Otake Shimon 大竹志門

Researcher Number	50813060
Other IDs
Affiliation (Current)	2025: 日本大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 日本大学, 医学部, 助教 2022 – 2023: 日本大学, 医学部, 助教 2022: 山梨大学, 大学院総合研究部, 助教 2021: 山梨大学, 大学院総合研究部, 医学研究員 2018 – 2020: 山梨大学, 大学院総合研究部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 血小板 / Podoplanin / ポドプラニン / CLEC-2 / 類洞内皮細胞 / 肝類洞閉塞症候群 / 赤芽球造血 / 骨髄微小環境 / 巨核球 / 骨髄間質細胞 / 赤血球造血 … More Except Principal Investigator … More 抗体医薬 / 血小板 / CLEC-2 Less

肝類洞閉塞症候群モデルを用いた，肝類洞内皮下血栓形成メカニズムの解明Principal Investigator
- Principal Investigator
  
  大竹志門
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nihon University
Role of the platelet-activated receptor CLEC-2 in hepatic sinusoidal obstruction syndromePrincipal Investigator
- Principal Investigator
  
  OTAKE Shimon
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Nihon University
  University of Yamanashi
Development of antibody drugs targeting platelet activating receptor CLEC-2 and elucidation of the pharmacological actions
- Principal Investigator
  
  Sasaki Tomoyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi
Essential role of platelet-expressed C-type lectin-like receptor 2 (CLEC-2) in erythropoiesisPrincipal Investigator
- Principal Investigator
  
  Otake Shimon
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Yamanashi

All 2023 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ2021
- Author(s)
  S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, H. Shinmori, T. Inukai, T. Kondo, K. Suzuki-Inoue
- Journal Title
  
