Haraguchi Hirofumi 原口広史

Researcher Number	50804506
Affiliation (based on the past Project Information) *help	2019 – 2022: 東京大学, 医学部附属病院, 届出研究員 2017 – 2019: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Basic Section 42040:Laboratory animal science-related
Keywords	Principal Investigator MDM2 / SF1 / 性腺 / 転写因子 / マウスモデル / 卵丘膨化 / 顆粒膜細胞 / TNFα / プロゲステロン / 胚浸潤 … More / 胚着床 / ネクロトーシス / 子宮内膜管腔上皮 / 細胞増殖抑制 / 網膜芽細胞腫蛋白 / 卵子成熟 / 排卵 / 卵巣 / SF1/Ad4BP / Mdm2 / p53 / エピゲノム / 妊娠・着床 … More Except Principal Investigator RB遺伝子 / 管腔上皮 / 胚接着 / マウスモデル / LIF / ネクロプトーシス / RB / 細胞増殖 / ポリコーム複合体 / ヒストン修飾 / 細胞外基質 / TNFα / プロゲステロン / ネクロトーシス / 細胞周期 / 着床 / 胚浸潤 / 子宮内膜上皮 / 網膜芽細胞腫遺伝子 / STAT3 / プロゲステロン受容体 / 細胞増殖能 / 子宮内膜 / 胚着床 Less

p53 regulates sexual functions through SF1/Ad4BPPrincipal Investigator
- Principal Investigator
  
  Haraguchi Hirofumi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  The University of Tokyo
Roles of cell proliferation and differentiation in the acquisition of uterine receptivity
- Principal Investigator
  
  Hirota Yasushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  The University of Tokyo
Analysis of the interaction between embryo and uterus during the preimplantation period based on epigenomePrincipal Investigator
- Principal Investigator
  
  Haraguchi Hirofumi
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  The University of Tokyo

All 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion2021
- Author(s)
  Akaeda Shun、Hirota Yasushi、Fukui Yamato、Aikawa Shizu、Shimizu‐Hirota Ryoko、Kaku Tetsuaki、Gebril Mona、Hirata Tomoyuki、Hiraoka Takehiro、Matsuo Mitsunori、Haraguchi Hirofumi、Saito‐Kanatani Mayuko、Takeda Norihiko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 2
- DOI
  10.15252/embr.202050927
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-19K18630, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] National survey of primary amenorrhea and relevant conditions in Japan2021
- Author(s)
  Haraguchi H, Harada M, Kashimada K, Horikawa R, Sakakibara H, Shozu M, Fujii T, Osuga Y, Kugu K.
- Journal Title
  
  J Obstet Gynaecol Res.
  
  Volume: 47 Issue: 2 Pages: 774-777
- DOI
  10.1111/jog.14606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09749, KAKENHI-PROJECT-19K18631
[Journal Article] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment2020
- Author(s)
  Hiraoka Takehiro、Hirota Yasushi、Fukui Yamato、Gebril Mona、Kaku Tetsuaki、Aikawa Shizu、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Shimizu-Hirota Ryoko、Takeda Norihiko、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 15523-15523
- DOI
  10.1038/s41598-020-72640-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09823, KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-20J11585, KAKENHI-PROJECT-19K18630, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-20K22732, KAKENHI-PROJECT-19H03144
[Journal Article] 子宮粘膜下筋腫に対しGnRHアンタゴニストを使用して多量出血をきたした1例2020
- Author(s)
  石沢千尋, 浦田陽子, 真壁友子, 原口広史, 矢野倫子, 松尾光徳, 宮下真理子, 金谷真由子, 森嶋かほる, 廣田泰, 大須賀穣, 藤井知行
- Journal Title
  
  東京産科婦人科学会会誌
  
  Volume: 69 Pages: 23-28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18631
[Journal Article] 月経随伴症状を有する子宮腺筋症に対する子宮腺筋症病巣除去術の効果2019
- Author(s)
  賀来哲明, 廣田泰, 福井大和, 大村恵里香, 赤枝俊, 平岡毅大, 松尾光徳, 原口広史, 大須賀穣, 藤井知行
- Journal Title
  
  産科と婦人科
  
  Volume: 86 Pages: 767-771
- NAID
  40021920270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18631
[Journal Article] Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality2019
- Author(s)
  Haraguchi Hirofumi、Hirota Yasushi、Saito-Fujita Tomoko、Tanaka Tomoki、Shimizu-Hirota Ryoko、Harada Miyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Matsumoto Leona、Hirata Tetsuya、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  The FASEB Journal
  
