TSUJI Takahiro 辻貴宏

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Tsuji Takahiro 辻貴宏

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Researcher Number	50850046
Other IDs	https://orcid.org/0000-0002-5706-8300
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 客員研究者
Affiliation (based on the past Project Information) *help	2021 – 2023: 名古屋大学, 医学系研究科, 学振特別研究員(PD) 2020: 名古屋大学, 医学系研究科, 研究員 2019: 京都大学, 医学研究科, 医員
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator 転移性脳腫瘍 / 生体イメージング / 転移性脳腫瘍モデル / 治療開発 / Don't eat meシグナル / 腫瘍免疫 / 微小環境 / ミクログリア / EML4-ALK陽性肺癌 / 分子標的薬 … More / アレクチニブ / 初期生存 / 肺癌 / チロシンキナーゼ / ALK / 画像解析 / 治療初期生存 / 治療抵抗性 / YAP1 / 薬剤耐性 / ALK陽性肺癌 Less

Visualization and Identification of Mechanisms Regulating the Elimination of Metastatic Lung Cancer Cells in the BrainPrincipal Investigator
- Principal Investigator
  
  TSUJI TAKAHIRO
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Nagoya University
A study on mechanisms underlying the initial survival of tumor cells against tyrosine kinase inhibitors based on patient-derived tumor models and in vivo real-time imagingPrincipal Investigator
- Principal Investigator
  
  Tsuji Takahiro
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Nagoya University
  Kyoto University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] PD-L1 polymorphisms predict survival outcomes in advanced non-small-cell lung cancer patients treated with PD-1 blockade2021
- Author(s)
  Yoshida Hironori、Nomizo Takashi、Ozasa Hiroaki、Tsuji Takahiro、Funazo Tomoko、Yasuda Yuto、Ajimizu Hitomi、Yamazoe Masatoshi、Kuninaga Kiyomitsu、Ogimoto Tatsuya、Hosoya Kazutaka、Itotani Ryo、Sakamori Yuichi、Kim Young Hak、Hirai Toyohiro
- Journal Title
  
  European Journal of Cancer
  
  Volume: 144 Pages: 317-325
- DOI
  10.1016/j.ejca.2020.11.035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23964
[Journal Article] YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation2020
- Author(s)
  Tsuji Takahiro、Ozasa Hiroaki、Aoki Wataru、Aburaya Shunsuke、Yamamoto Funazo Tomoko、Furugaki Koh、Yoshimura Yasushi、Yamazoe Masatoshi、Ajimizu Hitomi、Yasuda Yuto、Nomizo Takashi、Yoshida Hironori、Sakamori Yuichi、Wake Hiroaki、Ueda Mitsuyoshi、Kim Young Hak、Hirai Toyohiro
- Journal Title
  
  Nature Communications
  
  Volume: 11 Issue: 1 Pages: 19-19
- DOI
  10.1038/s41467-019-13771-5
- NAID
  120006782216
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08601, KAKENHI-PROJECT-20KK0170, KAKENHI-PUBLICLY-19H04753, KAKENHI-PUBLICLY-19H05219, KAKENHI-PLANNED-20H05899, KAKENHI-PROJECT-18H02598, KAKENHI-PROJECT-19K23964
[Journal Article] Acquired Resistance to Alectinib in ALK-Rearranged Lung Cancer due to ABCC11/MRP8 Overexpression in a Clinically Paired Resistance Model2020
- Author(s)
  Funazo Tomoko、Tsuji Takahiro、Ozasa Hiroaki、Furugaki Koh、Yoshimura Yasushi、Oguri Tetsuya、Ajimizu Hitomi、Yasuda Yuto、Nomizo Takashi、Sakamori Yuichi、Yoshida Hironori、Kim Young Hak、Hirai Toyohiro
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 19 Issue: 6 Pages: 1320-1327
- DOI
  10.1158/1535-7163.mct-19-0649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K23964
[Journal Article] MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression2020
- Author(s)
  Yasuda Yuto、Ozasa Hiroaki、Kim Young Hak、Yamazoe Masatoshi、Ajimizu Hitomi、Yamamoto Funazo Tomoko、Nomizo Takashi、Tsuji Takahiro、Yoshida Hironori、Sakamori Yuichi、Nakajima Naoki、Menju Toshi、Yoshizawa Akihiko、Date Hiroshi、Hirai Toyohiro
- Journal Title
  
