Itoyama Tomohiro 糸山知宏

Researcher Number	50884433
Affiliation (Current)	2025: 九州大学, 歯学研究院, 助教
Affiliation (based on the past Project Information) *help	2024: 九州大学, 歯学研究院, 助教 2020 – 2024: 九州大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / 0907:Oral science and related fields Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator 細胞老化 / 歯髄細胞 / 歯の老化 / カルシニューリン / 象牙質 / 歯周組織再生 / 歯根膜 / シュワン細胞 Except Principal Investigator 歯根膜幹細胞 / 歯周組織再生 … More / iPS細胞 / バイオミメティクス / 低分子化合物 / 神経堤細胞 / 破折歯修復 / SB / naHAp / セメント質 / シャーピー線維 / nano hydroxyapatite / ヒアルロン酸 / ナノファイバーメッシュ / ヒアルロン酸含有ナノファイバーメッシュ / SOD2 / スーパーオキサイドディスミューターゼ２ / 加齢変化 / 象牙質/歯髄複合体 / 歯髄細胞 / 老化 / ヒト歯髄細胞 / 幹細胞転換 / 歯周組織再生薬 / ゲノム創薬 / 賦活化 / WNT signaling / 歯根膜幹細胞誘導因子 / iPDLSC細胞 / PAX9 Less

歯根膜幹細胞転換を応用した革新的歯周組織再生法の創出
- Principal Investigator
  
  長谷川大学
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
PAI-1に着目した、歯髄細胞の老化とそれに伴う石灰化の促進の機序の解明Principal Investigator
- Principal Investigator
  
  糸山知宏
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
ナノハイドロキシアパタイト含有レジンを応用した歯周組織再生誘導型歯質接着材の開発
- Principal Investigator
  
  杉井英樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
ドーパミンの下流のシグナル経路による象牙質形成機構の解明Principal Investigator
- Principal Investigator
  
  糸山知宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
To elucidate the mechanism of senescence of dentin-pulp complex targeting the oxidative stress.
- Principal Investigator
  
  前田英史
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
歯周組織発生過程の模倣を基盤とするハイブリッド構造体の創成と歯周組織再生への応用
- Principal Investigator
  
  友清淳
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Hokkaido University
  Kyushu University
Identification of periodontal ligament stem cell inducer targeting transcription factor PAX9
- Principal Investigator
  
  Hamano Sayuri
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Kyushu University
Development of a new drug for periodontal regeneration based on the activation of neural crest cells
- Principal Investigator
  
  友清淳
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Hokkaido University
  Kyushu University
Development of new periodontal treatment using Schwann cell-derived factor Schwann cell-derived factorPrincipal Investigator
- Principal Investigator
  
  Itoyama Tomohiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Kyushu University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Effect of Fibrillin-2 on Differentiation into Periodontal Ligament Stem Cell?Like Cells Derived from Human-Induced Pluripotent Stem Cells2024
- Author(s)
  Hamano Sayuri、Yamashita Diaki、Hasegawa Daigaku、Sugii Hideki、Itoyama Tomohiro、Maeda Hidefumi
- Journal Title
  
  Stem Cells and Development
  
  Volume: - Issue: 9-10 Pages: 228-238
- DOI
  10.1089/scd.2024.0013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K09171
[Journal Article] Effect of fibrillin-2 on differentiation into periodontal ligament stem cell-like cells derived from human-induced pluripotent stem cells2024
- Author(s)
  Hamano S, Yamashita D, Hasegawa D, Sugii H, Itoyama T, Maeda H
- Journal Title
  
  Stem Cells and Development
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09876
[Journal Article] Dopamine is involved in reparative dentin formation through odontoblastic differentiation of dental pulp stem cells2023
- Author(s)
  Shoko Fujino, Sayuri Hamano, Atsushi Tomokiyo, Risa Sugiura, Daiki Yamashita, Daigaku Hasegawa, Hideki Sugii , Shinsuke Fujii, Tomohiro Itoyama , Hirofumi Miyaji , Hidefumi Maeda
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 5668-5668
- DOI
  10.1038/s41598-023-32126-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16995, KAKENHI-PROJECT-21K19608, KAKENHI-PROJECT-23K09171, KAKENHI-PROJECT-21K09876, KAKENHI-PROJECT-23K24528, KAKENHI-PROJECT-23K24529
[Journal Article] Involvement of M1/M2 Macrophage Polarization in Reparative Dentin Formation2022
- Author(s)
  Kadowaki Masataka、Yoshida Shinichiro、Itoyama Tomohiro、Tomokiyo Atsushi、Hamano Sayuri、Hasegawa Daigaku、Sugii Hideki、Kaneko Hiroshi、Sugiura Risa、Maeda Hidefumi
- Journal Title
  
