Hata Toshiaki 畑利彰

Researcher Number	50880887
Affiliation (Current)	2025: 独立行政法人国立病院機構四国がんセンター(臨床研究センター), その他部局等, 医師
Affiliation (based on the past Project Information) *help	2023 – 2024: 独立行政法人国立病院機構四国がんセンター(臨床研究センター), その他部局等, 医師 2021 – 2022: 岡山大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator サイトカイン / 腫瘍微小環境 / 軟部肉腫 / 浸潤性軟部肉腫 / 腫瘍随伴マクロファージ / TAM / CSF-1 Except Principal Investigator 体液診断 / 骨軟部腫瘍 / 未分化多型肉腫 … More / 粘液線維肉腫 / 循環分子 / 腫瘍随伴マクロファージ / サイトカイン / 細胞外小胞 / 核酸 / リキッドバイオプシー / 肉腫 / 骨軟部肉腫 / エクソソーム / 体液分子診断 Less

軟部肉腫における腫瘍由来液性因子に惹起される微小環境ネットワークの包括的解明Principal Investigator
- Principal Investigator
  
  畑利彰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Hospital Organization Shikoku Cancer Center
  Okayama University
肉腫における体液分子診断技術の統合的開発と循環分子の新規治療標的としての検証
- Principal Investigator
  
  尾崎敏文
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Development of diagnostic techniques using liquid biopsy and identification of novel mechanisms of tumor progression through circulating molecules in sarcoma
- Principal Investigator
  
  Ozaki Toshifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus2024
- Author(s)
  Uotani Koji、Tazawa Hiroshi、Hasei Joe、Fujiwara Tomohiro、Yoshida Aki、Yamakawa Yasuaki、Omori Toshinori、Sugiu Kazuhisa、Komatsubara Tadashi、Kondo Hiroya、Morita Takuya、Kiyono Masahiro、Yokoo Suguru、Hata Toshiaki、Kunisada Toshiyuki、Takeda Ken、Urata Yasuo、Fujiwara Toshiyoshi、Ozaki Toshifumi
- Journal Title
  
  PLOS ONE
  
  Volume: 19 Issue: 2 Pages: 0298292-0298292
- DOI
  10.1371/journal.pone.0298292
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18329, KAKENHI-PROJECT-21K07219, KAKENHI-PROJECT-23K24461
[Journal Article] Role of Tumor-Associated Macrophages in Sarcomas2021
- Author(s)
  Fujiwara Tomohiro、Healey John、Ogura Koichi、Yoshida Aki、Kondo Hiroya、Hata Toshiaki、Kure Miho、Tazawa Hiroshi、Nakata Eiji、Kunisada Toshiyuki、Fujiwara Toshiyoshi、Ozaki Toshifumi
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 5 Pages: 1086-1086
- DOI
  10.3390/cancers13051086
- NAID
  120007008531
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03784, KAKENHI-PROJECT-21K16709
[Journal Article] CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment2021
- Author(s)
  Fujiwara Tomohiro、Yakoub Mohamed A.、Chandler Andrew、Christ Alexander B.、Yang Guangli、Ouerfelli Ouathek、Rajasekhar Vinagolu K.、Yoshida Aki、Kondo Hiroya、Hata Toshiaki、Tazawa Hiroshi、Dogan Yildirim、Moore Malcolm A.S.、Fujiwara Toshiyoshi、Ozaki Toshifumi、Purdue Ed、Healey John H.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 20 Issue: 8 Pages: 1388-1399
- DOI
  10.1158/1535-7163.mct-20-0591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03784, KAKENHI-PROJECT-21K16709
[Presentation] Circulating CSF-1 predicts infiltration of tumor-associated macrophage and prognosis in patients with myxofibrosarcoma and undifferentiated sarcoma.2023
- Author(s)
  Toshiaki Hata
- Organizer
  ORS 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07303
[Presentation] 血中CSG-1濃度は浸潤繊維軟部肉腫における腫瘍随伴マクロファージの浸潤と相関し生存予後と相関する2023
- Author(s)
  畑利彰
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K07303
[Presentation] 軟部肉腫に対する抗 CSF-1R 阻害薬の有効性: 抗腫瘍効果と微小環境へ与える影響2022
- Author(s)
  近藤彩奈藤原智洋吉田晶畑利彰近藤宏也片山晴喜佐藤浩平棏平将太中田英二国定俊之尾﨑敏文
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K24461
[Presentation] 腫瘍随伴マクロファージの浸潤割合および予後を予測する血中バイオマーカーの特定:浸潤性軟部肉腫患者における検討2022
- Author(s)
  畑利彰藤原智洋吉田晶近藤彩奈近藤宏也佐藤浩平棏平将太中田英二国定俊之箱崎道之尾﨑敏文
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-23K24461
[Presentation] Circulating cytokines as a blood-based biomarker predictive of TAM infiltration and prognosis in patients with infiltrative soft-tissue sarcomas2022
- Author(s)
  畑利彰
- Organizer
  日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-22K07303
[Presentation] 腫瘍随伴マクロファージの浸潤及び予後を予測する血中バイオマーカーの特定：浸潤性軟部肉腫における検討2022
- Author(s)
  畑利彰
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K07303
[Presentation] 腫瘍関連マクロファージを誘導するCSF-1の分泌と血中発現の解析　浸潤性軟部肉腫における検討2021
- Author(s)
  畑利彰, 藤原智洋, 吉田晶, 近藤彩奈, 片山晴喜, 佐藤浩平, 近藤宏也, たき平将太, 中田英二, 国定俊之, 尾崎敏文
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] Pexidartinibの骨肉腫に対する前臨床的検討　CSF-1/CSF-1R阻害は肉腫微小環境の免疫細胞構成分画を変化させ抗腫瘍効果を発揮する2021
- Author(s)
  藤原智洋, Yakoub Mohamed, 吉田晶, 近藤宏也, 畑利彰, 佐藤浩平, たき平将太, 中田英二, 国定俊之, 尾崎敏文, Healey John
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03784

