FUJIHASHI KOHTARO 藤橋浩太郎

… Alternative Names

Fujihashi Kohtaro 藤橋浩太郎

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Researcher Number	50820354
Other IDs
Affiliation (Current)	2025: 東京大学, 医科学研究所, 特任教授 2025: 千葉大学, 医学部附属病院, 特任教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 千葉大学, 医学部附属病院, 特任教授 2020 – 2021: 東京大学, 医科学研究所, 特任教授
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Basic Section 57020:Oral pathobiological science-related / Studies on the Super-Aging Society Except Principal Investigator Basic Section 57080:Social dentistry-related
Keywords	Principal Investigator 粘膜免疫 / 分泌型IgA / アジュバント / 老化 / Influenza virus / Nasal Vaccine / Protection / IgA / influenza virus / Vaccine … More / 唾液IgA抗体 / 動脈硬化 / 粘膜ワクチン / 抗原特異的IgA / 歯槽骨吸収 / サイトカイン / 高原特異的IgA / 歯周病 / 舌下ワクチン / ワクチン / ダブルシグナル / メモリー免疫応答 / 肺炎球菌 / Foxp1 / Flt3リガンド / CpG ODN / 粘膜IgA / 記憶免疫 … More Except Principal Investigator マウス / 粘膜アジュバント / 抗免疫老化 / 樹状細胞 / NALT Less

Elucidation of mechanisms underlying immunosenescence resilience by NALT denritic cells-targeting mucosal adjuvant
- Principal Investigator
  
  片岡宏介
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  The University of Tokushima
Assessment of PilVax nasal vaccine for preventing influenza virus infectionHost Researcher
- Principal Investigator
  
  藤橋浩太郎
- Host Researcher
  
  藤橋浩太郎
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Chiba University
抗原非依存型ダブルシグナルシステムによる老化粘膜免疫の再生Principal Investigator
- Principal Investigator
  
  藤橋浩太郎
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Studies on the Super-Aging Society
- Research Institution
  Chiba University
  The University of Tokyo
Rejuvenation of mucosal immunosenescence by the sublingual vaccine: The prevention and treatment for periodontal disease and arteriosclerosisPrincipal Investigator
- Principal Investigator
  
  Fujihashi Kohtaro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Chiba University
  The University of Tokyo

All 2024 2023 2022 2021 2020

All Journal Article Presentation Book

[Book] Mucosal vaccine delivery. In Advanced Vaccination Technologies for Infectious and Chronic Diseases: A guide to Vaccinology.2024
- Author(s)
  Tsai J-Y., and Fujihashi, K.
- Total Pages
  528
- Publisher
  Elsevier Inc.
- ISBN
  9780443185649
- Data Source
  KAKENHI-PROJECT-20K20495
[Book] Advanced Vaccination Technologies for Infectious and Chronic Diseases: A guide to Vaccinology2024
- Author(s)
  49.Tsai J-Y., and Fujihashi, K.
- Total Pages
  528
- Publisher
  Elsevier Inc.
- ISBN
  9780443185649
- Data Source
  KAKENHI-PROJECT-22KF0065
[Journal Article] MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system2024
- Author(s)
  Yuki Yoshikazu、Kurokawa Shiho、Sugiura Kotomi、Kashima Koji、Maruyama Shinichi、Yamanoue Tomoyuki、Honma Ayaka、Mejima Mio、Takeyama Natsumi、Kuroda Masaharu、Kozuka-Hata Hiroko、Oyama Masaaki、Masumura Takehiro、Nakahashi-Ouchida Rika、Fujihashi Kohtaro、Hiraizumi Takashi、Goto Eiji、Kiyono Hiroshi
- Journal Title
  