  Cell Death & Disease
  
  Volume: 11 Issue: 3 Pages: 177-177
- DOI
  10.1038/s41419-020-2379-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J12545, KAKENHI-PROJECT-19K23964
[Presentation] Heterogeneous microglial response to cancer cells visualized by in vivo imaging model2023
- Author(s)
  Takahiro TSUJI, Mariko SHINDO, Daisuke KATO, Hiroaki WAKE
- Organizer
  CSH Asia, Novel Insights into Glia Function & Dysfunction
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] 生体内リアルタイムイメージングが可視化する脳内腫瘍微小環境の自然免疫応答2023
- Author(s)
  辻　貴宏、和氣　弘明
- Organizer
  バイオ・メディカル・フォーラム2024
- Invited
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Heterogeneous microglial response to cancer cells visualized by in vivo imaging model2023
- Author(s)
  Takahiro Tsuji; Mariko Shindo; Rahadian Y. Hartantio; MisuzuHorikoshi; Daisuke Kato; Hiroaki Wake
- Organizer
  ISN-ESN meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Interdisciplinary method to elucidate the interaction between brain microenvironment and cancer cells2023
- Author(s)
  Takahiro Tsuji; Hiroaki Wake; Mariko Shindo; Rahadian Y. Hartantio; Misuzu Horikoshi; Daisuke Kato; Hiroaki Ozasa; Toyohiro Hirai
- Organizer
  AACR Annual meeting 2023 in Orlando
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Microglial phagocytosis suppressed the development of metastatic tumors in the imaging model of brain metastasis2022
- Author(s)
  辻貴宏、和氣弘明、進藤麻理子、加藤大輔、小笹裕晃、平井豊博
- Organizer
  Neuro2022 (第45回神経科学大会）
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] In vivo Imaging of Cancer-Brain Immune Microenvironment Interactions2022
- Author(s)
  Takahiro TSUJI, Mariko SHINDO, Rahadian Yudo HARTANTIO, Misuzu HORIKOSHI, Daisuke KATO, Hiroaki WAKE
- Organizer
  第128回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Microglial phagocytosis suppressed the development of metastatic tumors in the imaging model of brain metastasis2022
- Author(s)
  T. Tsuji, H. Wake, M. Shindo, D. Kato, H. Ozasa, T. Hirai
- Organizer
  AACR Annual Meeting 2022
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Microglial phagocytosis suppressed the development of metastatic tumors in the imaging model of brain metastasis2022
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko. Shindo, Daisuke Kato, Hiroaki Ozasa, Toyohiro Hirai
- Organizer
  AACR Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Visualizing the effect of 'don't eat me signal' on microglial anti-tumor activity by in vivo imaging of brain metastases2022
- Author(s)
  辻貴宏、和氣弘明、進藤麻理子、加藤大輔、小笹裕晃、平井豊博
- Organizer
  第127回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] 転移性脳腫瘍の生体内可視化はミクログリアと癌細胞の相互作用の多様さを明らかにする2021
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko Shindo, Daisuke Kato, Hiroaki Ozasa, Toyohiro Hirai
- Organizer
  第 61 回日本呼吸器学会学術講演会.
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] Real time in vivo imaging of brain metastasis visualized dynamic reaction of microglia against cancer cells.2021
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko Shindo, Daisuke Kato, Hiroaki Ozasa, Toyohiro Hirai
- Organizer
  第 126 回日本解剖学会総会・全国学術集会・第 98 回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] Novel in vivo imaging method to evaluate "Don't eat me" signal of tumor against microglia.2021
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko Shindo, Daisuke Kato, Hiroaki Ozasa, Toyohiro Hirai
- Organizer
  2021 AACR Virtual Special Conference: The Evolving Tumor Microenvironment in Cancer Progression: Mechanisms and Emerging Therapeutic Opportunities.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] 転移性脳腫瘍モデルを用いた転移制御因子の探索2021
- Author(s)
  辻貴宏、和氣弘明、進藤麻理子、加藤大輔、小笹裕晃、平井豊博
- Organizer
  第62回日本肺癌学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] 転移性脳腫瘍の生体内可視化はミクログリアと癌細胞の相互作用の多様さを明らかにする2021
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko Shindo, Daisuke Kato, Hiroaki Ozasa, Toyohiro Hirai
- Organizer
  第61回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Microglia phagocytose metastatic tumors and suppress metastasis formation2021
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko Shindo, Daisuke Kato, Hiroaki Ozasa, Toyohiro Hirai
- Organizer
  第80回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16140
[Presentation] Real time in vivo imaging of brain metastasis visualized dynamic reaction of microglia against cancer cells2021
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko Shindo, Daisuke Kato, Hiroaki Ozasa, Toyohiro Hirai
- Organizer
  AACR Virtual Annual Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] YAP1 は抗 Apoptosis 因子 Mcl-1 と Bcl-xL の発現調節を介して，ALK 陽性肺癌細胞の初期生存を仲介する2020
- Author(s)
  辻貴宏、小笹裕晃、青木航、油屋駿介、船造智子、山添正敏、味水瞳、安田有斗、野溝岳、吉田博徳、阪森優一、和氣弘明、植田充美、平井豊博、金永学
- Organizer
  第 61 回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] Novel in vivo imaging method to evaluate “Don't eat me” signal of tumor against microglia2020
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Mariko Shindo, Koichiro Haruwaka, Hitomi Ajimizu, Masatoshi Yamazoe, Tomoko Funazo, Yuto Yasuda, Hironori Yoshida, Yuichi Sakamori, Young Hak Kim, Hiroaki Ozasa and Toyohiro Hirai
- Organizer
  AACR annual meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] 転移性脳腫瘍の可視化モデル2019
- Author(s)
  辻貴宏、和氣弘明、小笹裕晃、進藤麻理子、味水瞳、山添正敏、安田有斗、阪森優一、野溝岳、金永学、平井豊博
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] Real-time visualization of brain metastasis in vivo2019
- Author(s)
  Takahiro Tsuji, Hiroaki Wake, Hiroaki Ozasa, Koichiro Haruwaka, Hitomi Ajimizu, Yuto Yasuda, Yuichi Sakamori, Takashi Nomizo, Young Hak Kim and Toyohiro Hirai
- Organizer
  AACR annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23964
[Presentation] YAP1 mediates initial survival of alectinib therapy in ALK-rearranged lung cancer via pro-apoptotic protein regulation2019
- Author(s)
  Takahiro Tsuji, Hiroaki Ozasa, Wataru Aoki, Shunsuke Aburaya, Tomoko Funazo, Koh Furugaki, Yasushi Yoshimura, Hitomi Ajimizu, Yuto Yasuda, Takashi Nomizo, Yuichi Sakamori, Hironori Yoshida, Mitsuyoshi Ueda, Young Hak Kim and Toyohiro Hirai
- Organizer
  AACR annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23964