1. 藤原智洋 (80639211)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Ozaki Toshifumi (40294459)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 杉原進介 (60314671)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 近藤宏也 (40846911)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 吉田晶 (00910514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. 長谷井嬢 (40636213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横尾賢 (00781204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 清野正普 (60756097)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 近藤彩奈 (80910512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 長谷川翼 (61002564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hata Toshiaki 畑 利彰

Research Projects

Research Products

Co-Researchers

軟部肉腫における腫瘍由来液性因子に惹起される微小環境ネットワークの包括的解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肉腫における体液分子診断技術の統合的開発と循環分子の新規治療標的としての検証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of diagnostic techniques using liquid biopsy and identification of novel mechanisms of tumor progression through circulating molecules in sarcoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Role of Tumor-Associated Macrophages in Sarcomas2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Circulating CSF-1 predicts infiltration of tumor-associated macrophage and prognosis in patients with myxofibrosarcoma and undifferentiated sarcoma.2023

Author(s)

Organizer

Data Source

[Presentation] 血中CSG-1濃度は浸潤繊維軟部肉腫における腫瘍随伴マクロファージの浸潤と相関し生存予後と相関する2023

Author(s)

Organizer

Data Source

[Presentation] 軟部肉腫に対する抗 CSF-1R 阻害薬の有効性: 抗腫瘍効果と微小環境へ与える影響2022

Author(s)

Organizer

Data Source

[Presentation] 腫瘍随伴マクロファージの浸潤割合および予後を 予測する血中バイオマーカーの特定:浸潤性軟部 肉腫患者における検討2022

Author(s)

Organizer

Data Source

[Presentation] Circulating cytokines as a blood-based biomarker predictive of TAM infiltration and prognosis in patients with infiltrative soft-tissue sarcomas2022

Author(s)

Organizer

Data Source

[Presentation] 腫瘍随伴マクロファージの浸潤及び予後を予測する血中バイオマーカーの特定：浸潤性軟部肉腫における検討2022

Author(s)

Organizer

Data Source

[Presentation] 腫瘍関連マクロファージを誘導するCSF-1の分泌と血中発現の解析 浸潤性軟部肉腫における検討2021

Author(s)

Organizer

Data Source

[Presentation] Pexidartinibの骨肉腫に対する前臨床的検討 CSF-1/CSF-1R阻害は肉腫微小環境の免疫細胞構成分画を変化させ抗腫瘍効果を発揮する2021

Author(s)

Organizer

Data Source

Hata Toshiaki 畑利彰

[Presentation] 腫瘍随伴マクロファージの浸潤割合および予後を予測する血中バイオマーカーの特定:浸潤性軟部肉腫患者における検討2022

[Presentation] 腫瘍関連マクロファージを誘導するCSF-1の分泌と血中発現の解析　浸潤性軟部肉腫における検討2021

[Presentation] Pexidartinibの骨肉腫に対する前臨床的検討　CSF-1/CSF-1R阻害は肉腫微小環境の免疫細胞構成分画を変化させ抗腫瘍効果を発揮する2021