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IDE Toshinori  井出 利憲

ORCIDConnect your ORCID iD *help
… Alternative Names

井手 利憲  イデ トシノリ

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Researcher Number 60012746
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2006 – 2007: 広島国際大学, 薬学部, 教授
2005: Hiroshima University, Department of Cellular & Molecular Biology, Professor, 医歯薬総合研究科, 教授
2004: 国立大学法人広島大学, 大学院・医歯薬総合研究科, 教授
2004: Graduate School of Biomedical Sciences, Professor, 医歯薬学総合研究科, 教授
2002 – 2004: Hiroshima University, Graduated School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 … More
2003: 広島大学, 大学院・医師薬総合研究所, 教授
1987 – 2001: Hiroshima University School of Medicine, 医学部, 教授
1986: 広島大, 医学部, 助教授
1985: 広島大学, 医, 助教授 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Biological Sciences / Biological pharmacy
Except Principal Investigator
Chemical pharmacy / Cell biology / Biological pharmacy / Digestive surgery
Keywords
Principal Investigator
テロメラーゼ / テロメア / 細胞不死化 / telomerase / 細胞老化 / telomere / 温度感受性変異株 / 培養細胞 / 細胞周期 / hTERT … More / 増殖調節 / 不死化 / 癌診断 / 細胞増殖 / 体細胞遺伝学 / 分裂寿命 / 細胞分裂寿命 / 変異株 / プロテオーム / 増殖誘導 / 温度感受性変異 / オンコジン / がんウィルス / 突然変異株 / 哺乳類細胞 / 線維芽細胞 / cDNAライブラリー / T抗原 / ヒト細胞 / cellular senescence / 細胞癌化 / cancer diagnosis / TERT / プロテオーム解析 / 遺伝子発現 / 繊維芽細胞 / アストロサイト / immortalization / ECTR / proliferative life span / 血管内皮細胞 / 肝実質細胞 / シグナル伝達系 / Rポイント / サイクリン / cdk2 / 増殖変異株 / テロメア維持機構 / 染色体外テロメア断片DNA / 癌診断法 / 制癌剤 / TRAP / HPA法 / テロメラーゼ遺伝子 / テロメラーゼ複合体 / 診断マーカー / 癌早期診断 / DNA障害 / G1チェックポイント / タンパク質分解 / プロテアソーム / GO期 / 遺伝子クローニング / 細胞複製 / シグナルトランスダクション / 核タンパク質 / 増殖抑制因子 / 細胞表層分子 / Cell growth inhibition / Cell surface material / Bovine brain / サイトカイン / インターフェロン / 増殖抑制 / サイトカン / ヒト線維芽細胞 / Fibroblasts / Senescence / CDNA library / Cytokines / Interferon / Growth repression / 老化遺伝子 / 不死化遺伝子 / ディファレンシャル スクリーニング / ディファレンシャルスクリーニング / cDNA / cell immortality / senescence gene / immortality gene / cDNA library / differential screening / テロメラーゼcDNA / hTRT / テロメラーゼ発現 / 癌組織 / cellular lifespan / cellular immortality / SV40-T抗原 / SV40 T-antigen / Immortalization / 細胞内シグナル伝達 / トランスフォーメーション / カルチャーショック / 癌 / 遺伝子 / 細胞・組織 / バイオテクノロジー / 老化 / 癌細胞 / 分裂寿命延長 / 骨芽細胞 / proliferative lifespan / signal transduction / transformation / culture shock / growth induction / テロメアDNA / 染色体外テロメア配列 / テロメアタンパク質 / telomere DNA / extra chromosomal telomere repeats / telomere-binding proteins / immortalization of cell / ヒト正常体細胞 / human somatic cell / endothelial cell / astrocyte / hepatocyte / 乳腺上皮細胞 / ウイルスベクター / proteome / gene expression / fibroblasts / 幹細胞 / 不死化細胞 / ヒト培養細胞 / 間葉系幹細胞 / stem cells / cell life-span / immortal cells / celllar senescence / 細胞培養 / 温度感受性 / Cell cycle / growth regulation / mutants / somatic cell genetics / cell culture / tumor viruses / oncogene … More
Except Principal Investigator
細胞周期 / 温度感受性変異株 / 癌抑制遺伝子 / RB蛋白質 / 核内癌遺伝子 / サイクリン / 増殖因子 / テロメラーゼ / Premna subscandens / cdc2キナーゼ / 細胞分化 / cdc2キナ-ゼ / 癌遺伝子 / ユビキチン / TGFβ / がん遺伝子 / がん抑制遺伝子 / 癌と間質との相互作用 / シグナル伝達 / HGF / テロメア / テロメアーゼ / TRAP / 不死化 / コラーゲン / M細胞 / アクテオサイド / collagen / M cell / acteoside / デストリン / cーmos蛋白質 / DNA複製開始点 / トリコスタチン / アンチ癌遺伝子 / 転写制御 / 遺伝子のクローニング / 細胞のトランスフォーメーション / 細胞複製 / クロマチン凝縮 / DNAメチル化 / 減数分裂 / 遺伝子組換え / 発現の調節 / 染色体分配 / 遺伝子発現制御 / cDNAライブラリィ / 形質導入ベクタ- / ホスファチジルセリン / TGFーβ / cーmosキナ-ゼ / ヒストンデアセチラ-ゼ / 転写制御因子 / CDNAライブラリィ / 細胞のトランスフォ-メ-ション / RV蛋白質 / ^<cdc2>キナーゼ / サイトカイン / チロシンキナーゼ受容体 / 細胞接着分子 / ERMファミリー / DNAポリメラーゼalpha / TGFbeta / 増殖因子レセプター / c-met / p115 / インターフェロン / アポトーシス / Hrs / 癌 / テリハボク / オトギリソウ科 / 阻害物質 / 細胞変異株 / cDNAライブラリー / ゲノムライブラリー / がんウイルス / fos / myc / イノシトール輸送 / コフィリン / ホルボールエステル / N-myc蛋白質 / DnaA蛋白質 / DNA複製起点 / 細胞老化 / 放射線雑種細胞 / 遺伝子クローン化 / 7番染色体 / 遺伝子マッピング / 細部老化 / 細部不死化 / 細胞老化遺伝子 / 情報伝達 / 不死化細胞 / D群不死化細胞株 / cGMP-依存プロテインキナーゼ / シグナル伝達系 / SENESCENCE / IMMORTALIZATION / GENE / CHROMOSOME 7 / GENE MAPPING / RADIATION HYBRID / 肝線維化 / フェニルエタノイド / クマツヅラ科 / liver fibrosis / phenylethanoid / ヤエヤマハマクサビ / アクテオシド / モミジウリノキ / フラボノイド / ヤエヤマハマクサギ / Alangium platanifolium / flavonoid / 老化 / Telomere / Aging / Telomerase / Immortalization / 膵癌 / ECAチップ / HPA-TRAP / RAS / p53 / Pancreatic cancer / pancreatic juice / HPA / hTERT / real time PCR / ECA chip Less
  • Research Projects

