SASAKI Yuka 佐々木由香

Researcher Number	50823332
Other IDs
Affiliation (Current)	2025: 大阪歯科大学, 歯学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2025: 大阪歯科大学, 歯学部, 講師 2018 – 2020: 長崎大学, 医歯薬学総合研究科(医学系), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 57060:Surgical dentistry-related
Keywords	Principal Investigator ポリADP-リボシル化 / PARP1 / 抗がん剤耐性 / PARP阻害剤 / PARP阻害薬 / poly (ADP-ribose) / PARP / olaparib / バイオマーカー / 頭頸部がん … More / ポリＡDP-リボシル化 / NAMPT / 翻訳後修飾 / NAD+ / 膵がん / Olaparib / poly(ADP-ribose) / 耐性克服治療法 / ポリ(ADP-リボース) / 合成致死性抗がん剤 … More Except Principal Investigator ポリADP-リボース / PARG / PARP1 / 翻訳後修飾 / 破骨細胞分化 / PARP阻害剤 / PARG阻害薬 / PARP阻害薬 / ポリ(ADP-リボース) Less

マルチオミクス解析を用いたolaparib効果予測バイオマーカーの探索Principal Investigator
- Principal Investigator
  
  佐々木由香
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Osaka Dental University
マルチオミクス解析による翻訳後修飾系を介した破骨細胞分化に関する基礎的研究
- Principal Investigator
  
  野崎中成
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Osaka Dental University
PARP阻害薬の頭頸部がんへの適応拡大のための新規合成致死性バイオマーカーの探索Principal Investigator
- Principal Investigator
  
  佐々木由香
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Osaka Dental University
The molecular mechanism underlying the regulation of bone formation by post-translational modifications
- Principal Investigator
  
  Nozaki Tadashige
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Osaka Dental University
The exploration of PARP inhibitor resistance factors and development of treatment which overcomes resistance to PARP inhibitorPrincipal Investigator
- Principal Investigator
  
  Sasaki Yuka
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka Dental University
  Nagasaki University
Analysis of resistance mechanisms of PARP inhibitor and development of effective therapeutic method for overcoming drug resistancePrincipal Investigator
- Principal Investigator
  
  SASAKI Yuka
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Nagasaki University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Activated NAD+ biosynthesis pathway induces olaparib resistance in BRCA1 knockout pancreatic cancer cells2024
- Author(s)
  Yuka Sasaki , Takuma Inouchi, Ryusuke Nakatsuka, Amane Inoue, Mitsuko Masutani, Tadashige Nozaki
- Journal Title
  
  PLOS ONE
  
  Volume: 19 Issue: 4 Pages: e0302130-e0302130
- DOI
  10.1371/journal.pone.0302130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10184
[Journal Article] Inhibition of Poly (ADP-Ribose) Glycohydrolase Accelerates Osteoblast Differentiation in Preosteoblastic MC3T3-E1 Cells2022
- Author(s)
  Sasaki Yuka、Nakatsuka Ryusuke、Inouchi Takuma、Masutani Mitsuko、Nozaki Tadashige
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 9 Pages: 5041-5041
- DOI
  10.3390/ijms23095041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K10151
[Journal Article] Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Parg Deficiency2020
- Author(s)
  Sonoda Yuki、Sasaki Yuka、Gunji Akemi、Shirai Hidenori、Araki Tomonori、Imamichi Shoji、Onodera Takae、Ryden Anna-Margareta、Watanabe Masatoshi、Itami Jun、Honda Takuya、Ashizawa Kazuto、Nakao Kazuhiko、Masutani Mitsuko
- Journal Title
  
  Cancers
  
  Volume: 12 Issue: 4 Pages: 1056-1056
- DOI
  10.3390/cancers12041056
- NAID
  120006988211
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16388
[Journal Article] PARPとPARGを標的とする抗がん剤のバイオマーカー2019
- Author(s)
  荒木智徳 , 佐々木由香 , 小野寺貴恵 , 園田悠紀 , 鳥谷直紀 , 石飛俊介 , 今道祥二 , 高木正稔 , 益谷美都子 , 益谷美都子
- Journal Title
  
