Tomoshige Shusuke 友重秀介

Researcher Number	50822524
Other IDs
Affiliation (Current)	2025: 東北大学, 生命科学研究科, 助教
Affiliation (based on the past Project Information) *help	2025: 東北大学, 生命科学研究科, 助教 2019 – 2023: 東北大学, 生命科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 37030:Chemical biology-related
Keywords	Principal Investigator タンパク質分解 / ClpP / 抗菌薬 / in vitro / ミトコンドリア / 細菌 / 標的タンパク質分解 / K63結合型ユビキチン化 / RIP1 / IAP … More / K63型ユビキチン / ユビキチン化 / mHtt / 疎水性タグ Less

ミトコンドリアで機能する新規タンパク質分解誘導技術の学理開拓と高度化Principal Investigator
- Principal Investigator
  
  友重秀介
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Tohoku University
細菌タンパク質の分解誘導薬の創製Principal Investigator
- Principal Investigator
  
  友重秀介
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku University
Small molecules that induce atypical ubiquitinationsPrincipal Investigator
- Principal Investigator
  
  Tomoshige Shusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Allosteric Hsp70 Modulator YM-1 Induces Degradation of BRD42024
- Author(s)
  Mishima Yugo、Tomoshige Shusuke、Sato Shinichi、Ishikawa Minoru
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 161-165
- DOI
  10.1248/cpb.c23-00543
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15242, KAKENHI-PROJECT-23KJ0187
[Journal Article] Targeted Protein Degradation in the Mitochondrial Matrix and Its Application to Chemical Control of Mitochondrial Morphology2024
- Author(s)
  Yamada Wakana、TOMOSHIGE Shusuke、Nakamura Sho、Sato Shinichi、Ishikawa Minoru
- Journal Title
  
  ChemRxiv
  
  Volume: -
- DOI
  10.26434/chemrxiv-2024-4vrs0
- Data Source
  KAKENHI-PROJECT-22K15242
[Journal Article] Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties2022
- Author(s)
  Hirai Keigo、Yamashita Hiroko、Tomoshige Shusuke、Mishima Yugo、Niwa Tatsuya、Ohgane Kenji、Ishii Mayumi、Kanamitsu Kayoko、Ikemi Yui、Nakagawa Shinsaku、Taguchi Hideki、Sato Shinichi、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 3 Pages: 396-402
- DOI
  10.1021/acsmedchemlett.1c00500
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-PLANNED-20H05925
[Journal Article] PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders2021
- Author(s)
  Shusuke Tomoshige, Minoru Ishikawa
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 60 Issue: 7 Pages: 3346-3354
- DOI
  10.1002/anie.202004746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum.2020
- Author(s)
  Oka. S, Kuniba. R, Tsuboi. N, Tsuchida. S, Ushida. K, Tomoshige. S, Kuramochi. K.
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 84(1) Issue: 1 Pages: 31-36
- DOI
  10.1080/09168451.2019.1662279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14590, KAKENHI-PROJECT-19K16326
[Journal Article] Investigation on the Epoxidation of Piperitenone, and Structure-activity Relationships of Piperitenone Oxide for Differentiation-inducing Activity2020
- Author(s)
  R Sato, A Sasaki, Y Mori, M Komai, S Kamo, M Onuki, T Seki, Z Kawabe, S Miyajima, S Tomoshige, T Kawasaki, S Sato, T Nakamura, N Kubo, S Takeda, S Date, S Okamoto, P Boonyaritthongchai, K Thirapanmethee, M T Chomnawang, B Bongcheewin, T L Nguyen, H L T Nguyen, H T Le, Y Nakamura, K Kuramochi
- Journal Title
  
