Yokota Seiji 横田聖司

Researcher Number	50802401
Other IDs
Affiliation (Current)	2025: 岩手医科大学, 歯学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 岩手医科大学, 歯学部, 講師 2019 – 2022: 岩手医科大学, 歯学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57070:Developmental dentistry-related Except Principal Investigator Basic Section 57040:Regenerative dentistry and dental engineering-related / Basic Section 57010:Oral biological science-related / Basic Section 57070:Developmental dentistry-related
Keywords	Principal Investigator 滑膜細胞 / 変形性顎関節症 / 間葉系幹細胞 / 活性酸素種 / マトリックスメタロプロテアーゼ / ERK / プリン受容体 / ダメージ関連分子パターン / 顎関節由来線維芽細胞様滑膜細胞 / ADP / 細胞外ヌクレオチド / P2Y受容体 … More Except Principal Investigator … More 間葉系幹細胞 / ヒト口腔扁平上皮癌細胞 / exosome / noncoding RNA / オンコソーム / エクソソーム / ペプチド / 免疫抑制 / 組織再生 / SCRG1 / 抗炎症性マクロファージ / 細胞治療 / 炎症 / 顎関節 / 細胞内シグナル / ケモカイン / 酸化ストレス / 変形性顎関節症 / 浸潤・転移 / 口腔癌 / 口腔癌細胞 / 細胞間相互作用 / 癌微小環境 / ヒト間葉系幹細胞 / 癌転移 / 癌浸潤 / 口腔扁平上皮癌細胞 Less

Development of Next-Generation Bone Regeneration Therapy Using Novel Noncoding RNA to Preserve Mesenchymal Stem Cellularity
- Principal Investigator
  
  横田潤
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Iwate Medical University
Establishment of therapy involving tissue regeneration using anti-inflammatory peptide derived from mesenchymal stem cells
- Principal Investigator
  
  帖佐直幸
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Iwate Medical University
間葉系幹細胞由来細胞外小胞及び内包成分に着目した変形性顎関節症新規原因療法の開発Principal Investigator
- Principal Investigator
  
  横田聖司
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Iwate Medical University
口腔扁平上皮癌細胞の癌微小環境における細胞外小胞を介した浸潤・転移誘導機構の解明
- Principal Investigator
  
  石崎明
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Iwate Medical University
Elucidation of mechanisms underlying oral cancer invasion and metastasis promoted by mesenchymal stem cells in tumor microenvironment
- Principal Investigator
  
  Ishisaki Akira
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Iwate Medical University
Establishment of novel therapy against TMJ-OA with application of anti-inflammatory reaction by mesenchymal stem cells
- Principal Investigator
  
  Mayama Hisayo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Iwate Medical University
A novel therapeutic strategy for the temporomandibular joint osteoarthritis focusing on the osteoclast induction mechanism of temporomandibular joint synovial cellsPrincipal Investigator
- Principal Investigator
  
  Yokota Seiji
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Iwate Medical University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Hydrogen peroxide-induced oxidative stress promotes expression of CXCL15/Lungkine mRNA in a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint2023
- Author(s)
  Asanuma Kanna、Yokota Seiji、Chosa Naoyuki、Kamo Masaharu、Ibi Miho、Mayama Hisayo、Iri? Tarou、Satoh Kazuro、Ishisaki Akira
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 65 Issue: 1 Pages: 97-103
- DOI
  10.1016/j.job.2022.12.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K10234, KAKENHI-PROJECT-20K09883, KAKENHI-PROJECT-23K16191, KAKENHI-PROJECT-23K09155, KAKENHI-PROJECT-20K09884, KAKENHI-PROJECT-20K10014
[Journal Article] Extracellular adenosine 5?-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes2022
- Author(s)
  Yokota Seiji、Chosa Naoyuki、Matsumoto Shikino、Satoh Kazuro、Ishisaki Akira
- Journal Title
  
  Molecular Biology Reports
  
  Volume: 50 Issue: 2 Pages: 1595-1602
- DOI
  10.1007/s11033-022-08125-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19277, KAKENHI-PROJECT-20K10014
[Journal Article] TGF-β abrogates the LPS-induced activation of the NF-κB-mediated signaling pathway that suppresses osteogenic activity in human mesenchymal stem cells2020
- Author(s)
  Takaaki Aoki, Seiji Yokota, Naoyuki Chosa, Seiko Kyakumoto, and Mamoru Noda
- Journal Title
  
