KUROGI SHUSAKU 黒木秀作

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Kurogi Shusaku 黒木秀作

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Researcher Number	50905213
Other IDs
Affiliation (Current)	2025: 大分大学, 医学部, 技術専門職員
Affiliation (based on the past Project Information) *help	2021 – 2024: 大分大学, 医学部, 技術専門職員
Review Section/Research Field	Principal Investigator Basic Section 49020:Human pathology-related / 0803:Pathology, infection/immunology, and related fields
Keywords	Principal Investigator 膵癌 / Annexin A8 / MAPK阻害薬 / ATRA / ヒト膵癌オルガノイド / MAPK阻害薬抵抗性 / annexin A8 / ANXA8 / ストレス応答MAPキナーゼ / 細胞周期 / ZNF395

MAPK阻害薬耐性関連分子ANXA8を標的とした膵癌の新規治療法の開発Principal Investigator
- Principal Investigator
  
  黒木秀作
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Oita University
Elucidation of the functional role of ANXA8 in pancreatic cancer resistance to MAPK inhibitors and its therapeutic applicationPrincipal Investigator
- Principal Investigator
  
  Kurogi Shusaku
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Oita University
Elucidation of functional significance of ZNF395 downregulation and development of novel therapeutic strategy for pancreatic ductal adenocarcinoma.Principal Investigator
- Principal Investigator
  
  Kurogi Shusaku
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0803:Pathology, infection/immunology, and related fields
- Research Institution
  Oita University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Characterization of residual cancer by comparison of a pair of organoids established from a patient with esophageal squamous cell carcinoma before and after neoadjuvant chemotherapy2024
- Author(s)
  Fuchino Takafumi、Kurogi Shusaku、Tsukamoto Yoshiyuki、Shibata Tomotaka、Fumoto Shoichi、Fujishima Hajime、Kinoshita Keisuke、Mizukami Kazuhiro、Kodama Masaaki、Inomata Masafumi、Murakami Kazunari、Moriyama Masatsugu、Hijiya Naoki
- Journal Title
  
  Human Cell
  
  Volume: 37 Issue: 2 Pages: 491-501
- DOI
  10.1007/s13577-023-01020-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07443, KAKENHI-PROJECT-21K08010, KAKENHI-PROJECT-22K15408, KAKENHI-PROJECT-18KK0266, KAKENHI-PUBLICLY-21H00346
[Journal Article] Overexpression of VSNL1 Enhances Cell Proliferation in Colorectal Carcinogenesis2023
- Author(s)
  Aiba Takayuki、Hijiya Naoki、Akagi Tomonori、Tsukamoto Yoshiyuki、Hirashita Yuka、Kinoshita Keisuke、Uchida Tomohisa、Nakada Chisato、Kurogi Shusaku、Ueda Yoshitake、Shiroshita Hidefumi、Shiraishi Norio、Murakami Kazunari、Inomata Masafumi、Moriyama Masatsugu
- Journal Title
  
  Pathobiology
  
  Volume: 91 Issue: 2 Pages: 121-131
- DOI
  10.1159/000533877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16024, KAKENHI-PROJECT-23K06443, KAKENHI-PROJECT-21K06888, KAKENHI-PROJECT-21K06924, KAKENHI-PROJECT-22K15408
[Journal Article] Patient-Derived Ex Vivo Cultures and Endpoint Assays with Surrogate Biomarkers in Functional Testing for Prediction of Therapeutic Response2023
- Author(s)
  Tsukamoto Yoshiyuki、Hirashita Yuka、Shibata Tomotaka、Fumoto Shoichi、Kurogi Shusaku、Nakada Chisato、Kinoshita Keisuke、Fuchino Takafumi、Murakami Kazunari、Inomata Masafumi、Moriyama Masatsugu、Hijiya Naoki
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 16 Pages: 4104-4104
- DOI
  10.3390/cancers15164104
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16024, KAKENHI-PROJECT-20K07448, KAKENHI-PROJECT-23K06443, KAKENHI-PROJECT-23K07443, KAKENHI-PROJECT-21K06888, KAKENHI-PROJECT-22K15408
[Journal Article] Efficient Establishment of Bile-Derived Organoids From Patients With Biliary Cancer.2023
- Author(s)
  Kinoshita K, Tsukamoto Y, Hirashita Y, Fuchino T, Kurogi S, Uchida T, Nakada C, Matsumoto T, Okamoto K, Motomura M, Fukuchi S, Sagami R, Nagai T, Gotoh Y, Fukuda K, Ogawa R, Mizukami K, Okimoto T, Kodama M, Murakami K, Moriyama M, Hijiya N.
- Journal Title
  
  Lab Invest.
  