  blood advances
  
  Volume: 5 Issue: 7 Pages: 2017-2026
- DOI
  10.1182/bloodadvances.2020001698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K04724, KAKENHI-PROJECT-19K16554, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-20K08729, KAKENHI-PROJECT-21K04674, KAKENHI-PROJECT-21K06883
[Journal Article] CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice2021
- Author(s)
  Shimon Otake, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Shogo Tamura, Katsuhiro Takano, Yukio Ozaki, Katsue Suzuki-Inoue
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: - Issue: 6 Pages: 1572-1584
- DOI
  10.1111/jth.15317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05073, KAKENHI-PROJECT-18K16080, KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-20K08729
[Journal Article] Crosstalk between hemostasis and lymphangiogenesis2020
- Author(s)
  Suzuki‐Inoue Katsue、Tsukiji Nagaharu、Otake Shimon
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 18 Issue: 4 Pages: 767-770
- DOI
  10.1111/jth.14726
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08834, KAKENHI-PROJECT-18K06912, KAKENHI-PROJECT-18K16080
[Presentation] Measuring CD8-Positive T-Cells in the Tumor Microenvironment in Classical Hodgkin Lymphoma Using Multiplex Immunofluorescence Staining and Image Analysis: A Possible Prognostic Factor2023
- Author(s)
  Hiromichi Takahashi, Shun Ito, Yoko Nakanishi, Katsuhiro Miura, Masaru Nakagawa, Shimon Otake, Takashi Hamada, Takashi Koike, Kazuhide Iizuka, Yuichi Takeuchi, Kazuya Kurihara, Toshihide Endo, Hironao Nukariya, Yoshihiro Hatta, Shinobu Masuda, Hideki Nakamura
- Organizer
  American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16266
[Presentation] 自家移植適応マントル細胞リンパ腫におけるベンダムスチンを含む強化化学療法（R- B/R-Cレジメン）2023
- Author(s)
  伊藤駿、高橋宏通、中川優、三浦勝浩、大竹志門、濱田高志、小池隆、栗原一也、遠藤聖英、忽滑谷寛直、飯塚和秀、一戸崇、中村英樹
- Organizer
  日本造血免疫細胞療法学会
- Data Source
  KAKENHI-PROJECT-21K16266
[Presentation] CLEC-2はPDPN発現間質細胞からのIGF-1分泌を促進し、赤血球造血を正に制御する2021
- Author(s)
  大竹志門, 佐々木知幸, 白井俊光, 築地長治, 高野勝弘, 田村彰吾, 尾崎由基男, 井上克枝
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] CLEC-2 promotes IGF-1 secretion from PDPN+ stromal cells and positively regulates erythropoiesis2021
- Author(s)
  Shimon Otake, Tomoyuki Sasaki, Toshiaki Shirai, Nagaharu Tsukiji, Katsuhiro Takano, Shogo Tamura, Yukio Ozaki, Katsue Suzuki-Inoue
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-21K16266
[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割2021
- Author(s)
  大石沙織，築地長治、大竹志門、大石直輝、佐々木知幸、白井俊光、吉河佑莉、髙野勝弘、新森英之、犬飼岳史、近藤哲夫、井上克枝
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割2020
- Author(s)
  大竹志門，白井俊光，築地長治，佐々木知幸，田村彰吾，高野勝弘，尾崎由基男，井上克枝
- Organizer
  日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割2020
- Author(s)
  大竹志門, 白井俊光, 築地長治, 佐々木知幸, 田村彰吾, 高野勝弘, 尾崎由基男, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPⅥの役割2020
- Author(s)
  大石沙織，築地長治，大竹志門，大石直輝，佐々木知幸，白井俊光，吉河佑莉，高野勝弘，近藤哲夫，井上克枝
- Organizer
  日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] Heme Activates Platelets and Exacerbates Rhabdomyolysis-Induced Acute Kidney Injury via CLEC-2 and GPVI/FcRγ2020
- Author(s)
  S. Oishi, N. Tsukiji, S. Otake, N. Oishi, T. Sasaki, T. Shirai, Y. Yoshikawa, K. Takano, T. Kondo, K. Suzuki-Inoue
- Organizer
  ISTH 2020 Congress(2020.07.12)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] CLEC-2 stimulates IGF-1 secretion from PDPN+ stromal cells and positively regulated erythropoiesis2020
- Author(s)
  大竹志門，白井俊光，築地長治，佐々木知幸，高野勝弘，田村彰吾，尾崎由基男，井上克枝
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] 血小板受容体CLEC-2による関節リウマチの病態形成への関与2020
- Author(s)
  佐々木知幸，白井俊光，築地長治，小山賢介，田村彰吾，大竹志門，高野勝弘，長田誠，佐藤金夫，波呂浩考，尾崎由基男，井上克枝
- Organizer
  日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2およびGPVIの役割2020
- Author(s)
  大石沙織, 築地長治, 大竹志門, 大石直輝, 佐々木知幸, 白井俊光, 吉河佑莉, 高野勝弘, 近藤哲夫, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 血小板・巨核球上CLEC-2の，SOSマウスモデルにおける新規役割2020
- Author(s)
  大竹志門，白井俊光，築地長治，佐々木知幸，高野勝弘，尾崎由基男，井上克枝
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] 血小板受容体CLEC-2による関節リウマチの病態形成への関与2020
- Author(s)
  佐々木知幸, 白井俊光, 築地長治, 小山賢介, 田村彰吾, 大竹志門, 高野勝弘, 長田誠, 佐藤金夫, 波呂浩孝, 尾崎由基男, 井上克枝
- Organizer
  第42回日本血栓止血学会学術集会(2020.06.18)
- Data Source
  KAKENHI-PROJECT-20K08729
[Presentation] 血小板・巨核球上のC型レクチン様受容体（CLEC-2）が、赤血球造血に及ぼす役割2019
- Author(s)
  大竹志門, 白井俊光, 築地長治, 佐々木知幸, 田村彰吾, 尾崎由基男, 井上克枝
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] ヘム惹起血小板凝集及び横紋筋融解誘導性急性腎障害における血小板CLEC-2の関与2019
- Author(s)
  築地長治, 大竹志門, 佐々木知幸, 吉河佑莉, 高野勝弘, 井上克枝
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] Platelet C-type Lectin-Like Receptor 2 (CLEC-2) is Required for Optimal Regulation of Erythropoiesis2019
- Author(s)
  S. Otake, T. Shirai, N. Tsukiji, T. Sasaki, K. Satoh, S. Tamura, K. Takano, Y. Ozaki, K. Suzuki-Inoue
- Organizer
  27th International Society on Thrombosis and Haemostasis (ISTH)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] Heme Induces Platelet Aggregation via Two ITAM Receptors: Implications in Rhabdomyolysis-Induced Acute Kidney Injury2019
- Author(s)
  N. Tsukiji, S. Oishi, S. Otake, T. Sasaki, K. Takano, K. Suzuki-Inoue
- Organizer
  27th International Society on Thrombosis and Haemostasis (ISTH)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] 血小板・巨核球上のC型レクチン様受容体（CLEC-2)が、赤芽球の分化、成熟に及ぼす影響2018
- Author(s)
  大竹志門
- Organizer
  日本血栓止血学会
- Data Source
  KAKENHI-PROJECT-18K16080
[Presentation] Essential role of platelet-expressed C-type lectin-like receptor 2 (CLEC-2) in erythropoiesis2018
- Author(s)
  大竹志門
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-18K16080

