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TATEISHI HIROSHI  立石 大

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Tateishi Hiroshi  立石 大

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Researcher Number 50846011
Other IDs
Affiliation (Current) 2022: 熊本大学, 大学院生命科学研究部(薬), 特任助教
Affiliation (based on the past Project Information) *help 2019 – 2021: 熊本大学, 大学院生命科学研究部(薬), 特任助教
Review Section/Research Field
Principal Investigator
0801:Pharmaceutical sciences and related fields
Except Principal Investigator
Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords
Principal Investigator
HIV / Gag蛋白質 / MAドメイン / L-HIPPO / Lock-in and apoptosis / HIV-1 / Gag-MA / IP6 / Lock in and apoptosis / HIV Gag / プロドラッグ … More
Except Principal Investigator
… More HIV根絶 / Gag / イノシトールリン脂質 / アポトーシス / プロドラッグ体 / HIV Less
  • Research Projects

    (2 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (8 People)
  •  Structure optimization of compounds to confine HIV in a cell and induce apoptosis aiming at drugs

    • Principal Investigator
      藤田 美歌子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Kumamoto University
  •  Development of the novel HIV eradication methodPrincipal Investigator

    • Principal Investigator
      Tateishi Hiroshi
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0801:Pharmaceutical sciences and related fields
    • Research Institution
      Kumamoto University

All 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases2021

    • Author(s)
      Mohassab Aliaa M.、Hassan Heba A.、Abdelhamid Dalia、Gouda Ahmed M.、Youssif Bahaa G.M.、Tateishi Hiroshi、Fujita Mikako、Otsuka Masami、Abdel-Aziz Mohamed
    • Journal Title

      Bioorganic Chemistry

      Volume: 106 Pages: 104510-104510

    • DOI

      10.1016/j.bioorg.2020.104510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Journal Article] Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M2021

    • Author(s)
      Kamo Masahiro、Ito Miu、Toma Tsugumasa、Gotoh Haruna、Shimozono Rie、Nakagawa Riko、Koga Ryoko、Monde Kazuaki、Tateishi Hiroshi、Misumi Shogo、Otsuka Masami、Fujita Mikako
    • Journal Title

      Bioorganic Chemistry

      Volume: 107 Pages: 104627-104627

    • DOI

      10.1016/j.bioorg.2021.104627

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Journal Article] The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles2020

    • Author(s)
      Shimagaki Kazunori、Koga Ryoko、Fujino Haruna、Ahagon Ami、Tateishi Hiroshi、Otsuka Masami、Yamaguchi Yoshihiro、Fujita Mikako
    • Journal Title

      Journal of General Virology

      Volume: 101 Pages: 997-1007

    • DOI

      10.1099/jgv.0.001456

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Journal Article] HSP70 induction by bleomycin metal core analogs2020

    • Author(s)
      Ali Taha F.S.、Taira Naomi、Iwamaru Kana、Koga Ryoko、Kamo Masahiro、Radwan Mohamed O.、Tateishi Hiroshi、Kurosaki Hiromasa、Abdel-Aziz Mohamed、Abuo-Rahma Gamal El-Din A.A.、Beshr Eman A.M.、Otsuka Masami、Fujita Mikako
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30 Pages: 127002-127002

    • DOI

      10.1016/j.bmcl.2020.127002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Journal Article] In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors2020

    • Author(s)
      Belgin Sever, Mehlika Dilek Altintop, Ahmet Ozdemir, Gulsen Akalin Ciftci, Doha E. Ellakwa, Hiroshi Tateishi, Mohamed O. Radwan, Mahmoud A. A. Ibrahim, Masami Otsuka, Mikako Fujita, Halil I. Ciftci and Taha F. S. Ali
    • Journal Title

      Molecules

      Volume: 25 Pages: 5190-5190

    • DOI

      10.3390/molecules25215190

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Journal Article] Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers2020

    • Author(s)
      Radwan Mohamed O.、Takaya Daisuke、Koga Ryoko、Iwamaru Kana、Tateishi Hiroshi、Ali Taha F.S.、Takaori-Kondo Akifumi、Otsuka Masami、Honma Teruki、Fujita Mikako
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 28 Pages: 115409-115409