  Frontiers in Plant Science
  
  Volume: 15 Pages: 1342662-1342662
- DOI
  10.3389/fpls.2024.1342662
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PLANNED-21H05280
[Journal Article] Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents2023
- Author(s)
  Umemoto S、Nakahashi-Ouchida R、Yuki Y、Kurokawa S、Machita T、Uchida Y、Mori H、Yamanoue T、Shibata T、Sawada S、Ishige K、Hirano T、Fujihashi K、Akiyoshi Ki、Kurashima Y、Tokuhara D、Ernst PB、Suzuki M、Kiyono H
- Journal Title
  
  npj Vaccines
  
  Volume: 8 Issue: 1 Pages: 106-106
- DOI
  10.1038/s41541-023-00700-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K08514
[Journal Article] Mucosal vaccination: onward and upward2023
- Author(s)
  Tsai Catherine J. Y.、Loh Jacelyn M. S.、Fujihashi Kohtaro、Kiyono Hiroshi
- Journal Title
  
  Expert Review of Vaccines
  
  Volume: 22 Issue: 1 Pages: 885-899
- DOI
  10.1080/14760584.2023.2268724
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-22KF0065
[Journal Article] Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates2023
- Author(s)
  Yuki Yoshikazu、Harada Norihiro、Sawada Shin-ichi、Uchida Yohei、Nakahashi-Ouchida Rika、Mori Hiromi、Yamanoue Tomoyuki、Machita Tomonori、Kanazawa Masakatsu、Fukumoto Dai、Ohba Hiroyuki、Miyazaki Takashi、Akiyoshi Kazunari、Fujihashi Kohtaro、Kiyono Hiroshi
- Journal Title
  
  Vaccine
  
  Volume: 41 Issue: 34 Pages: 4941-4949
- DOI
  10.1016/j.vaccine.2023.06.065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K08514
[Journal Article] Nasal vaccines: solutions for respiratory infectious diseases2023
- Author(s)
  Nakahashi-Ouchida Rika、Fujihashi Kohtaro、Kurashima Yosuke、Yuki Yoshikazu、Kiyono Hiroshi
- Journal Title
  
  Trends in Molecular Medicine
  
  Volume: 29 Issue: 2 Pages: 124-140
- DOI
  10.1016/j.molmed.2022.10.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-18H05280, KAKENHI-PROJECT-21K19494, KAKENHI-PROJECT-18KK0432
[Journal Article] Human salivary protein-derived peptides specific-salivary SIgA antibodies enhanced by nasal double DNA adjuvant in mice play an essential role in preventing Porphyromonas gingivalis colonization: an in-vitro study2023
- Author(s)
  Koyanagi Kayo、Kataoka Kosuke、Yoshimatsu Hideki、Fujihashi Kohtaro、Miyake Tatsuro
- Journal Title
  
  BMC Oral Health
  
  Volume: 23 Issue: 1 Pages: 123-136
- DOI
  10.1186/s12903-023-02821-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20H03902
[Journal Article] Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults2022
- Author(s)
  Yuki Yoshikazu、Nojima Masanori、Kashima Koji、Sugiura Kotomi、Maruyama Shinichi、Kurokawa Shiho、Yamanoue Tomoyuki、Nakahashi-Ouchida Rika、Nakajima Hiroyuki、Hiraizumi Takashi、Kohno Hitoshi、Goto Eiji、Fujihashi Kohtaro、Kiyono Hiroshi
- Journal Title
  
  Vaccine
  
  Volume: 40 Issue: 24 Pages: 3372-3379
- DOI
  10.1016/j.vaccine.2022.04.051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-18H05280
[Journal Article] Induction of Mucosal IgA?Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel?Based P6 Nasal Vaccine2022
- Author(s)
  Nakahashi-Ouchida Rika、Mori Hiromi、Yuki Yoshikazu、Umemoto Shingo、Hirano Takashi、Uchida Yohei、Machita Tomonori、Yamanoue Tomoyuki、Sawada Shin-ichi、Suzuki Masashi、Fujihashi Kohtaro、Akiyoshi Kazunari、Kurono Yuichi、Kiyono Hiroshi
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13
- DOI
  10.3389/fimmu.2022.819859
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20H03856
[Journal Article] A nasal double DNA adjuvant system induces atheroprotective IgM antibodies via dendritic cell-B-1a B cell interactions2022
- Author(s)
  Yoshimatsu Hideki, Kataoka Kosuke, Fujihashi Kohtaro, Miyake Tatsuro, Ono Yoshiaki
- Journal Title
  
