TATEISHI HIROSHI 立石大

… Alternative Names

Tateishi Hiroshi 立石大

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Researcher Number	50846011
Other IDs
Affiliation (Current)	2025: 熊本大学, 薬学部, 客員准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 熊本大学, 薬学部, 客員准教授 2019 – 2022: 熊本大学, 大学院生命科学研究部(薬), 特任助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator 脂肪蓄積 / 線維化 / 時計遺伝子 / NASH / プロドラッグ / HIV Gag / Lock in and apoptosis / IP6 / Gag-MA / HIV-1 … More / Lock-in and apoptosis / L-HIPPO / MAドメイン / Gag蛋白質 / HIV … More Except Principal Investigator ナファモスタット / ADAM17 / TGF-b/Smad / COVID-19 / タンパク質発現 / Gag MAドメイン / HIV Gagタンパク質 / HIV潜伏感染細胞 / エイズ完全治癒 / プロドラッグ体 / HIV根絶 / X線結晶解析 / IP6 / プロドラッグ / Gag / アポトーシス / イノシトールリン脂質 / エイズ根絶 / HIV Less

時計遺伝子BMAL1を標的としたNASH治療薬の開発研究Principal Investigator
- Principal Investigator
  
  立石大
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kumamoto University
Development of therapeutic drugs that tandemly suppress infection, lung fibrosis, and malignant transformation of the new coronavirus
- Principal Investigator
  
  大塚雅巳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kumamoto University
Structure optimization of compounds to confine HIV in a cell and induce apoptosis aiming at drugs
- Principal Investigator
  
  Fujita Mikako
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Kumamoto University
Development of the novel HIV eradication methodPrincipal Investigator
- Principal Investigator
  
  Tateishi Hiroshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Kumamoto University

All 2021 2020 2019

All Journal Article Presentation

[Journal Article] Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases2021
- Author(s)
  Mohassab Aliaa M.、Hassan Heba A.、Abdelhamid Dalia、Gouda Ahmed M.、Youssif Bahaa G.M.、Tateishi Hiroshi、Fujita Mikako、Otsuka Masami、Abdel-Aziz Mohamed
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 106 Pages: 104510-104510
- DOI
  10.1016/j.bioorg.2020.104510
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365
[Journal Article] Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M2021
- Author(s)
  Kamo Masahiro、Ito Miu、Toma Tsugumasa、Gotoh Haruna、Shimozono Rie、Nakagawa Riko、Koga Ryoko、Monde Kazuaki、Tateishi Hiroshi、Misumi Shogo、Otsuka Masami、Fujita Mikako
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 107 Pages: 104627-104627
- DOI
  10.1016/j.bioorg.2021.104627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365
[Journal Article] The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles2020
- Author(s)
  Shimagaki Kazunori、Koga Ryoko、Fujino Haruna、Ahagon Ami、Tateishi Hiroshi、Otsuka Masami、Yamaguchi Yoshihiro、Fujita Mikako
- Journal Title
  
  Journal of General Virology
  
  Volume: 101 Issue: 9 Pages: 997-1007
- DOI
  10.1099/jgv.0.001456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365
[Journal Article] HSP70 induction by bleomycin metal core analogs2020
- Author(s)
  Ali Taha F.S.、Taira Naomi、Iwamaru Kana、Koga Ryoko、Kamo Masahiro、Radwan Mohamed O.、Tateishi Hiroshi、Kurosaki Hiromasa、Abdel-Aziz Mohamed、Abuo-Rahma Gamal El-Din A.A.、Beshr Eman A.M.、Otsuka Masami、Fujita Mikako
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 30 Issue: 7 Pages: 127002-127002
- DOI
  10.1016/j.bmcl.2020.127002
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365, KAKENHI-PROJECT-17H03999
[Journal Article] In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors2020
- Author(s)
  Belgin Sever, Mehlika Dilek Altintop, Ahmet Ozdemir, Gulsen Akalin Ciftci, Doha E. Ellakwa, Hiroshi Tateishi, Mohamed O. Radwan, Mahmoud A. A. Ibrahim, Masami Otsuka, Mikako Fujita, Halil I. Ciftci and Taha F. S. Ali
- Journal Title
  
