Kubo Naoki 久保直樹

Researcher Number	50914280
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, バイオリソース研究センター, チームディレクター
Affiliation (based on the past Project Information) *help	2024: 大阪大学, 微生物病研究所, 特任講師(常勤) 2022 – 2023: 九州大学, 生体防御医学研究所, 特任講師 2022: 九州大学, 生体防御医学研究所, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 43050:Genome biology-related / Biological Sciences / Basic Section 43010:Molecular biology-related
Keywords	Principal Investigator DNAメチル化 / エンハンサー・プロモーター相互作用 / ゲノム３次元構造 / エピゲノム / 生殖細胞 / 初期胚 / 転写制御 / 精子形成 / 細胞分化

Research Projects
(3 results)
Research Products
(38 results)

精子形成過程のDNAメチル化と３Dゲノム変化が織りなす遺伝子制御ネットワークの解明Principal Investigator
- Principal Investigator
  
  久保直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Osaka University
CTCFが制御する初期胚発生のゲノム３次元構造変化と遺伝子制御機構の解明Principal Investigator
- Principal Investigator
  
  久保直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Kyushu University
初期胚の全能性獲得と消失で起こるエンハンサー・プロモーター相互作用のダイナミクスPrincipal Investigator
- Principal Investigator
  
  久保直樹
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University

All 2024 2023 2022

All Journal Article Presentation Book

[Book] 月間『細胞』、 Vol 56 (3) 2024、ゲノム３次元構造が司る遺伝子制御2024
- Author(s)
  久保直樹
- Total Pages
  2
- Publisher
  ニューサイエンス
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Book] 月間『細胞』, Vol 56 (3)、2024、ゲノム３次元構造が司る遺伝子制御2024
- Author(s)
  久保直樹
- Total Pages
  2
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-22K15037
[Book] Medical Science Digest、Vol 49 (2)、2023、ゲノム３次元構造が司る遺伝子制御2024
- Author(s)
  久保直樹
- Total Pages
  2
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-22K15037
[Book] Medical Science Digest、Vol 49 (2)、2023、ゲノム３次元構造が司る遺伝子制御2023
- Author(s)
  久保直樹
- Total Pages
  2
- Publisher
  ニューサイエンス
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Journal Article] Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells2024
- Author(s)
  Naoki Kubo、Ryuji Uehara、Shuhei Uemura、Hiroaki Ohishi、Kenjiro Shirane、Hiroyuki Sasaki
- Journal Title
  
  Nature Communications（暫定受理、2024年3月時点）
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Journal Article] H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation2024
- Author(s)
  Kubo Naoki、Chen Poshen B.、Hu Rong、Ye Zhen、Sasaki Hiroyuki、Ren Bing
- Journal Title
  
  Molecular Cell
  
  Volume: - Issue: 9 Pages: 1742-1752.e5
- DOI
  10.1016/j.molcel.2024.02.030
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15037, KAKENHI-PUBLICLY-22H04675
[Journal Article] Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells2024
- Author(s)
  Naoki Kubo、Ryuji Uehara、Shuhei Uemura、Hiroaki Ohishi、Kenjiro Shirane、Hiroyuki Sasaki
- Journal Title
  
  Nature Communications (暫定受理、2024年3月時点)
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15037
[Journal Article] ゲノム３次元構造が司る遺伝子制御2023
- Author(s)
  久保直樹
- Journal Title
  
  Medical Science Digest
  
  Volume: 49 Pages: 40-41
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Journal Article] The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes2023
- Author(s)
  Uehara Ryuji、Au Yeung Wan Kin、Toriyama Keisuke、Ohishi Hiroaki、Kubo Naoki、Toh Hidehiro、Suetake Isao、Shirane Kenjiro、Sasaki Hiroyuki
- Journal Title
  
