Sasa Kiyohito 笹清人

… Alternative Names

SASA KIYOHITO 笹清人

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Researcher Number	50823069
Other IDs
Affiliation (Current)	2025: 昭和大学, 歯学部, 助教
Affiliation (based on the past Project Information) *help	2019 – 2023: 昭和大学, 歯学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57010:Oral biological science-related Except Principal Investigator Basic Section 57070:Developmental dentistry-related
Keywords	Principal Investigator 骨芽細胞 / 乳酸 / ラクチル化 / osteoblast / 間葉系幹細胞 / 分化 / osteoclast / Lactylation / 破骨細胞 / 骨リモデリング … More / 脂肪細胞分化 / 骨芽細胞分化 / differentiation / lactylation / defferentiation / adipogenesis / MCT1 / MCT / 脂肪細胞 … More Except Principal Investigator DSCR1 / SDF1 / PDL / SV40-Ag / Down's syndrome / Periodontal cell / 核型解析 / STR解析 / マイクロアレイ / カルシニュー林経路 / hTERT / SV40 / マイクロアレイ解析 / カルシニューリン経路 / 歯根膜由来細胞 / Down症候群 / TGFβ / FGF2 / 永久歯歯根膜由来細胞 / 血管新生 / Calcineurin singnaling / DSCR-1 / SDF-1 / Down syndrome Less

ヒストンラクチル化による骨リモデリング制御機構の解明Principal Investigator
- Principal Investigator
  
  笹清人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Showa University
Study on the mechanism of cell fate decisions by histone lactylation in mesenchymal stem cell differentiation.Principal Investigator
- Principal Investigator
  
  SASA KIYOHITO
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Showa University
Stromal cell-derived factor1 expression on periodontal ligament cells derived from Down syndrom
- Principal Investigator
  
  浅川剛吉
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Showa University
Functional analysis of monocarboxylate transporter 1 in bone and bone marrow adipose tissuesPrincipal Investigator
- Principal Investigator
  
  SASA KIYOHITO
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Showa University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Ctahepsin K degrades osteoprotegerin to promote osteoclastogenesis in vitro.2023
- Author(s)
  Kawai R, Sugisaki R, Miyamoto Y, Yano F, Sasa K, Minami E, Maki K, Kamijo R
- Journal Title
  
  In Vitro Cell Dev Biol Anim
  
  Volume: 59 Issue: 1 Pages: 10-18
- DOI
  10.1007/s11626-023-00747-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K09835, KAKENHI-PROJECT-19K09641, KAKENHI-PROJECT-21K16936, KAKENHI-PROJECT-22K19635, KAKENHI-PROJECT-22H03256
[Journal Article] Exploring the pathophysiological mechanism of interstitial edema focusing on the role of macrophages and their interaction with the glycocalyx.2023
- Author(s)
  Nishida R, Suzuki D, Akimoto Y, Matsubara S, Hayakawa J , Ushiyama A, Sasa K, Miyamoto Y, Iijima T, Kamijo R
- Journal Title
  
  J Oral Biosci
  
  Volume: 65 Issue: 1 Pages: 111-118
- DOI
  10.1016/j.job.2023.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06816, KAKENHI-PROJECT-21K16936, KAKENHI-PROJECT-22K19635, KAKENHI-PROJECT-21K09835, KAKENHI-PROJECT-21K10122, KAKENHI-PROJECT-22H03256
[Journal Article] Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.2023
- Author(s)
  Minami E, Sasa K,Yamada A, Kawai R, Yoshida H, Nakano H, Maki K, Kamijo R
- Journal Title
  
  PLoS One
  
  Volume: 18(12) Issue: 12 Pages: e0293676-e0293676
- DOI
  10.1371/journal.pone.0293676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09833, KAKENHI-PROJECT-23K09128
[Journal Article] Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1?2022
- Author(s)
  Tanaka Motohiro、Miyamoto Yoichi、Sasa Kiyohito、Yoshimura Kentaro、Yamada Atsushi、Shirota Tatsuo、Kamijo Ryutaro
- Journal Title
  