  Molecules
  
  Volume: 25 Issue: 21 Pages: 5190-5190
- DOI
  10.3390/molecules25215190
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365
[Journal Article] Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers2020
- Author(s)
  Radwan Mohamed O.、Takaya Daisuke、Koga Ryoko、Iwamaru Kana、Tateishi Hiroshi、Ali Taha F.S.、Takaori-Kondo Akifumi、Otsuka Masami、Honma Teruki、Fujita Mikako
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 8 Pages: 115409-115409
- DOI
  10.1016/j.bmc.2020.115409
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365, KAKENHI-PROJECT-17H03999
[Journal Article] Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.2020
- Author(s)
  Radwan, M.O., Ciftci, H.I., Ali, T.F.S., Koga, R., Tateishi, H., Nakata, A., Ito, A., Yoshida, M., Fujita, M., Otsuka, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 30(19) Issue: 19 Pages: 127458-127458
- DOI
  10.1016/j.bmcl.2020.127458
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-20H03365
[Journal Article] Minimum structural requirements for inhibitors of the zinc finger protein TRAF62019
- Author(s)
  Radwan Mohamed O.、Koga Ryoko、Hida Tomohiro、Ejima Tomohiko、Kanemaru Yosuke、Tateishi Hiroshi、Okamoto Yoshinari、Inoue Jun-ichiro、Fujita Mikako、Otsuka Masami
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 16 Pages: 2162-2167
- DOI
  10.1016/j.bmcl.2019.06.050
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-ORGANIZER-16H06573, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-17H03999
[Journal Article] Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement2019
- Author(s)
  Radwan Mohamed O.、Ciftci Halil I.、Ali Taha F. S.、Ellakwa Doha E.、Koga Ryoko、Tateishi Hiroshi、Nakata Akiko、Ito Akihiro、Yoshida Minoru、Okamoto Yoshinari、Fujita Mikako、Otsuka Masami
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 18 Pages: 3295-3295
- DOI
  10.3390/molecules24183295
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-17H03999
[Journal Article] Antileukemic Activity of Twig Components of Caucasian Beech in Turkey2019
- Author(s)
  Shida Wataru、Tateishi Hiroshi、Tahara Yurika、Fujita Mikako、Husham Majeed Alsaadi Doaa、Watanabe Masato、Koga Ryoko、Radwan Mohamed O.、Ciftci Halil I.、Gezici Sevgi、Kurauchi Yuki、Katsuki Hiroshi、Otsuka Masami、Sugimura Koji、Wada Mikiyo、Sekeroglu Nazim、Watanabe Takashi
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 21 Pages: 3850-3850
- DOI
  10.3390/molecules24213850
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07101, KAKENHI-PROJECT-19K22813, KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-16H04673, KAKENHI-PROJECT-17H03999
[Journal Article] Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity2019
- Author(s)
  I. Ciftci Halil、O. Radwan Mohamed、E. Ozturk Safiye、Ulusoy N. Gokce、Sozer Ece、E. Ellakwa Doha、Ocak Zeynep、Can Mustafa、F.S. Ali Taha、I. Abd-Alla Howaida、Yayli Nurettin、Tateishi Hiroshi、Otsuka Masami、Fujita Mikako
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 19 Pages: 3535-3535
- DOI
  10.3390/molecules24193535
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-17H03999
[Journal Article] Anti-cancer activity of the cell membrane-permeable phytic acid prodrug2019
- Author(s)
  Masunaga Takuya、Murao Naoki、Tateishi Hiroshi、Koga Ryoko、Ohsugi Takeo、Otsuka Masami、Fujita Mikako
- Journal Title
  
  Bioorganic Chemistry
  
  Volume: 92 Pages: 103240-103240
- DOI
  10.1016/j.bioorg.2019.103240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06036, KAKENHI-PROJECT-19K23802, KAKENHI-PROJECT-17K08861, KAKENHI-PROJECT-17H03999
[Presentation] IP6によるHIV制御メカニズムの解明とその誘導体L-HIPPOを用いたHIV根治薬の開発2019
- Author(s)
  立石大
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K23802
[Presentation] 人工イノシトールリン脂質誘導体を用いた新規HIV-1根絶法の開発2019
- Author(s)
  立石大
- Organizer
  日本ケミカルバイオロジー学会　第14回年会
- Data Source
  KAKENHI-PROJECT-19K23802

1. Fujita Mikako (00322256)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 大塚雅巳 (40126008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KURAUCHI Yuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 伊藤昭博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 大杉剛生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TATEISHI HIROSHI 立石 大

Tateishi Hiroshi 立石 大

Research Projects

Research Products

Co-Researchers

時計遺伝子BMAL1を標的としたNASH治療薬の開発研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of therapeutic drugs that tandemly suppress infection, lung fibrosis, and malignant transformation of the new coronavirus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure optimization of compounds to confine HIV in a cell and induce apoptosis aiming at drugs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the novel HIV eradication methodPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The stability of HIV-2 Vpx and Vpr proteins is regulated by the presence or absence of zinc-binding sites and poly-proline motifs with distinct roles2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HSP70 induction by bleomycin metal core analogs2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Minimum structural requirements for inhibitors of the zinc finger protein TRAF62019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antileukemic Activity of Twig Components of Caucasian Beech in Turkey2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity2019

TATEISHI HIROSHI 立石大

Tateishi Hiroshi 立石大