Susukida Takeshi 薄田健史

Researcher Number	50880689
Other IDs	https://orcid.org/0000-0003-1512-0753
Affiliation (Current)	2025: 富山大学, 学術研究部薬学・和漢系, 助教
Affiliation (based on the past Project Information) *help	2020 – 2024: 富山大学, 学術研究部薬学・和漢系, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 0901:Oncology and related fields Except Principal Investigator Medium-sized Section 27:Chemical engineering and related fields / Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator HLA / 細胞内エネルギー代謝 / 薬物過敏症 / T細胞 / CD8陽性T細胞 / 細胞内代謝 / 免疫寛容 / 解糖系 / 腫瘍免疫 Except Principal Investigator smFISH法 … More / 光応答性材料 / がん免疫 / 細胞間相互作用 / 1細胞解析 / 癌性胸膜炎 / 胸膜播種 / VEGF / 胸腔内ガス環境 / ナノバブル / マイクロバブル Less

Elucidation of the pathogenic mechanism of HLA-related drug hypersensitivity focusing on the intracellular energy metabolism environment of immune cellsPrincipal Investigator
- Principal Investigator
  
  薄田健史
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Toyama
Development of a Process for Integrative Single-Cell Analysis of Genes Related to Cancer Immunity
- Principal Investigator
  
  山口哲志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 27:Chemical engineering and related fields
- Research Institution
  Osaka University
帯電性ナノバブルによる胸膜播種抑制効果の研究
- Principal Investigator
  
  本間崇浩
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  St. Marianna University School of Medicine
  University of Toyama
Evaluation of the importance of intracellular metabolism in individual differences in drug hypersensitivity using a mouse model of cutaneous adverse drug reactionPrincipal Investigator
- Principal Investigator
  
  Susukida Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Toyama
Development of a novel anti-cancer immunotherapy based on tumor immunogenicity improvement by abnormal self-antigensPrincipal Investigator
- Principal Investigator
  
  Susukida Takeshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  University of Toyama

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] HLA-B*57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir2024
- Author(s)
  Kazaoka Akira、Fujimori Sota、Yamada Yushiro、Shirayanagi Tomohiro、Gao Yuying、Kuwahara Saki、Sakamoto Naoki、Susukida Takeshi、Aoki Shigeki、Ito Kousei
- Journal Title
  
  PNAS Nexus
  
  Volume: 3 Issue: 4 Pages: 140-140
- DOI
  10.1093/pnasnexus/pgae140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15311, KAKENHI-PROJECT-22KJ0478, KAKENHI-PUBLICLY-23H04764, KAKENHI-PROJECT-23K21366
[Journal Article] Drug-induced altered self-presentation increases tumor immunogenicity2023
- Author(s)
  Susukida Takeshi、Sasaki So-ichiro、Shirayanagi Tomohiro、Aoki Shigeki、Ito Kousei、Hayakawa Yoshihiro
- Journal Title
  
  Biomedicine & Pharmacotherapy
  
  Volume: 165 Pages: 115241-115241
- DOI
  10.1016/j.biopha.2023.115241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15311
[Journal Article] Calorie Restriction Impairs Anti-Tumor Immune Responses in an Immunogenic Preclinical Cancer Model2023
- Author(s)
  Dung Nguyen Tien、Susukida Takeshi、Ucche Sisca、He Ka、Sasaki So-ichiro、Hayashi Ryuji、Hayakawa Yoshihiro
- Journal Title
  
  Nutrients
  
  Volume: 15 Issue: 16 Pages: 3638-3638
- DOI
  10.3390/nu15163638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15311
[Journal Article] The PD1 inhibitory pathway and mature dendritic cells contribute to abacavir hypersensitivity in human leukocyte antigen transgenic PD1 knockout mice2021
- Author(s)
  Song Binbin、Aoki Shigeki、Liu Cong、Susukida Takeshi、Kuwahara Saki、Ito Kousei
- Journal Title
  
