: 2655-2665
- DOI
  10.3390/cancers12092655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16313
[Journal Article] Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer.2019
- Author(s)
  Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Nagasaka T, Tazawa H, Kagawa S, Fujiwara T, Goel A.
- Journal Title
  
  Cancer letters
  
  Volume: 444 Pages: 127-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16313
[Presentation] AIを応用した進行消化器癌診療の最適化への挑戦深層学習による画像分類と機械学習による遺伝子発現分類に基づいた難治性消化器癌のAI分類2023
- Author(s)
  矢野修也, 谷悠真, 重安邦俊, 三村直毅, 岸本浩行, 母里淑子, 永坂岳司
- Organizer
  第78回　日本消化器外科学会総会　2023　PD1-8
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] 深層学習と機械学習を用いた人工知能による進行大腸癌に対する内視鏡外科手術適応の構築.2023
- Author(s)
  矢野修也, 重安邦俊, 谷悠真, 岸本浩行, 永坂岳司
- Organizer
  第36回　日本内視鏡外科学会　2023
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] さらなる大腸癌Precision Medicineを目指した深層学習による画像分類と機械学習による遺伝子発現分類に基づいたAI大腸癌分類2023
- Author(s)
  矢野修也, 重安邦俊, 岸本浩行, 母里淑子, 永坂岳司
- Organizer
  第123回　日本外科学会定期学術集会　2023　WS-8
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] 発生学の観点からリンパシステムを一括切除する横行結腸癌のD3郭清2023
- Author(s)
  矢野修也, 永坂岳司, 岸本浩行, 山辻知樹, 猶本良夫
- Organizer
  第85回　日本臨床外科学会　2023
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] 深層学習による画像分類と機械学習による機能発現分類に基づいた難治性大腸癌のAI分類2023
- Author(s)
  矢野修也, 永坂岳司, 山辻知樹, 猶本良夫
- Organizer
  第85回　日本臨床外科学会　2023
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] A new subtype of colorectal cancer based on RAS/RAF, microsatellite status, and mesenchymal type far-advanced CRC2022
- Author(s)
  矢野修也　重安邦俊　武田正　岡脇誠　谷岡洋亮　永坂岳司　藤原俊義　山口佳之
- Organizer
  日本臨床腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] RAS/RAF/Microsatellite statusに間葉型を加えた新しいサブタイプによる大腸癌のPrecision Medicine2022
- Author(s)
  矢野修也, 重安邦俊, 谷岡洋亮, 山崎泰史, 河内麻里子, 平沢晃, 武田正, 香川俊輔, 藤原俊義, 永坂岳司
- Organizer
  第19回日本臨床腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-21K19934
[Presentation] Mesenteric approachの概念によるdissection-first-approachは郭清手技を明確に、術式を定型化する2022
- Author(s)
  矢野修也, 重安邦俊, 母里淑子, 岸本浩行, 永坂岳司
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] 結腸脾弯曲の D3 郭清の明確化には，横行結腸脾弯曲は脾静脈を，下行結腸脾弯曲は下腸間膜静脈を軸にする腸間膜化が重要である2022
- Author(s)
  矢野修也, 重安邦俊, 母里淑子, 岸本浩行, 永坂岳司
- Organizer
  第77回日本大腸肛門病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] RAS/RAF/Microsatellite statusに間葉型を加えた新しいサブタイプによる大腸癌のPrecision Medicine2022
- Author(s)
  矢野修也　重安邦俊　母里淑子　岸本浩行　永坂岳司
- Organizer
  第122回外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] 大腸癌に対するPrecision Medicine　RAS/RAF/Microsatellite statusに間葉型タイプを加えた新しい分類方法による大腸癌Precision Medicineの実践2022
- Author(s)
  矢野修也, 重安邦俊, 母里淑子, 岸本浩行, 永坂岳司
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] "臓器別ワークショップ 28 進行再発大腸がんに対する効果的な外科治療介入を考える高度進行大腸癌に対する骨盤内臓全摘術は KRAS 野生型かつ分化型腺癌のみに効果的である"2022
- Author(s)
  矢野修也, 谷岡洋亮, 岡脇誠, 重安邦俊, 母里淑子, 岸本浩行, 山口佳之, 永坂岳司
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] 骨盤内臓全摘術が高度進行大腸癌へのコンバージョン手術となるかはRAS statusで決まる2021
- Author(s)
  矢野修也　重安邦俊　近藤喜太　寺石文則　香川俊輔　藤原俊義
- Organizer
  第60回癌治療学会
- Data Source
  KAKENHI-PROJECT-21K16474
[Presentation] EMT-MET 可視化バイオセンサーを用いて hybridE/M 状態での化学療法抵抗性をリアルタイムイメージングにより解き明かす2020
- Author(s)
  三村直毅、矢野修也、田澤大、家田偉史、岡林大樹、重安邦俊、武田正、吉田一博、寺石文則、楳田祐三、香川俊輔、藤原俊義
- Organizer
  日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16313
[Presentation] The Surgical Strategy for wider D3 area due to Skew and Distortion of a base of Transverse Mesocolon2019
- Author(s)
  SHUYA YANO, Hiroyuki Kishimoto, Fuminori Teraishi, Kunitoshi Shigeyasu, Yoshiko Mori, Yoshitaka Kondo, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara
- Organizer
  消化器外科学会
- Data Source
  KAKENHI-PROJECT-18K16313
[Presentation] 中結腸動静脈根部の上下左右のズレと副右結腸静脈のねじれの位置を意識した結腸右半切除D3郭清2019
- Author(s)
  矢野修也, 近藤喜太, 寺石文則, 重安邦俊, 母里淑子, 藤本卓也, 香川俊輔, 白川靖博, 藤原俊義
- Organizer
  内視鏡外科学会
- Data Source
  KAKENHI-PROJECT-18K16313
[Presentation] 細胞周期の可視化から見えてきた難治性がん細胞の存在と新規治療戦略 Novel therapeutic strategy for therapy-refractory tumor cells identified by cell cycle imaging2019
- Author(s)
  Shuya Yano, Hiroshi Tazawa, Kunitoshi Shigeyasu, Shunsuke Kagawa, Toshiyoshi Fujiwara
- Organizer
  癌学会がん組織の生体イメージング：現場を押さえろ！
- Data Source
  KAKENHI-PROJECT-18K16313