  Dental Journal of Iwate Medical University
  
  Volume: 掲載確定
- NAID
  130008084413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K19277
[Journal Article] Receptor tyrosine kinase ligands and inflammatory cytokines cooperatively suppress the fibrogenic activity in temporomandibular-joint-derived fibroblast-like synoviocytes through mitogen-activated protein kinase kinase/extracellular signal-regulated kinase2020
- Author(s)
  Shikino Matsumoto, Seiji Yokota, Naoyuki Chosa, Seiko Kyakumoto, Hitomichi Kimura, Masaharu Kamo, Kazuro Satoh, Akira Ishisaki
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K19277
[Journal Article] Adenosine 5′-triphosphate strengthens receptor tyrosine kinase-mediated suppression of fibrogenic activity in fibroblast-like synoviocytes derived from mouse temporomandibular joints possibly through P2Y2, P2Y4, and P2Y13 purinergic receptors2020
- Author(s)
 Shikino MATSUMOTO, Seiji YOKOTA, Seiko KYAKUMOTO, Naoyuki CHOSA, Kazuro SATOH
- Journal Title
 
 Dental Journal of Iwate Medical University
 
 Volume: 45 Issue: 1 Pages: 46-57
- DOI
 10.20663/iwateshigakukaishi.45.1_46
- NAID
 130007893393
- ISSN
 0385-1311, 2424-1822
- Year and Date
 2020-06-20
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-20K10014, KAKENHI-PROJECT-20K10234
[Presentation] 変形性顎関節症の発症における細胞外ヌクレオチドの役割2023
- Author(s)
  横田聖司、氏家隼人、石崎　明
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K16191
[Presentation] 変形性顎関節症において発現誘導される炎症性サイトカインの網羅的解析研究2023
- Author(s)
  阿部カレン、横田聖司、浅沼莞奈、吉田弘法、間山寿代、帖佐直幸、佐藤和朗、石崎明
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K10234
[Presentation] Oxidative stress increased expression of CXCL15 mRNA via a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint2022
- Author(s)
  浅沼莞奈、横田聖司、帖佐直幸、佐藤和朗、石崎明
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K19277
[Presentation] Oxidative stress increased expression of CXCL15 mRNA via a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint2022
- Author(s)
  浅沼莞奈、横田聖司、帖佐直幸、衣斐美歩、入江太朗、佐藤和朗、石崎　明
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09883
[Presentation] 酸化ストレスを介した顎関節周囲滑膜炎の発症メカニズムの解明2022
- Author(s)
  浅沼莞奈、横田聖司、間山寿代、帖佐直幸、桑島幸紀、松本識野、阿部カレン、吉田弘法、衣斐美歩、加茂政晴、入江太朗、佐藤和朗、石崎　明
- Organizer
  第60回特定非営利活動法人日本口腔科学会北日本地方部会
- Data Source
  KAKENHI-PROJECT-20K10234
[Presentation] 酸化ストレスを介した顎関節周囲滑膜炎の発症メカニズムの解明2022
- Author(s)
  浅沼莞奈、横田聖司、間山寿代、帖佐直幸、桑島幸紀、松本識野、阿部カレン、吉田弘法、衣斐美歩、加茂政晴、入江太朗、佐藤和朗、石崎明
- Organizer
  第60回　日本口腔外科学会北日本支部学術集会
- Data Source
  KAKENHI-PROJECT-19K19277
[Presentation] 酸化ストレスを介した顎関節周囲滑膜炎の発症メカニズムの解明2022
- Author(s)
  浅沼莞奈、横田聖司、間山寿代、帖佐直幸、桑島幸紀、松本識野、阿部カレン、吉田弘法、衣斐美歩、加茂政晴、入江太朗、佐藤和朗、石崎　明
- Organizer
  第60回特定非営利活動法人日本口腔科学会北日本地方部会
- Data Source
  KAKENHI-PROJECT-20K09883
[Presentation] 間葉系幹細胞を用いた新たな再生医療の樹立戦略2021
- Author(s)
  石崎明、客本齊子、横田聖司、加茂政晴、帖佐直幸
- Organizer
  第57回日本口腔組織培養学会
- Data Source
  KAKENHI-PROJECT-20K09883
[Presentation] 顎関節由来線維芽細胞様滑膜細胞におけるADPのケモカイン発現への影響2021
- Author(s)
  横田聖司、帖佐直幸、客本齊子、加茂政晴、石崎　明
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K10234
[Presentation] 酸化ストレスがマウス顎関節由来線維芽細胞様滑膜細胞におけるケモカインの発現に与える影響について2021
- Author(s)
  浅沼莞奈、横田聖司、帖佐直幸、松本識野、間山寿代、石崎明、佐藤和朗
- Organizer
  第80回日本矯正歯科学会学術大会
- Data Source
  KAKENHI-PROJECT-19K19277
[Presentation] 酸化ストレスがマウス顎関節由来線維芽細胞様滑膜細胞におけるケモカインの発現に与える影響について2021
- Author(s)
  浅沼莞奈、横田聖司、帖佐直幸、松本識野、間山寿代、石崎明、佐藤和朗
- Organizer
  第80回日本矯正歯科学会大会
- Data Source
  KAKENHI-PROJECT-20K10234
[Presentation] マウス顎関節由来線維芽細胞様滑膜細胞における酸化ストレスの影響によるケモカインの発現変化について2021
- Author(s)
  浅沼莞奈、横田聖司、帖佐直幸、加茂政晴、松本識野、吉田弘法、桑島幸紀、間山寿代、佐藤和朗、石崎明
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K19277
[Presentation] 顎関節由来線維芽細胞様滑膜細胞におけるADPのケモカイン発現への影響2021
- Author(s)
  横田聖司、帖佐直幸、客本齊子、加茂政晴、石崎　明
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K19277
[Presentation] 間葉系幹細胞を用いた新たな再生医療の樹立戦略2021
- Author(s)
  石崎明、客本齊子、横田聖司、加茂政晴、帖佐直幸
- Organizer
  第57回日本口腔組織培養学会
- Data Source
  KAKENHI-PROJECT-20K10234
[Presentation] マウス顎関節由来線維芽細胞様滑膜細胞における酸化ストレスの影響によるケモカインの発現変化について2021
- Author(s)
  浅沼莞奈、横田聖司、帖佐直幸、加茂政晴、松本識野、吉田弘法、桑島幸紀、間山寿代、佐藤和朗、石崎　明
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K10234
[Presentation] 顎関節由来線維芽細胞様滑膜細胞におけるケモカイン発現へのeATPの影響2020
- Author(s)
  横田聖司, 帖佐直幸, 松本識野, 客本斎子, 加茂政晴, 石崎明
- Organizer
  第93回日本生化学学会大会
- Data Source
  KAKENHI-PROJECT-20K10234
[Presentation] 顎関節由来線維芽細胞様滑膜細胞におけるケモカイン発現へのATPの影響2020
- Author(s)
  横田聖司、帖佐直幸、松本識野、客本斎子、加茂政晴、石崎　明
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K19277
[Presentation] 受容体チロシンキナーゼリガンドと炎症性サイトカインは相加的かつERK1/2依存的に顎関節由来線維芽細胞様滑膜細胞の線維組織産生能力を抑制する2019
- Author(s)
  松本識野、横田聖司、帖佐直幸、菊池恵美子、木村仁迪、加茂政晴、佐藤和朗、石崎明
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K19277