  Life
  
  Volume: 12 Issue: 11 Pages: 1812-1812
- DOI
  10.3390/life12111812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19608, KAKENHI-PROJECT-21K16994, KAKENHI-PROJECT-23K24528, KAKENHI-PROJECT-23K24529
[Journal Article] Decorin Promotes Osteoblastic Differentiation of Human Periodontal Ligament Stem Cells2022
- Author(s)
  Adachi Orie、Sugii Hideki、Itoyama Tomohiro、Fujino Shoko、Kaneko Hiroshi、Tomokiyo Atsushi、Hamano Sayuri、Hasegawa Daigaku、Obata Junko、Yoshida Shinichiro、Kadowaki Masataka、Sugiura Risa、Albougha Mhd Safwan、Maeda Hidefumi
- Journal Title
  
  Molecules
  
  Volume: 27 Issue: 23 Pages: 8224-8224
- DOI
  10.3390/molecules27238224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19608, KAKENHI-PROJECT-21K16994, KAKENHI-PROJECT-21K16995, KAKENHI-PROJECT-23K24528, KAKENHI-PROJECT-23K24529
[Journal Article] Inhibition of c-Jun N-terminal kinase signaling promotes osteoblastic differentiation of periodontal ligament stem cells and induces regeneration of periodontal tissues.2022
- Author(s)
  Kaneko H, Hasegawa D, Itoyama T, Yoshida S, Tomokiyo A, Hamano S, Sugii H, Maeda H.
- Journal Title
  
  Arch Oral Biol
  
  Volume: 134 Pages: 105323-105323
- DOI
  10.1016/j.archoralbio.2021.105323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01598, KAKENHI-PROJECT-21K19608, KAKENHI-PROJECT-22K21065
[Journal Article] Development of a novel direct dental pulp-capping material using 4-META/MMA-TBB resin with nano hydroxyapatite2021
- Author(s)
  Yoshida S, Sugii H, Itoyama T, Kadowaki M, Hasegawa D, Tomokiyo A, Hamano S, Ipposhi K, Yamashita K, Maeda H.
- Journal Title
  
  Materials Science & Engineering C: Materials for Biological Applications.
  
