Yamaguchi Akinori 山口晃巨

Researcher Number	50822087
Other IDs
Affiliation (Current)	2025: 科学警察研究所, 法科学第三部, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2024: 科学警察研究所, 法科学第三部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 34020:Analytical chemistry-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related Except Principal Investigator Basic Section 55060:Emergency medicine-related / Basic Section 58040:Forensics medicine-related
Keywords	Principal Investigator LC-MS/MS / 誘導体化 / ノビチョク / LC-MS / 神経剤 / チロシン / DABCOによる試薬除去 / ペンタフルオロベンジル誘導体化 / ノビチョク加水分解物 / 未知物質の構造推定 … More / 生体試料 / 活性エステル / 縮合剤 / LC/MS / RMPA / 加水分解物 / DABCO / リン酸 / DMTMM … More Except Principal Investigator 化学剤 / 化学テロ / 神経剤 / 免疫 / コリンエステラーゼ / 解毒剤 / 危機管理 / ルイサイト代謝物 / ヒ素化合物 / LC-ICP-MS / LC-ICP-MS/MS / 神経ガス / 紙デバイス / 化学テロ対策 / 神経剤検知デバイス / 現場検知 / 流体デバイス Less

Chemical approaches for toxicity assessment and damage minimization of the nerve agent Novichok.
- Principal Investigator
  
  宮口一
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Research Institute of Police Science
化学テロ災害被害者の中毒原因特定の研究－免疫学的手法による神経剤特定方法の開発－
- Principal Investigator
  
  大森毅
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Research Institute of Police Science
Development of a Novel Derivatization Method for Analysis of Nerve Agent Adducts in Biological SamplesPrincipal Investigator
- Principal Investigator
  
  山口晃巨
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  National Research Institute of Police Science
Development of a paper-based fluidic device to detect nerve agents at the site of a chemical terrorism outbreak
- Principal Investigator
  
  Miyaguchi Hajime
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  National Research Institute of Police Science
Development of a highly sensitive analytical method for nerve agent degradation products in biological samplesPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Akinori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Research Institute of Police Science
LC-ICP-MS/MSによる生体試料中ヒ素代謝物の化学形態別高感度分析法の開発
- Principal Investigator
  
  数井優子
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58040:Forensics medicine-related
- Research Institution
  National Research Institute of Police Science

All 2023 2022 2021

All Journal Article Presentation Patent

[Journal Article] Advances in Derivatization Techniques Enabled by DABCO for Novichok Agent Analysis in Biofluids Using LC-MS2023
- Author(s)
  Akinori Yamaguchi, Hajime Miyaguchi
- Journal Title
  
  Analytical Chemistry
  
  Volume: 95 Issue: 36 Pages: 13674-13682
- DOI
  10.1021/acs.analchem.3c02775
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K13777
[Journal Article] Dimethoxytriadinylation LC-MS/MS of Novichok A-Series Degradation Products in Human Urine2022
- Author(s)
  Akinori Yamaguchi, Hajime Miyaguchi, Manabu Tokeshi
- Journal Title
  
  Analytical Chemistry
  
  Volume: 94 Issue: 11 Pages: 4658-4665
- DOI
  10.1021/acs.analchem.1c04634
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16364
[Journal Article] Analysis of degradation products of Novichok agents in human urine by hydrophilic interaction liquid chromatography-tandem mass spectrometry2022
- Author(s)
  Otsuka Mai、Yamaguchi Akinori、Miyaguchi Hajime
- Journal Title
  
  Forensic Toxicology
  
  Volume: - Issue: 2 Pages: 0-0
- DOI
  10.1007/s11419-022-00656-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18990, KAKENHI-PROJECT-19K16364
[Journal Article] Paper-Based Analytical Device for the On-Site Detection of Nerve Agents2021
- Author(s)
  Yamaguchi Akinori、Miyaguchi Hajime、Ishida Akihiko、Tokeshi Manabu
- Journal Title
  