  J. Oleo Sci.
  
  Volume: 69 Issue: 8 Pages: 951-958
- DOI
  10.5650/jos.ess19278
- NAID
  130007885409
- ISSN
  1345-8957, 1347-3352
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16326
[Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020
- Author(s)
  Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Issue: 4 Pages: 74-74
- DOI
  10.3390/ph13040074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-ORGANIZER-18H05497
[Journal Article] Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins2020
- Author(s)
  Yamashita Hiroko、Tomoshige Shusuke、Nomura Sayaka、Ohgane Kenji、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 1 Pages: 115175-115175
- DOI
  10.1016/j.bmc.2019.115175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-17K15487
[Journal Article] Synthesis and Cytotoxic Evaluation of N-Alkyl-2-halophenazin-1-ones2020
- Author(s)
  Kohatsu Haruki、Kamo Shogo、Furuta Masateru、Tomoshige Shusuke、Kuramochi Kouji
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 42 Pages: 27667-27674
- DOI
  10.1021/acsomega.0c04253
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05868, KAKENHI-PROJECT-19K16326
[Journal Article] Dimerizations of 2-bromo-3-methyl-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone in tetra-n-butylammonium bromide2020
- Author(s)
  Onuki Mai、Ota Motohiro、Otokozawa Shoya、Kamo Shogo、Tomoshige Shusuke、Tsubaki Kazunori、Kuramochi Kouji
- Journal Title
  
  Tetrahedron
  
  Volume: 76 Issue: 6 Pages: 130899-130899
- DOI
  10.1016/j.tet.2019.130899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-18K19185
[Journal Article] Synthesis and structural revision of an indanone isolated from Triphyophyllum peltatum2020
- Author(s)
  Ishii Yunosuke、Ota Motohiro、Kamo Shogo、Tomoshige Shusuke、Tsubaki Kazunori、Kuramochi Kouji
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 61 Issue: 7 Pages: 151494-151494
- DOI
  10.1016/j.tetlet.2019.151494
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326
[Journal Article] Synthesis, antibacterial and cytotoxic evaluation of flavipucine and its derivatives.2019
- Author(s)
  Kusakabe Y, Mizutani S, Kamo S, Yoshimoto T, Tomoshige S, Kawasaki T, Takasawa R, Tsubaki K, Kuramochi K.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 29 Issue: 11 Pages: 1390-1394
- DOI
  10.1016/j.bmcl.2019.03.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05737, KAKENHI-PROJECT-19K16326
[Journal Article] Synthetic and Biological Studies of Juglorubin and Related Naphthoquinones2019
- Author(s)
  Kamo Shogo、Saito Tatsuo、Kusakabe Yasuha、Tomoshige Shusuke、Uchiyama Masanobu、Tsubaki Kazunori、Kuramochi Kouji
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 84 Issue: 21 Pages: 13957-13966
- DOI
  10.1021/acs.joc.9b02119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06571, KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-18K19185, KAKENHI-PROJECT-17H06173
[Journal Article] Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication2019
- Author(s)
  Kamata Mai、Takeuchi Toshifumi、Hayashi Ei、Nishioka Kazane、Oshima Mizuki、Iwamoto Masashi、Nishiuchi Kota、Kamo Shogo、Tomoshige Shusuke、Watashi Koichi、Kamisuki Shinji、Ohrui Hiroshi、Sugawara Fumio、Kuramochi Kouji
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 84 Issue: 2 Pages: 217-227
- DOI
  10.1080/09168451.2019.1673696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05343, KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-19K16672, KAKENHI-PROJECT-19K05726, KAKENHI-PROJECT-17H04085
[Journal Article] Unified Approach toward Syntheses of Juglomycins and Their Derivatives2019
- Author(s)
  Yoshioka Kai、Kamo Shogo、Hosaka Keisuke、Sato Ryohei、Miikeda Yuma、Manabe Yuri、Tomoshige Shusuke、Tsubaki Kazunori、Kuramochi Kouji
- Journal Title
  
  ACS Omega
  
  Volume: 4 Issue: 7 Pages: 11737-11748
- DOI
  10.1021/acsomega.9b01376
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16326
[Journal Article] Total Syntheses of Pyocyanin, Lavanducyanin, and Marinocyanins A and B2019
- Author(s)
  Kohatsu Haruki、Kamo Shogo、Tomoshige Shusuke、Kuramochi Kouji
- Journal Title
  