  Vaccine
  
  Volume: 40 Issue: 8 Pages: 1116-1127
- DOI
  10.1016/j.vaccine.2022.01.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10474, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20K20495
[Journal Article] The gut microbiota induces Peyer’s-patch-dependent secretion of maternal IgA into milk2021
- Author(s)
  Usami Katsuki、Niimi Kanae、Matsuo Ayumi、Suyama Yoshihisa、Sakai Yoshifumi、Sato Shintaro、Fujihashi Kohtaro、Kiyono Hiroshi、Uchino Saeka、Furukawa Mutsumi、Islam Jahidul、etc
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 10 Pages: 109655-109655
- DOI
  10.1016/j.celrep.2021.109655
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15478, KAKENHI-PROJECT-18H02326, KAKENHI-PROJECT-18H03969, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-21K19176, KAKENHI-PROJECT-21H02340
[Journal Article] Comparative whole-genome and proteomics analyses of the next seed bank and the original master seed bank of MucoRice-CTB 51A line, a rice-based oral cholera vaccine2021
- Author(s)
  Sasou Ai、Yuki Yoshikazu、Honma Ayaka、Sugiura Kotomi、Kashima Koji、Kozuka-Hata Hiroko、Nojima Masanori、Oyama Masaaki、Kurokawa Shiho、Maruyama Shinichi、Kuroda Masaharu、Tanoue Shinjiro、Takamatsu Narushi、Fujihashi Kohtaro、Goto Eiji、Kiyono Hiroshi
- Journal Title
  
  BMC Genomics
  
  Volume: 22 Issue: 1 Pages: 59-59
- DOI
  10.1186/s12864-020-07355-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PLANNED-16H06578, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-18H05280
[Journal Article] Development of Antibody-Fragment?Producing Rice for Neutralization of Human Norovirus2021
- Author(s)
  Sasou Ai、Yuki Yoshikazu、Kurokawa Shiho、Sato Shintaro、Goda Yuki、Uchida Masao、Matsumoto Naomi、Sagara Hiroshi、Watanabe Yuji、Kuroda Masaharu、Sakon Naomi、Sugiura Kotomi、Nakahashi-Ouchida Rika、Ushijima Hiroshi、Fujihashi Kohtaro、Kiyono Hiroshi
- Journal Title
  
  Frontiers in Plant Science
  
  Volume: 12 Pages: 639953-639953
- DOI
  10.3389/fpls.2021.639953
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-19K22532
[Journal Article] Mucosal vaccines: wisdom from now and then2021
- Author(s)
  Kiyono Hiroshi、Yuki Yoshikazu、Nakahashi-Ouchida Rika、Fujihashi Kohtaro
- Journal Title
  
  International Immunology
  
  Volume: 33 Issue: 12 Pages: 767-774
- DOI
  10.1093/intimm/dxab056
- Open Access
- Data Source
  KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-20K20495
[Journal Article] Respiratory FimA-Specific Secretory IgA Antibodies Upregulated by DC-Targeting Nasal Double DNA Adjuvant Are Essential for Elimination of Porphyromonas gingivalis2021
- Author(s)
  Kataoka Kosuke、Kawabata Shigetada、Koyanagi Kayo、Hashimoto Yoshiya、Miyake Tatsuro、Fujihashi Kohtaro
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 634923-634923
- DOI
  10.3389/fimmu.2021.634923
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10474, KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K21675, KAKENHI-PROJECT-20KK0210, KAKENHI-PROJECT-20H03856, KAKENHI-PROJECT-19H03825, KAKENHI-PROJECT-19K22710, KAKENHI-PROJECT-20H03902
[Journal Article] Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss2020
- Author(s)
  Chang Emily、Kobayashi Ryoki、Fujihashi Kohtaro、Komiya Masamichi、Kurita-Ochiai Tomoko
- Journal Title
  