1. Ishisaki Akira (20356439)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
2. 帖佐直幸 (80326694)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 入江太朗 (00317570)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Mayama Hisayo (90382639)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. 加茂政晴 (40214564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 藤原尚樹 (20190100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐藤和朗 (60295996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 小松祐子 (90781625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 横田潤 (60733730)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yokota Seiji 横田 聖司

Research Projects

Research Products

Co-Researchers

Development of Next-Generation Bone Regeneration Therapy Using Novel Noncoding RNA to Preserve Mesenchymal Stem Cellularity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of therapy involving tissue regeneration using anti-inflammatory peptide derived from mesenchymal stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

間葉系幹細胞由来細胞外小胞及び内包成分に着目した変形性顎関節症新規原因療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

口腔扁平上皮癌細胞の癌微小環境における細胞外小胞を介した浸潤・転移誘導機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms underlying oral cancer invasion and metastasis promoted by mesenchymal stem cells in tumor microenvironment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of novel therapy against TMJ-OA with application of anti-inflammatory reaction by mesenchymal stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel therapeutic strategy for the temporomandibular joint osteoarthritis focusing on the osteoclast induction mechanism of temporomandibular joint synovial cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Hydrogen peroxide-induced oxidative stress promotes expression of CXCL15/Lungkine mRNA in a MEK/ERK-dependent manner in fibroblast-like synoviocytes derived from mouse temporomandibular joint2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular adenosine 5?-diphosphate promotes MCP-1/CCL2 expression via the P2Y13 purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TGF-β abrogates the LPS-induced activation of the NF-κB-mediated signaling pathway that suppresses osteogenic activity in human mesenchymal stem cells2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Receptor tyrosine kinase ligands and inflammatory cytokines cooperatively suppress the fibrogenic activity in temporomandibular-joint-derived fibroblast-like synoviocytes through mitogen-activated protein kinase kinase/extracellular signal-regulated kinase2020

Author(s)

Journal Title

Data Source

[Journal Article] Adenosine 5′-triphosphate strengthens receptor tyrosine kinase-mediated suppression of fibrogenic activity in fibroblast-like synoviocytes derived from mouse temporomandibular joints possibly through P2Y<sub>2</sub>, P2Y<sub>4</sub>, and P2Y<sub>13</sub> purinergic receptors2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Presentation] 変形性顎関節症の発症における細胞外ヌクレオチドの役割2023

Author(s)

Organizer

Data Source

[Presentation] 変形性顎関節症において発現誘導される炎症性サイトカインの網羅的解析研究2023

Author(s)

Yokota Seiji 横田聖司