  Organic Letters
  
  Volume: 21 Issue: 18 Pages: 7311-7314
- DOI
  10.1021/acs.orglett.9b02601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] 標的タンパク質分解誘導化合物PROTAC および周辺技術による新規創薬モダリティ～基礎から最新の知見、そして産業における動向～2024
- Author(s)
  友重秀介
- Organizer
  （株）情報機構セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] ユビキチンリガーゼ CHIP を用いたタンパク質分解キメラ化合物の創製2024
- Author(s)
  小澤ときは, 友重秀介, 佐藤伸一, 大竹史明, 石川稔
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] 共有結合型ユビキチンリガーゼリガンドの創製2023
- Author(s)
  佐々木怜子, 岡部真琴, 佐藤伸一, 友重秀介, 田中良和, 石川稔
- Organizer
  第34回万有仙台シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] 共有結合型ユビキチンリガーゼリガンドの構造展開2023
- Author(s)
  佐々木怜子, 岡部真琴, 佐藤伸一, 友重秀介, 田中良和, 石川稔
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] Hsp70モジュレーターYM-1はBRD4の分解を誘導する2023
- Author(s)
  三島祐悟, 友重秀介, 佐藤伸一, 石川稔
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] ミトコンドリア内タンパク質を標的とするタンパク質分解誘導薬の開発2023
- Author(s)
  山田若菜, 佐藤伸一, 石川稔, 友重秀介
- Organizer
  第40回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] タンパク質構造の安定性制御を基盤とした神経変性疾患克服の試み2023
- Author(s)
  友重秀介
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] チロシン残基修飾反応による糖構造導入を基盤としたアミロイドβの凝集抑制・可溶化2023
- Author(s)
  樋口凛, 中根啓太, 池之上達哉, 佐藤伸一, 友重秀介, 石川稔
- Organizer
  第17回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] プロテアーゼClpPのハイジャックによるミトコンドリア内タンパク質の選択的分解技術2023
- Author(s)
  山田若菜, 佐藤伸一, 石川稔, 友重秀介
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] Lys 選択的凝集アミロイド β 修飾反応の開発2023
- Author(s)
  田中皓史, 佐藤伸一, 友重秀介, 石川稔
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] ミトコンドリア内タンパク質を標的とする新規タンパク質分解誘導技術2023
- Author(s)
  山田若菜, 佐藤伸一, 石川稔, 友重秀介
- Organizer
  日本ケミカルバイオロジー学会第17回年会
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] ミトコンドリア内タンパク質選択的分解技術の開発2022
- Author(s)
  山田若菜, 佐藤伸一, 石川稔, 友重秀介
- Organizer
  第16回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] タンパク質分解誘導に基づいた神経変性疾患に対する創薬の試み2022
- Author(s)
  友重秀介
- Organizer
  第26回ケムステVシンポ
- Invited
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] Development of technology for selective degradation of proteins in mitochondrial matrix2022
- Author(s)
  Wakana Yamada, Shinichi Sato, Minoru Ishikawa, Shusuke Tomoshige
- Organizer
  The International Symposium in Tokyo 2022 Ubiquitin New Frontier
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] チロシン残基修飾反応による糖構造導入を基盤としたアミロイドβの凝集抑制・可溶化2022
- Author(s)
  樋口凛, 中根啓太, 佐藤伸一, 友重秀介, 石川稔
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-22K15242
[Presentation] 脳移行性改善を指向したPROTACから疎水性タグへの構造展開2022
- Author(s)
  平井景梧, 山下博子, 友重秀介, 三島祐悟, 佐藤伸一, 橋本祐一, 石川稔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] 疎水性タグ法による凝集性タンパク質のケミカルノックダウン2021
- Author(s)
  平井景梧，山下博子，友重秀介，佐藤伸一，橋本祐一，石川稔
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Conversion of A PROTAC Mutant Huntingtin Degrader into Small-molecule Hydrophobic Tags Focusing on Druglike Properties2021
- Author(s)
  Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Kenji Ohgane, Shinichi Sato, Yuichi Hashimoto, Minoru Ishikawa
- Organizer
  13th AFMC INTERNATIONAL MEDICINAL CHEMISTRY SYMPOSIUM (AIMECS2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] フェナジノン類の網羅的合成法と活性・物性評価2021
- Author(s)
  加茂翔伍，古波津春希，古田将照，細貝拓也，友重秀介，大金賢司，倉持幸司
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Ru錯体担持アフィニティービーズを用いた抗体のFc領域選択的ヒスチジン残基修飾法の開発2021
- Author(s)
  中根啓太，丹羽達也，對馬理彦，田口英樹，友重秀介，中村浩之，石川稔，佐藤伸一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] 新規修飾剤開発によるチロシン残基選択的修飾2021
- Author(s)
  宮野翔伍，友重秀介，石川稔，佐藤伸一
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] 疎水性タグ法による凝集タンパク質のケミカルノックダウン2021
- Author(s)
  平井景梧, 山下博子, 三島祐悟, 友重秀介, 佐藤伸一, 橋本祐一, 石川稔
- Organizer
  新学術領域ケモユビキチン若手発表会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Crystal structure analysis of BIR3 domain of ubiquitin ligase in complex with its specific ligand for designing potent ligand2020
- Author(s)
  Makoto Okabe, Shinichi Sato, Takeshi Yokoyama, Shusuke Tomoshige, Minoru Ishikawa, Yoshikazu Tanaka
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Crystal structure analysis of BIR3 domain of ubiquitin ligase in complex with its specific ligand2020
- Author(s)
  Makoto Okabe, Takeshi Yokoyama, Shusuke Tomoshige, Tomohisa Ogawa, Minoru Ishikawa, Yoshikazu Tanaka
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Plakevulin Aの標的タンパク質の探索2019
- Author(s)
  古田将照，樺澤美咲，齋藤（倉持）史代，友重秀介，大和屋健二，中田一弥，小林進，倉持幸司
- Organizer
  第34回農薬デザイン研究会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] フェナジノン天然物群の全合成2019
- Author(s)
  古波津春樹, 加茂翔伍, 友重秀介, 倉持幸司
- Organizer
  第61回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] フェナジノン骨格の簡便合成法の開発と天然物全合成への応用2019
- Author(s)
  古波津春樹, 加茂翔伍, 友重秀介, 倉持幸司
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Plakevulin A両エナンチオマーの細胞毒性評価と標的タンパク質の探索2019
- Author(s)
  古田将照, 樺澤美咲, 友重秀介, 大和屋健二, 中田一弥, 倉持幸司
- Organizer
  日本農芸化学会関東支部大会2019年度大会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Efficient Synthesis of Neoechinulin B and Its Derivatives2019
- Author(s)
  Kota Nishiuchi, Shusuke Tomoshige, Koichi Watashi, Kouji Kuramochi
- Organizer
  International Congress on Pure & Applied Chemistry (ICPAC Yangon 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] イオン性液体中での1,4-ナフトキノン類の特異な二量化反応2019
- Author(s)
  大貫真依, 太田元博, 男澤翔矢, 加茂翔伍, 友重秀介, 椿一典, 倉持幸司
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] 1,4-ナフトキノン類の新規骨格転位反応を利用した天然物の合成と構造の訂正2019
- Author(s)
  石井優之介、太田元博、友重秀介、倉持幸司
- Organizer
  第34回農薬デザイン研究会
- Data Source
  KAKENHI-PROJECT-19K16326
[Presentation] Blugecin A Lowers Imipenem MICs in Clinical MDR Acinetobacter baumannii (ACB) Strains2019
- Author(s)
  Marion J. Skalweit, Laura J. Rojas, Robert A. Bonomo, David A. Dik, Shusuke Tomoshige, Shahriar Mobashery
- Organizer
  IDWeek2019
- Data Source
  KAKENHI-PROJECT-19K16326

