Hashimoto Takuma 橋本拓磨

Researcher Number	50799145
Other IDs	https://orcid.org/0000-0002-8762-6027
Affiliation (Current)	2025: 東北大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 東北大学, 医学系研究科, 講師 2023: 東北大学, 医学系研究科, 講師 2017 – 2022: 東北大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Radiation science Except Principal Investigator Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator 低酸素 / 放射線抵抗性 / DNA修復酵素 / がん細胞 / がん幹細胞 / 癌細胞 / DNA-PKcs / ATM / DNA修復因子 / Akt … More / 放射線生物学 / Sp1 / AMPK / 転写因子 / DNA-PK / 細胞培養 / 放射線 … More Except Principal Investigator Muse細胞 / 放射線障害 / 幹細胞 / ミューズ細胞 / 放射線抵抗性 / がん幹細胞 / 間葉系幹細胞 / 放射線 Less

低酸素・低栄養状態における癌細胞および癌幹細胞における放射線抵抗性の機序解明Principal Investigator
- Principal Investigator
  
  橋本拓磨
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
低酸素性癌細胞の放射線抵抗性を誘導するDNA-PKcsとAktの機序解明Principal Investigator
- Principal Investigator
  
  橋本拓磨
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
Treatment of radiation damage in normal tissues using Muse cells and elucidation of the mechanism of radiation resistance of stem cells
- Principal Investigator
  
  Hosoi Yoshio
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
Elucidation of radioresistance mechanisms in hypoxic cancer cells focusing on DNA repair enzymes and transcription factorsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Takuma
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Tohoku University
Elucidation of radioresistance mechanisms in cancer cells focusing on ATM and DNA-PKcs under hypoxic conditionsPrincipal Investigator
- Principal Investigator
  
  Hashimoto Takuma
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University

All 2023 2022 2020 2019 2018

All Journal Article Presentation

[Journal Article] AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation2023
- Author(s)
  Urushihara Yusuke、Hashimoto Takuma、Fujishima Yohei、Hosoi Yoshio
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 16 Pages: 12828-12828
- DOI
  10.3390/ijms241612828
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15857
[Journal Article] 低酸素環境が神経膠芽腫細胞株の放射線抵抗性に及ぼす影響の分子生物学的解析2023
- Author(s)
  橋本拓磨、細井義夫
- Journal Title
  
  アグリバイオ
  
  Volume: 7 Pages: 88-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15857
[Journal Article] 重度な低酸素環境下における癌細胞の放射線抵抗性とAMPKα/Sp1/ATMの寄与2022
- Author(s)
  橋本拓磨、ハーリドハタビー、細井義夫
- Journal Title
  
