Koga Keisuke 古賀啓祐

Researcher Number	50835189
Other IDs
Affiliation (Current)	2025: 兵庫医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2025: 兵庫医科大学, 医学部, 助教 2020 – 2023: 兵庫医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 46010:Neuroscience-general-related / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 下行性抑制 / 下行性疼痛制御 / 吻側延髄腹内側部 / ノルアドレナリン / 青斑核 / 脊髄 / 痛み / GRPR陽性神経 / かゆみ / 抑制性神経 … More / 慢性掻痒 / パッチクランプ / セロトニン / 脊髄後角 / 痒み Less

新たな前障活動調節回路の疼痛制御及び慢性疼痛における役割解明Principal Investigator
- Principal Investigator
  
  古賀啓祐
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Hyogo Medical University
Identification of interaction mechanisms of two descendign pathways using circuit specific gene manupulation methodsPrincipal Investigator
- Principal Investigator
  
  Keisuke Koga
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  Hyogo Medical University
Investigation of serotonergic modulation of spinal dorsal horn neurons by cell-type specific genome editing.Principal Investigator
- Principal Investigator
  
  Koga Keisuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Hyogo Medical University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict2024
- Author(s)
  Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Anthony E. Pickering, Hidemasa Furue
- Journal Title
  
  Communications Biology
  
  Volume: 7(1):330. Issue: 1 Pages: 1-15
- DOI
  10.1038/s42003-024-06008-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18441, KAKENHI-PROJECT-22K15206, KAKENHI-PROJECT-20H04043
[Journal Article] Optogenetic inhibition of spinal inhibitory neurons facilitates mechanical responses of spinal wide dynamic range neurons and causes mechanical hypersensitivity2024
- Author(s)
  Yuka Fujiwara, Keisuke Koga, Nozomu H Nakamura, Keishi Maruo, Toshiya Tachibana, Hidemasa Furue
- Journal Title
  
  Neuropharmacology
  
  Volume: 242:109763. Pages: 1-9
- DOI
  10.1016/j.neuropharm.2023.109763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18441, KAKENHI-PROJECT-22K15206, KAKENHI-PROJECT-20H04043
[Journal Article] Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury2023
- Author(s)
  Koga Keisuke、Kobayashi Kenta、Tsuda Makoto、Kubota Kazufumi、Kitano Yutaka、Furue Hidemasa
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 16 Pages: 1-13
- DOI
  10.3389/fnmol.2023.1099925
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15206, KAKENHI-PROJECT-20H04043, KAKENHI-PLANNED-20H05900
[Journal Article] Identification of Spinal Inhibitory Interneurons Required for Attenuating Effect of Duloxetine on Neuropathic Allodynia-like Signs in Rats2022
- Author(s)
  Ishibashi Tadayuki、Sueto Daichi、Yoshikawa Yu、Koga Keisuke、Yamaura Ken、Tsuda Makoto
- Journal Title
  
  Cells
  
  Volume: 11 Issue: 24 Pages: 4051-4051
- DOI
  10.3390/cells11244051
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15206, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658
[Journal Article] Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch2022
- Author(s)
  Kanehisa Kensho、Koga Keisuke、Maejima Sho、Shiraishi Yuto、Asai Konatsu、Shiratori-Hayashi Miho、Xiao Mei-Fang、Sakamoto Hirotaka、Worley Paul F.、Tsuda Makoto
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 2367-2367
- DOI
  10.1038/s41467-022-30089-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06578, KAKENHI-PROJECT-22K19332, KAKENHI-PROJECT-22K15206, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-22H04926, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-20K06722, KAKENHI-PROJECT-23K23919
[Journal Article] Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice2022
- Author(s)
  Uchiyama Sawako、Yoshihara Kohei、Kawanabe Riku、Hatada Izuho、Koga Keisuke、Tsuda Makoto
- Journal Title
  