  Volume: 103 Issue: 6 Pages: 100105-100105
- DOI
  10.1016/j.labinv.2023.100105
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07448, KAKENHI-PROJECT-21K06888, KAKENHI-PROJECT-21K08010, KAKENHI-PROJECT-22K15408, KAKENHI-PROJECT-20K07394, KAKENHI-PROJECT-21K20779, KAKENHI-PROJECT-23K21375, KAKENHI-PROJECT-22K16024, KAKENHI-PROJECT-23K06443, KAKENHI-PROJECT-23K07443
[Journal Article] Association of immune‐related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma2023
- Author(s)
  Tsukamoto Yoshiyuki、Kurogi Shusaku、Fujishima Hajime、Shibata Tomotaka、Fumoto Shoichi、Nishiki Kohei、Suzuki Kosuke、Etoh Tsuyoshi、Shiraishi Norio、Fuchino Takafumi、Hirashita Yuka、Nakada Chisato、Uchida Tomohisa、Inomata Masafumi、Moriyama Masatsugu、Hijiya Naoki
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 11 Pages: 4459-4474
- DOI
  10.1111/cas.15942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16024, KAKENHI-PROJECT-20K07448, KAKENHI-PROJECT-23K08176, KAKENHI-PROJECT-21K06888, KAKENHI-PROJECT-22K15408
[Journal Article] Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor.2023
- Author(s)
  Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, Kurogi S, Tsukamoto Y, Nakada C, Kinoshita K, Hirashita Y, Uchida T, Shin T, Yada K, Hirashita T, Kobayashi T, Murakami K, Inomata M, Shirao K, Aoki M, Takekawa M, Moriyama M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 114 Issue: 5 Pages: 2189-2202
- DOI
  10.1111/cas.15735
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07448, KAKENHI-PROJECT-21K07984, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-20K07394, KAKENHI-PROJECT-21K20779, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-PROJECT-17H04649, KAKENHI-PROJECT-23K21375, KAKENHI-PROJECT-23K24170, KAKENHI-PROJECT-22K16024, KAKENHI-PROJECT-23K06443, KAKENHI-PROJECT-23K07443, KAKENHI-PROJECT-21K06888, KAKENHI-PROJECT-22K15408, KAKENHI-PROJECT-21H02692
[Journal Article] Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids.2022
- Author(s)
  Tsukamoto Y, Kurogi S, Shibata T, Suzuki K, Hirashita Y, Fumoto S, Yano S, Yanagihara K, Nakada C, Mieno F, Kinoshita K, Fuchino T, Mizukami K, Ueda Y, Etoh T, Uchida T, Hanada T, Takekawa M, Daa T, Shirao K, Hironaka S, Murakami K, Inomata M, Hijiya N, Moriyama M.
- Journal Title
  
  Lab Invest.
  
  Volume: 102 (12) Issue: 12 Pages: 1355-1366
- DOI
  10.1038/s41374-022-00827-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07448, KAKENHI-PROJECT-21K06888, KAKENHI-PROJECT-22K15408, KAKENHI-PROJECT-22K16024, KAKENHI-PROJECT-20H03644, KAKENHI-PROJECT-21H02692, KAKENHI-PROJECT-20K07394, KAKENHI-PROJECT-21K20779, KAKENHI-INTERNATIONAL-16K21739, KAKENHI-PROJECT-23K21375
[Journal Article] Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.2021
- Author(s)
  Kurogi S, Hijiya N, Hidano S, Sato S, Uchida T, Tsukamoto Y, Nakada C, Yada K, Hirashita T, Inomata M, Murakami K, Takahashi N, Kobayashi T, Moriyama M.
- Journal Title
  
