Yoshino Ryunosuke 吉野龍ノ介

Researcher Number	50817575
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 筑波大学, 医学医療系, 助教 2018 – 2019: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator Basic Section 62010:Life, health and medical informatics-related Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 62010:Life, health and medical informatics-related
Keywords	Principal Investigator 分子設計 / 作用機序解析 / 分子動力学計算 / リンカー設計 / 構造探索 / 三者複合体 / PROTAC / 分子動力学方 / ケモインフォマティクス / in silico創薬 / IT創薬 / ファーマコフォアモデリング / フラグメント分子軌道法 … More Except Principal Investigator … More 分子標的治療 / キナーゼ / ゲノム解析 / ゲノム / 標的タンパク質選抜 / 創薬支援計算 / 分子設計 / 環状ペプチド / 共溶媒分子動力学 Less

Detection of oncodomains using mutation accumulation as an Indicator
- Principal Investigator
  
  中奥敬史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  National Cancer Center Japan
Designing cyclic peptide with target protein selection based on mixed-solvent molecular dynamics simulation
- Principal Investigator
  
  柳澤渓甫
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Institute of Science Tokyo
Development of linker design method for PROTAC based on ternary complex structure predictionPrincipal Investigator
- Principal Investigator
  
  吉野龍ノ介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  University of Tsukuba
Pharmacophore modeling using interaction analysis information by Fragment Molecular Orbital methodPrincipal Investigator
- Principal Investigator
  
  Yoshino Ryunosuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  University of Tsukuba

All 2024 2023 2019 2018

All Journal Article Presentation

[Journal Article] AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics2024
- Author(s)
  Genki Kudo, Keisuke Yanagisawa, Ryunosuke Yoshino, and Takatsugu Hirokawa
- Journal Title
  
  Journal of Chemical Information and Modeling
  
  Volume: 63(24) Issue: 24 Pages: 7768-7777
- DOI
  10.1021/acs.jcim.3c01677
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24939, KAKENHI-PROJECT-23K28185
[Journal Article] Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil2019
- Author(s)
  Yoshino Ryunosuke、Yasuo Nobuaki、Sekijima Masakazu
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 17464-17464
- DOI
  10.1038/s41598-019-53945-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18150
[Journal Article] A prospective compound screening contest identified broader inhibitors for Sirtuin 12019
- Author(s)
  Chiba Shuntaro et al.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 19585-19585
- DOI
  10.1038/s41598-019-55069-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01814, KAKENHI-PROJECT-19H03166, KAKENHI-PROJECT-16K07315, KAKENHI-PROJECT-18K18150
[Journal Article] Temperature-pressure shuffling outlier flooding method enhances the conformational sampling of proteins2019
- Author(s)
  Harada Ryuhei、Yoshino Ryunosuke、Nishizawa Hiroaki、Shigeta Yasuteru
- Journal Title
  
  Journal of Computational Chemistry
  
  Volume: 40 Issue: 15 Pages: 1530-1537
- DOI
  10.1002/jcc.25806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18150, KAKENHI-PROJECT-16H06164
[Journal Article] Parallel cascade selection molecular dynamics to screen for protein complexes generated by rigid docking2019
- Author(s)
  Harada Ryuhei、Yoshino Ryunosuke、Nishizawa Hiroaki、Shigeta Yasuteru
- Journal Title
  
  Journal of Molecular Graphics and Modelling
  
  Volume: 92 Pages: 94-99
- DOI
  10.1016/j.jmgm.2019.07.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18150
[Journal Article] Compound property enhancement by virtual compound synthesis2018
- Author(s)
  Arai Naoki、Yoshikawa Shunsuke、Yasuo Nobuaki、Yoshino Ryunosuke、Sekijima Masakazu
- Journal Title
  
