Kinoshita Hideyuki 木下英幸

Researcher Number	50797115
Affiliation (Current)	2025: 千葉県がんセンター(研究所), 整形外科, 医長
Affiliation (based on the past Project Information) *help	2020 – 2023: 千葉県がんセンター(研究所), 整形外科, 医長 2019: 千葉県がんセンター(研究所), 整形外科, 医員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator セレコキシブ / オーラノフィン (AUR) / 化学療法抵抗性 / 遠隔転移 / 酸化ストレス / PDXモデル / 酸化還元機構 / レドックス制御 / 骨・軟部肉腫 / Trx … More / ASK1 / アポトーシス / 肺転移 / Trx還元酵素 (TXNRD) / チオレドキシン (Trx) / 患者腫瘍組織移植モデル(PDX) / TXN還元酵素 (TXNRD) / PX-12 / チオレドキシン (TXN) / レドックス / 骨肉腫 Less

骨・軟部肉腫の腫瘍進展におけるレドックス制御機構の解明Principal Investigator
- Principal Investigator
  
  木下英幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)
Elucidation of molecular mechanisms and development of novel therapeutic agents in pulmonary metastasis of osteosarcomaPrincipal Investigator
- Principal Investigator
  
  Kinoshita Hideyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Chiba Cancer Center (Research Institute)

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Thioredoxin Reductase Inhibitor Suppresses the Local Progression of Rhabdomyosarcoma With PDX Models2024
- Author(s)
  Kinoshita H, Kinoshita S, Kamoda H, Hagiwara Y, Ohtori S, Yonemoto T.
- Journal Title
  
  Cancer Genomics Proteomics.
  
  Volume: 21(2) Issue: 2 Pages: 178-185
- DOI
  10.21873/cgp.20439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14608
[Journal Article] Combined Auranofin and Celecoxib Suppresses the Local Progression and Pulmonary Metastases of Osteosarcoma In Vivo2024
- Author(s)
  Kinoshita H, Kinoshita S, Kamoda H, Hagiwara Y, Ohtori S, Yonemoto T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 44(3) Issue: 3 Pages: 1045-1049
- DOI
  10.21873/anticanres.16899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14608
[Journal Article] Postoperative Limb Function and QOL in Elderly Patients With Malignant Bone Tumor/Soft Tissue Sarcoma2023
- Author(s)
  Kinoshita H, Kinoshita S, Hagiwara Y, Kamoda H, Ohtori S, Yonemoto T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 43(7) Issue: 7 Pages: 3273-3279
- DOI
  10.21873/anticanres.16502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14608
[Journal Article] Predictors of Postoperative Gain in Ambulatory Function After Decompressive Surgery for Metastatic Spinal Cord Compression2023
- Author(s)
  Kinoshita H, Kamoda H, Hagiwara Y, Kinoshita S, Ohtori S, Yonemoto T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 43(4) Issue: 4 Pages: 1767-1773
- DOI
  10.21873/anticanres.16330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14608
[Journal Article] Prognostic Factors for Survival in Patients With High-grade Chondrosarcoma.2022
- Author(s)
  Kinoshita H, Kamoda H, Hagiwara Y, Ishii T, Ohtori S, Yonemoto T.
- Journal Title
  
  Cancer Diagn Progn.
  
  Volume: 2(6) Issue: 6 Pages: 681-685
- DOI
  10.21873/cdp.10159
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Clavicula Pro Humero Reconstruction for Malignant Tumor of the Proximal Humerus in Children and Adults2022
- Author(s)
  Kinoshita H, Kamoda H, Hagiwara Y, Ishii T, Ohtori S, Yonemoto T.
- Journal Title
  
  Anticancer Res.
  