  細胞
  
  Volume: 5 Pages: 42-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15857
[Journal Article] AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines2022
- Author(s)
  Hashimoto Takuma、Urushihara Yusuke、Murata Yasuhiko、Fujishima Yohei、Hosoi Yoshio
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 590 Pages: 82-88
- DOI
  10.1016/j.bbrc.2021.12.076
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17222
[Journal Article] DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR12020
- Author(s)
  Shiga Soichiro、Murata Yasuhiko、Hashimoto Takuma、Urushihara Yusuke、Fujishima Yohei、Kudo Kanna、Sonohara Yaoki、Kurusu Miku、Takeda Kazuya、Jingu Keiichi、Hosoi Yoshio
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Issue: 3 Pages: 668-673
- DOI
  10.1016/j.bbrc.2019.10.133
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17128, KAKENHI-PROJECT-19K17222, KAKENHI-PROJECT-19K23935
[Journal Article] Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways2018
- Author(s)
  Hashimoto Takuma、Murata Yasuhiko、Urushihara Yusuke、Shiga Soichiro、Takeda Kazuya、Hosoi Yoshio
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 505 Issue: 1 Pages: 13-19
- DOI
  10.1016/j.bbrc.2018.09.068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06528, KAKENHI-PROJECT-17K16416
[Journal Article] Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.2018
- Author(s)
  Murata Y, Hashimoto T, Urushihara Y, Shiga S, Takeda K, Jingu K, Hosoi Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 495 Issue: 4 Pages: 2566-2572
- DOI
  10.1016/j.bbrc.2017.12.141
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293271, KAKENHI-PROJECT-17H06528, KAKENHI-PROJECT-17K16416
[Presentation] 低栄養状態において、AMPK/FOXO3a経路はATM、DNA-PKcs、Src、EGFR、PDK1、SOD2の活性や発現を亢進させ、放射線抵抗性を誘導する2023
- Author(s)
  漆原佑介、橋本拓磨、細井義夫
- Organizer
  第60回日本放射線腫瘍学会生物部会学術大会
- Data Source
  KAKENHI-PROJECT-22K15857
[Presentation] AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation2023
- Author(s)
  Yusuke Urushihara, Takuma Hashimoto, Yoshio Hosoi
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-22K15857
[Presentation] Effects of severe hypoxia on the expression of stemness factors in cancer cells2022
- Author(s)
  橋本拓磨、細井義夫
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-22K15857
[Presentation] 重度な低酸素状態が癌細胞の幹細胞性因子の発現に及ぼす影響2022
- Author(s)
  橋本拓磨、細井義夫
- Organizer
  第59回日本放射線腫瘍学会生物部会学術大会
- Data Source
  KAKENHI-PROJECT-22K15857
[Presentation] 栄養飢餓状態の乳がん細胞株MDA-MB-231におけるAMPKの転写因子を介したDNA損傷応答制御2020
- Author(s)
  漆原佑介、橋本拓磨、藤嶋洋平、細井義夫
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-19K17222
[Presentation] 重度な低酸素状態のヒト神経膠芽腫株T98GにおけるAMPKαを介したHIF-1αの発現制御の解析2020
- Author(s)
  橋本拓磨、園原八起、漆原佑介、藤嶋洋平、細井義夫
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-19K17222
[Presentation] AMPKα regulates expression of ATM and cellular radiosensitivity under severe hypoxia in glioblastoma cell line T98G.2019
- Author(s)
  T. Hashimoto, Y. Urushihara, Y. Murata1, Y. Fujishima, K Takeda, S. Shiga, K. Kudo, Y. Sonohara, Y. Hosoi
- Organizer
  The 62nd Annual Meeting of the Japanese Radiation Research Society
- Data Source
  KAKENHI-PROJECT-19K17222
[Presentation] Nutrient starvation activates ATM, DNA-PKcs and Src signaling pathways via AMPKa in MDA-MB-231 breast cancer cells.2019
- Author(s)
  Yusuke Urushihara, Takuma Hashimoto, Yasuhiko Murata, Yohei Fujishima, Kazuya Takeda, Soichiro Shiga, Kanna Kudo, Yaoki Sonohara, Yoshio Hosoi
- Organizer
  The 62nd Annual Meeting of the Japanese Radiation Research Society
- Data Source
  KAKENHI-PROJECT-19K17222
[Presentation] 低酸素状態がATMとDNA-PKcsの発現と活性化に及ぼす影響2019
- Author(s)
  橋本拓磨、村田泰彦、漆原佑介、藤嶋洋平、武田一也、志賀壮一郎、工藤香菜、園原八起、細井義夫
- Organizer
  第57回生物部会・第48回制癌シンポジウム
- Data Source
  KAKENHI-PROJECT-19K17222
[Presentation] 低酸素・低栄養環境下におけるDNA-PKcsを介したHsp90αのリン酸化制御機構2018
- Author(s)
  武田一也、村田泰彦、橋本拓磨、漆原佑介、志賀壮一郎、神宮啓一、細井義夫
- Organizer
  創生応用医学研究センター第1回若手研究者交流会
- Data Source
  KAKENHI-PROJECT-17H06528
[Presentation] 低酸素状態がATMとDNA-PKcsの発現と活性化に及ぼす影響2018
- Author(s)
  橋本拓磨、村田泰彦、漆原佑介、志賀壮一郎、武田一也、細井義夫
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-17H06528
[Presentation] 低栄養状態において活性化されたDNA-PKcsによるゴルジ体膜タンパク質GOLPH3の制御2018
- Author(s)
  村田泰彦、橋本拓磨、漆原佑介、志賀壮一郎、細井義夫
- Organizer
  日本放射線影響学会第61回大会
- Data Source
  KAKENHI-PROJECT-17H06528

1. Hosoi Yoshio (50238747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 漆原佑介 (30722269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Hashimoto Takuma 橋本 拓磨

Research Projects

Research Products

Co-Researchers

低酸素・低栄養状態における癌細胞および癌幹細胞における放射線抵抗性の機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

低酸素性癌細胞の放射線抵抗性を誘導するDNA-PKcsとAktの機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Treatment of radiation damage in normal tissues using Muse cells and elucidation of the mechanism of radiation resistance of stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of radioresistance mechanisms in hypoxic cancer cells focusing on DNA repair enzymes and transcription factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of radioresistance mechanisms in cancer cells focusing on ATM and DNA-PKcs under hypoxic conditionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 低酸素環境が神経膠芽腫細胞株の放射線抵抗性に及ぼす影響の分子生物学的解析2023

Author(s)

Journal Title

Data Source

[Journal Article] 重度な低酸素環境下における癌細胞の放射線抵抗性とAMPKα/Sp1/ATMの寄与2022

Author(s)

Journal Title

Data Source

[Journal Article] AMPK increases expression of ATM through transcriptional factor Sp1 and induces radioresistance under severe hypoxia in glioblastoma cell lines2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] 低栄養状態において、AMPK/FOXO3a経路はATM、DNA-PKcs、Src、EGFR、PDK1、SOD2の活性や発現を亢進させ、放射線抵抗性を誘導する2023

Author(s)

Organizer

Data Source

[Presentation] AMPK/FOXO3a Pathway Increases Activity and/or Expression of ATM, DNA-PKcs, Src, EGFR, PDK1, and SOD2 and Induces Radioresistance under Nutrient Starvation2023

Author(s)

Organizer

Data Source

[Presentation] Effects of severe hypoxia on the expression of stemness factors in cancer cells2022

Author(s)

Organizer

Data Source

[Presentation] 重度な低酸素状態が癌細胞の幹細胞性因子の発現に及ぼす影響2022

Hashimoto Takuma 橋本拓磨