Kashima Soki 嘉島相輝

Researcher Number	50842952
Other IDs
Affiliation (Current)	2025: 秋田大学, 医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 秋田大学, 医学系研究科, 助教 2019: 京都大学, 医学研究科, 特定病院助教
Review Section/Research Field	Principal Investigator Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 56030:Urology-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 56030:Urology-related / Basic Section 47040:Pharmacology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator バイオマーカー / 腫瘍微小環境 / 免疫チェックポイント阻害薬 / 腎細胞癌 / 複合療法 / PD-L1 / PD-1 / 抗PD1抗体 / 腫瘍免疫 / 制御性T細胞 … More / CD8 T細胞 / CAR-T細胞療法 / ゼノグラフト / 前立腺癌 / 免疫療法 / T細胞 / HLA / 固形がん / CAR-T / iPS細胞 … More Except Principal Investigator 腸内細菌 / 高脂肪食 / 肥満 / 前立腺癌 / 泌尿器癌 / 腫瘍免疫 / 腎癌 / 免疫チェックポイント阻害剤 / 治療抵抗性 / 食事 / PI3K / サイトカイン / 腫瘍微少環境 / 飽和脂肪酸 / 癌進展 / 多価不飽和脂肪酸 / LPS / 高脂肪 / 腸内細菌叢 / T細胞 / 腫瘍周囲微小環境 / 免疫微小環境 / KIR / 尿路上皮がん / 腎細胞がん / 泌尿器がん / HLA / シンジェニックマウス / ゼノグラフト / 癌ニッチ / 癌免疫 / 腫瘍間質相互作用 / 転移形成 / 薬剤抵抗性 / 患者癌組織由来ゼノグラフト / エクソソーム / 抗PD-1抗体 / 患者由来ゼノグラフト / ヒト化シンジェニックマウス / 腎細胞癌 Less

腎癌に対する免疫チェックポイント阻害薬抵抗性の克服Principal Investigator
- Principal Investigator
  
  嘉島相輝
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Akita University
T cell immune microenvironment on prostate cancer progression through the modulation of gut microbiome
- Principal Investigator
  
  成田伸太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Akita University
免疫チェックポイント阻害薬の治療有効性・抵抗性の要因評価～宿主腫瘍HLA環境解析
- Principal Investigator
  
  藤山信弘
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Akita University
Investigation of Biomarkers to Predict the Efficacy of Immune Checkpoint Inhibitor Therapy in Renal Cell CarcinomaPrincipal Investigator
- Principal Investigator
  
  Kashima Soki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Akita University
Molecular mechanisms and target molecules associated with progression and treatment resistance of urologic cancers associated with microbiome alterations by diet and obesity
- Principal Investigator
  
  羽渕友則
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Akita University
Establishment of an evaluation model for renal cancer immune niche replication and treatment using next-generation humanized syngeneic mice.
- Principal Investigator
  
  Ogawa Osamu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Development of CAR-T cell therapy derived from iPS cells for solid tumorPrincipal Investigator
- Principal Investigator
  
  Kashima Soki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Akita University
  Kyoto University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Update on Biomarkers in Renal Cell Carcinoma2024
- Author(s)
  Saliby RM, Saad E, Kashima S, Schoenfeld DA, Braun DA.
- Journal Title
  
  Am Soc Clin Oncol Educ Book
  
  Volume: 44 Issue: 2 Pages: 1-10
- DOI
  10.1200/edbk_430734
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16750
[Journal Article] BRCA2 Frameshift Mutation in de novo Small-Cell Neuroendocrine Carcinoma of the Prostate: A Case Report.2023
- Author(s)
  Okubo K, Narita S, Koizumi A, Takahashi Y, Sagehashi R, Mori K, Sobu R, Sato H, Kashima S, Kobayashi M, Yamamoto R, Nara T, Numakura K, Saito M, Nanjo H, Habuchi T.
- Journal Title
  
  Case Rep Oncol.
  