1. KURAMOCHI Kouji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. KAMISUKI Shinji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 土田さやか

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 出水庸介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 高澤涼子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 斉藤竜男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomoshige Shusuke 友重 秀介

Research Projects

Research Products

Co-Researchers

ミトコンドリアで機能する新規タンパク質分解誘導技術の学理開拓と高度化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細菌タンパク質の分解誘導薬の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Small molecules that induce atypical ubiquitinationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Allosteric Hsp70 Modulator YM-1 Induces Degradation of BRD42024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Targeted Protein Degradation in the Mitochondrial Matrix and Its Application to Chemical Control of Mitochondrial Morphology2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PROTACs and Other Chemical Protein Degradation Technologies for the Treatment of Neurodegenerative Disorders2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Investigation on the Epoxidation of Piperitenone, and Structure-activity Relationships of Piperitenone Oxide for Differentiation-inducing Activity2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and Cytotoxic Evaluation of N-Alkyl-2-halophenazin-1-ones2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dimerizations of 2-bromo-3-methyl-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone in tetra-n-butylammonium bromide2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis and structural revision of an indanone isolated from Triphyophyllum peltatum2020

Author(s)

Tomoshige Shusuke 友重秀介

[Presentation] 標的タンパク質分解誘導化合物PROTAC および周辺技術による新規創薬モダリティ～基礎から最新の知見、そして産業における動向～2024