Yohsuke Hayama 羽山陽介

Researcher Number	50802964
Affiliation (based on the past Project Information) *help	2020: 国立研究開発法人国立循環器病研究センター, 研究所, 客員研究員 2018 – 2019: 国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 55030:Cardiovascular surgery-related
Keywords	Principal Investigator 成人先天性心疾患 / 心筋成長 / 心筋障害 / 心臓支配神経 / 自律神経 / 拡張障害 / 細胞増殖 / 細胞外分泌小胞 / マクロファージ / 線維化 … More / 炎症 / 血管内皮 / リモデリング / 副交感神経 / 交感神経 Less

Pathogenesis in the mature myocardium following selective manipulation of the innervation of the heart in the larval stagePrincipal Investigator
- Principal Investigator
  
  Yohsuke Hayama
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  National Cardiovascular Center Research Institute

All 2020 2019 2018

All Journal Article Presentation

[Journal Article] Septal Flash-like Motion of the Earlier Activated Ventricular Wall Represents the Pathophysiology of Mechanical Dyssynchrony in Single-Ventricle Anatomy2020
- Author(s)
  Hayama Yohsuke、Miyazaki Aya、Ohuchi Hideo、Miike Hikari、Negishi Jun、Sakaguchi Heima、Kurosaki Kenichi、Shimizu Shuji、Kawada Toru、Sugimachi Masaru
- Journal Title
  
  Journal of the American Society of Echocardiography
  
  Volume: 33 Issue: 5 Pages: 612-621.e2
- DOI
  10.1016/j.echo.2019.11.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408
[Journal Article] Progressive stiffening and relatively slow growth of the dilated ascending aorta in long-term Fontan survivors―Serial assessment for 15 years2020
- Author(s)
  Hayama Yohsuke、Ohuchi Hideo、Negishi Jun、Iwasa Toru、Sakaguchi Heima、Miyazaki Aya、Tsuda Etsuko、Kurosaki Kenichi
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 316 Pages: 87-93
- DOI
  10.1016/j.ijcard.2020.04.071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408
[Journal Article] Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation2020
- Author(s)
  Kawada Toru、Hayama Yohsuke、Nishikawa Takuya、Suehara Satoru、Sawada Satoshi、Tanaka Tetsuo、Uenohara Minako、Sugimachi Masaru
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 70 Issue: 1 Pages: 32-32
- DOI
  10.1186/s12576-020-00759-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408
[Journal Article] Effect of Stiffened and Dilated Ascending Aorta on Aerobic Exercise Capacity in Repaired Patients With Complex Congenital Heart Disease2020
- Author(s)
  Hayama Yohsuke、Ohuchi Hideo、Negishi Jun、Iwasa Toru、Sakaguchi Heima、Miyazaki Aya、Tsuda Etsuko、Kurosaki Kenichi
- Journal Title
  
  The American Journal of Cardiology
  
  Volume: 129 Pages: 87-94
- DOI
  10.1016/j.amjcard.2020.05.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408
[Journal Article] Impact of delayed ventricular wall area ratio on pathophysiology of mechanical dyssynchrony: implication from single-ventricle physiology and 0D modeling2020
- Author(s)
  Hayama Yohsuke、Shimizu Shuji、Kawada Toru、Negishi Jun、Sakaguchi Heima、Miyazaki Aya、Ohuchi Hideo、Yamada Osamu、Kurosaki Kenichi、Sugimachi Masaru
- Journal Title
  
  The Journal of Physiological Sciences
  
  Volume: 70 Issue: 1 Pages: 38-38
- DOI
  10.1186/s12576-020-00765-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09282, KAKENHI-PROJECT-18K16408
[Journal Article] Abnormal glucose metabolism in patients with Fontan circulation: Unique characteristics and associations with Fontan pathophysiology2019
- Author(s)
  Hideo Ohuchi, Jun Negishi, Yohsuke Hayama, Hikari Miike, Dai Suzuki, Kimiko Nakajima, Nao Konagai, Toru Iwasa, Heima Sakaguchi, Kenichi Kurosaki, Michikazu Nakai
- Journal Title
  
  American Heart Journal
  
  Volume: 216 Pages: 125-135
- DOI
  10.1016/j.ahj.2019.07.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408
[Journal Article] Acute effects of intravenous carvedilol versus metoprolol on baroreflex-mediated sympathetic circulatory regulation in rats2019
- Author(s)
  Yamamoto Hiromi、Kawada Toru、Shimizu Shuji、Hayama Yohsuke、Shishido Toshiaki、Iwanaga Yoshitaka、Fukuda Kanji、Miyazaki Shunichi、Sugimachi Masaru
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 285 Pages: 65-71
- DOI
  10.1016/j.ijcard.2019.02.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K10695, KAKENHI-PROJECT-18K16408
[Journal Article] Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat.2019
- Author(s)
  Kawada T, Sonobe T, Hayama Y, Nishikawa T, Miyamoto T, Akiyama T, Pearson JT, Sugimachi M
- Journal Title
  
  Autonomic neuroscience : basic & clinical
  
  Volume: 218 Pages: 25-30
- DOI
  10.1016/j.autneu.2019.02.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408, KAKENHI-PROJECT-19K20690, KAKENHI-PROJECT-17K11604
[Journal Article] Even weak vasoconstriction from rilmenidine can be unmasked in vivo by opening the baroreflex feedback loop.2019
- Author(s)
  Kawada T, Hayama Y, Nishikawa T, Yamamoto H, Tanaka K, Sugimachi M.
- Journal Title
  