  Inflammation Research
  
  Volume: 70 Issue: 1 Pages: 151-158
- DOI
  10.1007/s00011-020-01418-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495, KAKENHI-PROJECT-20K23066, KAKENHI-PROJECT-20H03856
[Presentation] A novel recombinant Lactococcus lactis mucosal vaccine platform based on group A Streptococcus pili2024
- Author(s)
  Tsai, C. J-Y., Takahashi, R., Kiyono, H., and Fujihashi, K
- Organizer
  第５２回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495
[Presentation] A novel recombinant Lactococcus lactis mucosal vaccine platform based on group A Streptococcus pili.2024
- Author(s)
  Tsai, C. J-Y., Takahashi, R., Kiyono, H., and Fujihashi, K.
- Organizer
  日本免疫学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KF0065
[Presentation] Nasal double DNA adjuvant system induces CD11b-positive dendritic cells and regulatory T cells in ApoE KO mice2024
- Author(s)
  Yoshimatsu, H., Kataoka, K., Miyake, T., and Fujihashi, K.
- Organizer
  第５２回日本免疫学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495
[Presentation] A nasal double DNA adjuvant system induces atheroprotecitive IgM antibodies via dendritic cell-B-1a B cell interactions.2021
- Author(s)
  Yoshimatsu, H., Kataoka, K., Fujihashi, K., Miyake, T., and Yoshikai, O.
- Organizer
  The 50th Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03856
[Presentation] A nasal double DNA adjuvant system induces atheroprotective IgM antibodies via dendritic cell-B-1a B cell interactions2021
- Author(s)
  Yoshimatsu H, Kataoka K, Fujihashi K, Miyake T, Ono Y
- Organizer
  The 50th Annual Meeting of The Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20495

1. 中橋理佳 (80391887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 片岡宏介 (50283792)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. TSAI JIA-YUN

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
4. 落合智子 (20130594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 工藤保誠 (50314753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三宅達郎 (40200141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 吉松英樹 (20750003)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大内田理佳

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
9. イスラムジャヒドゥル

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJIHASHI KOHTARO 藤橋 浩太郎

Fujihashi Kohtaro 藤橋 浩太郎

Research Projects

Research Products

Co-Researchers

Elucidation of mechanisms underlying immunosenescence resilience by NALT denritic cells-targeting mucosal adjuvant

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Assessment of PilVax nasal vaccine for preventing influenza virus infectionHost Researcher

Principal Investigator

Host Researcher

Project Period (FY)

Research Category

Review Section

Research Institution

抗原非依存型ダブルシグナルシステムによる老化粘膜免疫の再生Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Rejuvenation of mucosal immunosenescence by the sublingual vaccine: The prevention and treatment for periodontal disease and arteriosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Mucosal vaccine delivery. In Advanced Vaccination Technologies for Infectious and Chronic Diseases: A guide to Vaccinology.2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Advanced Vaccination Technologies for Infectious and Chronic Diseases: A guide to Vaccinology2024

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] MucoRice-CTB line 19A, a new marker-free transgenic rice-based cholera vaccine produced in an LED-based hydroponic system2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cationic-nanogel nasal vaccine containing the ectodomain of RSV-small hydrophobic protein induces protective immunity in rodents2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mucosal vaccination: onward and upward2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biodistribution assessment of cationic pullulan nanogel, a nasal vaccine delivery system, in mice and non-human primates2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nasal vaccines: solutions for respiratory infectious diseases2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human salivary protein-derived peptides specific-salivary SIgA antibodies enhanced by nasal double DNA adjuvant in mice play an essential role in preventing Porphyromonas gingivalis colonization: an in-vitro study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oral MucoRice-CTB vaccine is safe and immunogenic in healthy US adults2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of Mucosal IgA?Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel?Based P6 Nasal Vaccine2022

Author(s)

Journal Title

FUJIHASHI KOHTARO 藤橋浩太郎

Fujihashi Kohtaro 藤橋浩太郎