  In Vitro Cellular & Developmental Biology - Animal
  
  Volume: 58 Issue: 7 Pages: 521-528
- DOI
  10.1007/s11626-022-00680-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09833, KAKENHI-PROJECT-21K09835, KAKENHI-PROJECT-21K16936, KAKENHI-PROJECT-21K21021, KAKENHI-PROJECT-22K19635
[Journal Article] Establishment of Down’s syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT2021
- Author(s)
  Asakawa Takeyoshi、Yamada Atsushi、Kugino Masumi、Hasegawa Tomokazu、Yoshimura Kentaro、Sasa Kiyohito、Kinoshita Mitsuhiro、Nitta Masakazu、Nagata Karin、Sugiyama Tomomi、Kamijo Ryutaro、Funatsu Takahiro
- Journal Title
  
  Human Cell
  
  Volume: 35 Issue: 1 Pages: 379-383
- DOI
  10.1007/s13577-021-00621-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21687, KAKENHI-PROJECT-19H03820, KAKENHI-PROJECT-20K10235, KAKENHI-PROJECT-21K09833
[Journal Article] Functional analysis of PTH1R variants found in primary failure of eruption.2020
- Author(s)
  Izumida E, Suzawa T, Miyamoto Y, Yamada A, Takimoto R, Otsu M, Saito T, Yamaguchi T, Nishimura K, Ohtaka M, Nakanishi M, Yoshimura K, Sasa K, Takimoto R, Uyama R, Shirota T, Maki K, Kamijo R.
- Journal Title
  
  Journal of Dental Research
  
  Volume: 99 Issue: 4 Pages: 429-436
- DOI
  10.1177/0022034520901731
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09511, KAKENHI-PROJECT-19K18950, KAKENHI-PROJECT-17K11947, KAKENHI-PROJECT-20K21687, KAKENHI-PROJECT-19H03820, KAKENHI-PROJECT-18K09512, KAKENHI-PROJECT-18K09513, KAKENHI-PROJECT-18K09528, KAKENHI-PROJECT-18K09844, KAKENHI-PROJECT-19K19278, KAKENHI-PROJECT-19K24103, KAKENHI-PROJECT-19H03203, KAKENHI-PROJECT-19K22945
[Journal Article] Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin.2020
- Author(s)
  Sugisaki R, Miyamoto Y, Yoshimura K, Sasa K, Kaneko K, Tanaka M, Itose M, Inoue S, Baba K, Shirota T, Chikazu D, Kamijo R
- Journal Title
  