  Molecular Brain
  
  Volume: 15 Issue: 1 Pages: 6-6
- DOI
  10.1186/s13041-021-00895-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16133, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-19J21063, KAKENHI-PROJECT-22KJ2471
[Journal Article] Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function2021
- Author(s)
  Kawai Momotaro、Imaizumi Kent、Ishikawa Mitsuru、Shibata Shinsuke、Shinozaki Munehisa、Shibata Takahiro、Hashimoto Shogo、Kitagawa Takahiro、Ago Kentaro、Kajikawa Keita、Shibata Reo、Kamata Yasuhiro、Ushiba Junichi、Koga Keisuke、Furue Hidemasa、Matsumoto Morio、Nakamura Masaya、Nagoshi Narihito、Okano Hideyuki
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 8 Pages: 110019-110019
- DOI
  10.1016/j.celrep.2021.110019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16133, KAKENHI-PROJECT-19H03983
[Journal Article] α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice2021
- Author(s)
  Shiraishi Yuto、Koga Keisuke、Yamagata Ryo、Hatada Izuho、Shiratori-Hayashi Miho、Tsuda Makoto
- Journal Title
  
  Molecular Brain
  
  Volume: 14 Issue: 1 Pages: 55-55
- DOI
  10.1186/s13041-021-00768-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16133, KAKENHI-PROJECT-19K22500, KAKENHI-PROJECT-19K16260, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658
[Journal Article] A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior2021
- Author(s)
  Tashima Ryoichi、Koga Keisuke、Yoshikawa Yu、Sekine Misuzu、Watanabe Moeka、Tozaki-Saitoh Hidetoshi、Furue Hidemasa、Yasaka Toshiharu、Tsuda Makoto
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 3
- DOI
  10.1073/pnas.2021220118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07394, KAKENHI-PROJECT-20K16133, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-20H04043
[Journal Article] Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity2020
- Author(s)
  Kohro Yuta、（他２０名）、Mikoshiba Katsuhiko、Taylor Verdon、Inoue Kazuhide、Tsuda Makoto
- Journal Title
  
  Nature Neuroscience
  
  Volume: 23 Issue: 11 Pages: 1376-1387
- DOI
  10.1038/s41593-020-00713-4
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06864, KAKENHI-PROJECT-19K16021, KAKENHI-PROJECT-20K16133, KAKENHI-ORGANIZER-20H05894, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-19J21063, KAKENHI-PROJECT-19J21452, KAKENHI-PROJECT-20J01824
[Journal Article] Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice2020
- Author(s)
  Koga Keisuke、Shiraishi Yuto、Yamagata Ryo、Tozaki-Saitoh Hidetoshi、Shiratori-Hayashi Miho、Tsuda Makoto
- Journal Title
  
  Molecular Brain
  
  Volume: 13 Issue: 1 Pages: 144-144
- DOI
  10.1186/s13041-020-00688-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16133, KAKENHI-PLANNED-20H05900, KAKENHI-PROJECT-19H05658, KAKENHI-PROJECT-19K22500, KAKENHI-PROJECT-19K16260
[Journal Article] A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice2020
- Author(s)
  Shuntaro Uchida, Shingo Soya, Yuki C Saito, Arisa Hirano, Keisuke Koga, Makoto Tsuda, Manabu Abe, Kenji Sakimura, Takeshi Sakurai
- Journal Title
  