  Volume: 14 Pages: 621-627
- DOI
  10.1159/000531134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09464
[Journal Article] The Changing Landscape of Immunotherapy for Advanced Renal Cancer2023
- Author(s)
  Soki Kashima, David A. Braun
- Journal Title
  
  Urologic Clinics of North America
  
  Volume: 50 Issue: 2 Pages: 335-349
- DOI
  10.1016/j.ucl.2023.01.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16750
[Journal Article] Severe Immune-Related Adverse Events in Patients Treated with Nivolumab for Metastatic Renal Cell Carcinoma Are Associated with PDCD1 Polymorphism2022
- Author(s)
  Kobayashi Mizuki、Numakura Kazuyuki、Hatakeyama Shingo、Muto Yumina、Sekine Yuya、Sasagawa Hajime、Kashima Soki、Yamamoto Ryohei、Koizumi Atsushi、Nara Taketoshi、Saito Mitsuru、Narita Shintaro、Ohyama Chikara、Habuchi Tomonori
- Journal Title
  
  Genes
  
  Volume: 13 Issue: 7 Pages: 1204-1204
- DOI
  10.3390/genes13071204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09553, KAKENHI-PROJECT-23K21469
[Journal Article] Real-world survival outcomes of adding docetaxel or abiraterone in patients with high-volume metastatic castration-sensitive prostate cancer: historically controlled, propensity score matched comparison with androgen deprivation therapy2022
- Author(s)
  Narita Shintaro、Kimura Takahiro、Hatakeyama Shingo、et al
- Journal Title
  
  World Journal of Urology
  
  Volume: - Issue: 5 Pages: 1135-1141
- DOI
  10.1007/s00345-022-03963-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09517, KAKENHI-PROJECT-23K21469
[Journal Article] Impact of germline HLA genotypes on clinical outcomes in patients with urothelial cancer treated with pembrolizumab2022
- Author(s)
  Takahashi Shuhei、Narita Shintaro、Ogawa Osamu、Habuchi Tomonori
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 12 Pages: 4059-4069
- DOI
  10.1111/cas.15488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K21469, KAKENHI-PROJECT-21K06592
[Journal Article] pecific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression.2022
- Author(s)
  Sato H, Narita S, Ishida M, Takahashi Y, Mingguo H, Kashima S, Yamamoto R, Koizumi A, Nara T, Numakura K, Saito M, Yoshioka T, Habuchi T.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 4 Pages: 2214-2214
- DOI
  10.3390/ijms23042214
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09663, KAKENHI-PROJECT-18K06981, KAKENHI-PROJECT-21K06880, KAKENHI-PROJECT-23K21469
[Journal Article] Altering phosphoinositides in high‐fat diet‐associated prostate tumor xenograft growth2021
- Author(s)
  Huang Mingguo、Koizumi Atsushi、Narita Shintaro、Nakanishi Hiroki、Sato Hiromi、Kashima Soki、Nara Taketoshi、Kanda Sohei、Numakura Kazuyuki、Saito Mitsuru、Satoh Shigeru、Nanjo Hiroshi、Sasaki Takehiko、Habuchi Tomonori
- Journal Title
  