1. Sasaki Tomoyuki (40739124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. 井上克枝 (10324211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. 築地長治 (20710362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. 白井俊光 (50710381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. 新森英之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 田村彰吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Otake Shimon 大竹 志門

Research Projects

Research Products

Co-Researchers

肝類洞閉塞症候群モデルを用いた，肝類洞内皮下血栓形成メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of the platelet-activated receptor CLEC-2 in hepatic sinusoidal obstruction syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of antibody drugs targeting platelet activating receptor CLEC-2 and elucidation of the pharmacological actions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Essential role of platelet-expressed C-type lectin-like receptor 2 (CLEC-2) in erythropoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Heme activates platelets and exacerbates rhabdomyolysis-induced acute kidney injury via CLEC-2 and GPVI/FcRγ2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CLEC-2 stimulates IGF-1 secretion from podoplanin-positive stromal cells and positively regulates erythropoiesis in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crosstalk between hemostasis and lymphangiogenesis2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Measuring CD8-Positive T-Cells in the Tumor Microenvironment in Classical Hodgkin Lymphoma Using Multiplex Immunofluorescence Staining and Image Analysis: A Possible Prognostic Factor2023

Author(s)

Organizer

Data Source

[Presentation] 自家移植適応マントル細胞リンパ腫におけるベンダムスチンを含む強化化学療法（R- B/R-Cレジメン）2023

Author(s)

Organizer

Data Source

[Presentation] CLEC-2はPDPN発現間質細胞からのIGF-1分泌を促進し、赤血球造血を正に制御する2021

Author(s)

Organizer

Data Source

[Presentation] CLEC-2 promotes IGF-1 secretion from PDPN+ stromal cells and positively regulates erythropoiesis2021

Author(s)

Organizer

Data Source

[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPVIの役割2021

Author(s)

Organizer

Data Source

[Presentation] 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割2020

Author(s)

Organizer

Data Source

[Presentation] 巨核球・血小板上C-type lectin-like receptor 2 (CLEC-2)の赤血球造血における役割2020

Author(s)

Organizer

Data Source

[Presentation] 横紋筋融解症に併発する腎障害における血小板CLEC-2及びGPⅥの役割2020

Author(s)

Organizer

Data Source

[Presentation] Heme Activates Platelets and Exacerbates Rhabdomyolysis-Induced Acute Kidney Injury via CLEC-2 and GPVI/FcRγ2020

Author(s)

Organizer

Data Source

[Presentation] CLEC-2 stimulates IGF-1 secretion from PDPN+ stromal cells and positively regulated erythropoiesis2020

Otake Shimon 大竹志門