  Bio Clinica
  
  Volume: 34
- Data Source
  KAKENHI-PROJECT-19K21286
[Journal Article] Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice2019
- Author(s)
  Chen Lichao、Gunji Akemi、Uemura Akiko、Fujihara Hisako、Nakamoto Kentaro、Onodera Takae、Sasaki Yuka、Imamichi Shoji、Isumi Mayu、Nozaki Tadashige、Kamada Nobuo、Jishage Kou-ichi、Masutani Mitsuko
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 167 Pages: 116-124
- DOI
  10.1016/j.bcp.2019.07.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09803, KAKENHI-PROJECT-19K21286
[Journal Article] Next-generation sequencing-based miRNA expression analysis in Parp1-deficient embryonic stem cell-derived exosomes.2018
- Author(s)
  Nozaki Tadashige、Sasaki Yuka、Fukuda Itsuko、Isumi Mayu、Nakamoto Keitaro、Onodera Takae、Masutani Mitsuko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 499 Issue: 3 Pages: 410-415
- DOI
  10.1016/j.bbrc.2018.03.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K11283, KAKENHI-PROJECT-17H01911, KAKENHI-PROJECT-19K21286
[Presentation] BRCA1ノックアウト膵がん細胞株におけるolaparib耐性機序の解析2023
- Author(s)
  佐々木由香、井内拓磨、中塚隆介、益谷美都子、野﨑中成
- Organizer
  第40回分子病理学研究会
- Data Source
  KAKENHI-PROJECT-22K10184
[Presentation] Exploration of olaparib resistance factors in BRCA1 knockout olaparib resistant cancer cells.2023
- Author(s)
  佐々木由香、益谷美都子、中塚隆介、井内拓磨、野﨑中成
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K10184
[Presentation] MC3T3-E1細胞におけるPARG阻害剤PDD00017273およびPARP阻害剤olaparibが骨芽細胞分化へ及ぼす影響2022
- Author(s)
  佐々木由香、中塚隆介、井内拓磨、益谷美都子、野﨑中成
- Organizer
  第39回分子病理学研究会
- Data Source
  KAKENHI-PROJECT-21K10151
[Presentation] PARP阻害薬olaparibは骨芽細胞の分化を抑制する2022
- Author(s)
  佐々木由香、中塚隆介、野﨑中成、益谷美都子
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K10151
[Presentation] Establishment of olaparib resistant clones from BRCA1 knockout cancer cells for the exploration of resistance genes.2022
- Author(s)
  佐々木由香、中塚隆介、井内拓磨、益谷美都子、野﨑中成
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K10184
[Presentation] 口腔がん細胞におけるPARP及びPARG阻害剤感受性とシスプラチンとの併用効果の検証2021
- Author(s)
  佐々木由香, 中塚隆介, 野崎中成, 益谷美都子
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K16388
[Presentation] Dysfunction of dual specificity phosphatase 22 (DUSP22) and poly(ADP ribose) glycohydrolase (PARG) induces synthetic lethal effects in lung cancer cell lines2021
- Author(s)
  Y. Sasaki, T. Onodera, M. Aung Bhone, F. Koizumi, T. Nozaki, M. Masutani
- Organizer
  FEBS PARP2021
- Data Source
  KAKENHI-PROJECT-20K16388
[Presentation] Dysfunction of DUSP22 induces synthetic lethal effects under the knockdown condition of poly(ADP-ribose) glycohydrolase (PARG) in lung cancer cell lines.2019
- Author(s)
  Yuka Sasaki, Hiroaki Fujimori, Takae Onodera, Tadashige Nozaki, Fumiaki Koizumi, Mitsuko Masutani
- Organizer
  PARP2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K21286
[Presentation] PARG機能阻害条件下における合成致死遺伝子の同定と細胞死誘導機序の解析2018
- Author(s)
  佐々木由香、藤森浩彰、穂積美幸、小野寺貴恵、村上康文、小泉史朗、井上謙吾、益谷美都子
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K21286

1. Nozaki Tadashige (90281683)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. 中塚隆介 (90454561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 益谷美都子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAKI Yuka 佐々木 由香

Research Projects

Research Products

Co-Researchers

マルチオミクス解析を用いたolaparib効果予測バイオマーカーの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マルチオミクス解析による翻訳後修飾系を介した破骨細胞分化に関する基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PARP阻害薬の頭頸部がんへの適応拡大のための新規合成致死性バイオマーカーの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The molecular mechanism underlying the regulation of bone formation by post-translational modifications

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The exploration of PARP inhibitor resistance factors and development of treatment which overcomes resistance to PARP inhibitorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of resistance mechanisms of PARP inhibitor and development of effective therapeutic method for overcoming drug resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Activated NAD+ biosynthesis pathway induces olaparib resistance in BRCA1 knockout pancreatic cancer cells2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of Poly (ADP-Ribose) Glycohydrolase Accelerates Osteoblast Differentiation in Preosteoblastic MC3T3-E1 Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Parg Deficiency2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] PARPとPARGを標的とする抗がん剤のバイオマーカー2019

Author(s)

Journal Title

Data Source

[Journal Article] Development of renal failure in PargParp-1 null and Timm23 hypomorphic mice2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Next-generation sequencing-based miRNA expression analysis in Parp1-deficient embryonic stem cell-derived exosomes.2018

Author(s)

Journal Title

DOI

Data Source

[Presentation] BRCA1ノックアウト膵がん細胞株におけるolaparib耐性機序の解析2023

Author(s)

Organizer

Data Source

[Presentation] Exploration of olaparib resistance factors in BRCA1 knockout olaparib resistant cancer cells.2023

Author(s)

Organizer

Data Source

[Presentation] MC3T3-E1細胞におけるPARG阻害剤PDD00017273およ びPARP阻害剤olaparibが骨芽細胞分化へ及ぼす影響2022

Author(s)

SASAKI Yuka 佐々木由香

[Presentation] MC3T3-E1細胞におけるPARG阻害剤PDD00017273およびPARP阻害剤olaparibが骨芽細胞分化へ及ぼす影響2022