  MedComm
  
  Volume: 2 Issue: 4 Pages: 756-764
- DOI
  10.1002/mco2.89
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K18084, KAKENHI-PROJECT-21K19329, KAKENHI-PROJECT-23K21469
[Presentation] 新規癌患者由来マウスモデルを用いた免疫チェックポイント阻害薬作用機構の網羅的解明と治療効果予測バイオマーカーの開発2023
- Author(s)
  蘇武竜太、嘉島相輝、藤山信弘、武田将司、小林瑞貴、山本竜平、奈良健平、沼倉一幸、齋藤満、成田伸太郎、赤松秀輔、井上高光、小林恭、羽渕友則
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K16750
[Presentation] Exploring predictive biomarkers for the efficacy of immune checkpoint inhibitors in advanced renal cell carcinoma2023
- Author(s)
  Ryuta Sobu, Soki Kashima, Nobuhiro Fujiyama, Mizuki Kobayashi, Ryohei Yamamoto, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Tomonori Habuchi
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K16750
[Presentation] Specific gut microbial environment and intratumoral lipid metabolism change in lard diet-induced prostate cancer progression2023
- Author(s)
  Sato H.S 1 , Narita S.N 1 , Takahashi Y.T 1 , Ishida M.I 1 , Kobayashi M.K 1 , Kashima S.K 1 , Yamamoto R.Y 1 , Nara T.N 1 , Huang M.H 1 , Numakura K.N 1 , Saito M.S 1 , Yoshioka T.Y 2 , Habuchi T.H 1
- Organizer
  The 38th Annual European Association of Urology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09464
[Presentation] 腎癌に対する免疫チェックポイント阻害薬の不応性機構の探索と新規治療標的の開発2023
- Author(s)
  蘇武竜太，嘉島相輝，奈良健平，沼倉一幸，齋藤満，成田伸太郎，赤松秀輔，井上高光，小林恭，羽渕友則
- Organizer
  第32回泌尿器科分子・細胞研究会
- Data Source
  KAKENHI-PROJECT-21K16750
[Presentation] Identification of biomarkers and development of novel therapeutic targets to overcome resistance to immune checkpoint inhibitor in renal cell carcinoma2023
- Author(s)
  Ryuta Sobu, Soki Kashima, Nobuhiro Fujiyama, Masashi Takeda, Mizuki Kobayashi, Ryohei Yamamoto, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Shintaro Narita, Shusuke Akamatsu, Takamitsu Inoue, Takashi Kobayashi, Tomonori Habuchi
- Organizer
  第110回日本泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-21K16750
[Presentation] Saturated-fat diet acceleration of castration-induced bone loss through specific gut microbial profiles in old male mice2023
- Author(s)
  Narita N.S. , Ishida M.I. , Sato H.S. , Takahashi Y.T. , Huang M.H. , Kobayashi M.K. , Kashima S.K. , Yamamoto R.Y. , Numakura K.N. , Saito M.S. , Habuchi T.H.
- Organizer
  The 38th Annual European Association of Urology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09464
[Presentation] Development of an experimental toolkit to assess T cell function in renal cell carcinoma (RCC)2023
- Author(s)
  Soulati HA*, Kashima S*, Madsen KN, Sadak KE, Kenney PA, Singh D, Hurwitz ME, Kluger HM, Adeniran A, Humphrey PA, Schindler NR, Braun DA.
- Organizer
  Kidney Cancer Research Sumit 2023 (KCRS23)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16750
[Presentation] Lard diet accelerates prostate cancer progression through tumor infiltrating regulatory T cell recruitment by gut microbial alteration in mice2023
- Author(s)
  Hiromi Sato 1, Shintaro Narita 1, Yoshiko Takahashi 1, Masanori Ishida 1, Huang Mingguo 1, Soki Kashima 1, Ryohei Yamamoto 1, Atsushi Koizumi 1, Taketoshi Nara 1, Kazuyuki Numakura 1, Mitsuru Saito 1, Toshiaki Yoshioka 2, Naoshi Dohmae 3 and Tomonori Habuchi 1
- Organizer
  The 82nd annual meeting of Japanese Cancer Association
- Data Source
  KAKENHI-PROJECT-22K09464
[Presentation] TIGIT as a potential therapeutic target in renal cell carcinoma2023
- Author(s)
  Kashima S, Soulati HA, Madsen KN, Sadak KE, Wirth L, Hurwitz ME, Kluger HM, Sznol M, Humphrey PA, Adeniran A, Kenney PA, Braun DA.
- Organizer
  Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16750
[Presentation] Lard diet promotes prostate caner progression through modulating gut microbiota and intratumoral lipid metabolism2022
- Author(s)
  Hiromi Sato , Shintaro Narita, Yoshiko Takahashi, Masanori Ishida, Soki Kashima,Ryohei Yamamoto,Atsushi Koizumi, Taketoshi Nara, Mingguo Huang, Kazuyuki Numakura, Mitsuru Saito,Toshiaki Yoshioka, Tomonori Habuchi
- Organizer
  The 117th Annual Meeting of the American Urological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09464
[Presentation] Immune score of tumor-infiltrating CD8+ and FoxP3+ lymphocytes as a novel prognostic biomarker in high-risk localized prostate cancer who underwent radical prostatectomy2022
- Author(s)
  Hiromi Sato , Shintaro Narita, Yoshiko Takahashi, Masanori Ishida, Mizuki Kobayashi, Soki Kashima, Ryohei Yamamoto, Taketoshi Nara, Mingguouyuki Numakura, Mitsuru Saito,Hiroshi Nanjo,Tomon Huang, Kazori Habuchi
- Organizer
  The 117th Annual Meeting of the American Urological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09464
[Presentation] Exploration of predictive markers for the efficacy of immune checkpoint inhibitors in metastatic renal cell carcinoma2022
- Author(s)
  蘇武竜太、嘉島相輝、小林瑞貴、山本竜平、奈良健平、沼倉一幸、齋藤満、成田伸太郎、羽渕友則
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16750
[Presentation] Specific gut microbial environment and intratumoral lipid metabolism change in lard diet-induced prostate cancer progression2022
- Author(s)
  Sato H.S, Narita S.N, Takahashi Y.T, Ishida M.I, Kobayashi M.K, Kashima S.K, Yamamoto R.Y, Nara T.N, Huang M.H, Numakura K.N, Saito M.S, Yoshioka T.Y, Habuchi T.H
- Organizer
  EAU23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09464
[Presentation] iPS細胞技術を融合した前立腺癌に対するCAR-T細胞療法の開発2021
- Author(s)
  嘉島相輝
- Organizer
  第16回 Basic Urology Research Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-19K23913
[Presentation] Impact of germline HLA status on clinical outcomes in patients with chemoresistant urothelial cancer treated with pembrolizumab2021
- Author(s)
  Shintaro Narita, Nobuhiro Fujiyama, Syuhei Takahashi, Takashi Kobayashi, Shingo Hatakeyama, Sei Naito, Renpei Kato, Toru Sakatani, Soki Kashima, Ryohei Yamamoto, Atsushi Koizumi, Taketoshi Nara, Kazuyuki Numakura, Mitsuru Saito, Tomonori Habuchi
- Organizer
  The 116th Annual Meeting of the American Urological Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06592