    (39 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (42 People)
  •  Role of telomerase on stem cellsPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima International University
  •  Development of genetic diagnosis system for pancreatic cancer using modified telomeric repeat amplification protocols and electrochemical array chip

    • Principal Investigator
      MIZUMOTO Kazuhiro
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Possible new function of telomerasePrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  DNA障害時に急速に分解するタンパク質群の役割Principal Investigator

    • Principal Investigator
      井出 利憲
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima University
  •  Immortalization of human somatic cells ; possible stem cells.Principal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Telomerase and telomere maintenance and cell immortalityPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Hiroshima University
  •  Analysis and clinical application of telomerase and telomere functionsPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Do telomere regulate in vivo aging?

    • Principal Investigator
      TAHARA Hidetoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  テロメラーゼ機能・テロメア維持機構の解明とその臨床応用Principal Investigator

    • Principal Investigator
      井出 利憲
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Hiroshima University
  •  テロメラーゼ酵素活性を阻害する植物成分検索法確立の可能性

    • Principal Investigator
      OTSUKA Hideaki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hiroshima University
  •  Mechanisms of cellular immortalization and, carcinogenesisPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima University
  •  SEARCH AND POSSIBLE USAGE OF FUNCTIONAL MOLECULES USING COLLAGEN-FORMING CULTURED CELLS

    • Principal Investigator
      OTSUKA Hideaki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Hiroshima University
  •  Cloning and clinical application of telomerase cDNAPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  細胞増殖因子からみた癌細胞と間質細胞との相互作用-その分子機構-

    • Principal Investigator
      田原 榮一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hiroshima University
  •  GO期特異的変異株を相補するcDNAのクローニングPrincipal Investigator

    • Principal Investigator
      井出 利憲
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hiroshima University
  •  Screening for biologically active compounds which influence the formation of collagen fibers using culltured liver M cells

    • Principal Investigator
      OTSUKA Hideaki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  cDNA cloning of cellular aging and cellular senescencePrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima University
  •  細胞増殖因子からみた癌細胞と間質細胞との相互作用 -その分子機構-

    • Principal Investigator
      田原 榮一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hiroshima University
  •  CHARACTERIZATION OF SENESCENCE GENES IN HUMAN CELLS

    • Principal Investigator
      AYUSAWA Dai
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cell biology
    • Research Institution
      KIHARA INSTITUTE FOR BIOLOGICAL RESEARCH
      The University of Tokyo
  •  細胞増殖因子からみた癌細胞と間質細胞との相互作用 -その分子機構-

    • Principal Investigator
      田原 榮一
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hiroshima University
  •  細胞周期の制御機構における癌遺伝子、癌抑制遺伝子および関連遺伝子の研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The Institute of Physical and Chemical Research
  •  細胞周期の制御機構における癌遺伝子・癌抑制遺伝子および関連遺伝子の研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The Institute of Physical and Chemical Research
  •  G1/S境界移行に関わる変異株細胞の解析Principal Investigator

    • Principal Investigator
      井出 利憲
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hiroshima University
  •  Cloning of genes which regulate mortalityPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  細胞増殖,分化の制御における核内癌遺伝子の機能