  Volume: 42(4) Issue: 4 Pages: 2139-2144
- DOI
  10.21873/anticanres.15696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Effectiveness of Salvage Knee Rotationplasty on Sarcoma Around the Knee in Adolescents and Young Adults.2021
- Author(s)
  Kinoshita H, Yonemoto T, Kamoda H, Hagiwara Y, Tsukanishi T, Inoue M, Terakawa F, Ohtori S, Ishii T.
- Journal Title
  
  Anticancer Res
  
  Volume: 41(2) Issue: 2 Pages: 1041-1046
- DOI
  10.21873/anticanres.14860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] The thioredoxin reductase inhibitor auranofin suppresses the pulmonary metastasis of osteosarcoma, but not local progression.2021
- Author(s)
  Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Tsukanishi T, Ohtori S, Yonemoto T.
- Journal Title
  
  Anticancer Res
  
  Volume: 41(10) Issue: 10 Pages: 4947-4955
- DOI
  10.21873/anticanres.15308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Poor efficacy of postoperative radiotherapy in infiltrative high-grade soft tissue sarcomas.2021
- Author(s)
  Kinoshita H, Yonemoto T, Kamoda H, Hagiwara Y, Tsukanishi T, Inoue M, Terakawa F, Ohtori S, Ishii T.
- Journal Title
  
  Anticancer Res
  
  Volume: 41(8) Issue: 8 Pages: 4027-4032
- DOI
  10.21873/anticanres.15202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression.2021
- Author(s)
  Kinoshita H, Shimozato O, Kamoda H, Hagiwara Y, Tsukanishi T, Ishii T, Ohtori S, Yonemoto T.
- Journal Title
  
  Anticancer Res
  
  Volume: 41(12) Issue: 12 Pages: 6013-6021
- DOI
  10.21873/anticanres.15420
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Doxorubicin Combined With Ifosfamide for Sarcoma Induces Muscle Atrophy and Sleep Disruption.2021
- Author(s)
  Kinoshita H, Hagiwara Y, Kamoda H, Hagiwara Y, Tsukanishi T, Ishii T, Ohtori S, Yonemoto T.
- Journal Title
  
  Anticancer Res
  
  Volume: 41(12) Issue: 12 Pages: 6273-6278
- DOI
  10.21873/anticanres.15448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome with purely osteolytic, not osteosclerotic, lesions mimicking a malignant tumor.2020
- Author(s)
  Kinoshita H, Ishii T, Kamoda H, Hagiwara Y, Tsukanishi T, Orita S, Inage K, Hirosawa N, Ohtori S, Yonemoto T.
- Journal Title
  
  Case Rep Reumato.
  
  Volume: 2020 Pages: 6316921-6316921
- DOI
  10.1155/2020/6316921
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Successful treatment of a massive desmoplastic fibroma of the ilium without surgery: A case report with long-term follow-up2020
- Author(s)
  Kinoshita H, Ishii T, Kamoda H, Tsukanishi T, Orita S, Inage K, Ohtori S, Yonemoto T.
- Journal Title
  
  Case Rep Orthop.
  
  Volume: 2020 Pages: 5380598-5380598
- DOI
  10.1155/2020/5380598
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Successful Neurological Recovery with Multimodality Therapy without Surgery for Spinal Metastases from Advanced Gastric Cancer2020
- Author(s)
  Kinoshita H, Kamoda H, Ishii T, Hagiwara Y, Tsukanishi T, Orita S, Inage K, Hirosawa N, Ohtori S, Yonemoto T.
- Journal Title
  
  Case Rep Orthop.
  
  Volume: 2020 Pages: 4753027-4753027
- DOI
  10.1155/2020/4753027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Giant protruding high grade undifferentiated pleomorphic sarcoma arising in a keloid scar on the abdominal wall.2020
- Author(s)
  Kinoshita H, Tsukanishi T, Ishii T, Kamoda H, Hagiwara Y, Orita S, Inage K, Hirosawa N, Ohtori S, Yonemoto T.
- Journal Title
  
  Case Rep Dermatol Med.
  
  Volume: 2020 Pages: 4898965-4898965
- DOI
  10.1155/2020/4898965
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction2020
- Author(s)
  Kinoshita H, Orita S, Inage K, Fujimoto K, Shiga Y, Abe K, Inoue M, Norimoto M, Umimura T, Ishii T, Yonemoto T, Kamoda H, Tsukanishi T, Akazawa T, Ohtori S
- Journal Title
  
  Asian Spine J.
  