  Volume: 33 Issue: 2 Pages: 2610-2620
- DOI
  10.1096/fj.201801401r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-18K19600, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-17J05930, KAKENHI-PROJECT-18K09284, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-19H03144
[Journal Article] Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor2019
- Author(s)
  Matsuo Mitsunori、Hirota Yasushi、Fukui Yamato、Fujita Hidetoshi、Saito-Fujita Tomoko、Kaku Tetsuaki、Gebril Mona、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Tanaka Tomoki、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Shimizu-Hirota Ryoko、Takeda Norihiko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Endocrinology
  
  Volume: 161 Issue: 2
- DOI
  10.1210/endocr/bqz005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16022, KAKENHI-PROJECT-19K18631, KAKENHI-PROJECT-18K19601, KAKENHI-PROJECT-19H03796, KAKENHI-PROJECT-19K18630
[Journal Article] Reports of the 2019 ACOG Annual Clinical and Scientific Meeting in Nashville, Tennessee2019
- Author(s)
  Haraguchi H, Imamura Y, Kokabu T, Hasegawa-Minato J, Kobayashi M, Nagayasu Y, Sekine M, Yanaihara N.
- Journal Title
  
  J Obstet Gynaecol Res
  
  Volume: 46 Issue: 1 Pages: 5-8
- DOI
  10.1111/jog.14127
- Open Access
- Data Source
  KAKENHI-PROJECT-19K18631
[Journal Article] 【子宮頸部の生理と病理】子宮頸部の生理　子宮頸部の周期的変化2019
- Author(s)
  原口広史、廣田泰
- Journal Title
  
  HORMONE FRONTIER IN GYNECOLOGY
  
  Volume: 26 Pages: 17-20
- Data Source
  KAKENHI-PROJECT-19K18631
[Journal Article] 腹腔鏡下子宮筋腫核出術の安全性を担保するための最適な筋腫個数に関する検討2019
- Author(s)
  森嶋かほる, 原口広史, 高村将司, 金谷真由子, 平野茉来, 秋山育美, 能瀬さやか, 原田美由紀, 平田哲也, 廣田泰, 甲賀かをり, 平池修, 大須賀穣, 藤井知行
- Journal Title
  
  臨床婦人科産科
  
  Volume: 73 Pages: 701-704
- NAID
  40021968534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18631
[Journal Article] 腹腔鏡手術術後ドレーン抜去時に発生した卵管ポートサイトヘルニアの一例2019
- Author(s)
  松尾光徳, 高村将司, 長嶋菜月, 原口広史, 原田美由紀, 甲賀かをり, 藤井知行, 大須賀穣
- Journal Title
  
  日本産科婦人科内視鏡学会雑誌
  
  Volume: 35 Pages: 299-303
- NAID
  130007783296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18631
[Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018
- Author(s)
  Matsumoto Leona、Hirota Yasushi、Saito-Fujita Tomoko、Takeda Norihiko、Tanaka Tomoki、Hiraoka Takehiro、Akaeda Shun、Fujita Hidetoshi、Shimizu-Hirota Ryoko、Igaue Shota、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Fujii Tomoyuki、Osuga Yutaka
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 128 Issue: 7 Pages: 3186-3197
- DOI
  10.1172/jci98931
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-18K19600, KAKENHI-PROJECT-18K19601, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-17J05930, KAKENHI-PROJECT-18K09284, KAKENHI-PROJECT-17K16833, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-16K09493
[Journal Article] F4/80+ macrophages contribute to clearance of senescent cells in the mouse postpartum uterus.2017
- Author(s)
  Egashira M, Hirota Y, Shimizu-Hirota R, Saito-Fujita T, Haraguchi H, Matsumoto L, Matsuo M, Hiraoka T, Tanaka T, Akaeda S, Takehisa C, Saito-Kanatani M, Maeda K, Fujii T, Osuga Y.
- Journal Title
  
