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FUJIHASHI KOHTARO  藤橋 浩太郎

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Fujihashi Kohtaro  藤橋 浩太郎

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Researcher Number 50820354
Other IDs
Affiliation (Current) 2025: 東京大学, 医科学研究所, 特任教授
2025: 千葉大学, 医学部附属病院, 特任教授
Affiliation (based on the past Project Information) *help 2022 – 2024: 千葉大学, 医学部附属病院, 特任教授
2020 – 2021: 東京大学, 医科学研究所, 特任教授
Review Section/Research Field
Principal Investigator
Basic Section 49070:Immunology-related / Basic Section 57020:Oral pathobiological science-related / Studies on the Super-Aging Society
Except Principal Investigator
Basic Section 57080:Social dentistry-related
Keywords
Principal Investigator
粘膜免疫 / 分泌型IgA / アジュバント / 老化 / Influenza virus / Nasal Vaccine / Protection / IgA / influenza virus / Vaccine … More / 唾液IgA抗体 / 動脈硬化 / 粘膜ワクチン / 抗原特異的IgA / 歯槽骨吸収 / サイトカイン / 高原特異的IgA / 歯周病 / 舌下ワクチン / ワクチン / ダブルシグナル / メモリー免疫応答 / 肺炎球菌 / Foxp1 / Flt3リガンド / CpG ODN / 粘膜IgA / 記憶免疫 … More
Except Principal Investigator
マウス / 粘膜アジュバント / 抗免疫老化 / 樹状細胞 / NALT Less
  • Research Projects

    (4 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (9 People)
  •  Elucidation of mechanisms underlying immunosenescence resilience by NALT denritic cells-targeting mucosal adjuvant

    • Principal Investigator
      片岡 宏介
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57080:Social dentistry-related
    • Research Institution
      The University of Tokushima
  •  Assessment of PilVax nasal vaccine for preventing influenza virus infectionHost Researcher

    • Principal Investigator
      藤橋 浩太郎
    • Host Researcher
      藤橋 浩太郎
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Chiba University
  •  抗原非依存型ダブルシグナルシステムによる老化粘膜免疫の再生Principal Investigator

    • Principal Investigator
      藤橋 浩太郎
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Studies on the Super-Aging Society
    • Research Institution
      Chiba University
      The University of Tokyo
  •  Rejuvenation of mucosal immunosenescence by the sublingual vaccine: The prevention and treatment for periodontal disease and arteriosclerosisPrincipal Investigator

    • Principal Investigator
      Fujihashi Kohtaro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Chiba University
      The University of Tokyo

All 2024 2023 2022 2021 2020

All Journal Article Presentation Book

  • [Book] Mucosal vaccine delivery. In Advanced Vaccination Technologies for Infectious and Chronic Diseases: A guide to Vaccinology.2024

    • Author(s)
      Tsai J-Y., and Fujihashi, K.
    • Total Pages
      528
    • Publisher
      Elsevier Inc.
    • ISBN
      9780443185649
    • Data Source
      KAKENHI-PROJECT-20K20495
  • [Book] Advanced Vaccination Technologies for Infectious and Chronic Diseases: A guide to Vaccinology2024

    • Author(s)
      49.Tsai J-Y., and Fujihashi, K.
    • Total Pages
      528
    • Publisher
      Elsevier Inc.
    • ISBN
      9780443185649
    • Data Source
      KAKENHI-PROJECT-22KF0065
  • [Journal Article] MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system2024

    • Author(s)
      Yuki Yoshikazu、Kurokawa Shiho、Sugiura Kotomi、Kashima Koji、Maruyama Shinichi、Yamanoue Tomoyuki、Honma Ayaka、Mejima Mio、Takeyama Natsumi、Kuroda Masaharu、Kozuka-Hata Hiroko、Oyama Masaaki、Masumura Takehiro、Nakahashi-Ouchida Rika、Fujihashi Kohtaro、Hiraizumi Takashi、Goto Eiji、Kiyono Hiroshi
    • Journal Title

      Frontiers in Plant Science

      Volume: 15 Pages: 1342662-1342662

    • DOI

      10.3389/fpls.2024.1342662

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PLANNED-21H05280
  • [Journal Article] Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents2023

    • Author(s)
      Umemoto S、Nakahashi-Ouchida R、Yuki Y、Kurokawa S、Machita T、Uchida Y、Mori H、Yamanoue T、Shibata T、Sawada S、Ishige K、Hirano T、Fujihashi K、Akiyoshi Ki、Kurashima Y、Tokuhara D、Ernst PB、Suzuki M、Kiyono H
    • Journal Title

      npj Vaccines

      Volume: 8 Issue: 1 Pages: 106-106

    • DOI

      10.1038/s41541-023-00700-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K08514
  • [Journal Article] Mucosal vaccination: onward and upward2023