  Toxicology
  
  Volume: 463 Pages: 152971-152971
- DOI
  10.1016/j.tox.2021.152971
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22801, KAKENHI-PROJECT-19H03386, KAKENHI-PROJECT-21K15311, KAKENHI-PROJECT-23K21366
[Journal Article] Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity2021
- Author(s)
  Susukida Takeshi、Kuwahara Saki、Song Binbin、Kazaoka Akira、Aoki Shigeki、Ito Kousei
- Journal Title
  
  Communications Biology
  
  Volume: 4 Issue: 1 Pages: 1137-1137
- DOI
  10.1038/s42003-021-02657-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22801, KAKENHI-PROJECT-19H03386, KAKENHI-PROJECT-21K15311, KAKENHI-PROJECT-23K21366
[Journal Article] Mechanism-based integrated assay systems for the prediction of drug-induced liver injury2020
- Author(s)
  Kawaguchi Moemi、Nukaga Takumi、Sekine Shuichi、Takemura Akinori、Susukida Takeshi、Oeda Shiho、Kodama Atsushi、Hirota Morihiko、Kouzuki Hirokazu、Ito Kousei
- Journal Title
  
  Toxicology and Applied Pharmacology
  
  Volume: 394 Pages: 114958-114958
- DOI
  10.1016/j.taap.2020.114958
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22801
[Journal Article] HLA transgenic mice: application in reproducing idiosyncratic drug toxicity2020
- Author(s)
  Susukida Takeshi、Aoki Shigeki、Shirayanagi Tomohiro、Yamada Yushiro、Kuwahara Saki、Ito Kousei
- Journal Title
  
  Drug Metabolism Reviews
  
  Volume: 52 Issue: 4 Pages: 540-567
- DOI
  10.1080/03602532.2020.1800725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22801, KAKENHI-PROJECT-19H03386
[Presentation] 薬物過敏症発症におけるCD8+ T細胞の解糖系代謝の重要性2024
- Author(s)
  薄田健史，孫雨晨, 青木重樹, 伊藤晃成, 早川芳弘
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] HLA多型の関与する薬物過敏症の発症における解糖系代謝の重要性2023
- Author(s)
  薄田健史, 青木重樹, 孫雨晨, 早川芳弘
- Organizer
  第30回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] 細胞内エネルギー代謝環境の変化がHLA多型の関与する薬物過敏症の発症に及ぼす影響2023
- Author(s)
  薄田健史，青木重樹，早川芳弘
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] Glycolysis in CD8+ T cells plays a major role in the onset of HLA-mediated idiosyncratic drug toxicity2023
- Author(s)
  Takeshi Susukida, Shigeki Aoki, Yoshihiro Hayakawa
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotic
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] カロリー制限がHLA多型の関与する薬物毒性発症に及ぼす影響2023
- Author(s)
  薄田健史, 青木重樹, 早川芳弘
- Organizer
  第50回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] Glycolysis in CD8+ T cells plays a major role in the onset of HLA-mediated idiosyncratic drug-induced autoimmune toxicity mouse model2023
- Author(s)
  Takeshi Susukida, Shigeki Aoki, Yuchen Sun, Yoshihiro Hayakawa
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] アバカビルとHLA-B*57:01分子との相互作用による腫瘍免疫原性の改善を志向とした新規がん免疫薬物療法の開発2022
- Author(s)
  薄田健史，青木重樹，白柳智弘, 伊藤晃成, 早川芳弘
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22801
[Presentation] 細胞内代謝環境の変化がHLA多型の関与する薬物過敏症の発症に及ぼす影響2022
- Author(s)
  薄田健史，青木重樹，早川芳弘
- Organizer
  第29回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] 薬物-HLA相互作用による腫瘍免疫原性の改善を志向とした新規がん免疫治療戦略の開発2022
- Author(s)
  薄田健史, 佐々木宗一郎，白柳智弘，青木重樹，伊藤晃成，早川芳弘
- Organizer
  第26回日本がん免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] Intracellular metabolism change affects the susceptibility to HLA-mediated idiosyncratic drug toxicity2022
- Author(s)
  Takeshi Susukida, Shigeki Aoki, Yoshihiro Hayakawa
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] Development of a novel anti-cancer immunotherapy based on tumor immunogenicity improvement by HLA-drug interaction2022
- Author(s)
  Takeshi Susukida, So-ichiro Sasaki, Shigeki Aoki, Yoshihiro Hayakawa
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] キメラ型HLA導入マウスを用いた特異体質薬物毒性の評価2021
- Author(s)
  風岡顯良, 薄田健史，桑原佐季，青木重樹，伊藤晃成
- Organizer
  第28回 HAB研究機構学術年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] 薬物-HLA相互作用を介した腫瘍免疫原性の改善に基づく新規がん免疫治療戦略の開発2021
- Author(s)
  薄田健史，青木重樹，白柳智弘, 伊藤晃成, 早川芳弘
- Organizer
  第25回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-20K22801
[Presentation] HLA多型依存的なアバカビル過敏症発症の個人差に対する免疫寛容系の関与2021
- Author(s)
  桑原佐季，薄田健史，風岡顯良，青木重樹，伊藤晃成
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22801
[Presentation] HLA-B*57:01 遺伝子導入マウスを用いた免疫抑制因子の排除によるアバカビル依存的特異体質毒性の再現2021
- Author(s)
  青木重樹，桑原佐季，薄田健史，風岡顯良，伊藤晃成
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-21K15311
[Presentation] HLA多型特異的な薬物性の免疫毒性発症に対する免疫寛容系の関与2020
- Author(s)
  青木重樹，桑原佐季，薄田健史，伊藤晃成
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K22801
[Presentation] アバカビルによるHLA多型依存的な特異体質毒性の発現への免疫寛容系の関与2020
- Author(s)
  桑原佐季，薄田健史，青木重樹，伊藤晃成
- Organizer
  第27回日本免疫毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K22801