  Life Sciences
  
  Volume: 219 Pages: 144-51
- DOI
  10.1016/j.lfs.2019.01.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408, KAKENHI-PROJECT-18K06451
[Journal Article] Contrasting open-loop dynamic characteristics of sympathetic and vagal systems during baroreflex-mediated heart rate control in rats.2019
- Author(s)
  Toru Kawada, Hiromi Yamamoto, Yohsuke Hayama, Takuya Nishikawa, Kunihiko Tanaka, Masaru Sugimachi.
- Journal Title
  
  American Journal of Physiology. Regulatory, Integratory and Comparative Physiology
  
  Volume: 317 Issue: 6 Pages: R879-R890
- DOI
  10.1152/ajpregu.00231.2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408
[Journal Article] Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats.2019
- Author(s)
  Kawada T, Shimizu S, Uemura K, Hayama Y, Yamamoto H, Shishido T, Nishikawa T, Sugimachi M
- Journal Title
  
  The journal of physiological sciences
  
  Volume: 69 Issue: 2 Pages: 211-22
- DOI
  10.1007/s12576-018-0636-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16408
[Journal Article] Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression2019
- Author(s)
  Kamiya Atsunori、Hayama Yohsuke、Kato Shigeki、Shimomura Akihiko、Shimomura Takushi、Irie Katsumasa、Kaneko Ryosuke、Yanagawa Yuchio、Kobayashi Kazuto、Ochiya Takahiro
- Journal Title
  
  Nature Neuroscience
  
  Volume: 22 Issue: 8 Pages: 1289-1305
- DOI
  10.1038/s41593-019-0430-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22474, KAKENHI-PROJECT-18K16408, KAKENHI-PUBLICLY-18H04707, KAKENHI-PUBLICLY-19H04895, KAKENHI-PROJECT-15H05791, KAKENHI-PROJECT-17H04365, KAKENHI-PROJECT-18K19950, KAKENHI-PROJECT-17K17795, KAKENHI-PROJECT-15KK0331
[Journal Article] Intravenous ivabradine augments the dynamic heart rate response to moderate vagal nerve stimulation in anesthetized rats.2019
- Author(s)
  Kawada T, Yamamoto H, Uemura K, Hayama Y, Nishikawa T, Sugimachi M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 317 Issue: 3 Pages: H597-H606
- DOI
  10.1152/ajpheart.00288.2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K12126, KAKENHI-PROJECT-18K16408
[Journal Article] Mild hypothermia is ineffective to protect against myocardial injury induced by chemical anoxia or forced calcium overload.2019
- Author(s)
  Kawada T, Yamazaki T, Akiyama T, Hayama Y, Sugimachi M
- Journal Title
  
  Journal of Cardiovascular Pharmacology
  
  Volume: 73 Issue: 2 Pages: 100-104
- DOI
  10.1097/fjc.0000000000000639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11604, KAKENHI-PROJECT-18K16408
[Presentation] Rebound Stretch Motion of the Earlier Activated Wall Represents the Pathophysiology of Mechanical Dyssynchrony in Single- Ventricle Anatomy2020
- Author(s)
  羽山陽介, 清水秀二, 川田徹, 三池虹, 坂口平馬, 宮﨑文, 大内秀雄, 黒嵜健一, 杉町勝
- Organizer
  第56回日本小児循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16408
[Presentation] Ventricular Morphology as Well as Conduction Delay Plays a Key Role in the Pathogenesis of Mechanical Dyssynchrony of Univentricular Heart2019
- Author(s)
  Yohsuke Hayama, Shuji Shimizu, Toru Kawada, Masaru Sugimachi
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16408
[Presentation] 心室域による拡張能の差がFontan術後単心室における機械的非同期の病態形成に重要である－シミュレーションによる考察2018
- Author(s)
  羽山陽介, 清水秀二, 川田徹, 杉町勝
- Organizer
  The 45th Annual Meeting of Japanese Society of Pediatric Cardiology and Cardiac Surgery
- Data Source
  KAKENHI-PROJECT-18K16408

1. AKIYAMA Tsuyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 山本裕美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 川田徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 小林和人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 上村和紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 清水秀二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yohsuke Hayama 羽山 陽介

Research Projects

Research Products

Co-Researchers

Pathogenesis in the mature myocardium following selective manipulation of the innervation of the heart in the larval stagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Septal Flash-like Motion of the Earlier Activated Ventricular Wall Represents the Pathophysiology of Mechanical Dyssynchrony in Single-Ventricle Anatomy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Progressive stiffening and relatively slow growth of the dilated ascending aorta in long-term Fontan survivors―Serial assessment for 15 years2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of Stiffened and Dilated Ascending Aorta on Aerobic Exercise Capacity in Repaired Patients With Complex Congenital Heart Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of delayed ventricular wall area ratio on pathophysiology of mechanical dyssynchrony: implication from single-ventricle physiology and 0D modeling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal glucose metabolism in patients with Fontan circulation: Unique characteristics and associations with Fontan pathophysiology2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acute effects of intravenous carvedilol versus metoprolol on baroreflex-mediated sympathetic circulatory regulation in rats2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Even weak vasoconstriction from rilmenidine can be unmasked in vivo by opening the baroreflex feedback loop.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contrasting open-loop dynamic characteristics of sympathetic and vagal systems during baroreflex-mediated heart rate control in rats.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intravenous ivabradine augments the dynamic heart rate response to moderate vagal nerve stimulation in anesthetized rats.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mild hypothermia is ineffective to protect against myocardial injury induced by chemical anoxia or forced calcium overload.2019

Author(s)

Journal Title

DOI

Data Source

Yohsuke Hayama 羽山陽介

[Presentation] 心室域による拡張能の差がFontan術後単心室における機械的非同期の病態形成に重要である－シミュレーションによる考察2018