  ACS Applied Bio Materials
  
  Volume: 4 Issue: 8 Pages: 6512-6518
- DOI
  10.1021/acsabm.1c00655
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09279, KAKENHI-PROJECT-20H02760
[Patent] 検知デバイス2021
- Inventor(s)
  渡慶次学、石田晃彦、山口晃巨、宮口　一
- Industrial Property Rights Holder
  国立大学法人北海道大学、警察庁科学警察研究所長
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-100887
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K09279
[Presentation] LC-ICP-MS/MSによるルイサイト分解物の分析2023
- Author(s)
  数井優子、山口晃巨、大塚麻衣、宮口一
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-19K10701
[Presentation] 神経剤A剤（ノビチョク）-ブチリルコリンエステラーゼ付加体からのA剤加水分解物の検出2023
- Author(s)
  山口晃巨，宮口一
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K13777
[Presentation] 尿中のルイサイト代謝物と無機ヒ素代謝物の同時分析法の開発2023
- Author(s)
  大塚麻衣、山口晃巨、宮口一、数井優子
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-19K10701
[Presentation] 神経剤ノビチョク分解物のペンタフルオロベンジル誘導体化LC-MS/MS法の開発2023
- Author(s)
  山口晃巨，宮口一
- Organizer
  日本分析化学会第72年会
- Data Source
  KAKENHI-PROJECT-23K13777
[Presentation] 尿中ルイサイト代謝物のLC-ICP-MS/MSによる分析2023
- Author(s)
  数井優子、山口晃巨、大塚麻衣、宮口一
- Organizer
  日本法科学技術学会第29回学術集会
- Data Source
  KAKENHI-PROJECT-19K10701
[Presentation] ノビチョクを含む神経剤加水分解物のジメトキシトリアジニル (DMT) 誘導体化LC?MS/MS法の開発2022
- Author(s)
  山口晃巨, 宮口一
- Organizer
  第29回クロマトグラフィーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16364

1. 大塚麻衣 (90801580)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
2. Miyaguchi Hajime (10370884)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 数井優子 (90356197)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 大森毅 (70356195)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 渡慶次学 (60311437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Yamaguchi Akinori 山口 晃巨

Research Projects

Research Products

Co-Researchers

Chemical approaches for toxicity assessment and damage minimization of the nerve agent Novichok.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

化学テロ災害被害者の中毒原因特定の研究－免疫学的手法による神経剤特定方法の開発－

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Novel Derivatization Method for Analysis of Nerve Agent Adducts in Biological SamplesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a paper-based fluidic device to detect nerve agents at the site of a chemical terrorism outbreak

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a highly sensitive analytical method for nerve agent degradation products in biological samplesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

LC-ICP-MS/MSによる生体試料中ヒ素代謝物の化学形態別高感度分析法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Advances in Derivatization Techniques Enabled by DABCO for Novichok Agent Analysis in Biofluids Using LC-MS2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dimethoxytriadinylation LC-MS/MS of Novichok A-Series Degradation Products in Human Urine2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of degradation products of Novichok agents in human urine by hydrophilic interaction liquid chromatography-tandem mass spectrometry2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Paper-Based Analytical Device for the On-Site Detection of Nerve Agents2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 検知デバイス2021

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Presentation] LC-ICP-MS/MSによるルイサイト分解物の分析2023

Author(s)

Organizer

Data Source

[Presentation] 神経剤A剤（ノビチョク）-ブチリルコリンエステラーゼ付加体からのA剤加水分解物の検出2023

Author(s)

Organizer

Data Source

[Presentation] 尿中のルイサイト代謝物と無機ヒ素代謝物の同時分析法の開発2023

Author(s)

Organizer

Data Source

[Presentation] 神経剤ノビチョク分解物のペンタフルオロベンジル誘導体化LC-MS/MS法の開発2023

Yamaguchi Akinori 山口晃巨