  PLOS Genetics
  
  Volume: 19 Issue: 8 Pages: e1010855-e1010855
- DOI
  10.1371/journal.pgen.1010855
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15037, KAKENHI-PROJECT-22K15084, KAKENHI-PROJECT-22K06174, KAKENHI-PROJECT-18K06095, KAKENHI-PROJECT-22K15125, KAKENHI-PUBLICLY-22H04675
[Journal Article] ゲノム３次元構造が司る遺伝子制御2023
- Author(s)
  久保直樹
- Journal Title
  
  Medical Science Digest
  
  Volume: 49 Pages: 40-41
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] Fine-tuned Gene Expression Dynamics Regulated by Non-coding Regions2024
- Author(s)
  久保直樹
- Organizer
  Young Scientists Networking Symposium 2024
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] Fine-tuned Gene Expression Dynamics Regulated by Non-coding Regions2024
- Author(s)
  久保直樹
- Organizer
  Young Scientists Networking Symposium 2024
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] Dynamics of chromatin organization at distal enhancers during cell differentiation2023
- Author(s)
  久保直樹
- Organizer
  Human Genetics Asia 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] 卵子・精子のDNAメチル化修飾におけるDNMT3AとDNMT3LのADDドメインの協調的役割2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム第5回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] KMT2C/KMT2D (MLL3/MLL4) のヒストンメチル化活性依存的または非依存的なエンハンサーによる、細胞分化過程におけるクロマチン構造変化と遺伝子制御の仕組み2023
- Author(s)
  久保直樹
- Organizer
  第46回　分子生物学会
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2ファミリータンパク質によるES細胞の分化過程におけるエンハンサー活性とクロマチン構造変化2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム第5回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] 生殖細胞のDNAメチル化へのDNMT3AとDNMT3LのADDドメインの協調的役割2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム若手勉強会 2023
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] 細胞分化における遠位エンハンサーとクロマチン構造変化の役割2023
- Author(s)
  久保直樹
- Organizer
  第21回ゲノム医科学とバイオインフォマティクスの接点と集学研究
- Invited
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] Dynamics of chromatin organization at distal enhancers during cell differentiation2023
- Author(s)
  久保直樹
- Organizer
  Human Genetics Asia 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2C/KMT2D (MLL3/MLL4) histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation2023
- Author(s)
  久保直樹
- Organizer
  第16回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] 細胞分化における遠位エンハンサーとクロマチン構造変化の役割2023
- Author(s)
  久保直樹
- Organizer
  第21回ゲノム医科学とバイオインフォマティクスの接点と集学研究
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2C/KMT2D (MLL3/MLL4) のヒストンメチル化活性によるES 細胞分化過程におけるクロマチン構造制御と転写制御2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム若手勉強会 2023
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] "KMT2C/KMT2D (MLL3/MLL4) のヒストンメチル化活性によるES 細胞分化過程におけるクロマチン構造制御と転写制御"2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム若手勉強会 2023
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2ファミリータンパク質によるES細胞の分化過程におけるエンハンサー活性とクロマチン構造変化2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム第5回公開シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] "生殖細胞のDNAメチル化へのDNMT3AとDNMT3LのADDドメインの協調的役割"2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム若手勉強会 2023
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2C/KMT2D (MLL3/MLL4) のヒストンメチル化活性依存的または非依存的なエンハンサーによる、細胞分化過程におけるクロマチン構造変化と遺伝子制御の仕組み2023
- Author(s)
  久保直樹
- Organizer
  第46回　分子生物学会
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] KMT2C/KMT2D (MLL3/MLL4) histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation2023
- Author(s)
  久保直樹
- Organizer
  第16回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] 卵子・精子のDNAメチル化修飾におけるDNMT3AとDNMT3LのADDドメインの協調的役割2023
- Author(s)
  久保直樹
- Organizer
  全能性プログラム第5回公開シンポジウム
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2C/KMT2D (MLL3/MLL4) histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  The International Symposium on Totipotency and Germ Cell Development
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2C/KMT2D (MLL3/MLL4) histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  The International Symposium on Totipotency and Germ Cell Development
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] KMT2C/KMT2D (MLL3/MLL4) histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  Cold Spring Habor Laboratory Meetings（epigenetics & chromatin)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] 細胞分化におけるエンハンサー・プロモーター相互作用のダイナミクス2022
- Author(s)
  久保直樹
- Organizer
  第67回日本人類遺伝学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] Dynamics of enhancer-promoter contacts during cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] Dynamics of CTCF-dependent and -independent enhancer-promoter contacts during cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  The 29th Federation of Asian and Oceanian Biochemists and Molecular Biologists Conference & the 2022 Chinese Society of Biochemistry and Molecular Biology Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] 細胞分化におけるエンハンサー・プロモーター相互作用のダイナミクス2022
- Author(s)
  久保直樹
- Organizer
  第67回日本人類遺伝学会
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] Dynamics of CTCF-dependent and -independent enhancer-promoter contacts during cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  The 29th Federation of Asian and Oceanian Biochemists and Molecular Biologists Conference & the 2022 Chinese Society of Biochemistry and Molecular Biology Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04675
[Presentation] KMT2C/KMT2D (MLL3/MLL4) histone methyltranferase activity dependent chromatin organization at enhancers during embryonic stem cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  Cold Spring Habor Laboratory Meetings（epigenetics & chromatin)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15037
[Presentation] Dynamics of enhancer-promoter contacts during cell differentiation2022
- Author(s)
  久保直樹
- Organizer
  第95回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15037