1. 成田伸太郎 (40396552)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
2. 沼倉一幸 (90566415)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. Ogawa Osamu (90260611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 中村英二郎 (90293878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 後藤崇之 (90806605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 藤山信弘 (90603275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 細道一善 (50420948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 羽渕友則 (00293861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 堂前直 (00321787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 南條博 (70250892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 土谷順彦 (70282176)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大山力 (80282135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAITO Mitsuru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 小林瑞貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 畠山真吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kashima Soki 嘉島 相輝

Research Projects

Research Products

Co-Researchers

腎癌に対する免疫チェックポイント阻害薬抵抗性の克服Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

T cell immune microenvironment on prostate cancer progression through the modulation of gut microbiome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫チェックポイント阻害薬の治療有効性・抵抗性の要因評価～宿主腫瘍HLA環境解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of Biomarkers to Predict the Efficacy of Immune Checkpoint Inhibitor Therapy in Renal Cell CarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms and target molecules associated with progression and treatment resistance of urologic cancers associated with microbiome alterations by diet and obesity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of an evaluation model for renal cancer immune niche replication and treatment using next-generation humanized syngeneic mice.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of CAR-T cell therapy derived from iPS cells for solid tumorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Update on Biomarkers in Renal Cell Carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BRCA2 Frameshift Mutation in de novo Small-Cell Neuroendocrine Carcinoma of the Prostate: A Case Report.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Changing Landscape of Immunotherapy for Advanced Renal Cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Severe Immune-Related Adverse Events in Patients Treated with Nivolumab for Metastatic Renal Cell Carcinoma Are Associated with PDCD1 Polymorphism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Real-world survival outcomes of adding docetaxel or abiraterone in patients with high-volume metastatic castration-sensitive prostate cancer: historically controlled, propensity score matched comparison with androgen deprivation therapy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of germline HLA genotypes on clinical outcomes in patients with urothelial cancer treated with pembrolizumab2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] pecific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression.2022

Author(s)

Journal Title

DOI

Kashima Soki 嘉島相輝

[Presentation] 新規癌患者由来マウスモデルを用いた免疫チェックポイント阻害薬作用機構の網羅的解明と治療効果予測バイオマーカーの開発2023

[Presentation] 腎癌に対する免疫チェックポイント阻害薬の不応性機構の探索と新規治療標的の開発2023