  Volume: 14(1) Issue: 1 Pages: 1-8
- DOI
  10.31616/asj.2019.0048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760, KAKENHI-PROJECT-18K09093
[Journal Article] Successful total en bloc spondylectomy of the L3 vertebra with a paravertebral giant cell tumor following preoperative treatment with denosumab.2019
- Author(s)
  Kinoshita H, Orita S, Yonemoto T, Ishii T, Iwata S, Kamoda H, Tsukanishi T, Inage K, Abe K, Inoue M, Norimoto M, Umimura T, Fujimoto K, Shiga Y, Kanamoto H, Furuya T, Takahashi K, Ohtori S.
- Journal Title
  
  J Med Case Rep.
  
  Volume: 13(1) Issue: 1 Pages: 116-116
- DOI
  10.1186/s13256-019-2029-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Skeletal Muscle Cell Oxidative Stress as a Possible Therapeutic Target in a Denervation-Induced Experimental Sarcopenic Model2019
- Author(s)
  Kinoshita H, Orita S, Inage K, Yamauchi K, Abe K, Inoue M, Norimoto M, Umimura T, Eguchi Y, Fujimoto K, Shiga Y, Kanamoto H, Aoki Y, Furuya T, Suzuki M, Akazawa T, Takahashi K, Ohtori S.
- Journal Title
  
  Spine
  
  Volume: 44 Issue: 8 Pages: 446-455
- DOI
  10.1097/brs.0000000000002891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09093, KAKENHI-PROJECT-19K16760
[Journal Article] Muscle Invasive Dermatofibroma Clinically Mimicking a Malignant Tumor.2019
- Author(s)
  Kinoshita H, Ishii T, Kamoda H, Tsukanishi T, Orita S, Inage K, Ohtori S, Yonemoto T.
- Journal Title
  
  Case Rep Dermatol Med.
  
  Volume: 2019 Pages: 4503272-4503272
- DOI
  10.1155/2019/4503272
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760
[Journal Article] Giant protruding nodular fasciitis of the anterior chest wall clinically mimicking a soft tissue sarcoma.2019
- Author(s)
  Kinoshita H, Yonemoto T, Kamoda H, Tsukanishi T, Orita S, Inage K, Hirosawa N, Ohtori S, Ishii T.
- Journal Title
  
  Case Rep Orthop.
  