    • Author(s)
      Tsai Catherine J. Y.、Loh Jacelyn M. S.、Fujihashi Kohtaro、Kiyono Hiroshi
    • Journal Title

      Expert Review of Vaccines

      Volume: 22 Issue: 1 Pages: 885-899

    • DOI

      10.1080/14760584.2023.2268724

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-22KF0065
  • [Journal Article] Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates2023

    • Author(s)
      Yuki Yoshikazu、Harada Norihiro、Sawada Shin-ichi、Uchida Yohei、Nakahashi-Ouchida Rika、Mori Hiromi、Yamanoue Tomoyuki、Machita Tomonori、Kanazawa Masakatsu、Fukumoto Dai、Ohba Hiroyuki、Miyazaki Takashi、Akiyoshi Kazunari、Fujihashi Kohtaro、Kiyono Hiroshi
    • Journal Title

      Vaccine

      Volume: 41 Issue: 34 Pages: 4941-4949

    • DOI

      10.1016/j.vaccine.2023.06.065

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K08514
  • [Journal Article] Nasal vaccines: solutions for respiratory infectious diseases2023

    • Author(s)
      Nakahashi-Ouchida Rika、Fujihashi Kohtaro、Kurashima Yosuke、Yuki Yoshikazu、Kiyono Hiroshi
    • Journal Title

      Trends in Molecular Medicine

      Volume: 29 Issue: 2 Pages: 124-140

    • DOI

      10.1016/j.molmed.2022.10.009

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-21K19494, KAKENHI-PROJECT-18KK0432
  • [Journal Article] Human salivary protein-derived peptides specific-salivary SIgA antibodies enhanced by nasal double DNA adjuvant in mice play an essential role in preventing Porphyromonas gingivalis colonization: an in-vitro study2023

    • Author(s)
      Koyanagi Kayo、Kataoka Kosuke、Yoshimatsu Hideki、Fujihashi Kohtaro、Miyake Tatsuro
    • Journal Title

      BMC Oral Health

      Volume: 23 Issue: 1 Pages: 123-136

    • DOI

      10.1186/s12903-023-02821-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20H03902
  • [Journal Article] Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults2022

    • Author(s)
      Yuki Yoshikazu、Nojima Masanori、Kashima Koji、Sugiura Kotomi、Maruyama Shinichi、Kurokawa Shiho、Yamanoue Tomoyuki、Nakahashi-Ouchida Rika、Nakajima Hiroyuki、Hiraizumi Takashi、Kohno Hitoshi、Goto Eiji、Fujihashi Kohtaro、Kiyono Hiroshi
    • Journal Title

      Vaccine

      Volume: 40 Issue: 24 Pages: 3372-3379

    • DOI

      10.1016/j.vaccine.2022.04.051

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-18H05280
  • [Journal Article] Induction of Mucosal IgA?Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel?Based P6 Nasal Vaccine2022

    • Author(s)
      Nakahashi-Ouchida Rika、Mori Hiromi、Yuki Yoshikazu、Umemoto Shingo、Hirano Takashi、Uchida Yohei、Machita Tomonori、Yamanoue Tomoyuki、Sawada Shin-ichi、Suzuki Masashi、Fujihashi Kohtaro、Akiyoshi Kazunari、Kurono Yuichi、Kiyono Hiroshi
    • Journal Title

      Frontiers in Immunology

      Volume: 13

    • DOI

      10.3389/fimmu.2022.819859

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20H03856
  • [Journal Article] A nasal double DNA adjuvant system induces atheroprotective IgM antibodies via dendritic cell-B-1a B cell interactions2022

    • Author(s)
      Yoshimatsu Hideki, Kataoka Kosuke, Fujihashi Kohtaro, Miyake Tatsuro, Ono Yoshiaki
    • Journal Title

      Vaccine

      Volume: 40 Issue: 8 Pages: 1116-1127

    • DOI

      10.1016/j.vaccine.2022.01.027

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K10474, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20K20495
  • [Journal Article] The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk2021

    • Author(s)
      Usami Katsuki、Niimi Kanae、Matsuo Ayumi、Suyama Yoshihisa、Sakai Yoshifumi、Sato Shintaro、Fujihashi Kohtaro、Kiyono Hiroshi、Uchino Saeka、Furukawa Mutsumi、Islam Jahidul、etc
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 10 Pages: 109655-109655

    • DOI

      10.1016/j.celrep.2021.109655

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K15478, KAKENHI-PROJECT-18H02326, KAKENHI-PROJECT-18H03969, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-21K19176, KAKENHI-PROJECT-21H02340
  • [Journal Article] Comparative whole-genome and proteomics analyses of the next seed bank and the original master seed bank of MucoRice-CTB 51A line, a rice-based oral cholera vaccine2021