1. 小笹裕晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 青木航

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 吉田博徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUJI Takahiro 辻 貴宏

Tsuji Takahiro 辻 貴宏

Research Projects

Research Products

Co-Researchers

Visualization and Identification of Mechanisms Regulating the Elimination of Metastatic Lung Cancer Cells in the BrainPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A study on mechanisms underlying the initial survival of tumor cells against tyrosine kinase inhibitors based on patient-derived tumor models and in vivo real-time imagingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] PD-L1 polymorphisms predict survival outcomes in advanced non-small-cell lung cancer patients treated with PD-1 blockade2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] YAP1 mediates survival of ALK-rearranged lung cancer cells treated with alectinib via pro-apoptotic protein regulation2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Acquired Resistance to Alectinib in ALK-Rearranged Lung Cancer due to ABCC11/MRP8 Overexpression in a Clinically Paired Resistance Model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Heterogeneous microglial response to cancer cells visualized by in vivo imaging model2023

Author(s)

Organizer

Data Source

[Presentation] 生体内リアルタイムイメージングが可視化する脳内腫瘍微小環境の自然免疫応答2023

Author(s)

Organizer

Data Source

[Presentation] Heterogeneous microglial response to cancer cells visualized by in vivo imaging model2023

Author(s)

Organizer

Data Source

[Presentation] Interdisciplinary method to elucidate the interaction between brain microenvironment and cancer cells2023

Author(s)

Organizer

Data Source

[Presentation] Microglial phagocytosis suppressed the development of metastatic tumors in the imaging model of brain metastasis2022

Author(s)

Organizer

Data Source

[Presentation] In vivo Imaging of Cancer-Brain Immune Microenvironment Interactions2022

Author(s)

Organizer

Data Source

[Presentation] Microglial phagocytosis suppressed the development of metastatic tumors in the imaging model of brain metastasis2022

Author(s)

Organizer

Data Source

[Presentation] Microglial phagocytosis suppressed the development of metastatic tumors in the imaging model of brain metastasis2022

Author(s)

Organizer

Data Source

[Presentation] Visualizing the effect of 'don't eat me signal' on microglial anti-tumor activity by in vivo imaging of brain metastases2022

Author(s)

Organizer

Data Source

[Presentation] 転移性脳腫瘍の生体内可視化はミクログリアと癌細胞の相互作用の多様さを明らかにする2021

Author(s)

Organizer

Data Source

[Presentation] Real time in vivo imaging of brain metastasis visualized dynamic reaction of microglia against cancer cells.2021

Author(s)

TSUJI Takahiro 辻貴宏

Tsuji Takahiro 辻貴宏