    • DOI

      10.1016/j.bmc.2020.115409

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Journal Article] Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition2020

    • Author(s)
      Radwan, M.O., Ciftci, H.I., Ali, T.F.S., Koga, R., Tateishi, H., Nakata, A., Ito, A., Yoshida, M., Fujita, M., Otsuka, M.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30(19) Pages: 127458-127458

    • DOI

      10.1016/j.bmcl.2020.127458

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19K23802
  • [Journal Article] Minimum structural requirements for inhibitors of the zinc finger protein TRAF62019

    • Author(s)
      Radwan Mohamed O.、Koga Ryoko、Hida Tomohiro、Ejima Tomohiko、Kanemaru Yosuke、Tateishi Hiroshi、Okamoto Yoshinari、Inoue Jun-ichiro、Fujita Mikako、Otsuka Masami
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Pages: 2162-2167

    • DOI

      10.1016/j.bmcl.2019.06.050

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23802, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-ORGANIZER-16H06573, KAKENHI-PLANNED-16H06575
  • [Journal Article] Antiproliferative S-trityl-l-cysteine-derived compounds as SIRT2 inhibitors: Repurposing and solubility enhancement.2019

    • Author(s)
      Radwan Mohamed O.、Ciftci Halil I.、Ali Taha F. S.、Ellakwa Doha E.、Koga Ryoko、Tateishi Hiroshi、Nakata Akiko、Ito Akihiro、Yoshida Minoru、Okamoto Yoshinari、Fujita Mikako、Otsuka Masami
    • Journal Title

      Molecules

      Volume: 24 Pages: 3295-3295

    • DOI

      10.3390/molecules24183295

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-26221204
  • [Journal Article] Antileukemic Activity of Twig Components of Caucasian Beech in Turkey.2019

    • Author(s)
      Shida Wataru、Tateishi Hiroshi、Tahara Yurika、Fujita Mikako、Husham Majeed Alsaadi Doaa、Watanabe Masato、Koga Ryoko、Radwan Mohamed O.、Ciftci Halil I.、Gezici Sevgi、Kurauchi Yuki、Katsuki Hiroshi、Otsuka Masami、Sugimura Koji、Wada Mikiyo、Sekeroglu Nazim、Watanabe Takashi
    • Journal Title

      Molecules.

      Volume: 24 Pages: 3850-3850

    • DOI

      10.3390/molecules24213850

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07101, KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-16H04673
  • [Journal Article] Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity2019

    • Author(s)
      I. Ciftci Halil、O. Radwan Mohamed、E. Ozturk Safiye、Ulusoy N. Gokce、Sozer Ece、E. Ellakwa Doha、Ocak Zeynep、Can Mustafa、F.S. Ali Taha、I. Abd-Alla Howaida、Yayli Nurettin、Tateishi Hiroshi、Otsuka Masami、Fujita Mikako
    • Journal Title

      Molecules

      Volume: 24 Pages: 3535-3535

    • DOI

      10.3390/molecules24193535

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Journal Article] Anti-cancer activity of the cell membrane-permeable phytic acid prodrug.2019

    • Author(s)
      Masunaga Takuya、Murao Naoki、Tateishi Hiroshi、Koga Ryoko、Ohsugi Takeo、Otsuka Masami、Fujita Mikako
    • Journal Title

      Bioorgamic Chemistry

      Volume: 92 Pages: 103240-103240

    • DOI

      10.1016/j.bioorg.2019.103240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-17K08861
  • [Presentation] IP6によるHIV制御メカニズムの解明とその誘導体L-HIPPOを用いたHIV根治薬の開発2019

    • Author(s)
      立石大
    • Organizer
      第42回 日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K23802
  • [Presentation] 人工イノシトールリン脂質誘導体を用いた新規HIV-1根絶法の開発2019

    • Author(s)
      立石大
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Data Source
      KAKENHI-PROJECT-19K23802
  • 1.  藤田 美歌子 (00322256)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  大塚 雅巳 (40126008)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  KURAUCHI Yuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  井上 純一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  伊藤 昭博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 6.  吉田 稔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 7.  香月 博志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  大杉 剛生
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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