  Volume: 2019 Pages: 4174985-4174985
- DOI
  10.1155/2019/4174985
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] PDXモデルを用いた横紋筋肉腫の腫瘍進展におけるレドックス制御の解明2023
- Author(s)
  木下英幸，鴨田博人，萩原洋子，米本司
- Organizer
  第56回日本整形外科学会　骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-23K14608
[Presentation] レドックス制御を標的とする骨肉腫新規治療薬の開発および分子機序解明2023
- Author(s)
  木下英幸
- Organizer
  第76回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14608
[Presentation] レドックス制御を標的とする骨肉腫新規治療薬の開発および分子機序解明2022
- Author(s)
  木下英幸，石井猛，鴨田博人，萩原洋子，塚西敏則，米本司
- Organizer
  第95回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome with purely osteolytic, not osteosclerotic, lesions mimicking a malignant tumor2022
- Author(s)
  Kinoshita H
- Organizer
  European Calcified Tissue Society (ECTS) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] 転移性脊髄圧迫に対する椎弓切除術の術後歩行機能獲得に及ぼす予測因子の検討2022
- Author(s)
  木下英幸，鴨田博人，萩原洋子，大鳥精司，米本司
- Organizer
  第55回日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] Development of novel therapeutic agents targeting redox regulation system in osteosarcoma2022
- Author(s)
  Kinoshita H
- Organizer
  European Calcified Tissue Society (ECTS) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] レドックス制御を標的とする骨肉腫新規治療薬の開発および分子機序解明2022
- Author(s)
  木下英幸，石井猛，鴨田博人，萩原洋子，塚西敏則，米本司
- Organizer
  第5回日本サルコーマ治療研究学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] レドックス制御を標的とする骨肉腫新規治療薬の開発および分子機序解明2021
- Author(s)
  木下英幸
- Organizer
  日本整形外科学会　骨軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] Skeletal muscle cell oxidative stress as a possible therapeutic target for sarcopenia2021
- Author(s)
  Kinoshita H, Orita S, Inage K, and Ohtori S.
- Organizer
  European Calcified Tissue Society (ECTS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] Effectiveness of salvage knee rotationplasty on sarcoma around the knee in adolescents and young adults2021
- Author(s)
  Kinoshita H, Yonemoto T, Kamoda H, Hagiwara Y, Tsukanishi T, Ishi T.
- Organizer
  European Calcified Tissue Society (ECTS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] The evaluation of bone union activity of freeze-dried platelet-rich plasma2021
- Author(s)
  Kinoshita H, Orita S, Inage K, Shiga Y, Ohtori S.
- Organizer
  European Calcified Tissue Society (ECTS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] The evaluation of bone union activity of freeze-dried platelet-rich plasma2020
- Author(s)
  Kinoshita H, Orita S, Inage K, Shiga Y, Ohtori S.
- Organizer
  American Society for Bone and Mineral Research (ASBMR)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] Giant muscle invasive dermatofibroma clinically mimicking a malignant tumor2019
- Author(s)
  Kinoshita H, Yonemoto T, Kamoda H, Hagiwara Y, Tsukanishi T, Ishi T
- Organizer
  International Society of Limb Salvage (2019 Athens,Greece)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] Successful total en bloc spondylectomy of the L3 vertebra with a paravertebral giant cell tumor following preoperative treatment with denosumab2019
- Author(s)
  Kinoshita H, Yonemoto T, Kamoda H, Hagiwara Y, Tsukanishi T, Ishi T
- Organizer
  International Society of Limb Salvage (2019 Athens,Greece)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760
[Presentation] Skeletal muscle cell oxidative stress as a possible therapeutic target for sarcopenia2019
- Author(s)
  Kinoshita H, Yonemoto T, Kamoda H, Hagiwara Y, Tsukanishi T, Ishi T
- Organizer
  International Society of Limb Salvage (2019 Athens,Greece)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16760

1. SUZUKI Masahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 大鳥精司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 折田純久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kinoshita Hideyuki 木下 英幸

Research Projects

Research Products

Co-Researchers

骨・軟部肉腫の腫瘍進展におけるレドックス制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms and development of novel therapeutic agents in pulmonary metastasis of osteosarcomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Thioredoxin Reductase Inhibitor Suppresses the Local Progression of Rhabdomyosarcoma With PDX Models2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined Auranofin and Celecoxib Suppresses the Local Progression and Pulmonary Metastases of Osteosarcoma In Vivo2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Postoperative Limb Function and QOL in Elderly Patients With Malignant Bone Tumor/Soft Tissue Sarcoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictors of Postoperative Gain in Ambulatory Function After Decompressive Surgery for Metastatic Spinal Cord Compression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic Factors for Survival in Patients With High-grade Chondrosarcoma.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clavicula Pro Humero Reconstruction for Malignant Tumor of the Proximal Humerus in Children and Adults2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effectiveness of Salvage Knee Rotationplasty on Sarcoma Around the Knee in Adolescents and Young Adults.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The thioredoxin reductase inhibitor auranofin suppresses the pulmonary metastasis of osteosarcoma, but not local progression.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Poor efficacy of postoperative radiotherapy in infiltrative high-grade soft tissue sarcomas.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Doxorubicin Combined With Ifosfamide for Sarcoma Induces Muscle Atrophy and Sleep Disruption.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome with purely osteolytic, not osteosclerotic, lesions mimicking a malignant tumor.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful treatment of a massive desmoplastic fibroma of the ilium without surgery: A case report with long-term follow-up2020

Author(s)

Journal Title

DOI

Kinoshita Hideyuki 木下英幸

[Presentation] レドックス制御を標的とする骨肉腫新規治療薬の開発および分子機序解明2022

[Presentation] 転移性脊髄圧迫に対する椎弓切除術の術後歩行機能獲得に及ぼす予測因子の検討2022

[Presentation] レドックス制御を標的とする骨肉腫新規治療薬の開発および分子機序解明2022