  Pathobiology
  
  Volume: 2021 Issue: 5 Pages: 1-9
- DOI
  10.1159/000514593
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07448, KAKENHI-PROJECT-18H02631, KAKENHI-PROJECT-19K07416, KAKENHI-PROJECT-20K07394, KAKENHI-PROJECT-21K06888, KAKENHI-PROJECT-21K07984, KAKENHI-PROJECT-21K20779, KAKENHI-PROJECT-17H04649, KAKENHI-PROJECT-23K21375
[Presentation] Clusterinは膵癌細胞のMAPキナーゼ不応性に関与する2023
- Author(s)
  泥谷直樹、塚本善之、黒木秀作、中田知里、守山正胤
- Organizer
  第82回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15408
[Presentation] 膵癌においてANXA8はMAPK阻害薬耐性に関与する2023
- Author(s)
  黒木秀作、泥谷直樹、塚本善之、中田知里、猪股雅史、小林隆志、守山正胤
- Organizer
  第82回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15408
[Presentation] シスプラチン処理後のc-Junリン酸化亢進をバイオマーカーとした食道癌術前化学療法の効果予測2023
- Author(s)
  塚本善之、黒木秀作、柴田智隆、鈴木浩輔、藤島紀、麓祥一、平下有香、中田知里、泥谷直樹、守山正胤
- Organizer
  第112回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-22K15408
[Presentation] 術前化学療法の効果が低かった食道癌1例の化学療法前・後から樹立した癌オルガノイドの解析2023
- Author(s)
  塚本善之、渕野貴文、黒木秀作、柴田智隆、藤島紀、板井勇介、麓祥一、猪股雅史、村上和成、泥谷直樹
- Organizer
  第41回　日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15408
[Presentation] ZNF395の発現低下はJNKの不活性化を介して膵癌細胞の増殖を促進する2021
- Author(s)
  黒木秀作, 泥谷直樹, 塚本善之, 中田知里, 猪股雅史, 小林隆志, 守山正胤
- Organizer
  第80回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K20779

1. 平下有香

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 中田知里

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
3. 木下慶亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 泥谷直樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 塚本善之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 村上和成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KUROGI SHUSAKU 黒木 秀作

Kurogi Shusaku 黒木 秀作

Research Projects

Research Products

Co-Researchers

MAPK阻害薬耐性関連分子ANXA8を標的とした膵癌の新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the functional role of ANXA8 in pancreatic cancer resistance to MAPK inhibitors and its therapeutic applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of functional significance of ZNF395 downregulation and development of novel therapeutic strategy for pancreatic ductal adenocarcinoma.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Characterization of residual cancer by comparison of a pair of organoids established from a patient with esophageal squamous cell carcinoma before and after neoadjuvant chemotherapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of VSNL1 Enhances Cell Proliferation in Colorectal Carcinogenesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Patient-Derived Ex Vivo Cultures and Endpoint Assays with Surrogate Biomarkers in Functional Testing for Prediction of Therapeutic Response2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient Establishment of Bile-Derived Organoids From Patients With Biliary Cancer.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of immune‐related expression profile with sensitivity to chemotherapy in esophageal squamous cell carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced phosphorylation of c-Jun by cisplatin treatment as a potential predictive biomarker for cisplatin response in combination with patient-derived tumor organoids.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Clusterinは膵癌細胞のMAPキナーゼ不応性に関与する2023

Author(s)

Organizer

Data Source

[Presentation] 膵癌においてANXA8はMAPK阻害薬耐性に関与する2023

Author(s)

Organizer

Data Source

[Presentation] シスプラチン処理後のc-Junリン酸化亢進をバイオマーカーとした食道癌術前化学療法の効果予測2023

Author(s)

Organizer

Data Source

[Presentation] 術前化学療法の効果が低かった食道癌1例の化学療法前・後から樹立した癌オルガノイドの解析2023

Author(s)

Organizer

Data Source

[Presentation] ZNF395の発現低下はJNKの不活性化を介して膵癌細胞の増殖を促進する2021

KUROGI SHUSAKU 黒木秀作

Kurogi Shusaku 黒木秀作