    • Author(s)
      Sasou Ai、Yuki Yoshikazu、Honma Ayaka、Sugiura Kotomi、Kashima Koji、Kozuka-Hata Hiroko、Nojima Masanori、Oyama Masaaki、Kurokawa Shiho、Maruyama Shinichi、Kuroda Masaharu、Tanoue Shinjiro、Takamatsu Narushi、Fujihashi Kohtaro、Goto Eiji、Kiyono Hiroshi
    • Journal Title

      BMC Genomics

      Volume: 22 Issue: 1 Pages: 59-59

    • DOI

      10.1186/s12864-020-07355-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-18H05280
  • [Journal Article] Development of Antibody-Fragment?Producing Rice for Neutralization of Human Norovirus2021

    • Author(s)
      Sasou Ai、Yuki Yoshikazu、Kurokawa Shiho、Sato Shintaro、Goda Yuki、Uchida Masao、Matsumoto Naomi、Sagara Hiroshi、Watanabe Yuji、Kuroda Masaharu、Sakon Naomi、Sugiura Kotomi、Nakahashi-Ouchida Rika、Ushijima Hiroshi、Fujihashi Kohtaro、Kiyono Hiroshi
    • Journal Title

      Frontiers in Plant Science

      Volume: 12 Pages: 639953-639953

    • DOI

      10.3389/fpls.2021.639953

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-19K22532
  • [Journal Article] Mucosal vaccines: wisdom from now and then2021

    • Author(s)
      Kiyono Hiroshi、Yuki Yoshikazu、Nakahashi-Ouchida Rika、Fujihashi Kohtaro
    • Journal Title

      International Immunology

      Volume: 33 Issue: 12 Pages: 767-774

    • DOI

      10.1093/intimm/dxab056

    • Open Access
    • Data Source
      KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20K20495
  • [Journal Article] Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of Porphyromonas gingivalis2021

    • Author(s)
      Kataoka Kosuke、Kawabata Shigetada、Koyanagi Kayo、Hashimoto Yoshiya、Miyake Tatsuro、Fujihashi Kohtaro
    • Journal Title

      Frontiers in Immunology

      Volume: 12 Pages: 634923-634923

    • DOI

      10.3389/fimmu.2021.634923

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10474, KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K21675, KAKENHI-PROJECT-20KK0210, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-19H03825, KAKENHI-PROJECT-19K22710, KAKENHI-PROJECT-20H03902
  • [Journal Article] Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss2020

    • Author(s)
      Chang Emily、Kobayashi Ryoki、Fujihashi Kohtaro、Komiya Masamichi、Kurita-Ochiai Tomoko
    • Journal Title

      Inflammation Research

      Volume: 70 Issue: 1 Pages: 151-158

    • DOI

      10.1007/s00011-020-01418-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K23066, KAKENHI-PROJECT-20H03856
  • [Presentation] A novel recombinant Lactococcus lactis mucosal vaccine platform based on group A Streptococcus pili2024

    • Author(s)
      Tsai, C. J-Y., Takahashi, R., Kiyono, H., and Fujihashi, K
    • Organizer
      第52回日本免疫学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495
  • [Presentation] A novel recombinant Lactococcus lactis mucosal vaccine platform based on group A Streptococcus pili.2024

    • Author(s)
      Tsai, C. J-Y., Takahashi, R., Kiyono, H., and Fujihashi, K.
    • Organizer
      日本免疫学会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22KF0065
  • [Presentation] Nasal double DNA adjuvant system induces CD11b-positive dendritic cells and regulatory T cells in ApoE KO mice2024

    • Author(s)
      Yoshimatsu, H., Kataoka, K., Miyake, T., and Fujihashi, K.
    • Organizer
      第52回日本免疫学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495
  • [Presentation] A nasal double DNA adjuvant system induces atheroprotecitive IgM antibodies via dendritic cell-B-1a B cell interactions.2021

    • Author(s)
      Yoshimatsu, H., Kataoka, K., Fujihashi, K., Miyake, T., and Yoshikai, O.
    • Organizer
      The 50th Annual Meeting of The Japanese Society for Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03856
  • [Presentation] A nasal double DNA adjuvant system induces atheroprotective IgM antibodies via dendritic cell-B-1a B cell interactions2021

    • Author(s)
      Yoshimatsu H, Kataoka K, Fujihashi K, Miyake T, Ono Y
    • Organizer
      The 50th Annual Meeting of The Japanese Society for Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20495
  • 1.  中橋 理佳 (80391887)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  片岡 宏介 (50283792)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  TSAI JIA-YUN
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 4.  落合 智子 (20130594)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  工藤 保誠 (50314753)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  三宅 達郎 (40200141)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  吉松 英樹 (20750003)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  大内田 理佳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 8 results
  • 9.  イスラム ジャヒドゥル
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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