  Volume: 130 Pages: 112426-112426
- DOI
  10.1016/j.msec.2021.112426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K18538, KAKENHI-PROJECT-17H01598, KAKENHI-PROJECT-21K09876, KAKENHI-PROJECT-21K16994
[Journal Article] Mineral trioxide aggregate immersed in sodium hypochlorite reduce the osteoblastic differentiation of human periodontal ligament stem cells.2021
- Author(s)
  Yamashita K, Tomokiyo A, Ono T, Ipposhi K, Alhasan MA, Tsuchiya A, Hamano S, Sigii H, Yoshida S, Itoyama T, Maeda H.
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 22091-22091
- DOI
  10.1038/s41598-021-01545-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01598, KAKENHI-PROJECT-21K19608, KAKENHI-PROJECT-21K16971
[Journal Article] Secreted frizzled-related protein 1 promotes odontoblastic differentiation and reparative dentin formation by regulating Notch signaling in dental pulp cells.2021
- Author(s)
  Ipposhi K, Tomokiyo A, Ono T, Yamashita K, Alhasan MA, Hasegawa D, Hamano S, Yoshida S, Sugii H, Itoyama T, Ogawa M, Maeda H.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 9 Pages: 2491-2491
- DOI
  10.3390/cells10092491
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01598, KAKENHI-PROJECT-21K09876, KAKENHI-PROJECT-21K19608, KAKENHI-PROJECT-21K16971, KAKENHI-PROJECT-21K21069
[Presentation] c-Jun N-terminal kinase阻害剤を用いた歯周組織再生過程における抗炎症作用の検討2024
- Author(s)
  兼子大志、長谷川大学、糸山知宏、門脇正敬、前田英史
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] iPS細胞由来歯根膜幹細胞様細胞の分化誘導におけるFibrillin-2の役割2023
- Author(s)
  濱野さゆり、山下大輝、糸山知宏、友清淳、長谷川大学、杉井英樹、兼子大志、Bara Madini、前田英史
- Organizer
  第158回日本歯科保存学会2023年度春季学術大会
- Data Source
  KAKENHI-PROJECT-21K09876
[Presentation] Superoxide Dismutase 2の発現抑制が歯髄細胞の老化に及ぼす影響2023
- Author(s)
  糸山知宏、前田英史
- Organizer
  第46回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] Exosomes from human periodontal ligament stem cells promote bone healing.2023
- Author(s)
  Albougha MS, Sugii H, Tomokiyo A, Hamano S, Hasegawa D, Yoshida S, Obata J, Itoyama T, Kaneko H, Kadowaki M, Kinoshita K, Maeda H
- Organizer
  The 71st Annual Meeting of Japanese Association for Demtal Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] AhRシグナルの活性化はヒト歯根膜細胞のMMP12発現を亢進する2023
- Author(s)
  門脇正敬、友清淳、糸山知宏、長谷川大学、濱野さゆり、杉井英樹、前田英史
- Organizer
  第158回日本歯科保存学会春季学術大会
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] The 4-META/MMA-TBB resin containing nano hydroxyapatite regenerates wounded periodontal tissue at the perforation site2023
- Author(s)
  Hideki Sugii, Shinichiro Yoshida, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Tomohiro Itoyama, Mha Safwan Albougha, Fumiko Minowa, Atsushi Tomokiyo, Hidefumi Maeda
- Organizer
  Asian Pacific Endodontic Confederation (APEC) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K09171
[Presentation] The 4-META/MMA-TBB resin containing nano hydroxyapatite regenerates wounded periodontal tissue at the perforation site2023
- Author(s)
  Hideki Sugii, Shinichiro Yoshida, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Tomohiro Itoyama, Mhd Safwan Albougha, Fumiko Minowa, Atsushi Tomokiyo, Hidefumi Maeda
- Organizer
  Asian Pacific Endodontic Confederation (APEC) 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09876
[Presentation] The 4-META/MMA-TBB Resin Containing Nano Hydroxyapatite Regenerates Wounded Periodontal Tissue At The Perforation Site.2023
- Author(s)
  Sugii S, Yoshida S, Hamano S, Hasegawa D, Obata J, Itoyama T, Albougha MS, Minowa F, Tomokiyo A, Maeda H.
- Organizer
  The 22nd Scientific Congress of Asian Pacific Endodontic Confederation.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] iPS細胞由来歯根膜幹細胞様細胞の分化誘導におけるFibrillin-2の役割2023
- Author(s)
  濱野さゆり、山下大輝、糸山知宏、友清淳、長谷川大学、杉井英樹、兼子大志、Bara Mardini、前田英史
- Organizer
  第158回日本歯科保存学会春季学術大会
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] AhRシグナルの活性化はヒト歯根膜細胞のMMP12発現を亢進する2023
- Author(s)
  門脇正敬、友清淳、糸山知宏、長谷川大学、濱野さゆり、杉井英樹、前田英史
- Organizer
  第158回日本歯科保存学会2023年度春季学術大会
- Data Source
  KAKENHI-PROJECT-21K09876
[Presentation] Fibrillin-2がiPS細胞の歯根膜幹細胞様細胞への分化誘導に及ぼす影響について．2022
- Author(s)
  濱野さゆり、杉浦梨紗、山下大輝、友清淳、杉井英樹、吉田晋一郎、糸山知宏、前田英史
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-23K24529
[Presentation] ドーパミンは修復象牙質形成能を有する．2022
- Author(s)
  藤野翔香、杉浦梨沙、濱野さゆり、友清淳、山下大樹、長谷川大学、杉井英樹、糸山知宏、前田英史．
- Organizer
  第３回象牙質歯髄治療学会学術大会
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] Fibrillin-2がiPS細胞の歯根膜幹細胞様細胞への分化誘導に及ぼす影響について2022
- Author(s)
  濱野さゆり、杉浦梨紗、山下大輝、友清淳、杉井英樹、吉田晋一郎、糸山知宏、前田英史
- Organizer
  第21回再生医療学会
- Data Source
  KAKENHI-PROJECT-21K09876
[Presentation] Exosome derived human periodontal ligament stem cells promote bone formation of rat calvarial bone defects.2022
- Author(s)
  Mhd Safwan Albougha, Hideki Sugii, Orie Adachi, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Hidefumi Maeda.
- Organizer
  第156回日本歯科保存学会春季学術大会
- Data Source
  KAKENHI-PROJECT-21K19608
[Presentation] xosome derived human periodontal ligament stem cells promote bone formation of rat calvarial bone defects.2022
- Author(s)
  Mhd Safwan Albougha, Hideki Sugii, Orie Adachi, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Junko Obata, Shinichiro Yoshida, Tomohiro Itoyama, Shoko Fujino, Hiroshi Kaneko, Hidefumi Maeda.
- Organizer
  第156回日本歯科保存学会春季学術大会.
- Data Source
  KAKENHI-PROJECT-23K24529
[Presentation] Exosomes derived from human periodontal ligament stem cells promote osteoblastic differentiation of pre-osteoblasts.2022
- Author(s)
  Mhd Safwan Albougha, Hideki Sugii, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Shinichiro Yoshida, Tomohiro Itoyama, Shoko Fujino, Taiga Ono, Orie Adachi, Hidefumi Maeda.
- Organizer
  第156回日本歯科保存学会春季学術大会
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] Decorinによるヒト歯根膜幹細胞の骨芽細胞様分化誘導に関する分子機構の解析.2022
- Author(s)
  足立織利恵、杉井英樹、糸山知宏、兼子大志、友清淳、濱野さゆり、長谷川大学、小幡純子、　吉田晋一郎、藤野翔香、Mhd Safwan Albougha、前田英史.
- Organizer
  第156回日本歯科保存学会春季学術大会.
- Data Source
  KAKENHI-PROJECT-23K24529
[Presentation] Fibrillin-2がiPS細胞の歯根膜幹細胞様細胞への分化誘導に及ぼす影響について．2022
- Author(s)
  濱野さゆり、杉浦梨紗、山下大輝、友清淳、杉井英樹、吉田晋一郎、糸山知宏、前田英史
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K19608
[Presentation] Decorinによるヒト歯根膜幹細胞の骨芽細胞様分化誘導に関する分子機構の解析．2022
- Author(s)
  足立織利恵、杉井英樹、糸山知宏、兼子大志、友清淳、濱野さゆり、長谷川大学、小幡純子、吉田晋一郎、藤野翔香、Mhd Safwan Albougha、前田英史．
- Organizer
  第156回日本歯科保存学会春季学術大会
- Data Source
  KAKENHI-PROJECT-23K24528
[Presentation] The effects of MTA exposed to NaOC l on osteoblastic differentiation of a human periodontal ligament stem cell line2021
- Author(s)
  Kozue Yamashita, Atsushi Tomokiyo, Taiga Ono, Keita Ipposhi, M. Anas Alhasan, Akira Tsuchiya, Sayuri Hamano, Hideki Sugii, Shinichiro Yoshida, Tomohiro Itoyama, Hidefumi Maeda.
- Organizer
  The 69th Annual Meeting of Japanese Association for Dental Research.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19608
[Presentation] Maeda. Hyaluronic Acid Could Enhance the Differentiation of Neural Crest like Cells to Periodontal Ligament Stem Cells.2021
- Author(s)
  M Anas Alhasan, Atsushi Tomokiyo, Sayuri Hamano, Daigaku Hasegawa, Shinichiro Yoshida, Hideki Sugii, Tomohiro Itoyama, Taiga Ono, Keita Ipposhi, Kozue Yamashita, Hidefumi Maeda.
- Organizer
  第154回日本歯科保存学会春季学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19608