  journal of neuroscience
  
  Volume: 41 Issue: 7 Pages: 1582-1596
- DOI
  10.1523/jneurosci.0688-20.2020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K15921, KAKENHI-PROJECT-20K16133, KAKENHI-ORGANIZER-16H06400, KAKENHI-PLANNED-16H06401, KAKENHI-PUBLICLY-19H04894, KAKENHI-PUBLICLY-19H05305, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-18H02595, KAKENHI-PROJECT-18J21114
[Presentation] 脊髄後角興奮性神経に発現するα2δ-1サブユニットの機械性痛覚過敏における役割解明2024
- Author(s)
  古賀啓祐、小林憲太、津田誠、窪田一史、北野裕、古江秀昌
- Organizer
  第101回　生理学会大会
- Data Source
  KAKENHI-PROJECT-22K15206
[Presentation] 疼痛制御に関与する新たな中枢神経機構の探索と役割解明2024
- Author(s)
  古賀　啓祐，古江　秀昌
- Organizer
  痛み研究会2023
- Invited
- Data Source
  KAKENHI-PROJECT-22K15206
[Presentation] 脊髄後角神経に発現するα2δ-1サブユニットの神経障害性疼痛における役割2023
- Author(s)
  Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Kazufumi Kubota, Yutaka Kitano, Hidemasa Furue
- Organizer
  生理学研究会
- Data Source
  KAKENHI-PROJECT-22K15206
[Presentation] α2δ-1 expressed in spinal dorsal horn neurons is involved in aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury.2023
- Author(s)
  Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Kazufumi Kubota, Yutaka Kitano, Hidemasa Furue
- Organizer
  第100回生理学会年会
- Data Source
  KAKENHI-PROJECT-22K15206
[Presentation] Involvement of the voltage-gated calcium channel subunit, α2δ-1, expressed in spinal dorsal horn excitatory neurons for facilitation of excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury.2023
- Author(s)
  古賀啓祐、小林憲太、津田誠、窪田一史、北野裕、古江秀昌
- Organizer
  Neuroscience 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15206
[Presentation] 神経障害性疼痛における脊髄後角神経に発現するα2δ-1サブユニットの役割2023
- Author(s)
  古賀啓祐、小林憲太、津田誠、窪田一史、北野裕、古江秀昌
- Organizer
  第45回日本疼痛学会
- Data Source
  KAKENHI-PROJECT-22K15206
[Presentation] Effects of sleep deprivations on nociception threshold and neural activity in the anterior cingulate cortex of mice2022
- Author(s)
  中野康佑、古賀啓祐、角谷学、小山英則、古江秀昌
- Organizer
  第99回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K16133
[Presentation] α2δ-1 expressed in spinal dorsal horn excitatory neurons contributes to nerve injury-induced neuropathic pain.2022
- Author(s)
  Keisuke Koga, Kenta Kobayashi, Makoto Tsuda, Kazufumi Kubota, Yutaka Kitano, Hidemasa Furue
- Organizer
  Neuro 2022
- Data Source
  KAKENHI-PROJECT-22K15206
[Presentation] 光遺伝学による抑制性ニューロンの活動操作と脊髄後角神経応答の変調2021
- Author(s)
  藤原　優香、古賀　啓祐、橘　俊哉、古江　秀昌
- Organizer
  第43回日本疼痛学会
- Data Source
  KAKENHI-PROJECT-20K16133

1. 御子柴克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 古江秀昌

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 白鳥美穂(林美穂)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 坪田有沙

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 八坂敏一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koga Keisuke 古賀 啓祐

Research Projects

Research Products

Co-Researchers

新たな前障活動調節回路の疼痛制御及び慢性疼痛における役割解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of interaction mechanisms of two descendign pathways using circuit specific gene manupulation methodsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of serotonergic modulation of spinal dorsal horn neurons by cell-type specific genome editing.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Anterior cingulate cross-hemispheric inhibition via the claustrum resolves painful sensory conflict2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optogenetic inhibition of spinal inhibitory neurons facilitates mechanical responses of spinal wide dynamic range neurons and causes mechanical hypersensitivity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Voltage-gated calcium channel subunit α2δ-1 in spinal dorsal horn neurons contributes to aberrant excitatory synaptic transmission and mechanical hypersensitivity after peripheral nerve injury2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of Spinal Inhibitory Interneurons Required for Attenuating Effect of Duloxetine on Neuropathic Allodynia-like Signs in Rats2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stress-induced antinociception to noxious heat requires α1A-adrenaline receptors of spinal inhibitory neurons in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-term selective stimulation of transplanted neural stem/progenitor cells for spinal cord injury improves locomotor function2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intrinsic braking role of descending locus coeruleus noradrenergic neurons in acute and chronic itch in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Discrete Glycinergic Neuronal Population in the Ventromedial Medulla That Induces Muscle Atonia during REM Sleep and Cataplexy in Mice2020

Author(s)

Journal Title

Koga Keisuke 古賀啓祐