  Bone
  
  Volume: 132 Pages: 115216-115216
- DOI
  10.1016/j.bone.2019.115216
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09513, KAKENHI-PROJECT-18K09528, KAKENHI-PROJECT-19K18950, KAKENHI-PROJECT-19K19244, KAKENHI-PROJECT-19K19246, KAKENHI-PROJECT-19H03820, KAKENHI-PROJECT-18K19655
[Journal Article] Roles of monocarboxylate transporter subtypes in promotion and suppression of osteoclast differentiation and survival on bone.2019
- Author(s)
  Imai H, Yoshimura K, Miyamoto Y, Sasa K, Sugano M, Chatani M, Takami M, Yamamoto M, Kamijo R
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 15608-15608
- DOI
  10.1038/s41598-019-52128-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09513, KAKENHI-PROJECT-18K09528, KAKENHI-PROJECT-19K18950, KAKENHI-PROJECT-19K19034, KAKENHI-PUBLICLY-18H04986, KAKENHI-PROJECT-19H03820, KAKENHI-PROJECT-18K19655, KAKENHI-ORGANIZER-15H05935
[Presentation] 骨芽細胞分化における乳酸の新規遺伝子調節機構の解明2023
- Author(s)
  笹清人, 南えりか, 山田篤, 中納治久
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K09128
[Presentation] 乳酸による骨芽細胞分化の新規制御機構の解明2023
- Author(s)
  南えりか, 笹清人, 山田篤, 中納治久
- Organizer
  第59回日本口腔組織培養学会・学術大会・総会
- Data Source
  KAKENHI-PROJECT-23K09128
[Presentation] 乳酸の新規ヒストン修飾による骨芽細胞分化制御機構の解明2023
- Author(s)
  南えりか、笹清人、山田　篤、槇宏太郎、中納治久
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09128
[Presentation] 不死化ヒトDown症候群永久歯歯根膜由来細胞におけるSDF-1発現解析(会議録)2023
- Author(s)
  紀田優和子, 浅川剛吉, 笹清人, 新田雅一, 五十嵐悠, 石川悟, 黒田実優, 杉本卓海, 柴原果衣, 船津敬弘
- Organizer
  日本小児歯科学会
- Data Source
  KAKENHI-PROJECT-20K10235
[Presentation] SV40T-Ag およびhTERT遺伝子導入による不死化ダウン症候群歯根膜由来細胞の樹立2021
- Author(s)
  浅川剛吉,山田篤,吉村健太郎,笹清人,木下三博,紀田優和子, 上條竜太郎,船津敬弘.
- Organizer
  ヒト細胞学会
- Data Source
  KAKENHI-PROJECT-20K10235
[Presentation] モノカルボン酸トランスポーター1は骨芽細胞分化の負の調節因子p53の抑制を介して骨芽細胞分化を促進する2020
- Author(s)
  笹清人
- Organizer
  歯科基礎医学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K18950
[Presentation] モノカルボン酸トランスポーター（MCT）は新規骨代謝調節因子である2019
- Author(s)
  笹清人, 吉村健太郎, 今井裕子, 山本松男, 上條竜太郎
- Organizer
  日本ヒト細胞学会
- Data Source
  KAKENHI-PROJECT-19K18950
[Presentation] Respiration using hydrogen sulfide promotes chondrocyte proliferation and bone growth2019
- Author(s)
  Yuji Sasama, Kentaro Yoshimura, Yoichi Miyamoto, Kiyohito Sasa, Takaaki Akaike, Masanobu Morita, Tetsuro Matsunaga, Tatsuo Shirota, Ryutaro Kamijo
- Organizer
  第67回JADR総会・学術大会／（第4回IADR APR（Asia Pacific Region）学術大会（4th Meeting of the International Association for Dental Research Asia Pacific Region 2019）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18950
[Presentation] モノカルボン酸輸送担体は骨形成と骨吸収の両者を調節する2019
- Author(s)
  笹清人, 吉村健太郎, 今井裕子, 山本松男, 上條竜太郎
- Organizer
  日本口腔組織培養学会
- Data Source
  KAKENHI-PROJECT-19K18950

1. 浅川剛吉 (20347884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 吉村健太郎 (10585699)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 長谷川智一 (50274668)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 上條竜太郎 (70233939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 山田篤 (50407558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. 片桐岳信 (80245802)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 加藤憲 (20644305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUZAWA Tetsuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 宮本洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 秋元義弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sasa Kiyohito 笹 清人

SASA KIYOHITO 笹 清人

Research Projects

Research Products

Co-Researchers

ヒストンラクチル化による骨リモデリング制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the mechanism of cell fate decisions by histone lactylation in mesenchymal stem cell differentiation.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Stromal cell-derived factor1 expression on periodontal ligament cells derived from Down syndrom

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of monocarboxylate transporter 1 in bone and bone marrow adipose tissuesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Ctahepsin K degrades osteoprotegerin to promote osteoclastogenesis in vitro.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring the pathophysiological mechanism of interstitial edema focusing on the role of macrophages and their interaction with the glycocalyx.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Low oxygen tension suppresses the death of chondrocyte-like ATDC5 cells induced by interleukin-1?2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of Down’s syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional analysis of PTH1R variants found in primary failure of eruption.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of monocarboxylate transporter subtypes in promotion and suppression of osteoclast differentiation and survival on bone.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 骨芽細胞分化における乳酸の新規遺伝子調節機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] 乳酸による骨芽細胞分化の新規制御機構の解明2023

Author(s)

Organizer

Data Source

[Presentation] 乳酸の新規ヒストン修飾による骨芽細胞分化制御機構の解明2023

Author(s)

Organizer

Sasa Kiyohito 笹清人

SASA KIYOHITO 笹清人

[Presentation] SV40T-Ag およびhTERT遺伝子導入による不死化ダウン症候群歯根膜由来細胞の樹立2021