  Journal of Bioinformatics and Computational Biology
  
  Volume: 16 Issue: 03 Pages: 1840016-1840016
- DOI
  10.1142/s0219720018400164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18150, KAKENHI-PROJECT-15H02776, KAKENHI-PROJECT-16J09021
[Presentation] バーチャルスクリーニングモデル作成のためのParallel Cascade Selection Molecular Dynamicsの応用2023
- Author(s)
  平尾巧、工藤玄己、吉野龍ノ介、広川貴次
- Organizer
  第51回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-23K16987
[Presentation] Comprehensive structual analysis of PROTAC mediated ternary complexes using enhanced conformational sampling methods2023
- Author(s)
  工藤玄己、平尾巧、広川貴次、吉野龍ノ介
- Organizer
  情報計算化学生物学会（CBI学会）
- Data Source
  KAKENHI-PROJECT-23K16987
[Presentation] 拡張アンサンブル法を用いたPROTACリンカー設計のための三元複合体構造探索2023
- Author(s)
  吉野龍ノ介、工藤玄己、平尾巧、広川貴次
- Organizer
  第51回構造活性相関シンポジウム
- Data Source
  KAKENHI-PROJECT-23K16987
[Presentation] Conformation Search of Ternary Complexes for Rational PROTAC Linker Design Using Enhanced Sampling Method2023
- Author(s)
  吉野龍ノ介、工藤玄己、平尾巧、広川貴次
- Organizer
  情報計算化学生物学会（CBI学会）
- Data Source
  KAKENHI-PROJECT-23K16987
[Presentation] Quantitative Evaluation of Protein-Chemical Substructure Interaction with Inverse Mixed-Solvent Molecular Dynamics Simulation2023
- Author(s)
  Keisuke Yanagisawa, Ryunosuke Yoshino, Genki Kudo, Takatsugu Hirokawa
- Organizer
  第61回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K28185
[Presentation] Application of Parallel Cascade Selection Molecular Dynamics for generating virtual screening models2023
- Author(s)
  平尾巧、工藤玄己、吉野龍ノ介、広川貴次
- Organizer
  情報計算化学生物学会（CBI学会）
- Data Source
  KAKENHI-PROJECT-23K16987
[Presentation] Quantitative Estimation of Protein-Chemical Substructure Interaction with Inverse Mixed-Solvent Molecular Dynamics Simulation2023
- Author(s)
  Keisuke Yanagisawa, Ryunosuke Yoshino, Genki Kudo, Takatsugu Hirokawa
- Organizer
  CBI学会2023年大会
- Data Source
  KAKENHI-PROJECT-23K28185
[Presentation] Investigation of drug resistance acquisition mechanism of influenza cap-dependent endonuclease against Baloxavir marboxil by molecular dynamics simulation2019
- Author(s)
  Yoshino Ryunosuke、Yasuo Nobuaki、Sekijima Masakazu
- Organizer
  The Chem-Bio Informatics Society
- Data Source
  KAKENHI-PROJECT-18K18150
[Presentation] 分子動力学シミュレーションを用いた標的タンパク質の分子認識機構の解明2019
- Author(s)
  Yoshino Ryunosuke
- Organizer
  計算メディカルサイエンス事業部発足キックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K18150
[Presentation] キャップ依存性エンドヌクレアーゼの薬剤耐性メカニズムの解明2019
- Author(s)
  Yoshino Ryunosuke、Yasuo Nobuaki、Sekijima Masakazu
- Organizer
  第46回生体分子科学討論会
- Data Source
  KAKENHI-PROJECT-18K18150
[Presentation] Discovery of a novel inhibitor of spermidine synthase for Chagas' disease by molecular dynamics and docking simulation2018
- Author(s)
  Yoshino Ryunosuke、Yasuo Nobuaki、Hagiwara Yohsuke、Ishida Takashi、Inaoka Ken Daniel、Amano Yasushi、Tateishi Yukihiro、Ohno Kazuki、Namatame Ichiji、Niimi Tatsuya、Orita Masaya、Kita Kiyoshi、Akiyama Yutaka、Sekijima Masakazu
- Organizer
  Asia Hub for e-Drug Discovery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18150

1. 柳澤渓甫 (40866646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 和久井直樹 (80786038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中奥敬史 (20779491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Yoshino Ryunosuke 吉野 龍ノ介

Research Projects

Research Products

Co-Researchers

Detection of oncodomains using mutation accumulation as an Indicator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Designing cyclic peptide with target protein selection based on mixed-solvent molecular dynamics simulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of linker design method for PROTAC based on ternary complex structure predictionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pharmacophore modeling using interaction analysis information by Fragment Molecular Orbital methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A prospective compound screening contest identified broader inhibitors for Sirtuin 12019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Temperature-pressure shuffling outlier flooding method enhances the conformational sampling of proteins2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Parallel cascade selection molecular dynamics to screen for protein complexes generated by rigid docking2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Compound property enhancement by virtual compound synthesis2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] バーチャルスクリーニングモデル作成のためのParallel Cascade Selection Molecular Dynamicsの応用2023

Author(s)

Organizer

Data Source

[Presentation] Comprehensive structual analysis of PROTAC mediated ternary complexes using enhanced conformational sampling methods2023

Author(s)

Organizer

Data Source

[Presentation] 拡張アンサンブル法を用いたPROTACリンカー設計のための三元複合体構造探索2023

Author(s)

Organizer

Data Source

[Presentation] Conformation Search of Ternary Complexes for Rational PROTAC Linker Design Using Enhanced Sampling Method2023

Author(s)

Organizer

Data Source

[Presentation] Quantitative Evaluation of Protein-Chemical Substructure Interaction with Inverse Mixed-Solvent Molecular Dynamics Simulation2023

Author(s)

Organizer

Data Source

[Presentation] Application of Parallel Cascade Selection Molecular Dynamics for generating virtual screening models2023

Author(s)

Yoshino Ryunosuke 吉野龍ノ介