1. Nagasaka Takeshi (30452569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 上野富雄 (70284255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 伊藤達男 (80789123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山口佳之 (10230377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 岡脇誠 (40509254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 谷岡洋亮 (40775491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. MICHIUE Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. UMEDA Yuzo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 武田正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 藤原俊義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 岸本浩行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yano Shuya 矢野 修也

Research Projects

Research Products

Co-Researchers

AIとイメージングでEMT型膵癌の機能を定量化しCRISPRで機能的RNAを狙う新規治療の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fluorescence imaging of EMT demonstrates overcoming of EMT is a therapeutic strategy for poor prognosis colorectal cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new strategy to treat cancerous peritonitis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Real-time imaging and PDX based treatment strategy for poor-prognosis mesenchymal-type colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Tumor-Specific S/G2-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction. In: Hoffman R. (eds) Methionine Dependence of Cancer and Aging. Methods in Molecular Biology, vol 18662019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Methioninase Cell-Cycle Trap Cancer Chemotherapy. In: Hoffman R. (eds) Methionine Dependence of Cancer and Aging. Methods in Molecular Biology2019

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genomically Stable Gastric Cancer Characterized by Hypomethylation in Wnt Signal Cascade2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neutrophil and lymphocyte ratio before each chemotherapy line predicts clinical outcomes in patients with unresectable gastric cancer.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RNA editing facilitates the enhanced production of neoantigens during the simultaneous administration of oxaliplatin and radiotherapy in colorectal cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model.2021

Author(s)

Journal Title

Data Source

[Journal Article] Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] eal-time fluorescence image-guided oncolytic virotherapy for precise cancer treatment.2021

Yano Shuya 矢野修也

[Presentation] AIを応用した進行消化器癌診療の最適化への挑戦深層学習による画像分類と機械学習による遺伝子発現分類に基づいた難治性消化器癌のAI分類2023

[Presentation] 大腸癌に対するPrecision Medicine　RAS/RAF/Microsatellite statusに間葉型タイプを加えた新しい分類方法による大腸癌Precision Medicineの実践2022

[Presentation] "臓器別ワークショップ 28 進行再発大腸がんに対する効果的な外科治療介入を考える高度進行大腸癌に対する骨盤内臓全摘術は KRAS 野生型かつ分化型腺癌のみに効果的である"2022

[Presentation] EMT-MET 可視化バイオセンサーを用いて hybridE/M 状態での化学療法抵抗性をリアルタイムイメージングにより解き明かす2020