1. 前田英史 (10284514)

# of Collaborated Projects: 6 results

# of Collaborated Products: 28 results
2. 小幡純子 (70759448)

# of Collaborated Projects: 6 results

# of Collaborated Products: 9 results
3. 杉井英樹 (80802280)

# of Collaborated Projects: 6 results

# of Collaborated Products: 25 results
4. 友清淳 (20507777)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
5. Hamano Sayuri (40757978)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
6. 藤野翔香 (60883832)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
7. 長谷川大学 (20757992)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
8. 吉田晋一郎 (30778866)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
9. 和田尚久 (60380466)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 兼子大志 (50962495)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 小野太雅 (90884734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Itoyama Tomohiro 糸山 知宏

Research Projects

Research Products

Co-Researchers

歯根膜幹細胞転換を応用した革新的歯周組織再生法の創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PAI-1に着目した、歯髄細胞の老化とそれに伴う石灰化の促進の機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ナノハイドロキシアパタイト含有レジンを応用した歯周組織再生誘導型歯質接着材の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ドーパミンの下流のシグナル経路による象牙質形成機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

To elucidate the mechanism of senescence of dentin-pulp complex targeting the oxidative stress.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

歯周組織発生過程の模倣を基盤とするハイブリッド構造体の創成と歯周組織再生への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of periodontal ligament stem cell inducer targeting transcription factor PAX9

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new drug for periodontal regeneration based on the activation of neural crest cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new periodontal treatment using Schwann cell-derived factor Schwann cell-derived factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Effect of Fibrillin-2 on Differentiation into Periodontal Ligament Stem Cell?Like Cells Derived from Human-Induced Pluripotent Stem Cells2024

Author(s)

Journal Title

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[Journal Article] Decorin Promotes Osteoblastic Differentiation of Human Periodontal Ligament Stem Cells2022

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Itoyama Tomohiro 糸山知宏