Kubo Naoki 久保 直樹

Research Projects

Research Products

精子形成過程のDNAメチル化と３Dゲノム変化が織りなす遺伝子制御ネットワークの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CTCFが制御する初期胚発生のゲノム３次元構造変化と遺伝子制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

初期胚の全能性獲得と消失で起こるエンハンサー・プロモーター相互作用のダイナミクスPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 月間『細胞』、 Vol 56 (3) 2024、ゲノム３次元構造が司る遺伝子制御2024

Author(s)

Total Pages

Publisher

Data Source

[Book] 月間『細胞』, Vol 56 (3)、2024、ゲノム３次元構造が司る遺伝子制御2024

Author(s)

Total Pages

Publisher

Data Source

[Book] Medical Science Digest、Vol 49 (2)、2023、ゲノム３次元構造が司る遺伝子制御2024

Author(s)

Total Pages

Publisher

Data Source

[Book] Medical Science Digest、Vol 49 (2)、2023、ゲノム３次元構造が司る遺伝子制御2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells2024

Author(s)

Journal Title

Data Source

[Journal Article] H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Combined and differential roles of ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells2024

Author(s)

Journal Title

Data Source

[Journal Article] ゲノム３次元構造が司る遺伝子制御2023

Author(s)

Journal Title

Data Source

[Journal Article] The DNMT3A ADD domain is required for efficient de novo DNA methylation and maternal imprinting in mouse oocytes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ゲノム３次元構造が司る遺伝子制御2023

Author(s)

Journal Title

Data Source

[Presentation] Fine-tuned Gene Expression Dynamics Regulated by Non-coding Regions2024

Author(s)

Organizer

Data Source

[Presentation] Fine-tuned Gene Expression Dynamics Regulated by Non-coding Regions2024

Author(s)

Organizer

Data Source

[Presentation] Dynamics of chromatin organization at distal enhancers during cell differentiation2023

Author(s)

Organizer

Data Source

[Presentation] 卵子・精子のDNAメチル化修飾におけるDNMT3AとDNMT3LのADDドメインの協調的役割2023

Kubo Naoki 久保直樹

[Presentation] 生殖細胞のDNAメチル化へのDNMT3AとDNMT3LのADDドメインの協調的役割2023

[Presentation] "生殖細胞のDNAメチル化へのDNMT3AとDNMT3LのADDドメインの協調的役割"2023