1. 早川芳弘 (10541956)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 本間崇浩 (50436797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大平猛 (00275695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 佐々木宗一郎 (50583473)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山口哲志 (80398106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Susukida Takeshi 薄田 健史

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenic mechanism of HLA-related drug hypersensitivity focusing on the intracellular energy metabolism environment of immune cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a Process for Integrative Single-Cell Analysis of Genes Related to Cancer Immunity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

帯電性ナノバブルによる胸膜播種抑制効果の研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Evaluation of the importance of intracellular metabolism in individual differences in drug hypersensitivity using a mouse model of cutaneous adverse drug reactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel anti-cancer immunotherapy based on tumor immunogenicity improvement by abnormal self-antigensPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] HLA-B*57:01-dependent intracellular stress in keratinocytes triggers dermal hypersensitivity reactions to abacavir2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drug-induced altered self-presentation increases tumor immunogenicity2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calorie Restriction Impairs Anti-Tumor Immune Responses in an Immunogenic Preclinical Cancer Model2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The PD1 inhibitory pathway and mature dendritic cells contribute to abacavir hypersensitivity in human leukocyte antigen transgenic PD1 knockout mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mechanism-based integrated assay systems for the prediction of drug-induced liver injury2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HLA transgenic mice: application in reproducing idiosyncratic drug toxicity2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 薬物過敏症発症におけるCD8+ T細胞の解糖系代謝の重要性2024

Author(s)

Organizer

Data Source

[Presentation] HLA多型の関与する薬物過敏症の発症における解糖系代謝の重要性2023

Author(s)

Organizer

Data Source

[Presentation] 細胞内エネルギー代謝環境の変化がHLA多型の関与する薬物過敏症の発症に及ぼす影響2023

Author(s)

Organizer

Susukida Takeshi 薄田健史