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Murai Kazuhiro
村井 一裕
Researcher Number
50867314
Other IDs
https://orcid.org/0000-0001-8634-2922
Affiliation (Current)
2025: 大阪大学, 医学部附属病院, 特任助教(常勤)
Affiliation (based on the past Project Information)
*help
2025: 大阪大学, 医学部附属病院, 特任助教(常勤)
2022 – 2023: 大阪大学, 医学部附属病院, 特任助教(常勤)
2021: 大阪大学, 医学系研究科, 特任助教(常勤)
2020: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related
Keywords
Principal Investigator
HBV / HCC / MASH / MASLD / ecDNA / 星細胞 / single cell RNA sequence / ISG / ヒト肝細胞キメラマウス / scRNAseq
…
More
/ 共感染 / HCV / プロテオーム解析 / 肝細胞癌 / 核酸アナログ製剤 / single RNA sequence / B型肝炎 / CRISPR/Cas9 / 非相同末端修復 / オラパリブ / PARP / cccDNA / LIG4 / HPF1 / PARP阻害薬 / olaparib / 非相同末端修復結合
Less
Research Projects
(
3
results)
Research Products
(
7
results)
Project Start Year (Newest)
Project Start Year (Oldest)
Elucidation of the impact of extrachromosomal circular DNA on metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma
Principal Investigator
Principal Investigator
村井 一裕
Project Period (FY)
2025 – 2027
Research Category
Grant-in-Aid for Scientific Research (C)
Review Section
Basic Section 53010:Gastroenterology-related
Research Institution
The University of Osaka
Elucidation of the mechanism of acceleration of fibrosis progression in coinfection with hepatitis B and C viruses
Principal Investigator
Principal Investigator
Murai Kazuhiro
Project Period (FY)
2022 – 2023
Research Category
Grant-in-Aid for Early-Career Scientists
Review Section
Basic Section 53010:Gastroenterology-related
Research Institution
Osaka University
Elucidation of pathophysiology after hepatitis B virus cccDNA cleavage by CRISPR / Cas9 treatment
Principal Investigator
Principal Investigator
Murai Kazuhiro
Project Period (FY)
2020 – 2021
Research Category
Grant-in-Aid for Early-Career Scientists
Review Section
Basic Section 53010:Gastroenterology-related
Research Institution
Osaka University
All
2022
2021
2020
All
Presentation
[Presentation] Single cell RNA sequence using the liver tissue derived from humanized liver chimeric mice infected hepatitis C virus
2022
Author(s)
Kazuhiro Murai, Hayato Hikita, Kumiko Shirai, Hiroshi Suemizu, Kunimaro Furuta, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Organizer
The 6th International Workshop on Humanized Mice (IWHM6)
Int'l Joint Research
Data Source
KAKENHI-PROJECT-22K16042
[Presentation] CRISPR/Cas9とPARP阻害薬(オラパリブ)によるB型肝炎根治を目指した新規治療法の検討
2021
Author(s)
村井一裕, 小玉尚宏, 疋田隼人, 下田彬允, 福岡誠, 福富啓祐, 田畑優貴, 牧野祐紀, 山田涼子, 阪森亮太郎, 巽智秀, 竹原徹郎
Organizer
第57回日本肝臓学会総会
Data Source
KAKENHI-PROJECT-20K17020
[Presentation] Novel anti-HBV combination treatment using CRISPR/Cas9 targeting HBV genome and suppression of NHEJ-mediated DNA repair.
2021
Author(s)
Kazuhiro Murai, Takahiro Kodama, Hayato Hikita, Akiyoshi Shimoda, Jihyun Sung, Makoto Fukuoka, Satoshi Shigeno, Keisuke Fukutomi, Yuki Tahata, Yuki Makino, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara 
Organizer
AASLD The Liver Meeting 2021
Int'l Joint Research
Data Source
KAKENHI-PROJECT-20K17020
[Presentation] Novel anti-HBV combination treatment of CRISPR/Cas9 and suppression of NHEJ-mediated DNA repair
2021
Author(s)
Kazuhiro Murai, Takahiro Kodama, Tetsuo Takehara
Organizer
第25回日本肝臓学会大会(JDDW2021)
Data Source
KAKENHI-PROJECT-20K17020
[Presentation] Novel anti-HBV therapies using CRISPR/Cas9 targeting HBV genome strongly suppress HBV
2020
Author(s)
Kazuhiro Murai, Takahiro Kodama, Hayato Hikita, Akiyoshi Shimoda, Makoto Fukuoka, Keisuke Fukutomi, Yuki Tahata, Yuki Makino, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Organizer
AASLD The Liver Meeting Digital Experience (TLMdX)
Int'l Joint Research
Data Source
KAKENHI-PROJECT-20K17020
[Presentation] Efficacy of novel anti-HBV combination therapy with CRISPR/Cas9 targeting HBV genome and inhibitors of host DNA synthesis/repair pathways.
2020
Author(s)
Kazuhiro Murai, Takahiro Kodama, Tetsuo Takehara
Organizer
第24回日本肝臓学会大会（JDDW2020）
Data Source
KAKENHI-PROJECT-20K17020
[Presentation] HBVに対するアデノ随伴ウイルス型CRISPR/Cas9による治療効果の検討
2020
Author(s)
村井一裕、小玉尚宏、疋田隼人、下田彬允、福岡誠、福富啓祐、山井琢陽、中堀輔、山田涼子、阪森亮太郎、巽智秀、竹原徹郎
Organizer
第56回日本肝臓学会総会
Data Source
KAKENHI-PROJECT-20K17020
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