  Endocrinology
  
  Volume: 印刷中 Issue: 7 Pages: 2344-2353
- DOI
  10.1210/en.2016-1886
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K15701, KAKENHI-PROJECT-16K10668, KAKENHI-PROJECT-17K16833, KAKENHI-PROJECT-16H04679, KAKENHI-PROJECT-16H05469, KAKENHI-PROJECT-17H06640, KAKENHI-PROJECT-15J40160, KAKENHI-PROJECT-15K10660, KAKENHI-PROJECT-16K15700, KAKENHI-PROJECT-16H06279
[Presentation] Levonorgestrel Inhibits Embryo Implantation by Downregulation of Uterine LIF Expression2018
- Author(s)
  Mitsunori Matsuo, Yasushi Hirota, Tomoko Saito-Fujita, Hirofumi Haraguchi, Shota Igaue, Leona Matsumoto, Takehiro Hiraoka, Shun Akaeda, Tomoki Tanaka, Tomoyuki Fujii, Yutaka Osuga. 
- Organizer
  Society for Reproductive Investigation, 65th Annual Scientific Meeting, Endometrium Satellite Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06640
[Presentation] Mdm2-p53 axis is a key machinery of ovulation.2018
- Author(s)
  原口広史廣田泰藤田知子松本玲央奈松尾光徳平岡毅大赤枝俊田中智基大須賀穣藤井知行
- Organizer
  第70回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17H06640
[Presentation] Mdm2-p53 axis is a key machinery of ovulation.2018
- Author(s)
  原口広史，廣田泰，藤田知子，松本玲央奈，松尾光徳，平岡毅大，赤枝俊，田中智基，大須賀穣，藤井知行
- Organizer
  第70回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17H06640
[Presentation] 卵巣のMouse double minute 2 homolog（Mdm2）欠損による過剰なp53はsteroidogenic factor 1（SF1）を誘導し排卵障害を引き起こす2017
- Author(s)
  原口広史廣田泰藤田知子松本玲央奈松尾光徳平岡毅大赤枝俊田中智基大須賀穣藤井知行
- Organizer
  第62回日本生殖医学会学術講演会
- Data Source
  KAKENHI-PROJECT-17H06640
[Presentation] DNA methylation and its transcriptional regulation of pre-implantation mouse blastocyst in the process of blastocyst activation2017
- Author(s)
  平塚大輝廣田泰原口広史藤田知子松本玲央奈松尾光徳平岡毅大赤枝俊田中智基大須賀穣藤井知行
- Organizer
  第69回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17H06640
[Presentation] Global gene expression profile in the luminal epithelium of the mouse uterus during embryo attachment.2017
- Author(s)
  伊賀上翔太廣田泰藤田知子原口広史松本玲於奈松尾光徳平岡毅大田中智基赤枝俊大須賀穣藤井知行
- Organizer
  第69回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17H06640
[Presentation] Tumor suppressor p53 impairs cumulus cell-oocyte complex expansion and ovulation2017
- Author(s)
  原口広史廣田泰藤田知子松本玲央奈松尾光徳平岡毅大赤枝俊田中智基大須賀穣藤井知行
- Organizer
  第69回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-17H06640

1. Hirota Yasushi (40598653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 清水良子 (30348643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 金谷真由子 (60748862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松尾光徳 (00823618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. HARADA Miyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 平岡毅大

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 吉野修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 齊藤知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Haraguchi Hirofumi 原口 広史

Research Projects

Research Products

Co-Researchers

p53 regulates sexual functions through SF1/Ad4BPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Roles of cell proliferation and differentiation in the acquisition of uterine receptivity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the interaction between embryo and uterus during the preimplantation period based on epigenomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] National survey of primary amenorrhea and relevant conditions in Japan2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 子宮粘膜下筋腫に対しGnRHアンタゴニストを使用して多量出血をきたした1例2020

Author(s)

Journal Title

Data Source

[Journal Article] 月経随伴症状を有する子宮腺筋症に対する子宮腺筋症病巣除去術の効果2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reports of the 2019 ACOG Annual Clinical and Scientific Meeting in Nashville, Tennessee2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【子宮頸部の生理と病理】子宮頸部の生理 子宮頸部の周期的変化2019

Author(s)

Journal Title

Data Source

[Journal Article] 腹腔鏡下子宮筋腫核出術の安全性を担保するための最適な筋腫個数に関する検討2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] 腹腔鏡手術術後ドレーン抜去時に発生した卵管ポートサイトヘルニアの一例2019

Author(s)

Journal Title

NAID

Data Source

[Journal Article] HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment2018

Author(s)

Journal Title

DOI

Data Source

Haraguchi Hirofumi 原口広史

[Journal Article] 【子宮頸部の生理と病理】子宮頸部の生理　子宮頸部の周期的変化2019