    • Principal Investigator
      小田 鈎一郎
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo University of Science
  •  細胞周期の制御機構における癌遺伝子、癌抑制遺伝子および関連遺伝子の研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The Institute of Physical and Chemical Research
  •  細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The Institute of Physical and Chemical Research
  •  増殖誘導時にのみ機能する細胞遺伝子群の探索と解析Principal Investigator

    • Principal Investigator
      井出 利憲
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hiroshima University
  •  細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The Institute of Physical and Chemical Research
  •  細胞増殖、分化の制御における核内癌遺伝子の機能

    • Principal Investigator
      小田 鈎一郎
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo University of Science
  •  細胞複製と遺伝子発現の相関

    • Principal Investigator
      堀田 康雄
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University
  •  細胞増殖,分化の制御における核内癌遺伝子の機能

    • Principal Investigator
      小田 鈎一郎
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tokyo University of Science
  •  Purification of Growth Inhibitory Material from Bovine BrainPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Hiroshima University
  •  細胞核内に局在するがん遺伝子産物の機能

    • Principal Investigator
      山口 宣生
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  哺乳類細胞の細胞の細胞複製調節に関与する遺伝子群の遺伝学的解析Principal Investigator

    • Principal Investigator
      井手 利憲
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hiroshima University
  •  GoーG1移行期にのみ働らく遺伝子のクローニングPrincipal Investigator

    • Principal Investigator
      井出 利憲
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hiroshima University
  •  Isolation and analysis of temperature-sensitive mutants defective in growth regulationPrincipal Investigator

    • Principal Investigator
      IDE Toshinori
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  増殖誘導時にのみ機能する細胞遺伝子群の探索Principal Investigator

    • Principal Investigator
      井出 利憲
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hiroshima University

All 2007 2006

All Journal Article Presentation Book

  • [Book] 細胞の老化2006

    • Author(s)
      井出利憲
    • Total Pages
      179
    • Publisher
      サイエンス社
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] Telomerase activation induces elongation of the telomeric single-strand overhang, but does not prevent chromosome aberrations in human vascular endothelial cells.2007

    • Author(s)
      井出利憲ほか5名
    • Journal Title

      Biochem.Biophys.Res.Commun. 353

      Pages: 926-932

    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] 細胞老化機構とヒトの老化2007

    • Author(s)
      井出 利憲
    • Journal Title

      再生医療 6

      Pages: 336-343

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] Simulated microgravity facilitates human mesenchymal stem cell proliferation and chondrocyte differentiation after transplantation.2007

    • Author(s)
      井出利憲ほか10名
    • Journal Title

      Stem Cells and Development (印刷中)

    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] 細胞老化---細胞老化は個体老化の原因である2006

    • Author(s)
      井出利憲
    • Journal Title

      医学の歩み 217

      Pages: 787-762

    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3'telomeric overhang in cancer cells2006

    • Author(s)
      Hidetoshi Tahara
    • Journal Title

      Oncogene 25

      Pages: 1955-1966

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] 細胞増殖のしくみ-細胞周期,癌遺伝子,細胞老化-2006

    • Author(s)
      井出 利憲
    • Journal Title

      薬学雑誌 126

      Pages: 1087-1115

    • NAID

      110004857373

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells2006

    • Author(s)
      Hidetoshi Tahara
    • Journal Title

      Oncogene 25

      Pages: 1955-1966

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] 細胞老化-細胞老化は個体老化の原因である2006

    • Author(s)
      井出 利憲
    • Journal Title

      医学の歩み 217

      Pages: 757-762

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] 細胞増殖のしくみ-細胞周期,癌遺伝子,細胞老化-2006

    • Author(s)
      井出 利憲
    • Journal Title

      広島医学雑誌 54

      Pages: 1-43

    • NAID

      110004857373

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells.2006

    • Author(s)
      井出利憲ほか6名
    • Journal Title

      Oncogene 25

      Pages: 1955-1966

    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] 内因性細胞老化(老化時計)2006

    • Author(s)
      井出 利憲
    • Journal Title

      肝, 胆, 膵 55

      Pages: 13-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] 細胞増殖のしくみ--細胞周期、癌遺伝子、細胞老化2006

    • Author(s)
      井出利憲
    • Journal Title

      薬学雑誌 126

      Pages: 1087-1115

    • NAID

      110004857373

    • Data Source
      KAKENHI-PROJECT-18590058
  • [Journal Article] Mitogenic signalling and the p16^<ink4a>-Rb pathway cooperate to enforce irreversible cellular senescence through activating ROS/PKC-delta signalling pathway.2006

    • Author(s)
      井出利憲ほか9名
    • Journal Title

      Nature Cell Biology 8

      Pages: 1291-1297

    • Data Source
      KAKENHI-PROJECT-18590058
  • [Presentation] Development of anti-cancer drugs targeted on telomere G-tail2006

    • Author(s)
      Hidetoshi Tahara
    • Organizer
      Sixty-fifth Annual Meeting of the Japanese Canser Association
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Kanagawa, Japan
    • Year and Date
      2006-09-26
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590058
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  • 2.  田矢 洋一 (60133641)
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